3.4.24.11: neprilysin

This is an abbreviated version!
For detailed information about neprilysin, go to the full flat file.

Reaction

preferential cleavage of polypeptides between hydrophobic residues, particularly with Phe or Tyr at P1' =

Synonyms

Abeta-degrading enzyme, acute lymphoblastic leukemia antigen, antigen, CALLA (common acute lymphoblastic leukemia-associated), atriopeptidase, CALLA, CALLA (common acute lymphoblastic leukemia-associated) antigens, CALLA antigen, CALLA glycoproteins, CD10, CD10/neutral endopeptidase, CD10/neutral endopeptidase 24.11, common acute lymphoblastic leukemia antigen, common acute lymphoblastic leukemia-associated antigens, Common acute lymphocytic leukemia antigen, endopeptidase CD10, Endopeptidase-2, endopeptidase-24.11, enkephalinase, EP24.11, glycoprotein, CALLA, kidney-brush-border neutral endopeptidase, kidney-brush-border neutral peptidase, kidney-brush-border neutral proteinase, membrane metallo-endopeptidase, membrane metalloendopeptidase, MME, NEP, NEP 24.11, NEP, enkephalinase, neutrophil cluster-differentiation antigen 10, common acute lymphoblastic leukemia antigen, NEP-1, NEP/CD10, NEP2, NEP4A, NEP4B, neprilypsin, neprilysin, neprilysin 4, neutral endopeptidase, neutral endopeptidase 24.11, neutral endopeptidase 24.11/CD10, neutral metallendopeptidase, NL-1, peptidase, endo-, peptidase, membrane metalloendo-, SEP, skin fibroblast elastase

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.24 Metalloendopeptidases

                3.4.24.11 neprilysin

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Results	in table
8	Activating Compound
1426	AA Sequence
16	Application
1	CAS Registry Number
30	Cloned(Commentary)
5	Crystallization (Commentary)
5034	Disease/ Diagnostics
8	Expression
54	General Information
122	IC50 Value
302	Inhibitors
20	kcat/KM [mM/s]
18	Ki Value [mM]
162	KM Value [mM]
41	Localization
26	Metals/Ions
18	Molecular Weight [Da]
67	Natural Substrates/ Products (Substrates)
174	Organism
25	PDB ID
32	pH Optimum
8	pH Range
14	Posttranslational Modification
50	Protein Variants
18	Purification (Commentary)
1	Reaction
6	Reaction Type
173	Reference
229	Source Tissue
9	Specific Activity [micromol/min/mg]
446	Substrates and Products (Substrate)
9	Subunits
145	Synonyms
17	Temperature Optimum [°C]
1	Temperature Stability [°C]
77	Turnover Number [1/s]

Molecular Weight

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Molecular Weight on EC 3.4.24.11 - neprilysin

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MOLECULAR WEIGHT

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

104000

Canis lupus familiaris

-

x * 104000, enzyme from glomeruli, SDS-PAGE

81638

113000

Drosophila melanogaster

Q9I7I4

isoform B, SDS-PAGE using purified NEP4 antiserum

709308

120000

Drosophila melanogaster

Q9I7I4

isoform A, SDS-PAGE using purified NEP4 antiserum

709308

270000 - 320000

Mus musculus

-

gel filtration

31018

280000

Sus scrofa

-

brain enzyme, gel filtration

81634

320000

Sus scrofa

-

kidney enzyme, gel filtration

81635

81000

Mus musculus

-

probably 4 * 81000, SDS-PAGE in presence of 2-mercaptoethanol

31018

82000 - 82410

Homo sapiens

P08473

recombinant enzyme, gel filtration

735116

84000

Homo sapiens

P08473

x * 84000, recombinant soluble screted His-tagged enzyme, SDS-PAGE

733595

87000

Sus scrofa

-

x * 87000, brain enzyme, SDS-PAGE

81630, 81634

89000

Sus scrofa

-

x * 89000, kidney enzyme, SDS-PAGE

81635

90000

Bos taurus

-

gel filtration

81641

91000

Sus scrofa

-

x * 91000, SDS-PAGE

81623

92000

Rattus norvegicus

-

gel filtration

81645

94000

2 entries

97000

Homo sapiens

-

-

688534

94000

Homo sapiens

-

-

685866

94000

Canis lupus familiaris

-

x * 94000, enzyme from tubules, SDS-PAGE

81638