Information on EC 3.4.24.11 - neprilysin

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The expected taxonomic range for this enzyme is: Eukaryota, Bacteria

EC NUMBER
COMMENTARY hide
3.4.24.11
-
RECOMMENDED NAME
GeneOntology No.
neprilysin
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
preferential cleavage of polypeptides between hydrophobic residues, particularly with Phe or Tyr at P1'
show the reaction diagram
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of peptide bond
CAS REGISTRY NUMBER
COMMENTARY hide
82707-54-8
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
evolution
malfunction
metabolism
physiological function
additional information
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
2-aminobenzoyl-ARFK-2,4-dinitrophenyl ester + H2O
2-aminobenzoyl-AR + FK-2,4-dinitrophenyl ester
show the reaction diagram
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-
-
-
ir
2-aminobenzoyl-DRFK-2,4-dinitrophenyl ester + H2O
2-aminobenzoyl-DR + FK-2,4-dinitrophenyl ester
show the reaction diagram
-
-
-
-
ir
2-aminobenzoyl-FRFK-2,4-dinitrophenyl ester + H2O
2-aminobenzoyl-FR + FK-2,4-dinitrophenyl ester
show the reaction diagram
-
-
-
-
ir
2-aminobenzoyl-HRFK-2,4-dinitrophenyl ester + H2O
2-aminobenzoyl-HR + FK-2,4-dinitrophenyl ester
show the reaction diagram
-
-
-
-
ir
2-aminobenzoyl-IRFK-2,4-dinitrophenyl ester + H2O
2-aminobenzoyl-IR + FK-2,4-dinitrophenyl ester
show the reaction diagram
-
-
-
-
ir
2-aminobenzoyl-KRFK-2,4-dinitrophenyl ester + H2O
2-aminobenzoyl-KR + FK-2,4-dinitrophenyl ester
show the reaction diagram
-
-
-
-
ir
2-aminobenzoyl-LRFK-2,4-dinitrophenyl ester + H2O
2-aminobenzoyl-LR + FK-2,4-dinitrophenyl ester
show the reaction diagram
-
-
-
-
ir
2-aminobenzoyl-NRFK-2,4-dinitrophenyl ester + H2O
2-aminobenzoyl-NR + FK-2,4-dinitrophenyl ester
show the reaction diagram
-
-
-
-
ir
2-aminobenzoyl-RAFK-2,4-dinitrophenyl ester + H2O
2-aminobenzoyl-RA + FK-2,4-dinitrophenyl ester
show the reaction diagram
-
-
-
-
ir
2-aminobenzoyl-RDFK-2,4-dinitrophenyl ester + H2O
2-aminobenzoyl-RD + FK-2,4-dinitrophenyl ester
show the reaction diagram
-
-
-
-
ir
2-aminobenzoyl-REFK-2,4-dinitrophenyl ester + H2O
2-aminobenzoyl-RE + FK-2,4-dinitrophenyl ester
show the reaction diagram
-
-
-
-
ir
2-aminobenzoyl-rGF-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-D-Arg-Gly + Phe-N-(2,4-dinitrophenyl)ethylenediamine
show the reaction diagram
-
-
-
-
ir
2-aminobenzoyl-RGFK(Dnp)-OH + H2O
2-aminobenzoyl-RG + FK-2,4-dinitrophenyl ester
show the reaction diagram
-
-
-
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ir
2-aminobenzoyl-RGFK-2,4-dinitrophenyl amide + H2O
2-aminobenzoyl-RG + FK-2,4-dinitrophenyl amide
show the reaction diagram
-
-
-
-
ir
2-aminobenzoyl-RGFK-2,4-dinitrophenyl ester + H2O
2-aminobenzoyl-RG + FK-2,4-dinitrophenyl ester
show the reaction diagram
-
-
-
-
ir
2-aminobenzoyl-rGL-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-D-Arg-Gly + Leu-N-(2,4dinitrophenyl)ethylenediamine
show the reaction diagram
-
-
-
-
ir
2-aminobenzoyl-rGV-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-D-Arg-Gly + Val-N-(2,4-dinitrophenyl)ethylenediamine
show the reaction diagram
-
-
-
-
ir
2-aminobenzoyl-RHFK-2,4-dinitrophenyl ester + H2O
2-aminobenzoyl-RH + FK-2,4-dinitrophenyl ester
show the reaction diagram
-
-
-
-
ir
2-aminobenzoyl-RKFK-2,4-dinitrophenyl ester + H2O
2-aminobenzoyl-RK + FK-2,4-dinitrophenyl ester
show the reaction diagram
-
-
-
-
ir
2-aminobenzoyl-RNFK-2,4-dinitrophenyl ester + H2O
2-aminobenzoyl-RN + FK-2,4-dinitrophenyl ester
show the reaction diagram
-
-
-
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ir
2-aminobenzoyl-RPFK-2,4-dinitrophenyl ester + H2O
2-aminobenzoyl-RP + FK-2,4-dinitrophenyl ester
show the reaction diagram
-
-
-
-
ir
2-aminobenzoyl-RQFK-2,4-dinitrophenyl ester + H2O
2-aminobenzoyl-RQ + FK-2,4-dinitrophenyl ester
show the reaction diagram
-
-
-
-
ir
2-aminobenzoyl-RRFK-2,4-dinitrophenyl amide + H2O
2-aminobenzoyl-RR + FK-2,4-dinitrophenyl amide
show the reaction diagram
-
-
-
-
ir
2-aminobenzoyl-RRFK-2,4-dinitrophenyl ester + H2O
2-aminobenzoyl-RG + FK-2,4-dinitrophenyl ester
show the reaction diagram
-
-
-
-
ir
2-aminobenzoyl-RRFK-2,4-dinitrophenyl ester + H2O
2-aminobenzoyl-RR + FK-2,4-dinitrophenyl ester
show the reaction diagram
-
-
-
-
ir
2-aminobenzoyl-rRL-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-D-Arg-L-Arg + Leu-N-(2,4-dinitrophenyl)ethylenediamine
show the reaction diagram
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-
-
-
ir
2-aminobenzoyl-RSFK-2,4-dinitrophenyl ester + H2O
2-aminobenzoyl-RS + FK-2,4-dinitrophenyl ester
show the reaction diagram
-
-
-
-
ir
2-aminobenzoyl-rSL-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-D-Arg-L-Ser + Leu-N-(2,4-dinitrophenyl)ethylenediamine
show the reaction diagram
-
-
-
-
ir
2-aminobenzoyl-RTFK-2,4-dinitrophenyl ester + H2O
2-aminobenzoyl-RT + FK-2,4-dinitrophenyl ester
show the reaction diagram
-
-
-
-
ir
2-aminobenzoyl-SRFK-2,4-dinitrophenyl ester + H2O
2-aminobenzoyl-SR + FK-2,4-dinitrophenyl ester
show the reaction diagram
-
-
-
-
ir
2-aminobenzoyl-TRFK-2,4-dinitrophenyl ester + H2O
2-aminobenzoyl-TR + FK-2,4-dinitrophenyl ester
show the reaction diagram
-
-
-
-
ir
2-aminobenzoyl-VRFK-2,4-dinitrophenyl ester + H2O
2-aminobenzoyl-VR + FK-2,4-dinitrophenyl ester
show the reaction diagram
-
-
-
-
ir
2-aminobenzoyl-WRFK-2,4-dinitrophenyl ester + H2O
2-aminobenzoyl-WR + FK-2,4-dinitrophenyl ester
show the reaction diagram
-
-
-
-
ir
2-aminobenzoyl-YRFK-2,4-dinitrophenyl ester + H2O
2-aminobenzoyl-YR + FK-2,4-dinitrophenyl ester
show the reaction diagram
-
-
-
-
ir
acetyl-Arg-Pro-Pro-Gly-Phe-Ser-Ala-Phe-Lys(2,4-dinitrophenyl)-7-methoxy-4-coumarine + H2O
?
show the reaction diagram
-
bradykinin-based quenched fluorescent substrate assay
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-
?
adrenocorticotropic hormone + H2O
?
show the reaction diagram
-
-
-
-
?
Aldolase + H2O
?
show the reaction diagram
-
-
-
-
?
alpha-endorphin + H2O
?
show the reaction diagram
-
-
-
-
?
alpha-neoendorphin + H2O
?
show the reaction diagram
amyloid beta peptide + H2O
?
show the reaction diagram
amyloid beta peptide Abeta42 + H2O
?
show the reaction diagram
-
the peptide primarily undergoes degradation by NEP in vivo in the brain
-
-
?
amyloid beta peptide1-40 + H2O
?
show the reaction diagram
amyloid beta peptide1-40 + H2O
Asp1-Lys16 + Asp1-Leu17 + Asp1-Phe19
show the reaction diagram
-
the wild-type enzyme cleaves Ab1-40 predominantly at Lys16-Leu17, Leu17-Val18 and Phe19-Phe20. The mutant G399V/G714K cleaves preferentially at Phe20-Ala21
main cleavage fragments after 60 min with the wild-type enzyme. After 360 min these fragments are degraded further, accompanied by the appearance of Val12-Leu17 and Tyr10-Leu17 fragments
-
?
amyloid beta peptide1-42 + H2O
?
show the reaction diagram
amyloid beta(1-40) mutant A21G + H2O
?
show the reaction diagram
-
Flemish variant of amyloid beta. Decreased degradation by neprilysin compared to either wild-type peptide or the other mutant peptides
-
-
?
amyloid beta(1-40) mutant D23N + H2O
?
show the reaction diagram
-
Iowa variant of amyloid beta
-
-
?
amyloid beta(1-40) mutant E22G + H2O
?
show the reaction diagram
-
Arctic variant of amyloid beta
-
-
?
amyloid beta(1-40) mutant E22K + H2O
?
show the reaction diagram
-
Italian variant of amyloid beta
-
-
?
amyloid beta(1-40) mutant E22Q + H2O
?
show the reaction diagram
-
Dutch variant of amyloid beta
-
-
?
amyloid beta(1-40) peptide + H2O
?
show the reaction diagram
-
-
-
-
?
