3.4.24.11: neprilysin

This is an abbreviated version!
For detailed information about neprilysin, go to the full flat file.

Word Map on EC 3.4.24.11

3.4.24.11

angiotensin

natriuretic

alzheimer

angiotensin-converting

phosphoramidon

atrial

amyloid

thiorphan

cardiovascular

hypertension

bradykinin

neuropeptides

aminopeptidase

ejection

airway

anp

ventricular

blocker

captopril

endothelins

opioids

metallopeptidase

tachykinins

renin-angiotensin

hf

valsartan

enalapril

renin-angiotensin-aldosterone

neurokinin

vasoactive

endothelin-converting

hfref

naloxone

insulin-degrading

bestatin

kinin

diuretic

3.4.15.1

lily

aceis

met-enkephalin

bronchoconstriction

angioedema

amastatin

angiotensin-1-7

kininase

lisinopril

nt-probnp

medicine

bronchoconstrictors

pharmacology

analysis

molecular biology

angiotensin-receptor

Reaction

preferential cleavage of polypeptides between hydrophobic residues, particularly with Phe or Tyr at P1' =

Synonyms

Abeta-degrading enzyme, acute lymphoblastic leukemia antigen, antigen, CALLA (common acute lymphoblastic leukemia-associated), atriopeptidase, CALLA, CALLA (common acute lymphoblastic leukemia-associated) antigens, CALLA antigen, CALLA glycoproteins, CD10, CD10/neutral endopeptidase, CD10/neutral endopeptidase 24.11, common acute lymphoblastic leukemia antigen, common acute lymphoblastic leukemia-associated antigens, Common acute lymphocytic leukemia antigen, endopeptidase CD10, Endopeptidase-2, endopeptidase-24.11, enkephalinase, EP24.11, glycoprotein, CALLA, kidney-brush-border neutral endopeptidase, kidney-brush-border neutral peptidase, kidney-brush-border neutral proteinase, membrane metallo-endopeptidase, membrane metalloendopeptidase, MME, NEP, NEP 24.11, NEP, enkephalinase, neutrophil cluster-differentiation antigen 10, common acute lymphoblastic leukemia antigen, NEP-1, NEP/CD10, NEP2, NEP4A, NEP4B, neprilypsin, neprilysin, neprilysin 4, neutral endopeptidase, neutral endopeptidase 24.11, neutral endopeptidase 24.11/CD10, neutral metallendopeptidase, NL-1, peptidase, endo-, peptidase, membrane metalloendo-, SEP, skin fibroblast elastase

ECTree

3 Hydrolases

3.4 Acting on peptide bonds (peptidases)

3.4.24 Metalloendopeptidases

3.4.24.11 neprilysin

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Results	in table
8	Activating Compound
1426	AA Sequence
16	Application
1	CAS Registry Number
30	Cloned(Commentary)
5	Crystallization (Commentary)
5034	Disease/ Diagnostics
8	Expression
54	General Information
122	IC50 Value
302	Inhibitors
20	kcat/KM [mM/s]
18	Ki Value [mM]
162	KM Value [mM]
41	Localization
26	Metals/Ions
18	Molecular Weight [Da]
67	Natural Substrates/ Products (Substrates)
174	Organism
25	PDB ID
32	pH Optimum
8	pH Range
14	Posttranslational Modification
50	Protein Variants
18	Purification (Commentary)
1	Reaction
6	Reaction Type
173	Reference
229	Source Tissue
9	Specific Activity [micromol/min/mg]
446	Substrates and Products (Substrate)
9	Subunits
145	Synonyms
17	Temperature Optimum [°C]
1	Temperature Stability [°C]
77	Turnover Number [1/s]

KI Value

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KI Value on EC 3.4.24.11 - neprilysin

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0.036

angiotensin I

Homo sapiens

hydrolysis of Leu5-enkephalin

670479

0.162

bradykinin

Homo sapiens

hydrolysis of Leu5-enkephalin

670479

0.001 - 0.0025

Insulin B chain

5 entries

0.022

Met5-enkephalin

Homo sapiens

hydrolysis of Leu5-enkephalin

670479

0.039

neurotensin

Homo sapiens

hydrolysis of Leu5-enkephalin

670479

0.000003

omapatrilat

Homo sapiens

P08473

pH and temperature not specified in the publication

754689

0.0000008

phosphoramidon

Homo sapiens

P08473

pH and temperature not specified in the publication

754689

0.19

Substance P

Homo sapiens

hydrolysis of Leu5-enkephalin

670479

0.44 - 1.24

Tat peptide 5118

4 entries

0.000004 - 0.00191

thiorphan

2 entries