3.4.24.11: neprilysin
This is an abbreviated version!
For detailed information about neprilysin, go to the full flat file.
Word Map on EC 3.4.24.11
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3.4.24.11
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angiotensin
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natriuretic
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alzheimer
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angiotensin-converting
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phosphoramidon
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atrial
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amyloid
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thiorphan
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cardiovascular
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hypertension
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bradykinin
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neuropeptides
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aminopeptidase
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ejection
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airway
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anp
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ventricular
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blocker
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captopril
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endothelins
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opioids
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metallopeptidase
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tachykinins
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renin-angiotensin
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hf
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valsartan
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enalapril
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renin-angiotensin-aldosterone
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neurokinin
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vasoactive
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endothelin-converting
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hfref
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naloxone
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insulin-degrading
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bestatin
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kinin
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diuretic
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3.4.15.1
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lily
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aceis
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met-enkephalin
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bronchoconstriction
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angioedema
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amastatin
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angiotensin-1-7
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kininase
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lisinopril
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nt-probnp
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medicine
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bronchoconstrictors
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pharmacology
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analysis
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molecular biology
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angiotensin-receptor
- 3.4.24.11
- angiotensin
-
natriuretic
- alzheimer
-
angiotensin-converting
- phosphoramidon
- atrial
-
amyloid
- thiorphan
- cardiovascular
- hypertension
- bradykinin
- neuropeptides
- aminopeptidase
-
ejection
- airway
- anp
- ventricular
-
blocker
- captopril
- endothelins
-
opioids
- metallopeptidase
- tachykinins
-
renin-angiotensin
- hf
- valsartan
- enalapril
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renin-angiotensin-aldosterone
- neurokinin
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vasoactive
-
endothelin-converting
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hfref
- naloxone
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insulin-degrading
- bestatin
- kinin
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diuretic
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3.4.15.1
-
lily
-
aceis
- met-enkephalin
-
bronchoconstriction
- angioedema
- amastatin
-
angiotensin-1-7
-
kininase
- lisinopril
-
nt-probnp
- medicine
-
bronchoconstrictors
- pharmacology
- analysis
- molecular biology
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angiotensin-receptor
Reaction
preferential cleavage of polypeptides between hydrophobic residues, particularly with Phe or Tyr at P1' =
Synonyms
Abeta-degrading enzyme, acute lymphoblastic leukemia antigen, antigen, CALLA (common acute lymphoblastic leukemia-associated), atriopeptidase, CALLA, CALLA (common acute lymphoblastic leukemia-associated) antigens, CALLA antigen, CALLA glycoproteins, CD10, CD10/neutral endopeptidase, CD10/neutral endopeptidase 24.11, common acute lymphoblastic leukemia antigen, common acute lymphoblastic leukemia-associated antigens, Common acute lymphocytic leukemia antigen, endopeptidase CD10, Endopeptidase-2, endopeptidase-24.11, enkephalinase, EP24.11, glycoprotein, CALLA, kidney-brush-border neutral endopeptidase, kidney-brush-border neutral peptidase, kidney-brush-border neutral proteinase, membrane metallo-endopeptidase, membrane metalloendopeptidase, MME, NEP, NEP 24.11, NEP, enkephalinase, neutrophil cluster-differentiation antigen 10, common acute lymphoblastic leukemia antigen, NEP-1, NEP/CD10, NEP2, NEP4A, NEP4B, neprilypsin, neprilysin, neprilysin 4, neutral endopeptidase, neutral endopeptidase 24.11, neutral endopeptidase 24.11/CD10, neutral metallendopeptidase, NL-1, peptidase, endo-, peptidase, membrane metalloendo-, SEP, skin fibroblast elastase
ECTree
3.4.24.11 neprilysinAdvanced search results
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results (Source Tissue
Source Tissue on EC 3.4.24.11 - neprilysin
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SOURCE TISSUE 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
