Reference on EC 3.4.24.11 - neprilysin
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Beynon, R.J.; Shannon, J.D.; Bond, J.S.
Purification and characterization of a metallo-endoproteinase from mouse kidney
Biochem. J.
199
591-598
1981
Mus musculus
Stephenson, S.L.; Kenny, A.J.
The metabolism of neuropeptides. Hydrolysis of peptides by the phosphoramidon-insensitive rat kidney enzyme endopeptidase-2 and by rat microvillar membranes
Biochem. J.
255
45-51
1988
Rattus norvegicus
Danilewicz, J.C.; Barclay, P.L.; Barnish, I.T.; Brown, D.; Campbell, S.F.; James, K.; Samuels, G.M.R.; Terrett, N.K.; Wythes, M.J.
UK-69,578, a novel inhibitor of EC 3.4.24.11 which increases endogenous ANF levels and is natriuretic and diuretic
Biochem. Biophys. Res. Commun.
164
58-65
1989
Rattus norvegicus
Gros, C.; Souque, A.; Schwartz, J.C.; Duchier, J.; Cournot, A.; Baumer, P.; Lecomte, J.M.
Protection of atrial natriuretic factor against degradation: diuretic and natriuretic responses after in vivo inhibition of enkephalinase (EC 3.4.24.11) by acetorphan
Proc. Natl. Acad. Sci. USA
86
7580-7584
1989
Homo sapiens
D'Adamio, L.; Shipp, M.A.; Masteller, E.L.; Reinherz, E.L.
Organization of the gene encoding common acute lymphoblastic leukemia antigen (neutral endopeptidase 24.11): multiple miniexons and separate 5 untranslated regions
Proc. Natl. Acad. Sci. USA
86
7103-7107
1989
Homo sapiens
Sullivan, J.; Johnson, A.R.
Detection and analysis of neutral endopeptidase from tissues with substrate gel electrophoresis
Biochem. Biophys. Res. Commun.
162
300-307
1989
Bos taurus, Homo sapiens
Pauwels, S.; Najdovski, T.; Dimaline, R.; Lee, C.M.; Deschodt-Lanckman, M.
Degradation of human gastrin and CCK by endopeptidase 24.11: differential behaviour of the sulphated and unsulphated peptides
Biochim. Biophys. Acta
996
82-88
1989
Homo sapiens
Beaumont, A.; Brouet, J.C.; Roques, B.P.
Neutral endopeptidase 24.11 and angiotensin converting enzyme like activity in CALLA positive and CALLA negative lymphoid cells
Biochem. Biophys. Res. Commun.
160
1323-1329
1989
Homo sapiens
Bourne, A.; Barnes, K.; Taylor, B.A.; Turner, A.J.; Kenny, A.J.
Membrane peptidases in the pig choroid plexus and on other cell surfaces in contact with the cerebrospinal fluid
Biochem. J.
259
69-80
1989
Sus scrofa
Erds, E.G.; Skidgel, R.A.
Neutral endopeptidase 24.11 (enkephalinase) and related regulators of peptide hormones
FASEB J.
3
145-151
1989
Oryctolagus cuniculus, Homo sapiens, Rattus norvegicus, Sus scrofa
Isaac, R.E.
Neuropeptide-degrading endopeptidase activity of locust (Schistocerca gregaria) synaptic membranes
Biochem. J.
255
843-847
1988
Schistocerca gregaria, Sus scrofa
Vanneste, Y.; Michel, A.; Dimaline, R.; Najdovski, T.; Deschodt-Lanckman, M.
Hydrolysis of alpha-human atrial natriuretic peptide in vitro by human kidney membranes and purified endopeptidase-24.11. Evidence for a novel cleavage site
Biochem. J.
254
531-537
1988
Homo sapiens
Painter, R.G.; Dukes, R.; Sullivan, J.; Carter, R.; Erds, E.G.; Johnson, A.R.
Function of neutral endopeptidase on the cell membrane of human neutrophils
J. Biol. Chem.
263
9456-9461
1988
Homo sapiens
Malfroy, B.; Kuang, W.J.; Seeburg, P.H.; Mason, A.J.; Schofield, P.R.
Molecular cloning and amino acid sequence of human enkephalinase (neutral endopeptidase)
FEBS Lett.
229
206-210
1988
Homo sapiens
Sajid, M.; Isaac, R.E.
Identification and properties of a neuropeptide-degrading endopeptidase (neprilysin) of Ascaris suum muscle
Parasitology
111
599-608
1995
Ascaris suum
Lorkowski, G.; Zijderhand-Bleekemolen, J.E.; Erds, E.G.; von Figura, K.; Hasilik, A.
Neutral endopeptidase-24.11 (enkephalinase). Biosynthesis and localization in human fibroblasts
Biochem. J.
248
345-350
1987
Homo sapiens
Kanazawa, M.; Casley, D.J.; Sybertz, E.J.; Haslanger, M.F.; Johnston, C.I.
Localization and characterization of neutral metalloendopeptidase (EC 3.4.24.11), the degradative enzyme for atrial natriuretic peptide, in rat kidney using a radioiodinated neutral metalloendopeptidase inhibitor
J. Pharmacol. Exp. Ther.
261
1231-1237
1992
Rattus norvegicus
Zajac, J.M.; Charnay, Y.; Soleilhac, J.M.; Sales, N.; Roques, B.P.
Enkephalin-degrading enzymes and angiotensin-converting enzyme in human and rat meninges
FEBS Lett.
216
118-122
1987
Homo sapiens, Rattus norvegicus
Malfroy, B.; Burnier, J.
New substrates for enkephalinase (neutral endopeptidase) based on fluorescence energy transfer
Biochem. Biophys. Res. Commun.