Angiotensin + H2O
?
show the reaction diagram
-
-
-
-
?
Angiotensin I + H2O
?
show the reaction diagram
Angiotensin II + H2O
?
show the reaction diagram
angiotensin III + H2O
?
show the reaction diagram
-
-
-
-
?
angiotensin(1-9) + H2O
?
show the reaction diagram
-
-
-
-
?
Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2 + H2O
?
show the reaction diagram
Arg-vasopressin + H2O
?
show the reaction diagram
-
-
-
-
?
Asp-Tyr(SO3H)-Met-Gly-Trp-Met-Asp-PheNH2 + H2O
?
show the reaction diagram
Atrial natriuretic factor + H2O
?
show the reaction diagram
atrial natriuretic peptide + H2O
?
show the reaction diagram
azocasein + H2O
?
show the reaction diagram
-
-
-
-
?
Azocoll + H2O
?
show the reaction diagram
-
-
-
-
?
benzoyl-Gly-Gly-Leu-p-nitroanilide + H2O
benzoyl-Gly-Gly + Leu-p-nitroanilide
show the reaction diagram
-
-
-
?
benzyloxycarbonyl-Ala-Gly-Leu-Ala + H2O
?
show the reaction diagram
-
-
-
-
?
benzyloxycarbonyl-Phe-Arg-4-methyl-7-coumarylamide + H2O
?
show the reaction diagram
-
-
-
-
?
beta-amyloid peptide + H2O
?
show the reaction diagram
-
-
-
-
?
beta-lipotropin(61-69) + H2O + H2O
?
show the reaction diagram
beta-neoendorphin + H2O
?
show the reaction diagram
Bradykinin + H2O
?
show the reaction diagram
casein + H2O
?
show the reaction diagram
-
-
-
-
?
cholecystokinin-8 + H2O
?
show the reaction diagram
D-Ala2-Leu5-enkephalin + H2O
Tyr-D-Ala-Gly + Phe-Leu
show the reaction diagram
D-Ala2-Leu5-enkephalinamide + H2O
?
show the reaction diagram
-
-
-
-
?
dansyl-Gly-Trp-Gly + H2O
dansyl-Gly + Trp-Gly
show the reaction diagram
-
-
-
?
dansyl-Gly-Tyr-Gly + H2O
dansyl-Gly + Tyr-Gly
show the reaction diagram
-
-
-
?
dansyl-Gly-Tyr-Gly-NH2 + H2O
dansyl-Gly + Tyr-Gly-NH2
show the reaction diagram
-
-
-
-
?
dynorphin + H2O
?
show the reaction diagram
dynorphin(1-9) + H2O
?
show the reaction diagram
-
-
-
-
?
Elastin + H2O
?
show the reaction diagram
endothelin-1 + H2O
?
show the reaction diagram
-
-
-
-
?
enkephalin + H2O
?
show the reaction diagram
exendin-4 + H2O
?
show the reaction diagram
-
poor substrate
-
-
?
FMRF amide + H2O
?
show the reaction diagram
galanin + H2O
?
show the reaction diagram
-
-
-
-
?
gamma-endorphin + H2O
?
show the reaction diagram
gastric inhibitor peptide + H2O
?
show the reaction diagram
-
poor substrate
-
-
?
gastrin + H2O
?
show the reaction diagram
gastrin G-17 + H2O
?
show the reaction diagram
gastrin releasing peptide-10 + H2O
?
show the reaction diagram
GLP-1 + H2O
?
show the reaction diagram
-
-
-
-
?
GLP-1(7-36)amide + H2O
?
show the reaction diagram
-
insulinotropic peptide hormone
-
-
?
Glucagon + H2O
?
show the reaction diagram
glucagon-like peptide 1 + H2O
?
show the reaction diagram
-
-
-
-
?
glutaryl-Ala-Ala-Phe-2-naphthylamide + H2O
glutaryl-Ala-Ala + Phe-2-naphthylamide
show the reaction diagram
-
-
-
?
glutaryl-Ala-Ala-Phe-4-methoxy-2-naphthylamide + H2O
glutaryl-Ala-Ala + Phe-4-methoxy-2-naphthylamide
show the reaction diagram
-
-
-
?
glutaryl-Ala-Ala-Phe-4-methoxy-2-naphthylamide + H2O
glutaryl-Ala-Ala-Phe + 4-methoxy-2-naphthylamide
show the reaction diagram
glutaryl-Ala-Ala-Phe-4-methoxy-2-naphthylamine + H2O
?
show the reaction diagram
-
-
-
-
?
glutaryl-Gly-Gly-Phe-2-naphthylamide + H2O
glutaryl-Gly-Gly + Phe-2-naphthylamide
show the reaction diagram
-
-
-
?
glutaryl-Gly-Gly-Phe-2-naphthylamide + H2O
glutaryl-Gly-Gly-Phe + 2-naphthylamine
show the reaction diagram
-
-
-
-
?
Gly-Trp-Gly + H2O
?
show the reaction diagram
-
-
-
-
?
GRP 2664 + H2O
?
show the reaction diagram
-
-
-
-
?
haemoglobin + H2O
?
show the reaction diagram
-
-
-
-
?
hippuryl-Arg-Arg-Ala-2-naphthylamide + H2O
hippuryl-Arg-Arg + Ala-2-naphthylamide
show the reaction diagram
-
-
-
-
?
hippuryl-Arg-Arg-Leu-2-naphthylamide + H2O
hippuryl-Arg-Arg + Leu-2-naphthylamide
show the reaction diagram
His-Lys-Thr-Asp-Ser-Phe-Val-Gly-Leu-Met-NH2 + H2O
His-Lys-Thr-Asp-Ser + Phe-Val-Gly + Leu-Met-NH2
show the reaction diagram
insulin B chain + H2O
?
show the reaction diagram
interleukin 1beta + H2O
?
show the reaction diagram
Leu-2-naphthylamide + H2O
?
show the reaction diagram
-
-
-
-
?
Leu5-enkephalin + H2O
?
show the reaction diagram
Leu5-enkephalin-Arg6 + H2O
?
show the reaction diagram
-
-
-
-
?
Leu5-enkephalinamide + H2O
?
show the reaction diagram
leucine5-enkephalin + H2O
?
show the reaction diagram
-
Tyr-Gly-Gly-Phe-Leu is cleaved at the Gly-Phe bond by the wild-type enzyme
-
-
?
Luliberin + H2O
?
show the reaction diagram
-
poor substrate
-
-
?
Luteinizing hormone-releasing hormone + H2O
?
show the reaction diagram
Met-enkephalin-Arg6-Gly7-Leu + H2O
?
show the reaction diagram
Met-Leu-Phe + H2O
?
show the reaction diagram
Met5-enkephalin-Arg6 + H2O
?
show the reaction diagram
-
-
-
-
?
Met5-enkephalin-Arg6-Phe7 + H2O
?
show the reaction diagram
N-(4-carboxy-1-oxobutyl)-L-alanyl-L-alanyl-N-(4-methoxy-2-naphthalenyl)-L-phenylalaninamide + H2O
N-(4-carboxy-1-oxobutyl)-L-alanyl-L-alanyl-L-phenylalanine + 4-methoxy-beta-naphthylamide
show the reaction diagram
-
-
-
-
?
N-acetyl-Gly-Trp-Gly + H2O
N-acetyl-Gly + Trp-Gly
show the reaction diagram
-
-
-
-
?
N-dansyl-Ala-Gly-D-(4-nitro-Phe)-Gly + H2O
?
show the reaction diagram
-
-
-
-
?
N-dansyl-D-Ala-Gly-p-nitrophenyl-Ala-Gly + H2O
?
show the reaction diagram
N-formyl-L-Met-Leu-Phe + H2O
?
show the reaction diagram
-
the enzyme may play an important role in modulating chemotactic response by cleavage of the chemotactic substance N-formyl-Met-Leu-Phe
-
-
-
N-Formyl-Met-Leu-Phe + H2O
N-Formyl-Met + Leu-Phe
show the reaction diagram
-
-
-
?
Na,K-ATPase alpha subunit + H2O
?
show the reaction diagram
-
-
-
-
?
Nalpha-benzoyl-Gly-Arg-Arg-Ala-2-naphthylamide + H2O
Nalpha-benzoyl-Gly-Arg-Arg + Ala-2-naphthylamide
show the reaction diagram
-
-
-
?
Nalpha-benzoyl-Gly-Arg-Arg-Leu-2-naphthylamide + H2O
Nalpha-benzoyl-Gly-Arg-Arg + Leu-2-naphthylamide
show the reaction diagram
-
-
-
?
Nalpha-benzoyl-Gly-Arg-Arg-Phe-2-naphthylamide + H2O
Nalpha-benzoyl-Gly-Arg-Arg + Phe-2-naphthylamide
show the reaction diagram
-
-
-
?