SOURCE
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tissue NEP activity and its protein and mRNA expression are lower in the late phase of the septic shock compared to the early phase of the shock and the control
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NEP expression is down-regulated in bovine vascular endothelial cells by physiological laminar shear, possibly via a mechanotransduction mechanism involving NADPH oxidase-induced reactive oxygen species production
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a large fraction of the enzyme is localized on intrinsic striatal neurons
Q9I7I4
expression is demonstrated during embryogenesis in pericardial cells, muscle founder cells, glia cells and male gonads. At least one isoform of NEP4 is found in every developmental stage
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both staurosporine-stimulated caspase-3 activation, p53 and neprilysin expression and activity are not affected by over-expression or depletion of presenilin complex component TMP21
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tissue NEP activity and its protein and mRNA expression are lower in the late phase of the septic shock compared to the early phase of the shock and the control
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neutral endopeptidase 24.11/CD10 is expressed in tumor cells as well as stromal tissues
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expression throughout development with highest mRNA level in embryos, 1.3 larvae and adult worms. Expression of nep-1 is limited to pharyngeal cells and a single head neuron
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induction of neutral endopeptidase (NEP) activity of SK-N-SH cells by natural compounds from green tea. Caffeine leads to an increase in specific cellular neutral endopeptidase activity more than theophylline, theobromine or theanine. The combination of epigallocatechin and epigallocatechingallate with caffeine, theobromine or theophylline induces cellular neutral endopeptidase activity. The enhancement of cellular neutral endopeptidase activity by green tea extract and its natural products might be correlated with an elevated level of intracellular cyclic adenosine monophosphate
additional information
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distribution of neprilysin is almost identical in dogs and cats, being high in the striatum, globus pallidus, and substantia nigra, but very low in the cerebral cortex. The white matter and hippocampus are negative. Neprilysin activity in the brain regions is ranked from high to low as follows: thalamus/striatum > cerebral cortex > hippocampus > white matter. Amyloid-beta deposition is first detected at 7 years of age in dogs, and both the quantity and frequency of deposition increase with age. Amyloid-beta deposition appears in the cerebral cortex and the hippocampus
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distribution of neprilysin is almost identical in dogs and cats, being high in the striatum, globus pallidus, and substantia nigra, but very low in the cerebral cortex. The white matter and hippocampus are negative. Neprilysin activity in the brain regions is ranked from high to low as follows: thalamus/striatum > cerebral cortex > hippocampus > white matter. Amyloid-beta deposition is first detected at 10 years of age in cats, and both the quantity and frequency of deposition increase with age. Amyloid-beta deposition appears in the cerebral cortex and the hippocampus
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NEP-like immunoreactivity is significantly reduced in Alzheimer's disease brains compared with normal brains, in the CA4 region NEP is preserved in the hippocampal formation of Alzheimer's disease brains
the enzyme level is reduced in the brains of patients with Alzheimer's disease
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neprilysin specific activity varies across mouse strains, with the highest activities in kidney and brain of SW mice. Aging is associated with a reduction in brain neprilysin specific activity in SW strain and C57B1/6J strain. The aging- and strain-dependent differences in neprilysin specific activity may explain, at least in part, the roles that aging and background mouse strain play in differential specification of the susceptibility towards the development of cerebral Abeta amyloidosis
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in globus pallidus and substantia nigra much of the enzyme is associated with presynaptic nerve terminals originating from efferent striatal neurons
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highest activity in choroid plexus, substantia nigra, caudate putamen, globus pallidus, olfactory tubercle, nucleus accumbens. Moderate activity in amygdala, interpenducular nucleus, molecular layer of the cerebellum, periaqueductal gray matter, and the hippocampus
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enzyme in sustantia nigra and globus pallidus is localized on nerve terminals originating from neurones in the caudate putamen
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estrogen regulates neprilysin activity in brain. Ovariectomy leads to a 30% decrease in neprilysin activity at 45 or 85 days, but not 21 days, post surgery
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ethanol induces a transitory increase in NEP activities in the frontal cortex and ventral tegmental area, and in the nucleus accumbens
six-week intermittent hypoxia increases NEP expression and activity, selectively in temporal cortex, but not in the hippocampus and frontal cortex. The increase in NEP activity and expression is reverted followed by two weeks recovery in normoxia
Rattus norvegicus Wistar-Hannover
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six-week intermittent hypoxia increases NEP expression and activity, selectively in temporal cortex, but not in the hippocampus and frontal cortex. The increase in NEP activity and expression is reverted followed by two weeks recovery in normoxia
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low level of neprilysin. Amyloid-beta deposition appears in the cerebral cortex and the hippocampus