143
58-66
1987
Rattus norvegicus
Malfroy, B.; Schofield, P.R.; Kuang, W.J.; Seeburg, P.H.; Mason, A.J.; Henzel, W.J.
Molecular cloning and amino acid sequence of rat enkephalinase
Biochem. Biophys. Res. Commun.
144
59-66
1987
Rattus norvegicus
Waksman, G.; Hamel, E.; Delay-Goyet, P.; Roques, B.P.
Neuronal localization of the neutral endopeptidase enkephalinase in rat brain revealed by lesions and autoradiography
EMBO J.
5
3163-3166
1986
Rattus norvegicus
Jackson, D.G.; Hersh, L.B.
Reaction of neutral endopeptidase 24.11 (enkephalinase) with arginine reagents
J. Biol. Chem.
261
8649-8654
1986
Rattus norvegicus
Bowes, M.A.; Kenny, A.J.
Endopeptidase-24.11 in pig lymph nodes. Purification and immunocytochemical localization in reticular cells
Biochem. J.
236
801-810
1986
Sus scrofa
Vogt-Schaden, M.; Gagelmann, M.; Hock, D.; Herbst, F.; Forssmann, W.G.
Degradation of porcine brain natriuretic peptide (pBNP-26) by endoprotease-24.11 from kidney cortical membranes
Biochem. Biophys. Res. Commun.
161
1177-1183
1989
Canis lupus familiaris
Bowes, M.A.; Kenny, A.J.
Endopeptidase-24.11 in lymphoid tissues
Biochem. Soc. Trans.
14
75-76
1986
Sus scrofa
-
Dion, N.; Cohen, P.; Crine, P.; Boileau, G.
Characterisation of neprilysin (EC 3.4.24.11) S2 subsite
FEBS Lett.
411
140-144
1997
Oryctolagus cuniculus
Hooper, N.M.; Kenny, A.J.; Turner, A.J.
The metabolism of neuropeptides. Neurokinin A (substance K) is a substrate for endopeptidase-24.11 but not for peptidyl dipeptidase A (angiotensin-converting enzyme)
Biochem. J.
231
357-361
1985
Sus scrofa
Kenny, A.J.; Bowes, M.A.; Gee, N.S.; Matsas, R.
Endopeptidase-24.11: a cell-surface enzyme for metabolizing regulatory peptides
Biochem. Soc. Trans.
13
293-295
1985
Sus scrofa
Fournie-Zaluski, M.C.; Soleilhac, J.M.; Turcaud, S.; Lai-Kuen, R.; Crine, P.; Beaumont, A.; Roques, B.P.
Development of [125I]RB104, a potent inhibitor of neutral endopeptidase 24.11, and its use in detecting nanogram quantities of the enzyme by inhibitor gel electrophoresis
Proc. Natl. Acad. Sci. USA
89
6388-6392
1992
Oryctolagus cuniculus
Turner, A.J.; Matsas, R.; Kenny, A.J.
Endopeptidase-24.11 and neuropeptide metabolism
Biochem. Soc. Trans.
13
39-42
1985
Sus scrofa
Gee, N.S.; Bowes, M.A.; Buck, P.; Kenny, A.J.
An immunoradiometric assay for endopeptidase-24.11 shows it to be a widely distributed enzyme in pig tissues
Biochem. J.
228
119-126
1985
Sus scrofa
Matsas, R.; Kenny, A.J.; Turner, A.J.
The metabolism of neuropeptides. The hydrolysis of peptides, including enkephalins, tachykinins and their analogues, by endopeptidase-24.11
Biochem. J.
223
433-440
1984
Sus scrofa
Matsas, R.; Turner, A.J.; Kenny, A.J.
Endopeptidase-24.11 and aminopeptidase activity in brain synaptic membranes are jointly responsible for the hydrolysis of cholecystokinin octapeptide (CCK-8)
FEBS Lett.
175
124-128
1984
Sus scrofa
Relton, J.M.; Gee, N.S.; Matsas, R.; Turner, A.J.; Kenny, A.J.
Purification of endopeptidase-24.11 ( enkephalinase ) from pig brain by immunoadsorbent chromatography
Biochem. J.
215
519-523
1983
Sus scrofa
Fulcher, I.S.; Kenny, A.J.
Proteins of the kidney microvillar membrane. The amphipathic forms of endopeptidase purified from pig kidneys
Biochem. J.
211
743-753
1983
Sus scrofa
Matsas, R.; Fulcher, I.S.; Kenny, A.J.; Turner, A.J.
Substance P and [Leu]enkephalin are hydrolyzed by an enzyme in pig caudate synaptic membranes that is identical with the endopeptidase of kidney microvilli
Proc. Natl. Acad. Sci. USA
80
3111-3115
1983
Sus scrofa
Lian, W.; Wu, D.; Konings, W.N.; Mierau, I.; Hersh, L.B.
Heterologous expression and characterization of recombinant Lactococcus lactis neutral endopeptidase (neprilysin)
Arch. Biochem. Biophys.
333
121-126
1996
Lactococcus lactis
Landry, C.; Santagata, P.; Bawab, W.; Fournie-Zaluski, M.C.; Roques, B.P.; Vinay, P.; Crine, P.
Characterization of neutral endopeptidase 24.11 in dog glomeruli
Biochem. J.
291
773-779
1993
Canis lupus familiaris
Malfroy, B.; Schwartz, J.C.
Properties of enkephalinase from rat kidney: comparison of dipeptidyl-carboxypeptidase and endopeptidase activities
Biochem. Biophys. Res. Commun.
106
276-285
1982
Mus musculus, Rattus norvegicus
Orlowski, M.; Wilk, S.