Nalpha-benzoyl-Gly-Arg-Leu-2-naphthylamide + H2O
Nalpha-benzoyl-Gly-Arg + Leu-2-naphthylamide
show the reaction diagram
-
-
-
?
Nalpha-benzoyl-Gly-Gly-Arg-Leu-2-naphthylamide + H2O
Nalpha-benzoyl-Gly-Gly-Arg + Leu-2-naphthylamide
show the reaction diagram
-
-
-
?
Nalpha-benzoyl-Gly-Lys-Arg-Arg-Leu-2-naphthylamide + H2O
Nalpha-benzoyl-Gly-Lys-Arg-Arg + Leu-2-naphthylamide
show the reaction diagram
-
-
-
?
Nalpha-benzoyl-Gly-Lys-Lys-Arg-Arg-Leu-2-naphthylamide + H2O
Nalpha-benzoyl-Gly-Lys-Lys-Arg-Arg + Leu-2-naphthylamide
show the reaction diagram
-
-
-
?
Neurokinin A + H2O
?
show the reaction diagram
-
-
-
-
?
neurokinin B + H2O
?
show the reaction diagram
neuropeptide Y + H2O
truncated neuropeptide Y + C-terminal fragments of neuropeptide Y
show the reaction diagram
-
-
neuropeptide Y 21-36 and 31-36 are the most abundant fragments generated in vivo
-
?
neurotensin + H2O
?
show the reaction diagram
nociceptin + H2O
?
show the reaction diagram
-
-
-
-
?
oxytocin + H2O
?
show the reaction diagram
pBNP-26 + H2O
?
show the reaction diagram
-
cleaved at several sites
-
-
?
physalaemin + H2O
?
show the reaction diagram
pulmonary vasodilative vasoactive intestinal peptide + H2O
?
show the reaction diagram
-
rapid inactivation
-
-
?
pyroglutamyl-Leu-Asn-Phe-Thr-Pro-Asn-Trp-Gly-Thr-NH2 + H2O
pyroglutamyl-Leu-Asn + Phe-Thr-Pro-ASn-Trp-Gly-Thr-NH2
show the reaction diagram
Secretin + H2O
?
show the reaction diagram
-
-
-
-
?
somatostatin 14 + H2O
?
show the reaction diagram
-
-
-
-
?
somatostatin 28 + H2O
?
show the reaction diagram
-
-
-
-
?
striatal natriuretic factor + H2O
?
show the reaction diagram
-
-
-
-
?
Substance P + H2O
?
show the reaction diagram
succinyl-Ala-Ala-Phe-4-methylcoumarin 7-amide + H2O
succinyl-Ala-Ala + Phe-4-methylcoumarin 7-amide
show the reaction diagram
succinyl-Ala-Ala-Phe-7-amido-4-methylcoumarin + H2O
?
show the reaction diagram
succinyl-Ala-Ala-Phe-p-nitroanilide + H2O
?
show the reaction diagram
-
-
-
-
?
succinyl-Arg-Arg-Leu-2-naphthylamide + H2O
succinyl-Arg-Arg + Leu-2-naphthylamide
show the reaction diagram
-
-
-
?
succinyl-Arg-Pro-Phe-His-Leu-Leu-Val-Tyr-7-amido-4-methylcoumarin + H2O
?
show the reaction diagram
-
-
-
-
?
tachykinin + H2O
?
show the reaction diagram
27.8% degradation
-
-
?
Tyr-D-Ala-Gly-Phe-Leu + H2O
Tyr-D-Ala-Gly + Phe-Leu
show the reaction diagram
-
-
-
?
Tyr-D-Ala-Gly-Phe-Met + H2O
Tyr-D-Ala-Gly + Phe-Met
show the reaction diagram
Tyr-D-Ala-Gly-Phe-Met-NH2 + H2O
Tyr-D-Ala-Gly + Phe-Met-NH2
show the reaction diagram
Tyr-Gly-Gly-Phe-Met + H2O
Tyr-Gly-Gly + Phe-Met
show the reaction diagram
Vasoactive intestinal peptide + H2O
?
show the reaction diagram
-
-
-
-
?
Z-Ala-Ala-Leu-4-nitroanilide + H2O
Z-Ala-Ala-Leu + 4-nitroaniline
show the reaction diagram
-
-
-
-
?
additional information
?
-
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
amyloid beta peptide + H2O
?
show the reaction diagram
amyloid beta peptide Abeta42 + H2O
?
show the reaction diagram
-
the peptide primarily undergoes degradation by NEP in vivo in the brain
-
-
?
amyloid beta peptide1-40 + H2O
?
show the reaction diagram
amyloid beta peptide1-42 + H2O
?
show the reaction diagram
Atrial natriuretic factor + H2O
?
show the reaction diagram
-
dominant enzyme in the hydrolysis of atrial natriuretic factor
-
-
-
Bradykinin + H2O
?
show the reaction diagram
-
-
-
-
?
Elastin + H2O
?
show the reaction diagram
Glucagon + H2O
?
show the reaction diagram
-
NEP24.11 is an important mediator of the degradation of both endogenous and exogenous glucagon in vivo
-
-
?
insulin B chain + H2O
?
show the reaction diagram
-
multiple cleavage sites
-
-
?
leucine5-enkephalin + H2O
?
show the reaction diagram
-
Tyr-Gly-Gly-Phe-Leu is cleaved at the Gly-Phe bond by the wild-type enzyme
-
-
?
N-formyl-L-Met-Leu-Phe + H2O
?
show the reaction diagram
-
the enzyme may play an important role in modulating chemotactic response by cleavage of the chemotactic substance N-formyl-Met-Leu-Phe
-
-
-
Na,K-ATPase alpha subunit + H2O
?
show the reaction diagram
-
-
-
-
?
neuropeptide Y + H2O
truncated neuropeptide Y + C-terminal fragments of neuropeptide Y
show the reaction diagram
-
-
neuropeptide Y 21-36 and 31-36 are the most abundant fragments generated in vivo
-
?
pulmonary vasodilative vasoactive intestinal peptide + H2O
?
show the reaction diagram
-
rapid inactivation
-
-
?
additional information
?
-
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Cu2+
-
enzymatic activity is decreased in a dose-and time-dependent manner
additional information
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(2(R,S)-2-sulfanyl-2-benzyl)acetyl-Ala-Pro
-
-
(2(R,S)-2-sulfanyl-2-benzyl)acetyl-Leu-Tyr
-
-
(2(R,S)-2-sulfanyl-2-benzyl)acetyl-Phe-Ala
-
-
(2(R,S)-2-sulfanyl-2-benzyl)acetyl-Phe-Tyr
-
-
(2(R,S)-2-sulfanyl-2-isopropyl)acetyl-Ile-Tyr
-
-
(2R)-2-([1-[(5-ethyl-1,3,4-thiadiazol-2-yl)carbamoyl]cyclopentyl]methyl)pentanoic acid
-
-
(2R)-2-[(1-[[(1S)-1-carboxy-2-(3-phenyl-1,2,4-oxadiazol-5-yl)ethyl]carbamoyl]cyclopentyl)methyl]-5-oxopentanoic acid
-
-
(2R)-2-[(1-[[(1S)-1-carboxy-2-(4-ethyl-1,3-oxazol-2-yl)ethyl]carbamoyl]cyclopentyl)methyl]pentanoic acid
-
-
(2R)-2-[(1-[[(1S)-1-carboxy-2-(4-phenyl-1,3-oxazol-2-yl)ethyl]carbamoyl]cyclopentyl)methyl]-5-oxopentanoic acid
-
-
(2R)-2-[(1-[[(1S)-1-carboxy-2-(4-phenyl-1,3-oxazol-2-yl)ethyl]carbamoyl]cyclopentyl)methyl]pentanoic acid
-
-
(2R)-2-[(1-[[(1S)-1-carboxy-2-(5-phenyl-1,3,4-oxadiazol-2-yl)ethyl]carbamoyl]cyclopentyl)methyl]-5-oxopentanoic acid
-
-
(2R)-2-[(1-[[(1S)-1-carboxy-2-(5-phenyl-1,3-oxazol-2-yl)ethyl]carbamoyl]cyclopentyl)methyl]-5-oxopentanoic acid
-
-
(2R)-2-[(1-[[(1S)-1-carboxy-2-(5-phenyl-1,3-oxazol-2-yl)ethyl]carbamoyl]cyclopentyl)methyl]pentanoic acid
-
-
(2R)-2-[[1-([(1S)-1-carboxy-2-[4-(2-methylpropyl)-1,3-oxazol-2-yl]ethyl]carbamoyl)cyclopentyl]methyl]pentanoic acid
-
-
(2R)-2-[[1-([(1S)-1-carboxy-2-[5-(4-chlorophenyl)-1,3-oxazol-2-yl]ethyl]carbamoyl)cyclopentyl]methyl]-5-oxopentanoic acid
-
-
(2S)-2-[(1-[[2-(hydroxymethyl)-2,3-dihydro-1H-inden-2-yl]carbamoyl]cyclopentyl)methyl]-4-methoxybutanoic acid
-
-
(2S)-2-[(1-[[3-(4-chlorophenyl)propyl]carbamoyl]cyclopentyl)methyl]-4-methoxybutanoic acid
-
-
(2S)-2-[(1-[[3-(4-fluorophenyl)propyl]carbamoyl]cyclopentyl)methyl]-4-methoxybutanoic acid
-
-
(2S)-2-[[(2S)-1-[[(1S)-2-(biphenyl-4-yl)-1-carboxyethyl]amino]-5-methyl-1-oxohexan-2-yl]amino]-4-phenylbutanoic acid (non-preferred name)
-
-