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low level of neprilysin. Amyloid-beta deposition appears in the cerebral cortex and the hippocampus
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distribution of neprilysin is high in the striatum, globus pallidus, and substantia nigra, but very low in the cerebral cortex
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distribution of neprilysin is high in the striatum, globus pallidus, and substantia nigra, but very low in the cerebral cortex
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distribution of neprilysin is high in the striatum, globus pallidus, and substantia nigra, but very low in the cerebral cortex
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distribution of neprilysin is high in the striatum, globus pallidus, and substantia nigra, but very low in the cerebral cortex
hair follicles are isolated from occipital scalp specimens, enzyme is localized in extracellular matrix, dermal papilla, and follicular epithelium, and during all stages of the hair cycle
extracellular matrix, dermal papilla, and follicular epithelium
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amyloid-beta deposition appears in the cerebral cortex and the hippocampus
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amyloid-beta deposition appears in the cerebral cortex and the hippocampus
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tissue NEP activity and its protein and mRNA expression are lower in the late phase of the septic shock compared to the early phase of the shock and the control
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neprilysin specific activity varies across mouse strains, with the highest activities in kidney and brain of SW mice
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no significant change in NEP activity and its protein and mRNA expression between late phase of the septic shock compared to the early phase of the shock and the control
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renal mRNA expression and protein of neprilysin is substantially downregulated during rapid atrial pacing. Irbesartan therapy does not prevent down-regulation of neprilysin. In contrast, TGF-beta1 mRNA expression is up-regulated. Collagen and angiotensin II type 1 receptor expression are not significantly altered by rapid atrial pacing. Application of aldosterone, atrial natriuretic peptide, asymmetric dimethylarginine, and angiotensin peptides fail to cause down-regulation of renal neprilysin expression in vitro
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tissue NEP activity and its protein and mRNA expression are lower in the late phase of the septic shock compared to the early phase of the shock and the control
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in all myopathies NEP expression is directly associated with the degree of muscle fibre regeneration. In inclusion body myositis muscle, the NEP protein is also strongly accumulated in Abeta-bearing abnormal fibres. NEP plays an important role during muscle cell differentiation, possibly through the regulation
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in neuroblastoma SH-SY5Y cells neprilysin expression is up-regulated estrogen
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two neuroblastoma cell lines differing substantially in NEP expression are compared: using chromatin immunoprecipitation it is shown that amyloid precursor protein is bound directly to the NEP promoter in high NEP-expresser (NB7) cells but not in low-expresser (SH-SY5Y) cells. The methylation status of the NEP promoter does not regulate expression in these cells, whereas the histone deacetylase inhibitors trichostatin A and valproate partly restore NEP expression and activity in SH-SY5Y cells
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expression of nep-1 is limited to pharyngeal cells and a single head neuron
CA1 neuron, NEP is almost exclusively expressed in neurons. Presynaptic terminals and intracellular locations are likely the main sites of NEP-mediated amyloid-beta degradation
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neprilysin is expressed in the neurons and axonally transported to presynaptic sites. Presynaptic neprilysin efficiently degrades amyloid-beta peptide and retards development of amyloid pathology
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androgens positively regulate neural expression of neprilysin in adult male rats
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chromatin immunoprecipitation analysis demonstrates amyloid precursor protein binding to tht NEP promoter in primary neurons
the enzyme activity in the skin is elevated at early anagen, and decreased during catagen to telogen of the hair cycle
the enzyme activity in the skin is elevated at early anagen, and decreased during catagen to telogen of the hair cycle
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distribution of neprilysin is high in the striatum, globus pallidus, and substantia nigra, but very low in the cerebral cortex
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distribution of neprilysin is high in the striatum, globus pallidus, and substantia nigra, but very low in the cerebral cortex
additional information
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the enzyme is expressed all along the differentiation pathway in B and T cell lineage
additional information
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no activity of CD10/neutral endopeptidase is detected in cultured, non-stimulated keratinocytes from healthy skin
additional information
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in cerebrocortical blood vessels and in pyramidal neurons
additional information
membrane-bound NEP from cells overexpressing the murine peptidase
additional information
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membrane-bound NEP from cells overexpressing the murine peptidase
additional information
expression and activity of NEP in cognitive-related brain structures of rats submitted to chronic intermittent hypoxia (CIH)
additional information
Rattus norvegicus Wistar-Hannover
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expression and activity of NEP in cognitive-related brain structures of rats submitted to chronic intermittent hypoxia (CIH)
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