Purification and specificity of a membrane-bound metalloendopeptidase from bovine pituitaries
Biochemistry
20
4942-4950
1981
Bos taurus
Soleilhac, J.M.; Lafuma, C.; Porcher, J.M.; Auburtin, G.; Roques, B.P.
Characterization of a soluble form of neutral endopeptidase-24.11 (EC 3.4.24.11) in human serum: enhancement of its activity in serum of underground miners exposed to coal dust particles
Eur. J. Clin. Invest.
26
1011-1017
1996
Homo sapiens
Roques, B.P.; Noble, F.; Dauge, V.; Fournie-Zaluski, M.C.; Beaumont, A.
Neutral endopeptidase 24.11: structure, inhibition, and experimental and clinical pharmacology
Pharmacol. Rev.
45
87-146
1993
Homo sapiens, Rattus norvegicus, Sus scrofa
Welches, W.R.; Broshihan, K.B.; Ferrario, C.M.
A comparison of the properties and enzymatic activities of three angiotensin processing enzymes: angiotensin converting enzyme, prolyl endopeptidase and neutral endopeptidase 24.11
Life Sci.
52
1461-1480
1993
Bos taurus, Oryctolagus cuniculus, Homo sapiens, Mus musculus, Rattus norvegicus, Sus scrofa
Schulz, R.; Sakane, Y.; Berry, C.; Ghai, R.
Characterisation of neutral endopeptidase 3.4.24.11 (NEP) in the kidney: comparison between normotensive, genetically hypertensive and experimentally hypertensive rats
J. Enzyme Inhib.
4
347-358
1991
Rattus norvegicus
Spillantini, M.G.; Sicuteri, F.; Salmon, S.; Malfroy, B.
Characterization of endopeptidase 3.4.24.11 ( enkephalinase ) activity in human plasma and cerebrospinal fluid
Biochem. Pharmacol.
39
1353-1356
1990
Homo sapiens, Mus musculus, Rattus norvegicus
Li, C.; Hersh, L.B.
Neprilysin: assay methods, purification, and characterization
Methods Enzymol.
248
253-263
1995
Rattus norvegicus
Hupe-Sodmann, K.; McGregor, G.P.; Bridenbaugh, R.; Goke, R.; Goke, B.; Thole, H.; Zimmermann, B.; Voigt, K.
Characterisation of the processing by human neutral endopeptidase 24.11 of GLP-1(7-36) amide and comparison of the substrate specificity of the enzyme for other glucagon-like peptides
Regul. Pept.
58
149-156
1995
Homo sapiens
Milhiet, P.E.; Dennin, F.; Giocondi, M.C.; le Grimellec, C.; Garbay-Jaureguiberry, C.; Boucheix, C.; Roques, B.P.
Detection of neutral endopeptidase-24.11/CD10 by flow cytometry and photomicroscopy using a new fluorescent inhibitor
Anal. Biochem.
205
57-64
1992
Homo sapiens
Gabrilovac, J.; Cupic, B.; Breljak, D.; Zekusic, M.; Boranic, M.
Expression of CD13/aminopeptidase N and CD10/neutral endopeptidase on cultured human keratinocytes
Immunol. Lett.
91
39-47
2004
Homo sapiens
Trebbien, R.; Klarskov, L.; Olesen, M.; Holst, J.J.; Carr, R.D.; Deacon, C.F.
Neutral endopeptidase 24.11 is important for the degradation of both endogenous and exogenous glucagon in anesthetized pigs
Am. J. Physiol. Endocrinol. Metab.
287
E431-E438
2004
Sus scrofa
Sansoe, G.; Aragno, M.; Mastrocola, R.; Cutrin, J.C.; Silvano, S.; Mengozzi, G.; Smedile, A.; Rosina, F.; Danni, O.; Rizzetto, M.
Overexpression of kidney neutral endopeptidase (EC 3.4.24.11) and renal function in experimental cirrhosis
Am. J. Physiol. Renal Physiol.
290
F1337-F1343
2006
Rattus norvegicus
Rice, G.I.; Thomas, D.A.; Grant, P.J.; Turner, A.J.; Hooper, N.M.
Evaluation of angiotensin-converting enzyme (ACE), its homologue ACE2 and neprilysin in angiotensin peptide metabolism
Biochem. J.
383
45-51
2004
Homo sapiens
Walther, T.; Stepan, H.; Pankow, K.; Becker, M.; Schultheiss, H.P.; Siems, W.E.
Biochemical analysis of neutral endopeptidase activity reveals independent catabolism of atrial and brain natriuretic peptide
Biol. Chem.
385
179-184
2004
Mus musculus
Kajiyama, H.; Shibata, K.; Terauchi, M.; Morita, T.; Ino, K.; Mizutani, S.; Kikkawa, F.
Neutral endopeptidase 24.11/CD10 suppresses progressive potential in ovarian carcinoma in vitro and in vivo
Clin. Cancer Res.
11
1798-1808
2005
Homo sapiens
Pryde, D.C.; Maw, G.N.; Planken, S.; Platts, M.Y.; Sanderson, V.; Corless, M.; Stobie, A.; Barber, C.G.; Russell, R.; Foster, L.; Barker, L.; Wayman, C.; Van Der Graaf, P.; Stacey, P.; Morren, D.; Kohl, C.; Beaumont, K.; Coggon, S.; Tute, M.
Novel selective inhibitors of neutral endopeptidase for the treatment of female sexual arousal disorder. Synthesis and activity of functionalized glutaramides
J. Med. Chem.
49
4409-4424
2006
Canis lupus familiaris
Spanier, B.; Stuerzenbaum, S.R.; Holden-Dye, L.M.; Baumeister, R.