(2S)-4-methoxy-2-([1-[(1-methyl-2-phenylethyl)carbamoyl]cyclopentyl]methyl)butanoic acid
-
-
(2S)-4-methoxy-2-[(1-[[(1R,2S)-2-(4-methoxyphenyl)cyclopropyl]carbamoyl]cyclopentyl)methyl]butanoic acid
-
-
(S)-N-[2-(phosphonomethylamino)-3-(4-biphenylyl)-propionyl]-3-aminopropionic acid
-
effects of neutral endopeptidase in acute inflammation in the lung are studied using a newly developed murine model of smoke and burn injury using NEP antagonist CGS-24592. Smoke and burn-induced lung injury and inflammation in mice pretreated with CGS-24592 is exacerbated, leading to more plasma extravasation and severe airway inflammation
1,10-phenanthroline
2,3-Dimercaptopropan-1-ol
-
weak
2-(1-heptylcarbamoyl-cyclopentylmethyl)-4-methoxy-butyric acid tert-butyl ester
-
-
2-([1-[(1,3-benzodioxol-5-ylmethyl)carbamoyl]cyclopentyl]methyl)pentanoic acid
-
IC50: 1500 nM
2-([1-[(1-benzyl-2-hydroxyethyl)carbamoyl]cyclopentyl]methyl)pentanoic acid
-
IC50: 384 nM
2-([1-[(1-benzyl-6-oxo-1,6-dihydropyridin-3-yl)carbamoyl]cyclopentyl]methyl)pentanoic acid
-
IC50: 313 nM
2-([1-[(1-ethyl-1H-1,2,3-triazol-4-yl)carbamoyl]cyclopentyl]methyl)pentanoic acid
-
IC50: 82 nM
2-([1-[(3-ethylpyridin-2-yl)carbamoyl]cyclopentyl]methyl)pentanoic acid
-
IC50: 1710 nM
2-([1-[(4-benzylpyridin-2-yl)carbamoyl]cyclopentyl]methyl)pentanoic acid
-
IC50: 96 nM
2-([1-[(4-butylpyridin-2-yl)carbamoyl]cyclopentyl]methyl)pentanoic acid
-
IC50: 184 nM
2-([1-[(4-carbamoylcyclohexyl)carbamoyl]cyclopentyl]methyl)pentanoic acid
-
IC50: 150 nM
2-([1-[(5-benzyl-1,3,4-thiadiazol-2-yl)carbamoyl]cyclopentyl]methyl)pentanoic acid
-
IC50: 30 nM
2-([1-[(5-ethyl-1,3,4-thiadiazol-2-yl)carbamoyl]cyclopentyl]methyl)-4-phenylbutanoic acid
-
IC50: 46 nM
2-([1-[(5-ethyl-1,3,4-thiadiazol-2-yl)carbamoyl]cyclopentyl]methyl)-5-methylhexanoic acid
-
IC50: 120 nM
2-([1-[(5-ethyl-1,3,4-thiadiazol-2-yl)carbamoyl]cyclopentyl]methyl)hexanoic acid
-
IC50: 84 nM
2-([1-[(5-ethyl-1,3,4-thiadiazol-2-yl)carbamoyl]cyclopentyl]methyl)pentanoic acid
-
IC50: 60 nM
2-([1-[(5-methyl-1,3,4-thiadiazol-2-yl)carbamoyl]cyclopentyl]methyl)pentanoic acid
-
IC50: 176 nM
2-([1-[(5-phenyl-1,3,4-thiadiazol-2-yl)carbamoyl]cyclopentyl]methyl)pentanoic acid
-
IC50: 283 nM
2-([1-[(6-methoxypyridazin-3-yl)carbamoyl]cyclopentyl]methyl)pentanoic acid
-
IC50: 374 nM
2-([1-[5-(1-benzyl-6-oxo-1,6-dihydropyridin-3-yl)-1,3,4-oxadiazol-2-yl]cyclopentyl]methyl)pentanoic acid
-
IC50: 1139 nM
2-mercaptoethanol
2-methoxymethyl-3-[1-(trans-2-phenyl-cyclopropylcarbamoyl)-cyclopentyl]-propionic acid tert-butyl ester
-
-
2-[(1-[[(1R)-1-phenylethyl]carbamoyl]cyclopentyl)methyl]pentanoic acid
-
IC50: 530 nM
2-[(1-[[(1R)-3-(dimethylcarbamoyl)cyclohexyl]carbamoyl]cyclopentyl)methyl]pentanoic acid
-
IC50: 297 nM
2-[(1-[[(1R,2R)-2-benzylcyclohexyl]carbamoyl]cyclopentyl)methyl]pentanoic acid
-
IC50: 195 nM
2-[(1-[[(1R,2S)-2-propylcyclohexyl]carbamoyl]cyclopentyl)methyl]pentanoic acid
-
IC50: 890 nM
2-[(1-[[(3R)-1-benzylpyrrolidin-3-yl]carbamoyl]cyclopentyl)methyl]pentanoic acid
-
IC50: 1060 nM
2-[(1-[[(3R)-1-carbamoylpyrrolidin-3-yl]carbamoyl]cyclopentyl)methyl]pentanoic acid
-
IC50: 213 nM
2-[(1-[[(5-methyl-1,3,4-thiadiazol-2-yl)methyl]carbamoyl]cyclopentyl)methyl]pentanoic acid
-
IC50: 700 nM
2-[(1-[[1-(hydroxymethyl)cyclopentyl]carbamoyl]cyclopentyl)methyl]pentanoic acid
-
IC50: 1710 nM
2-[(1-[[2-(hydroxymethyl)-2,3-dihydro-1H-inden-2-yl]carbamoyl]cyclopentyl)methyl]pentanoic acid
-
IC50: 96 nM
2-[(1-[[4-(dimethylcarbamoyl)cyclohexyl]carbamoyl]cyclopentyl)methyl]pentanoic acid
-
IC50: 370 nM
2-[(1-[[5-(2-methylpropyl)-1,3,4-thiadiazol-2-yl]carbamoyl]cyclopentyl)methyl]pentanoic acid
-
IC50: 124 nM
2-[(1-[[5-(cyclopropylmethyl)-1,3,4-thiadiazol-2-yl]carbamoyl]cyclopentyl)methyl]pentanoic acid
-
IC50: 38 nM
2-[(3-iodo-4-hydroxy)phenylmethyl]-4-N-[3-hydroxyamino-3-oxo-1(phenylmethyl)propyl]amino-4-oxobutanoic acid
-
i.e. RB104, use of the inhibitor in detecting nanogram quantities of the enzyme by inhibitor gel electrophoresis
2-[(3-iodohydroxy)phenylmethyl]-4-N-[3-hydroxyamino-3-oxo-1-phenylmethylpropyl]-amino-4-oxobutanoic acid
-
i.e. RB104, highly selective and potent inhibitor
2-[1-(2-hydroxymethyl-indan-2-ylcarbamoyl)-cyclopentylmethyl]-4-methoxy-butyric acid tert-butyl ester
-
-
2-[1-(4-butyl-pyridin-2-ylcarbamoyl)-cyclopentylmethyl]-4-methoxybutyric acid benzyl ester
-
-
2-[1-(5-ethyl-[1,3,4]thiadiazol-2-ylcarbamoyl)-cyclopentylmethyl]-pentanoic acid
-
-
2-[1-[2-(trans-4-chlorophenyl)-cyclopropylcarbamoyl]-cyclopentylmethyl]-4-methoxy-butyric acid tert-butyl ester
-
-
2-[1-[3-(4-chloro-phenyl)-propylcarbamoyl]-cyclopentylmethyl]-4-methoxy-butyric acid tert-butyl ester
-
-
2-[1-[3-(4-fluoro-phenyl)-propylcarbamoyl]-cyclopentylmethyl]-4-methoxy-butyric acid tert-butyl ester
-
-
2-[[1-(1,3,4-thiadiazol-2-ylcarbamoyl)cyclopentyl]methyl]pentanoic acid
-
IC50: 377 nM
2-[[1-(2,3-dihydro-1H-inden-2-ylcarbamoyl)cyclopentyl]methyl]pentanoic acid
-
IC50: 313 nM
2-[[1-(5-benzyl-1,3,4-oxadiazol-2-yl)cyclopentyl]methyl]pentanoic acid
-
IC50: 3100 nM
2-[[1-(pyridin-2-ylcarbamoyl)cyclopentyl]methyl]pentanoic acid
-
IC50: 1500 nM
3-[1-[(5-ethyl-1,3,4-thiadiazol-2-yl)carbamoyl]cyclopentyl]propanoic acid
-
IC50: 237 nM
3-[1-[2-(trans-4-chlorophenyl)-cyclopropylcarbamoyl]-cyclopentyl]-2-methoxymethyl-propionic acid tert-butyl ester
-
-
4-hydroxy-nonenal
-
intracellular neprilysin develops 4-hydroxy-nonenal adducts after 24 h of 4-hydroxy-nonenal treatment. 4-Hydroxy-nonenal-modified neprilysin shows decreased catalytic activity, which is associated with elevations in amyloid beta1-40 in SH-SY5Y and H4 APP695wt cells. Incubation of cells with amyloid beta1-42 also induces 4-hydroxy-nonenal adduction of neprilysin
4-methoxy-2-(1-phenethylcarbamoyl-cyclopentylmethyl)-butyric acid benzyl ester
-
-
4-methoxy-2-[1-(3-phenyl-propylcarbamoyl)-cyclopentylmethyl]-butyric acid tert-butyl ester
-
-
4-methoxy-2-[1-(trans-2-pentyl-cyclopropylcarbamoyl)-cyclopentylmethyl]-butyric acid tert-butyl ester
-
-
4-methoxy-2-[1-(trans-2-phenyl-cyclopropylcarbamoyl)-cyclopentylmethyl]-butyric acid tert-butyl ester
-
-
4-methoxy-2-[1-[(trans-2-(4-fluorophenyl)-cyclopropylcarbamoyl)]-cyclopentylmethyl]-butyric acid tert-butyl ester
-
-
4-methoxy-2-[1-[(trans-2-(4-methoxy-phenyl)-cyclopropylcarbamoyl)]-cyclopentylmethyl]-butyric acid tert-butyl ester
-
-
4-methoxy-2-[1-[2-(4-methoxy-phenoxy)-ethylcarbamoyl]-cyclopentylmethyl]-butyric acid tert-butyl ester
-
-