Caenorhabditis elegans neprilysin NEP-1: an effector of locomotion and pharyngeal pumping
J. Mol. Biol.
352
429-437
2005
Caenorhabditis elegans
Marr, R.A.; Guan, H.; Rockenstein, E.; Kindy, M.; Gage, F.H.; Verma, I.; Masliah, E.; Hersh, L.B.
Neprilysin regulates amyloid Beta peptide levels
J. Mol. Neurosci.
22
5-11
2004
Mus musculus
Broccolini, A.; Gidaro, T.; Morosetti, R.; Gliubizzi, C.; Servidei, T.; Pescatori, M.; Tonali, P.A.; Ricci, E.; Mirabella, M.
Neprilysin participates in skeletal muscle regeneration and is accumulated in abnormal muscle fibres of inclusion body myositis
J. Neurochem.
96
777-789
2006
Homo sapiens
Pardossi-Piquard, R.; Dunys, J.; Yu, G.; St.George-Hyslop, P.; Alves da Costa, C.; Checler, F.
Neprilysin activity and expression are controlled by nicastrin
J. Neurochem.
97
1052-1056
2006
Mus musculus
Iwata, N.; Mizukami, H.; Shirotani, K.; Takaki, Y.; Muramatsu, S.; Lu, B.; Gerard, N.P.; Gerard, C.; Ozawa, K.; Saido, T.C.
Presynaptic localization of neprilysin contributes to efficient clearance of amyloid-beta peptide in mouse brain
J. Neurosci.
24
991-998
2004
Mus musculus
Ayoub, S.; Melzig, M.F.
Induction of neutral endopeptidase (NEP) activity of SK-N-SH cells by natural compounds from green tea
J. Pharm. Pharmacol.
58
495-501
2006
Homo sapiens
Huang, J.; Guan, H.; Booze, R.M.; Eckman, C.B.; Hersh, L.B.
Estrogen regulates neprilysin activity in rat brain
Neurosci. Lett.
367
85-87
2004
Rattus norvegicus
Carter, T.L.; Pedrini, S.; Ghiso, J.; Ehrlich, M.E.; Gandy, S.
Brain neprilysin activity and susceptibility to transgene-induced Alzheimer amyloidosis
Neurosci. Lett.
392
235-239
2006
Homo sapiens, Mus musculus
Skidgel, R.A.; Erdoes, E.G.
Angiotensin converting enzyme (ACE) and neprilysin hydrolyze neuropeptides: a brief history, the beginning and follow-ups to early studies
Peptides
25
521-525
2004
Homo sapiens
Song, J.; Aumueller, G.; Xiao, F.; Wilhelm, B.; Albrecht, M.
Cell specific expression of CD10/neutral endopeptidase 24.11 gene in human prostatic tissue and cells
Prostate
58
394-405
2004
Homo sapiens
Jiang, W.; Jiang, H.F.; Cai, D.Y.; Pan, C.S.; Qi, Y.F.; Pang, Y.Z.; Tang, C.S.
Relationship between contents of adrenomedullin and distributions of neutral endopeptidase in blood and tissues of rats in septic shock
Regul. Pept.
118
199-208
2004
Rattus norvegicus
Schmid, C.; Ghirlanda-Keller, C.; Gosteli-Peter, M.
Ascorbic acid decreases neutral endopeptidase activity in cultured osteoblastic cells
Regul. Pept.
130
57-66
2005
Rattus norvegicus (P07861)
Oefner, C.; Pierau, S.; Schulz, H.; Dale, G.E.
Structural studies of a bifunctional inhibitor of neprilysin and DPP-IV
Acta Crystallogr. Sect. D
63
975-981
2007
Homo sapiens (P08473), Homo sapiens
Oh-Hashi, K.; Ohkubo, K.; Shizu, K.; Fukuda, H.; Hirata, Y.; Kiuchi, K.
Biosynthesis, processing, trafficking, and enzymatic activity of mouse neprilysin 2
Mol. Cell. Biochem.
313
103-111
2008
Mus musculus
de Gortari, P.; Vargas, M.A.; Martinez, A.; Garcia-Vazquez, A.I.; Uribe, R.M.; Chavez-Gutierrez, L.; Magdaleno, V.; Boileau, G.; Charli, J.L.; Joseph-Bravo, P.
Stage-specific modulation of neprilysin and aminopeptidase N in the limbic system during kindling progression
J. Mol. Neurosci.
33
252-261
2007
Rattus norvegicus
Barros, N.M.; Campos, M.; Bersanetti, P.A.; Oliveira, V.; Juliano, M.A.; Boileau, G.; Juliano, L.; Carmona, A.K.
Neprilysin carboxydipeptidase specificity studies and improvement in its detection with fluorescence energy transfer peptides
Biol. Chem.
388
447-455
2007
Homo sapiens
Pryde, D.C.; Cook, A.S.; Burring, D.J.; Jones, L.H.; Foll, S.; Platts, M.Y.; Sanderson, V.; Corless, M.; Stobie, A.;Middleton, D.S.; Foster, L.; Barker, L.; Van Der Graaf, P.; Stacey, P.; Kohl, C.; Coggon, S.; Beaumont, K.
Novel selective inhibitors of neutral endopeptidase for the treatment of female sexual arousal disorder
Bioorg. Med. Chem.
15
142-159
2007
Canis lupus familiaris
Moro, C.; Klimcakova, E.; Lafontan, M.; Berlan, M.; Galitzky, J.
Phosphodiesterase-5A and neutral endopeptidase activities in human adipocytes do not control atrial natriuretic peptide-mediated lipolysis
Br. J. Pharmacol.
152
1102-1110
2007
Homo sapiens
Barber, M.N.; Kanagasundaram, M.; Anderson, C.R.; Burrell, L.M.; Woods, R.L.
Vascular neutral endopeptidase inhibition improves endothelial function and reduces intimal hyperplasia
Cardiovasc. Res.