4-methoxy-2-[1-[2-(4-methoxy-phenyl)-ethylcarbamoyl]-cyclopentylmethyl]-butyric acid tert-butyl ester
-
-
4-methoxy-2-[1-[3-(4-methoxy-phenyl)-propylcarbamoyl]-cyclopentylmethyl]-butyric acid tert-butyl ester
-
-
Acetorphan
-
-
AHU-377
-
LCZ696 comprises molecular moieties of valsartan, and of the NEP inhibitor prodrug AHU377 ((2R,4S)-5-biphenyl-4-yl-5-(3-carboxy-propionylamino)-2-methyl-pentanoic acid ethyl ester) (1:1 molar ratio). Oral administration of LCZ696 causes dose-dependent increases in atrial natriuretic peptide immunoreactivity due to NEP inhibition in Sprague-Dawley rats and provides sustained, dose-dependent blood pressure reductions in hypertensive double-transgenic rats
amyloid beta
amyloid beta1-42
-
incubation of cells with amyloid beta1-42 induces 4-hydroxy-nonenal adduction of neprilysin. In an apparent compensatory response, amyloid beta-treated cells show increased neprilysin mRNA and protein expression. Despite elevations in neprilysin protein, the activity is significantly lower compared with the neprilysin protein level
-
angiotensin I
-
-
Atrial natriuretic factor
-
-
-
bradykinin
-
-
Butanedione
-
-
candoxatril
-
treatment increases plasma atrial natriuretic peptide levels and leads to significantly higher levels of atrial tissue cyclic GMP as well as plasma cyclic GMP. Candoxatril suppresses the shortening of atrial effective refractory period and monophasic action potential duration in the rapid atrial pacing model
candoxatrilat
CGS24592
-
-
chymostatin
-
-
cis-4-[([1-[(2S)-2-carboxy-3-(2-methoxyethoxy)propyl]cyclopentyl]carbonyl)amino]cyclohexanecarboxylic acid
-
-
diethyl dicarbonate
-
-
diisopropyl fluorophosphate
-
-
dithiothreitol
DL-[N-(3-mercapto-2-benzylpropanoyl)]glycine
-
following neprilysin inhibition, islet amyloid deposition and beta-cell apoptosis increase by 54 and 75%, respectively
EGTA
-
-
GSH
-
-
heparin
-
-
Hg2+
-
0.001-0.05 mM, modifies the recombinant enzyme conformation, and highly reduces the enzyme activity. Hg2+ incubation increases NEP protein levels, but does not change NEP mRNA levels nor the levels of the amyloid intracellular domain peptide, a protein fragment with transcriptional activity. The Hg2+-induced inhibition of the enzyme activity may be mediated by a conformational change resulting in reduced amyloid beta1-42 degradation
Insulin B chain
-
inhibits the activity with substrate N-(4-carboxy-1-oxobutyl)-L-alanyl-L-alanyl-N-(4-methoxy-2-naphthalenyl)-L-phenylalaninamide
LCZ696
-
LCZ696 is a dual-acting angiotensin II-receptor and neprilysin inhibitor (ARNI) in a single molecule: angiotensin-receptor blockade via its valsartan molecular moiety, and neprilysin inhibition via its AHU377 molecular moiety. In a randomized, double-blind, placebo-controlled, active comparator study it is shown that compared with valsartan, dual-acting LCZ696 provides complementary and fully additive reduction of blood pressure
Leu5-enkephalin
MCB3937
-
bifunctional inhibitor of NEP and DPP-IV
MCB4241
-
bifunctional inhibitor of NEP and DPP-IV
Met5-enkephalin
N-(2-benzyl-3-sulfanylpropanoyl)glycine
-
synthetic NEP inhibitor
N-([1-[(2S)-2-carboxy-3-[[N2-(methylsulfonyl)-L-lysyl]amino]propyl]cyclopentyl]carbonyl)-L-tyrosine
-
-
N-phenethylphosphonyl-L-leucyl-L-tryptophane
N-[(2RS)-3-hydroxyaminocarbonyl-2-benzyl-1-oxopropyl]-Gly
-
-
N-[1(R,S)-carboxy-2-phenylethyl]-Phe-p-aminobenzoate
-
-
N-[5-fluoresceinyl]-N'-[6-(3-mercapto-2-benzyl-1-oxopropyl)amino-1-hexyl]thiocarbamide
-
the inhibitor is a very potent probe for detecting membrane-bound enzyme for biological studies or diagnostic applications. Particularly useful for detecting the membrane-bound enzyme by flow cytometry
N-[N-[1(5)-carboxy-3-(4-hydroxyphenyl)propyl]-(5)-phenylalanyl]-(5)-isoserine
-
-
neurotensin
-
-
opiorphin
-
-
Pepstatin
-
-
Phenylglyoxal
-
-
phosphate
-
-
phosphoramidon
puromycin
-
-
SCH39370
-
-
SCH48446
-
i.e. the diiodo analog of N-[N-[1(5)-carboxy-3-(4-hydroxyphenyl)propyl]-(5)-phenylalanyl]-(5)-isoserine
-
sialorphin
-
opiorphin homologue inhibits NEP
SQ 28603
-
-
Substance P
-
-
Tat peptide 5118
-
-
tert-butyl 2-([1-[(5-benzyl-1,3,4-thiadiazol-2-yl)carbamoyl]cyclopentyl]methyl)-4-methoxybutanoate
-
-
thiorphan
thiorphan-NH2
U46619
-
a thromboxane mimetic
UK-69,578
-
-
valsartan
-
LCZ696 comprises molecular moieties of valsartan, and of the NEP inhibitor prodrug AHU377 ((2R,4S)-5-biphenyl-4-yl-5-(3-carboxy-propionylamino)-2-methyl-pentanoic acid ethyl ester) (1:1 molar ratio). Oral administration of healthy volunteers is associated with increases in plasma cGMP, renin concentration and activity, and angiotensin II, providing evidence for NEP inhibition and angiotensin receptor blockade
Z-Leu-Leu-Leu-H
-
-
-
additional information
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
androgen
-
androgens positively regulate neural expression of neprilysin in adult male rats
-
dihydrotestosterone
-
induces a time-dependent increase in neprilysin expression. Dihydrotestosterone also significantly decreases levels of amyloid beta in androgen receptor-expressing cells transfected with amyloid precursor protein, but does not affect levels of either full-length or non-amyloidogenic, soluble amyloid precursor protein. The dihydrotestosterone-induced decrease of amyloid beta is blocked by pharmacological inhibition of neprilysin. The dihydrotestosterone-mediated increase in neprilysin expression and decrease in amyloid beta levels are not observed in rat pheochromocytoma cell 12 lacking androgen receptor and blocked in androgen receptor-expressing cells by the antagonists, cyproterone acetate and flutamide
estrogen
-
estrogen stimulates degradation of beta-amyloid peptide by up-regulating neprilysin
minocycline
-
minocycline abrogates the amyloid beta(25-35)-induced decrease of somatostatin-like immunoreactive content, somatostatin mRNA levels, phosphorylated-cAMP-response element binding protein CREB content and neprilysin levels. Minocycline alone enhances these targets
additional information
-
both staurosporine-stimulated caspase-3 activation, p53 and neprilysin expression and activity are not affected by over-expression or depletion of presenilin complex component TMP21
-
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0687
2-aminobenzoyl-ARFK-2,4-dinitrophenyl ester
-
-
0.0178
2-aminobenzoyl-DRFK-2,4-dinitrophenyl ester
-
-
0.0097
2-aminobenzoyl-FRFK-2,4-dinitrophenyl ester
-
-
0.0161