71
179-188
2006
Oryctolagus cuniculus
Goodman, O.B.; Febbraio, M.; Simantov, R.; Zheng, R.; Shen, R.; Silverstein, R.L.; Nanus, D.M.
Neprilysin inhibits angiogenesis via proteolysis of fibroblast growth factor-2
J. Biol. Chem.
281
33597-33605
2006
Mus musculus
Broccolini, A.; Gidaro, T.; De Cristofaro, R.; Morosetti, R.; Gliubizzi, C.; Ricci, E.; Tonali, P.A.; Mirabella, M.
Hyposialylation of neprilysin possibly affects its expression and enzymatic activity in hereditary inclusion-body myopathy muscle
J. Neurochem.
105
971-981
2008
Homo sapiens
Miners, J.S.; Van Helmond, Z.; Chalmers, K.; Wilcock, G.; Love, S.; Kehoe, P.G.
Decreased expression and activity of neprilysin in Alzheimer disease are associated with cerebral amyloid angiopathy
J. Neuropathol. Exp. Neurol.
65
1012-1021
2006
Homo sapiens
Miners, J.S.; Verbeek, M.M.; Rikkert, M.O.; Kehoe, P.G.; Love, S.
Immunocapture-based fluorometric assay for the measurement of neprilysin-specific enzyme activity in brain tissue homogenates and cerebrospinal fluid
J. Neurosci. Methods
167
229-236
2008
Homo sapiens
Daily, A.; Nath, A.; Hersh, L.B.
Tat peptides inhibit neprilysin
J. NeuroVirol.
12
153-160
2006
Homo sapiens
Kozlovski, V.I.; Lomnicka, M.; Jakubowski, A.; Chlopicki, S.
Inhibition of neutral endopeptidase by thiorphan does not modify coronary vascular responses to angiotensin I, angiotensin II and bradykinin in the isolated guinea pig heart
Pharmacol. Rep.
59
421-427
2007
Cavia porcellus
Kiss, A.; Kowalski, J.; Melzig, M.F.
Effect of Epilobium angustifolium L. extracts and polyphenols on cell proliferation and neutral endopeptidase activity in selected cell lines
Pharmazie
61
66-69
2006
Homo sapiens
El-Amouri, S.S.; Zhu, H.; Yu, J.; Marr, R.; Verma, I.M.; Kindy, M.S.
Neprilysin: an enzyme candidate to slow the progression of Alzheimer's disease
Am. J. Pathol.
172
1342-1354
2008
Homo sapiens
Dempsey, E.C.; Wick, M.J.; Karoor, V.; Barr, E.J.; Tallman, D.W.; Wehling, C.A.; Walchak, S.J.; Laudi, S.; Le, M.; Oka, M.; Majka, S.; Cool, C.D.; Fagan, K.A.; Klemm, D.J.; Hersh, L.B.; Gerard, N.P.; Gerard, C.; Miller, Y.E.
Neprilysin null mice develop exaggerated pulmonary vascular remodeling in response to chronic hypoxia
Am. J. Pathol.
174
782-796
2009
Mus musculus
Dolcini, V.; Dunys, J.; Sevalle, J.; Chen, F.; Guillot-Sestier, M.V.; St George-Hyslop, P.; Fraser, P.E.; Checler, F.
TMP21 regulates Abeta production but does not affect caspase-3, p53, and neprilysin
Biochem. Biophys. Res. Commun.
371
69-74
2008
Homo sapiens
Chen, K.L.; Wang, S.S.; Yang, Y.Y.; Yuan, R.Y.; Chen, R.M.; Hu, C.J.
The epigenetic effects of amyloid-beta(1-40) on global DNA and neprilysin genes in murine cerebral endothelial cells
Biochem. Biophys. Res. Commun.
378
57-61
2009
Mus musculus
Spencer, B.; Marr, R.A.; Rockenstein, E.; Crews, L.; Adame, A.; Potkar, R.; Patrick, C.; Gage, F.H.; Verma, I.M.; Masliah, E.
Long-term neprilysin gene transfer is associated with reduced levels of intracellular Abeta and behavioral improvement in APP transgenic mice
BMC Neurosci.
9
109
2008
Homo sapiens
Fleischmann, A.; Schlomm, T.; Huland, H.; Koellermann, J.; Simon, P.; Mirlacher, M.; Salomon, G.; Chun, F.H.; Steuber, T.; Simon, R.; Sauter, G.; Graefen, M.; Erbersdobler, A.
Distinct subcellular expression patterns of neutral endopeptidase (CD10) in prostate cancer predict diverging clinical courses in surgically treated patients
Clin. Cancer Res.
14
7838-7842
2008
Homo sapiens
Bukowska, A.; Lendeckel, U.; Krohn, A.; Keilhoff, G.; ten Have, S.; Neumann, K.H.; Goette, A.
Atrial fibrillation down-regulates renal neutral endopeptidase expression and induces profibrotic pathways in the kidney
Europace
10
1212-1217
2008
Sus scrofa
Thomas, C.J.; McAllen, R.M.; Salo, L.M.; Woods, R.L.
Restorative effect of atrial natriuretic peptide or chronic neutral endopeptidase inhibition on blunted cardiopulmonary vagal reflexes in aged rats
Hypertension
52
696-701
2008
Rattus norvegicus
Imaki, R.; Niwano, S.; Niwano, H.; Satoh, D.; Yoshida, T.; Masaki, Y.; Izumi, T.
Neutral endopeptidase inhibitor suppresses the early phase of atrial electrical remodeling in a canine rapid atrial pacing model
Indian Pacing Electrophysiol. J.
8
102-113
2008
Canis lupus familiaris
Mak, I.T.; Kramer, J.H.; Chmielinska, J.J.; Khalid, M.H.; Landgraf, K.M.; Weglicki, W.B.