2-aminobenzoyl-HRFK-2,4-dinitrophenyl ester
-
-
0.0093
2-aminobenzoyl-IRFK-2,4-dinitrophenyl ester
-
-
0.0528
2-aminobenzoyl-KRFK-2,4-dinitrophenyl ester
-
-
0.003
2-aminobenzoyl-LRFK-2,4-dinitrophenyl ester
-
-
0.0214
2-aminobenzoyl-NRFK-2,4-dinitrophenyl ester
-
-
0.0117
2-aminobenzoyl-RAFK-2,4-dinitrophenyl ester
-
-
0.0028
2-aminobenzoyl-RDFK-2,4-dinitrophenyl ester
-
-
0.0043
2-aminobenzoyl-REFK-2,4-dinitrophenyl ester
-
-
0.054
2-aminobenzoyl-rGF-N-(2,4-dinitrophenyl)ethylenediamine
-
-
0.0259
2-aminobenzoyl-RGFK-2,4-dinitrophenyl amide
-
-
0.014
2-aminobenzoyl-RGFK-2,4-dinitrophenyl ester
-
-
0.0273
2-aminobenzoyl-rGL-N-(2,4-dinitrophenyl)ethylenediamine
-
-
0.0089
2-aminobenzoyl-RHFK-2,4-dinitrophenyl ester
-
-
0.9981
2-aminobenzoyl-RKFK-2,4-dinitrophenyl ester
-
-
0.0024
2-aminobenzoyl-RNFK-2,4-dinitrophenyl ester
-
-
0.0075
2-aminobenzoyl-RPFK-2,4-dinitrophenyl ester
-
-
0.0121
2-aminobenzoyl-RQFK-2,4-dinitrophenyl ester
-
-
0.035
2-aminobenzoyl-RRFK-2,4-dinitrophenyl amide
-
-
0.0089
2-aminobenzoyl-RRFK-2,4-dinitrophenyl ester
-
-
0.028
2-aminobenzoyl-rRL-N-(2,4-dinitrophenyl)ethylenediamine
-
-
0.0084
2-aminobenzoyl-RSFK-2,4-dinitrophenyl ester
-
-
0.0259
2-aminobenzoyl-rSL-N-(2,4-dinitrophenyl)ethylenediamine
-
-
0.0108
2-aminobenzoyl-RTFK-2,4-dinitrophenyl ester
-
-
0.0081
2-aminobenzoyl-SRFK-2,4-dinitrophenyl ester
-
-
0.0095
2-aminobenzoyl-TRFK-2,4-dinitrophenyl ester
-
-
0.0109
2-aminobenzoyl-VRFK-2,4-dinitrophenyl ester
-
-
0.051
2-aminobenzoyl-WRFK-2,4-dinitrophenyl ester
-
-
0.0583
2-aminobenzoyl-YRFK-2,4-dinitrophenyl ester
-
-
0.0028
adrenocorticotropic hormone
-
-
-
0.109
Ala-Leu-enkephalin
-
wild type enzyme
0.024
alpha-endorphin
-
wild-type enzyme, pH and temperature not specified in the publication
-
0.135
alpha-neoendorphin
-
-
0.014 - 0.104
amyloid beta peptide1-40
0.0086
angiotensin
-
wild-type enzyme, pH and temperature not specified in the publication
0.0004 - 34.1
angiotensin I
0.179
angiotensin II
-
37C, pH 7.4
0.1114
angiotensin(1-9)
-
37C, pH 7.4
0.0062
Arg-vasopressin
-
wild-type enzyme, pH and temperature not specified in the publication
-
0.13
benzoyl-Gly-Gly-Leu-p-nitroanilide
-
-
0.25
benzyloxycarbonyl-Ala-Gly-Leu-Ala
-
-
0.00654
beta-endorphin
-
-
0.005 - 0.162
bradykinin
0.296
cholecystokinin-8
-
-
0.07 - 2.137
D-Ala2-Leu5-enkephalin
0.773
D-Ala2-Leu5-enkephalinamide
-
-
0.432
D-Ala2-Met5-enkephalinamide
-
-
0.03
dansyl-Gly-Trp-Gly
-
-
0.041
dansyl-Gly-Tyr-Gly
-
-
0.09
dansyl-Gly-Tyr-Gly-NH2
-
-
0.035
dynorphin A-10
-
-
0.01
dynorphin A-13
-
-
0.0082
dynorphin A-17
-
-
0.025
dynorphin A-6
-
-
0.298
dynorphin A-8
-
-
0.04
dynorphin A-9
-
-
0.119
dynorphin(1-9)
-
-
0.053
endothelin-1
-
wild-type enzyme, pH and temperature not specified in the publication
0.013
gamma-endorphin
-
wild-type enzyme, pH and temperature not specified in the publication
0.049 - 0.068
gastrin G-17
0.024
GLP-1
-
wild-type enzyme, pH and temperature not specified in the publication
-
0.025
glucagon
-
wild-type enzyme, pH and temperature not specified in the publication
0.59
glutaryl-Ala-Ala-Phe-2-naphthylamide
-
-
0.12
glutaryl-Ala-Ala-Phe-4-methoxy-2-naphthylamine
-
-
0.42
glutaryl-Ala-Ala-Phe-4-methyoxy-2-naphthylamide
-
-
-
0.0685
glutaryl-Gly-Gly-Phe-2-naphthylamide
-
-
0.15
GRP 2664
-
wild-type enzyme, pH and temperature not specified in the publication
-
0.38
hippuryl-Arg-Arg-Ala-2-naphthylamide
-
-
0.35
hippuryl-Arg-Arg-Leu-2-naphthylamide
-
-
0.133
His-Lys-Thr-Asp-Ser-Phe-Val-Gly-Leu-Met-NH2
-
-
0.074 - 0.2
Leu-enkephalin
0.612
Leu-enkephalinamide
-
-
0.086
Leu5-enkephalin
-
-
0.111
Leu5-enkephalin-Arg6
-
-
0.68
Leu5-enkephalinamide
-
-
0.755
Luteinizing hormone-releasing hormone
0.022 - 0.1
Met-enkephalin
0.41
Met-enkephalinamide
-
-
0.062
Met5-enkephalin
-
-
0.039
Met5-enkephalin-Arg6
-
-
-
0.05
Met5-enkephalin-Arg6Phe7
-
-
-
0.011 - 0.087
N-(4-carboxy-1-oxobutyl)-L-alanyl-L-alanyl-N-(4-methoxy-2-naphthalenyl)-L-phenylalaninamide
0.0408
N-2-aminobenzoyl-rGV-N-(2,4-dinitrophenyl)ethylenediamine
-
-
0.3
Nalpha-benzoyl-Gly-Arg-Arg-Ala-2-naphthylamide
-
-
0.18
Nalpha-benzoyl-Gly-Arg-Arg-Leu-2-naphthylamide
-
-
0.11
Nalpha-benzoyl-Gly-Arg-Arg-Phe-2-naphthylamide
-
-
0.19
Nalpha-benzoyl-Gly-Arg-Leu-2-naphthylamide
-
-
0.11
Nalpha-benzoyl-Gly-Gly-Arg-Leu-2-naphthylamide
-
-
0.08
Nalpha-benzoyl-Gly-Lys-Arg-Arg-Leu-2-naphthylamide
-
-
0.03
Nalpha-benzoyl-Gly-Lys-Lys-Arg-Arg-Leu-2-naphthylamide
-
-
0.0093
Neurokinin A
-
wild-type enzyme, pH and temperature not specified in the publication
0.022
neurokinin B
-
wild-type enzyme, pH and temperature not specified in the publication
0.016 - 0.078
neurotensin
0.02
nociceptin
-
wild-type enzyme, pH and temperature not specified in the publication
-
0.106
Physalaemin
-
-
0.0074
somatostatin 14
-
wild-type enzyme, pH and temperature not specified in the publication
0.031
somatostatin 28
-
wild-type enzyme, pH and temperature not specified in the publication
-
0.01 - 0.19
Substance P
0.043 - 0.073
succinyl-Ala-Ala-Phe-4-methylcoumarin 7-amide
0.058
succinyl-Ala-Ala-Phe-AMC
-
plasma enzyme
-
0.45
succinyl-Arg-Arg-Leu-2-naphthylamide
-
-
0.057
sulfated cholecystokinin octapeptide
-
-
0.018 - 0.019
Tyr-D-Ala-Gly-Phe-Leu
0.013
Tyr-D-Ala-Gly-Phe-Met
-
-
0.061 - 0.32
Tyr-D-Ala-Gly-Phe-met-NH2
0.008
Tyr-Gly-Gly-Phe-Met
-
-
0.033
unsulfated cholecystokinin octapeptide
-
-
0.0018
Vasoactive intestinal peptide
-
-
additional information
additional information
-
Michaelis-Menten profiles and steady-state kinetic parameters for cleavage of amyloid beta peptide1-40 and off-target peptide by wild-type and mutant enzymes, overview
-
TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1.7
adrenocorticotropic hormone
Lactococcus lactis
-
-
-
8.9
alpha-endorphin
Homo sapiens
-
wild-type enzyme, pH and temperature not specified in the publication
-
44.6
alpha-neoendorphin
Lactococcus lactis
-
-
0.83 - 2.7
amyloid beta peptide1-40
8.2
angiotensin
Homo sapiens
-
wild-type enzyme, pH and temperature not specified in the publication
0.0551
angiotensin I
Homo sapiens
-
37C, pH 7.4
40
angiotensin II
Homo sapiens
-
37C, pH 7.4
41.8
angiotensin(1-9)
Homo sapiens
-
37C, pH 7.4
2.8
Arg-vasopressin
Homo sapiens
-
wild-type enzyme, pH and temperature not specified in the publication
-
0.05
benzoyl-Gly-Gly-Arg-Leu-2-naphthylamide
Bos taurus
-
-
0.105
benzoyl-Gly-Gly-Leu-p-nitroanilide
Bos taurus
-
-
46.4
benzyloxycarbonyl-Ala-Gly-Leu-Ala
Rattus norvegicus
-
-
26
beta-endorphin
Lactococcus lactis
-
-
4.3 - 106
bradykinin
19 - 1260
D-Ala2-Leu5-enkephalin
15
dansyl-Gly-Trp-Gly
Rattus norvegicus
-
-
19.1
dansyl-Gly-Tyr-Gly
Rattus norvegicus
-
-
4.13
dansyl-Gly-Tyr-Gly-NH2
Rattus norvegicus
-
-
23.8
dynorphin A-10
Lactococcus lactis
-
-
18.6
dynorphin A-13
Lactococcus lactis
-
-
25.4
dynorphin A-17
Lactococcus lactis
-
-
14
dynorphin A-6
Lactococcus lactis
-
-
19.6
dynorphin A-8
Lactococcus lactis
-
-
32.2
dynorphin A-9
Lactococcus lactis
-
-
0.68
endothelin-1
Homo sapiens
-
wild-type enzyme, pH and temperature not specified in the publication
4.8
gamma-endorphin
Homo sapiens
-
wild-type enzyme, pH and temperature not specified in the publication
0.767 - 1.07
gastrin G-17
3.3
GLP-1
Homo sapiens
-
wild-type enzyme, pH and temperature not specified in the publication
-
4.5
glucagon
Homo sapiens
-
wild-type enzyme, pH and temperature not specified in the publication
9.87
glutaryl-Ala-Ala-Phe-2-naphthylamide
Bos taurus
-
-
5.28
glutaryl-Ala-Ala-Phe-4-methoxy-2-naphthylamide
Bos taurus
-
-
58.2
glutaryl-Ala-Ala-Phe-4-methoxy-2-naphthylamine
Rattus norvegicus
-
-
43.7
glutaryl-Gly-Gly-Phe-2-naphthylamide
Sus scrofa
-
-
0.883
Gly-Trp-Gly
Rattus norvegicus
-
-
26
GRP 2664
Homo sapiens
-
wild-type enzyme, pH and temperature not specified in the publication
-
6.83
hippuryl-Arg-Arg-Ala-2-naphthylamide
Rattus norvegicus
-
-
72
hippuryl-Arg-Arg-Leu-2-naphthylamide
Rattus norvegicus
-
-
15
Leu-enkephalin
Lactococcus lactis
-
-
8.2
Leu-enkephalinamide
Lactococcus lactis
-
-
14
Luteinizing hormone-releasing hormone
Rattus norvegicus
-
-
7.8
Met-enkephalin
Lactococcus lactis
-
-
0.5
Met-enkephalinamide
Lactococcus lactis
-
-
3.63
N-acetyl-Gly-Trp-Gly
Rattus norvegicus
-
-
0.147
Nalpha-benzoyl-Gly-Arg-Arg-Ala-2-naphthylamide
Bos taurus
-
-
4
Nalpha-benzoyl-Gly-Arg-Arg-Leu-2-naphthylamide
Bos taurus
-
-
2
Nalpha-benzoyl-Gly-Arg-Arg-Phe-2-naphthylamide
Bos taurus
-
-
0.0483
Nalpha-benzoyl-Gly-Arg-Leu-2-naphthylamide
Bos taurus
-
-
1.82
Nalpha-benzoyl-Gly-Lys-Arg-Arg-Leu-2-naphthylamide
Bos taurus
-
-
0.383
Nalpha-benzoyl-Gly-Lys-Lys-Arg-Arg-Leu-2-naphthylamide
Bos taurus
-
-
17
Neurokinin A
Homo sapiens
-
wild-type enzyme, pH and temperature not specified in the publication
20
neurokinin B
Homo sapiens
-
wild-type enzyme, pH and temperature not specified in the publication
13
neurotensin
Homo sapiens
-
wild-type enzyme, pH and temperature not specified in the publication
11
nociceptin
Homo sapiens
-
wild-type enzyme, pH and temperature not specified in the publication
-
32
somatostatin 14
Homo sapiens
-
wild-type enzyme, pH and temperature not specified in the publication
9.1
somatostatin 28
Homo sapiens
-
wild-type enzyme, pH and temperature not specified in the publication
-
18 - 84.4
Substance P
6.32
succinyl-Arg-Arg-Leu-2-naphthylamide
Bos taurus
-
-
31.1
sulfated cholecystokinin octapeptide
Homo sapiens
-
-
17.4
Tyr-D-Ala-Gly-Phe-Met
Rattus norvegicus
-
-
42
Tyr-D-Ala-Gly-Phe-met-NH2
Rattus norvegicus
-
-
21.1
Tyr-Gly-Gly-Phe-Met
Rattus norvegicus
-
-
24.6
unsulfated cholecystokinin octapeptide
Homo sapiens
-
-
1.8
Vasoactive intestinal peptide
Lactococcus lactis
-
-
kcat/KM VALUE [1/mMs-1]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
390
alpha-endorphin
Homo sapiens
-
wild-type enzyme, pH and temperature not specified in the publication
206893
8 - 150
amyloid beta peptide1-40
970
angiotensin
Homo sapiens
-
wild-type enzyme, pH and temperature not specified in the publication
3985
450
Arg-vasopressin
Homo sapiens
-
wild-type enzyme, pH and temperature not specified in the publication
206894
480
bradykinin
Homo sapiens
-
wild-type enzyme, pH and temperature not specified in the publication
466
13
endothelin-1
Homo sapiens
-
wild-type enzyme, pH and temperature not specified in the publication
7597
380
gamma-endorphin
Homo sapiens
-
wild-type enzyme, pH and temperature not specified in the publication
47235
140
GLP-1
Homo sapiens
-
wild-type enzyme, pH and temperature not specified in the publication
34425
180
glucagon
Homo sapiens
-
wild-type enzyme, pH and temperature not specified in the publication
1399
170
GRP 2664
Homo sapiens
-
wild-type enzyme, pH and temperature not specified in the publication
206895
1700
Neurokinin A
Homo sapiens
-
wild-type enzyme, pH and temperature not specified in the publication
9231
920
neurokinin B
Homo sapiens
-
wild-type enzyme, pH and temperature not specified in the publication
5679
820
neurotensin
Homo sapiens
-
wild-type enzyme, pH and temperature not specified in the publication
2209
570
nociceptin
Homo sapiens
-
wild-type enzyme, pH and temperature not specified in the publication
206892
4400
somatostatin 14
Homo sapiens
-
wild-type enzyme, pH and temperature not specified in the publication
97361
160
somatostatin 28
Homo sapiens
-
wild-type enzyme, pH and temperature not specified in the publication
206891
1100
Substance P
Homo sapiens
-
wild-type enzyme, pH and temperature not specified in the publication
1259
Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.036
angiotensin I
-
hydrolysis of Leu5-enkephalin
0.162
bradykinin
-
hydrolysis of Leu5-enkephalin
0.001 - 0.0025
Insulin B chain
0.022
Met5-enkephalin
-
hydrolysis of Leu5-enkephalin
0.039
neurotensin
-
hydrolysis of Leu5-enkephalin
0.19
Substance P
-
hydrolysis of Leu5-enkephalin
0.44 - 1.24
Tat peptide 5118
0.000004 - 0.00191
thiorphan
IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0000013
(2(R,S)-2-sulfanyl-2-benzyl)acetyl-Ala-Pro
Homo sapiens
-
-
0.0000022
(2(R,S)-2-sulfanyl-2-benzyl)acetyl-Leu-Tyr
Homo sapiens
-
-
0.0000023
(2(R,S)-2-sulfanyl-2-benzyl)acetyl-Phe-Ala
Homo sapiens
-
-
0.0000029
(2(R,S)-2-sulfanyl-2-benzyl)acetyl-Phe-Tyr
Homo sapiens
-
-
0.0000014
(2(R,S)-2-sulfanyl-2-isopropyl)acetyl-Ile-Tyr
Homo sapiens
-
-
0.00000237
(2R)-2-([1-[(5-ethyl-1,3,4-thiadiazol-2-yl)carbamoyl]cyclopentyl]methyl)pentanoic acid
Canis lupus familiaris
-
-
0.0000019
(2R)-2-[(1-[[(1S)-1-carboxy-2-(3-phenyl-1,2,4-oxadiazol-5-yl)ethyl]carbamoyl]cyclopentyl)methyl]-5-oxopentanoic acid
Homo sapiens
-
pH and temperature not specified in the publication
0.000022
(2R)-2-[(1-[[(1S)-1-carboxy-2-(4-ethyl-1,3-oxazol-2-yl)ethyl]carbamoyl]cyclopentyl)methyl]pentanoic acid
Homo sapiens
-
pH and temperature not specified in the publication
0.0000048
(2R)-2-[(1-[[(1S)-1-carboxy-2-(4-phenyl-1,3-oxazol-2-yl)ethyl]carbamoyl]cyclopentyl)methyl]-5-oxopentanoic acid
Homo sapiens
-