Inhibition of neutral endopeptidase potentiates neutrophil activation during Mg-deficiency in the rat
Inflamm. Res.
57
300-305
2008
Rattus norvegicus
Iijima-Ando, K.; Hearn, S.A.; Granger, L.; Shenton, C.; Gatt, A.; Chiang, H.C.; Hakker, I.; Zhong, Y.; Iijima, K.
Overexpression of neprilysin reduces Alzheimer amyloid-beta42 (Abeta42)-induced neuron loss and intraneuronal Abeta42 deposits but causes a reduction in cAMP-responsive element-binding protein-mediated transcription, age-dependent axon pathology, and premature death in Drosophila
J. Biol. Chem.
283
19066-19076
2008
Homo sapiens
Wang, R.; Wang, S.; Malter, J.S.; Wang, D.S.
Effects of HNE-modification induced by Abeta on neprilysin expression and activity in SH-SY5Y cells
J. Neurochem.
108
1072-1082
2009
Homo sapiens
Yao, M.; Nguyen, T.V.; Rosario, E.R.; Ramsden, M.; Pike, C.J.
Androgens regulate neprilysin expression: role in reducing beta-amyloid levels
J. Neurochem.
105
2477-2488
2008
Rattus norvegicus
Guan, H.; Liu, Y.; Daily, A.; Police, S.; Kim, M.H.; Oddo, S.; LaFerla, F.M.; Pauly, J.R.; Murphy, M.P.; Hersh, L.B.
Peripherally expressed neprilysin reduces brain amyloid burden: a novel approach for treating Alzheimer's disease
J. Neurosci. Res.
87
1462-1473
2009
Homo sapiens
Rose, J.B.; Crews, L.; Rockenstein, E.; Adame, A.; Mante, M.; Hersh, L.B.; Gage, F.H.; Spencer, B.; Potkar, R.; Marr, R.A.; Masliah, E.
Neuropeptide Y fragments derived from neprilysin processing are neuroprotective in a transgenic model of Alzheimer's disease
J. Neurosci.
29
1115-1125
2009
Homo sapiens
Meilandt, W.J.; Cisse, M.; Ho, K.; Wu, T.; Esposito, L.A.; Scearce-Levie, K.; Cheng, I.H.; Yu, G.Q.; Mucke, L.
Neprilysin overexpression inhibits plaque formation but fails to reduce pathogenic Abeta oligomers and associated cognitive deficits in human amyloid precursor protein transgenic mice
J. Neurosci.
29
1977-1986
2009
Homo sapiens
Burgos-Ramos, E.; Puebla-Jimenez, L.; Arilla-Ferreiro, E.
Minocycline prevents Abeta(25-35)-induced reduction of somatostatin and neprilysin content in rat temporal cortex
Life Sci.
84
205-210
2009
Rattus norvegicus
Zaheer-ul-Haq, M.S.; Iqbal, S.
Receptor-based 3D-QSAR study for recognizing true binding mode of mercaptoacyldipeptides at the active site of neutral endopeptidase
Med. Chem.
5
50-65
2009
Homo sapiens
Betts, V.; Leissring, M.A.; Dolios, G.; Wang, R.; Selkoe, D.J.; Walsh, D.M.
Aggregation and catabolism of disease-associated intra-Abeta mutations: reduced proteolysis of AbetaA21G by neprilysin
Neurobiol. Dis.
31
442-450
2008
Homo sapiens
Kraemer, H.H.; He, L.; Lu, B.; Birklein, F.; Sommer, C.
Increased pain and neurogenic inflammation in mice deficient of neutral endopeptidase
Neurobiol. Dis.
35
177-183
2008
Mus musculus
Mohajeri, M.H.; Wolfer, D.P.
Neprilysin deficiency-dependent impairment of cognitive functions in a mouse model of amyloidosis
Neurochem. Res.
34
717-726
2009
Mus musculus
Maeshiro, K.; Takamori, S.; Mifune, H.; Matsuo, T.; Kimura, N.Y.; Honda, J.; Shirouzu, K.
Changes in A-type natriuretic peptide and its receptors induced by a neutral endopeptidase inhibitor in a rat model of sepsis
Surg. Today
38
130-134
2008
Rattus norvegicus
Takeuchi, Y.; Uetsuka, K.; Murayama, M.; Kikuta, F.; Takashima, A.; Doi, K.; Nakayama, H.
Complementary distributions of amyloid-beta and neprilysin in the brains of dogs and cats
Vet. Pathol.
45
455-466
2008
Canis lupus familiaris, Felis catus
Belyaev, N.; Nalivaeva, N.; Makova, N.; Turner, A.
Neprilysin gene expression requires binding of the amyloid precursor protein intracellular domain to its promoter: Implications for Alzheimer disease
EMBO Rep.
10
94-100
2009
Homo sapiens, Rattus norvegicus
Davidson, E.; Coppey, L.; Lu, B.; Arballo, V.; Calcutt, N.A.; Gerard, C.; Yorek, M.
The roles of streptozotocin neurotoxicity and neutral endopeptidase in murine experimental diabetic neuropathy
Exp. Diabetes Res.
2009
431980
2009
Mus musculus
Fitzpatrick, P.A.; Guinan, A.F.; Walsh, T.G.; Murphy, R.P.; Killeen, M.T.; Tobin, N.P.; Pierotti, A.R.; Cummins, P.M.
Down-regulation of neprilysin (EC3.4.24.11) expression in vascular endothelial cells by laminar shear stress involves NADPH oxidase-dependent ROS production
Int. J. Biochem. Cell Biol.