pH and temperature not specified in the publication
0.000007
(2R)-2-[(1-[[(1S)-1-carboxy-2-(4-phenyl-1,3-oxazol-2-yl)ethyl]carbamoyl]cyclopentyl)methyl]pentanoic acid
Homo sapiens
-
pH and temperature not specified in the publication
0.000006
(2R)-2-[(1-[[(1S)-1-carboxy-2-(5-phenyl-1,3,4-oxadiazol-2-yl)ethyl]carbamoyl]cyclopentyl)methyl]-5-oxopentanoic acid
Homo sapiens
-
pH and temperature not specified in the publication
0.0000003
(2R)-2-[(1-[[(1S)-1-carboxy-2-(5-phenyl-1,3-oxazol-2-yl)ethyl]carbamoyl]cyclopentyl)methyl]-5-oxopentanoic acid
Homo sapiens
-
pH and temperature not specified in the publication
0.0000006
(2R)-2-[(1-[[(1S)-1-carboxy-2-(5-phenyl-1,3-oxazol-2-yl)ethyl]carbamoyl]cyclopentyl)methyl]pentanoic acid
Homo sapiens
-
pH and temperature not specified in the publication
0.00002
(2R)-2-[[1-([(1S)-1-carboxy-2-[4-(2-methylpropyl)-1,3-oxazol-2-yl]ethyl]carbamoyl)cyclopentyl]methyl]pentanoic acid
Homo sapiens
-
pH and temperature not specified in the publication
0.0000003 - 0.000005
(2R)-2-[[1-([(1S)-1-carboxy-2-[5-(4-chlorophenyl)-1,3-oxazol-2-yl]ethyl]carbamoyl)cyclopentyl]methyl]-5-oxopentanoic acid
0.00000054
(2S)-2-[(1-[[2-(hydroxymethyl)-2,3-dihydro-1H-inden-2-yl]carbamoyl]cyclopentyl)methyl]-4-methoxybutanoic acid
Canis lupus familiaris
-
-
0.000000009
(2S)-2-[(1-[[3-(4-chlorophenyl)propyl]carbamoyl]cyclopentyl)methyl]-4-methoxybutanoic acid
Canis lupus familiaris
-
-
0.0000002
(2S)-2-[(1-[[3-(4-fluorophenyl)propyl]carbamoyl]cyclopentyl)methyl]-4-methoxybutanoic acid
Canis lupus familiaris
-
-
0.000028
(2S)-2-[[(2S)-1-[[(1S)-2-(biphenyl-4-yl)-1-carboxyethyl]amino]-5-methyl-1-oxohexan-2-yl]amino]-4-phenylbutanoic acid (non-preferred name)
Homo sapiens
-
pH and temperature not specified in the publication
0.0000426
(2S)-4-methoxy-2-([1-[(1-methyl-2-phenylethyl)carbamoyl]cyclopentyl]methyl)butanoic acid
Canis lupus familiaris
-
-
0.0000008
(2S)-4-methoxy-2-[(1-[[(1R,2S)-2-(4-methoxyphenyl)cyclopropyl]carbamoyl]cyclopentyl)methyl]butanoic acid
0.0015
2-([1-[(1,3-benzodioxol-5-ylmethyl)carbamoyl]cyclopentyl]methyl)pentanoic acid
Canis lupus familiaris
-
IC50: 1500 nM
0.000384
2-([1-[(1-benzyl-2-hydroxyethyl)carbamoyl]cyclopentyl]methyl)pentanoic acid
Canis lupus familiaris
-
IC50: 384 nM
0.000313
2-([1-[(1-benzyl-6-oxo-1,6-dihydropyridin-3-yl)carbamoyl]cyclopentyl]methyl)pentanoic acid
Canis lupus familiaris
-
IC50: 313 nM
0.000082
2-([1-[(1-ethyl-1H-1,2,3-triazol-4-yl)carbamoyl]cyclopentyl]methyl)pentanoic acid
Canis lupus familiaris
-
IC50: 82 nM
0.00171
2-([1-[(3-ethylpyridin-2-yl)carbamoyl]cyclopentyl]methyl)pentanoic acid
Canis lupus familiaris
-
IC50: 1710 nM
0.000096
2-([1-[(4-benzylpyridin-2-yl)carbamoyl]cyclopentyl]methyl)pentanoic acid
Canis lupus familiaris
-
IC50: 96 nM
0.000184
2-([1-[(4-butylpyridin-2-yl)carbamoyl]cyclopentyl]methyl)pentanoic acid
Canis lupus familiaris
-
IC50: 184 nM
0.00015
2-([1-[(4-carbamoylcyclohexyl)carbamoyl]cyclopentyl]methyl)pentanoic acid
Canis lupus familiaris
-
IC50: 150 nM
0.00003
2-([1-[(5-benzyl-1,3,4-thiadiazol-2-yl)carbamoyl]cyclopentyl]methyl)pentanoic acid
Canis lupus familiaris
-
IC50: 30 nM
0.000046
2-([1-[(5-ethyl-1,3,4-thiadiazol-2-yl)carbamoyl]cyclopentyl]methyl)-4-phenylbutanoic acid
Canis lupus familiaris
-
IC50: 46 nM
0.00012
2-([1-[(5-ethyl-1,3,4-thiadiazol-2-yl)carbamoyl]cyclopentyl]methyl)-5-methylhexanoic acid
Canis lupus familiaris
-
IC50: 120 nM
0.000084
2-([1-[(5-ethyl-1,3,4-thiadiazol-2-yl)carbamoyl]cyclopentyl]methyl)hexanoic acid
Canis lupus familiaris
-
IC50: 84 nM
0.00006
2-([1-[(5-ethyl-1,3,4-thiadiazol-2-yl)carbamoyl]cyclopentyl]methyl)pentanoic acid
Canis lupus familiaris
-
IC50: 60 nM
0.000176
2-([1-[(5-methyl-1,3,4-thiadiazol-2-yl)carbamoyl]cyclopentyl]methyl)pentanoic acid
Canis lupus familiaris
-
IC50: 176 nM
0.000283
2-([1-[(5-phenyl-1,3,4-thiadiazol-2-yl)carbamoyl]cyclopentyl]methyl)pentanoic acid
Canis lupus familiaris
-
IC50: 283 nM
0.000374
2-([1-[(6-methoxypyridazin-3-yl)carbamoyl]cyclopentyl]methyl)pentanoic acid
Canis lupus familiaris
-
IC50: 374 nM
0.001139
2-([1-[5-(1-benzyl-6-oxo-1,6-dihydropyridin-3-yl)-1,3,4-oxadiazol-2-yl]cyclopentyl]methyl)pentanoic acid
Canis lupus familiaris
-
IC50: 1139 nM
0.0000065
2-methoxymethyl-3-[1-(trans-2-phenyl-cyclopropylcarbamoyl)-cyclopentyl]-propionic acid tert-butyl ester
Canis lupus familiaris
-
-
0.00053
2-[(1-[[(1R)-1-phenylethyl]carbamoyl]cyclopentyl)methyl]pentanoic acid
Canis lupus familiaris
-
IC50: 530 nM
0.000297
2-[(1-[[(1R)-3-(dimethylcarbamoyl)cyclohexyl]carbamoyl]cyclopentyl)methyl]pentanoic acid
Canis lupus familiaris
-
IC50: 297 nM
0.000195
2-[(1-[[(1R,2R)-2-benzylcyclohexyl]carbamoyl]cyclopentyl)methyl]pentanoic acid
Canis lupus familiaris
-
IC50: 195 nM
0.00089
2-[(1-[[(1R,2S)-2-propylcyclohexyl]carbamoyl]cyclopentyl)methyl]pentanoic acid
Canis lupus familiaris
-
IC50: 890 nM
0.00106
2-[(1-[[(3R)-1-benzylpyrrolidin-3-yl]carbamoyl]cyclopentyl)methyl]pentanoic acid
Canis lupus familiaris
-
IC50: 1060 nM
0.000213
2-[(1-[[(3R)-1-carbamoylpyrrolidin-3-yl]carbamoyl]cyclopentyl)methyl]pentanoic acid
Canis lupus familiaris
-
IC50: 213 nM
0.0007
2-[(1-[[(5-methyl-1,3,4-thiadiazol-2-yl)methyl]carbamoyl]cyclopentyl)methyl]pentanoic acid
Canis lupus familiaris
-
IC50: 700 nM
0.00171
2-[(1-[[1-(hydroxymethyl)cyclopentyl]carbamoyl]cyclopentyl)methyl]pentanoic acid
Canis lupus familiaris
-
IC50: 1710 nM
0.000096
2-[(1-[[2-(hydroxymethyl)-2,3-dihydro-1H-inden-2-yl]carbamoyl]cyclopentyl)methyl]pentanoic acid
Canis lupus familiaris
-
IC50: 96 nM
0.00037
2-[(1-[[4-(dimethylcarbamoyl)cyclohexyl]carbamoyl]cyclopentyl)methyl]pentanoic acid
Canis lupus familiaris
-
IC50: 370 nM
0.000124
2-[(1-[[5-(2-methylpropyl)-1,3,4-thiadiazol-2-yl]carbamoyl]cyclopentyl)methyl]pentanoic acid
Canis lupus familiaris
-
IC50: 124 nM
0.000038
2-[(1-[[5-(cyclopropylmethyl)-1,3,4-thiadiazol-2-yl]carbamoyl]cyclopentyl)methyl]pentanoic acid
Canis lupus familiaris
-
IC50: 38 nM
0.0000011
2-[1-(2-hydroxymethyl-indan-2-ylcarbamoyl)-cyclopentylmethyl]-4-methoxy-butyric acid tert-butyl ester
Canis lupus familiaris
-
-
0.0000017
2-[1-(4-butyl-pyridin-2-ylcarbamoyl)-cyclopentylmethyl]-4-methoxybutyric acid benzyl ester
Canis lupus familiaris
-
-
0.000006
2-[1-(5-ethyl-[1,3,4]thiadiazol-2-ylcarbamoyl)-cyclopentylmethyl]-pentanoic acid
Canis lupus familiaris
-
-
0.0000021
2-[1-[2-(trans-4-chlorophenyl)-cyclopropylcarbamoyl]-cyclopentylmethyl]-4-methoxy-butyric acid tert-butyl ester
Canis lupus familiaris