41
2287-2294
2009
Bos taurus
Zraika, S.; Aston-Mourney, K.; Marek, P.; Hull, R.L.; Green, P.S.; Udayasankar, J.; Subramanian, S.L.; Raleigh, D.P.; Kahn, S.E.
Neprilysin impedes islet amyloid formation by inhibition of fibril formation rather than peptide degradation
J. Biol. Chem.
285
18177-18183
2010
Mus musculus
Liang, K.; Yang, L.; Yin, C.; Xiao, Z.; Zhang, J.; Liu, Y.; Huang, J.
Estrogen stimulates degradation of beta-amyloid peptide by up-regulating neprilysin
J. Biol. Chem.
285
935-942
2010
Homo sapiens
Meyer, H.; Panz, M.; Zmojdzian, M.; Jagla, K.; Paululat, A.
Neprilysin 4, a novel endopeptidase from Drosophila melanogaster, displays distinct substrate specificities and exceptional solubility states
J. Exp. Biol.
212
3673-3683
2009
Drosophila melanogaster, Drosophila melanogaster (Q9I7I4)
Davies, K.P.
The role of opiorphins (endogenous neutral endopeptidase inhibitors) in urogenital smooth muscle biology
J. Sex Med.
6 Suppl 3
286-291
2009
Homo sapiens, Rattus norvegicus, Sus scrofa
Gu, J.; Noe, A.; Chandra, P.; Al-Fayoumi, S.; Ligueros-Saylan, M.; Sarangapani, R.; Maahs, S.; Ksander, G.; Rigel, D.F.; Jeng, A.Y.; Lin, T.H.; Zheng, W.; Dole, W.P.
Pharmacokinetics and pharmacodynamics of LCZ696, a novel dual-acting angiotensin receptor-neprilysin inhibitor (ARNi)
J. Clin. Pharmacol.
50
401-414
2010
Homo sapiens, Rattus norvegicus
Ruilope, L.M.; Dukat, A.; Boehm, M.; Lacourciere, Y.; Gong, J.; Lefkowitz, M.P.
Blood-pressure reduction with LCZ696, a novel dual-acting inhibitor of the angiotensin II receptor and neprilysin: a randomised, double-blind, placebo-controlled, active comparator study
Lancet
375
1255-1266
2010
Homo sapiens
Gunia, S.
Molecular interaction between arsenic hydrate microcrystals and the cell-surface endopeptidase CD10 (neprilysin) - a possible link to the development of renal and cutaneous malignancies upon occupational exposure to arsenic compounds?
Med. Hypotheses
75
35-37
2010
Homo sapiens
Huehne, K.; Schaal, U.; Leis, S.; Uebe, S.; Gosso, M.F.; van den Maagdenberg, A.M.; Maihoefner, C.; Birklein, F.; Rautenstrauss, B.; Winterpacht, A.
Lack of genetic association of neutral endopeptidase (NEP) with complex regional pain syndrome (CRPS)
Neurosci. Lett.
472
19-23
2010
Homo sapiens
Walther, T.; Albrecht, D.; Becker, M.; Schubert, M.; Kouznetsova, E.; Wiesner, B.; Maul, B.; Schliebs, R.; Grecksch, G.; Furkert, J.; Sterner-Kock, A.; Schultheiss, H.P.; Becker, A.; Siems, W.E.
Improved learning and memory in aged mice deficient in amyloid beta-degrading neutral endopeptidase
PLoS ONE
4
e4590
2009
Mus musculus
Sekiguchi, H.; Habuchi, C.; Iritani, S.; Arai, T.; Ozaki, N.
Expression of neprilysin, somatostatin and the somatostatin sst5 receptor in the hippocampal formation of brains from Alzheimers disease patients
Psychogeriatrics
9
132-138
2009
Homo sapiens
-
Jacob, S.; Deyo, D.J.; Cox, R.A.; Traber, D.L.; Herndon, D.N.; Hawkins, H.K.
Mechanisms of toxic smoke inhalation and burn injury: role of neutral endopeptidase and vascular leakage in mice
Toxicol. Mech. Methods
19
191-196
2009
Mus musculus
Hafez, D.; Huang, J.Y.; Huynh, A.M.; Valtierra, S.; Rockenstein, E.; Bruno, A.M.; Lu, B.; DesGroseillers, L.; Masliah, E.; Marr, R.A.
Neprilysin-2 is an important beta-amyloid degrading enzyme
Am. J. Pathol.
178
306-312
2011
Mus musculus
Groubman, M.A.; Kamanina, Y.V.; Petrushanko, I.I.u.; Rubtsov, A.M.; Lopina, O.D.
Neutral endopeptidase neprilysin is copurified with Na,K-ATPase from rabbit outer medulla and hydrolyzes its alpha-subunit
Biochemistry (Moscow)
75
1281-1284
2010
Oryctolagus cuniculus
Glossop, M.S.; Bazin, R.J.; Dack, K.N.; Fox, D.N.; MacDonald, G.A.; Mills, M.; Owen, D.R.; Phillips, C.; Reeves, K.A.; Ringer, T.J.; Strang, R.S.; Watson, C.A.
Synthesis and evaluation of heteroarylalanine diacids as potent and selective neutral endopeptidase inhibitors
Bioorg. Med. Chem. Lett.
21
3404-3406
2011
Homo sapiens
Li, M.; Sun, M.; Liu, Y.; Yu, J.; Yang, H.; Fan, D.; Chui, D.
Copper downregulates neprilysin activity through modulation of neprilysin degradation
J. Alzheimers Dis.
19
161-169
2010
Mus musculus
Morales-Mulia, M.; de Gortari, P.; Amaya, M.I.; Mendez, M.
Activity and expression of enkephalinase and aminopeptidase N in regions of the mesocorticolimbic system are selectively modified by acute ethanol administration
J. Mol. Neurosci.
46
58-67
2012
Rattus norvegicus
Chen, P.T.; Liao, T.Y.; Hu, C.J.; Wu, S.T.; Wang, S.S.; Chen, R.P.
A highly sensitive peptide substrate for detecting two Ass-degrading enzymes: neprilysin and insulin-degrading enzyme
J. Neurosci. Methods
190
57-62
2010
Homo sapiens
Leuchte, H.H.; Prechtl, C.; Callegari, J.; Meis, T.; Haziraj, S.; Bevec, D.; Behr, J.
Augmentation of the effects of vasoactive intestinal peptide aerosol on pulmonary hypertension via coapplication of a neutral endopeptidase 24.11 inhibitor
Am. J. Physiol. Lung Cell Mol. Physiol.
308
L563-L568
2015
Homo sapiens (P08473)
Kuruppu, S.; Rajapakse, N.W.; Minond, D.; Smith, A.I.
Production of soluble neprilysin by endothelial cells
Biochem. Biophys. Res. Commun.
446
423-427
2014
Homo sapiens (P08473), Homo sapiens
Park, M.H.; Lee, J.K.; Choi, S.; Ahn, J.; Jin, H.K.; Park, J.S.; Bae, J.S.
Recombinant soluble neprilysin reduces amyloid-beta accumulation and improves memory impairment in Alzheimers disease mice
Brain Res.
1529
113-124
2013
Homo sapiens (P08473), Homo sapiens
Marr, R.A.; Hafez, D.M.
Amyloid-beta and Alzheimers disease: the role of neprilysin-2 in amyloid-beta clearance
Front. Aging Neurosci.
6
187
2014
Rattus norvegicus, Homo sapiens (P08473), Mus musculus (Q61391)
Pope, D.; Madura, J.D.; Cascio, M.
beta-Amyloid and neprilysin computational studies identify critical residues implicated in binding specificity
J. Chem. Inf. Model.
54
1157-1165
2014
Homo sapiens (P08473)
Sato, K.; Tanabe, C.; Yonemura, Y.; Watahiki, H.; Zhao, Y.; Yagishita, S.; Ebina, M.; Suo, S.; Futai, E.; Murata, M.; Ishiura, S.
Localization of mature neprilysin in lipid rafts
J. Neurosci. Res.
90
870-877
2012
Homo sapiens (P08473)
Sexton, T.; Hitchcook, L.J.; Rodgers, D.W.; Bradley, L.H.; Hersh, L.B.
Active site mutations change the cleavage specificity of neprilysin
PLoS ONE
7
e32343
2012
Homo sapiens (P08473)
Morisaki, N.; Ohuchi, A.; Moriwaki, S.
The role of neprilysin in regulating the hair cycle
PLoS ONE
8
e55947
2013
Rattus norvegicus (P07861), Homo sapiens (P08473), Mus musculus (Q61391)
Webster, C.I.; Burrell, M.; Olsson, L.L.; Fowler, S.B.; Digby, S.; Sandercock, A.; Snijder, A.; Tebbe, J.; Haupts, U.; Grudzinska, J.; Jermutus, L.; Andersson, C.
Engineering neprilysin activity and specificity to create a novel therapeutic for Alzheimers disease
PLoS ONE
9
e104001
2014
Homo sapiens (P08473)
Chin-Chan, M.; Segovia, J.; Quintanar, L.; Arcos-Lopez, T.; Hersh, L.B.; Chow, K.M.; Rodgers, D.W.; Quintanilla-Vega, B.
Mercury reduces the enzymatic activity of neprilysin in differentiated SH-SY5Y cells
Toxicol. Sci.
145
128-137
2015
Homo sapiens (P08473), Homo sapiens
Poras, H.; Patouret, R.; Leiris, S.; Ouimet, T.; Fournie-Zaluski, M.C.; Roques, B.P.
Substituted alpha-mercaptoketones, new types of specific neprilysin inhibitors
Bioorg. Med. Chem. Lett.
27
3883-3890
2017
Homo sapiens (P08473)
McKinnie, S.M.; Fischer, C.; Tran, K.M.; Wang, W.; Mosquera, F.; Oudit, G.Y.; Vederas, J.C.
The metalloprotease neprilysin degrades and inactivates apelin peptides
ChemBioChem
17
1495-1498
2016
Homo sapiens (P08473)
Hornung, K.; Zampar, S.; Engel, N.; Klafki, H.; Liepold, T.; Bayer, T.A.; Wiltfang, J.; Jahn, O.; Wirths, O.
N-terminal truncated Abeta4-42 is a substrate for neprilysin degradation in vitro and in vivo
J. Alzheimers Dis.
67
849-858
2019
Homo sapiens (P08473)
Moss, S.; Subramanian, V.; Acharya, K.R.
High resolution crystal structure of substrate-free human neprilysin
J. Struct. Biol.
204
19-25
2018
Homo sapiens (P08473), Homo sapiens
Ul-Haq, Z.; Usmani, S.; Iqbal, S.; Zia, S.R.
In silico based investigation of dynamic variations in neprilysin (NEP and NEP2) proteins for extracting the point of specificity
Mol. Biosyst.
12
1024-1036
2016
Homo sapiens (P08473), Homo sapiens
de Oliveira, R.W.; Julian, G.S.; Perry, J.C.; Tufik, S.; Chagas, J.R.
Chronic intermittent hypoxia induces changes on the expression and activity of neprilysin (EC 3.4.24.11) in the brain of rats
Neurosci. Lett.
678
43-47
2018
Rattus norvegicus (P07861), Rattus norvegicus Wistar-Hannover (P07861)
Becker, M.; Moore, A.; Naughton, M.; Boland, B.; Siems, W.E.; Walther, T.
Neprilysin degrades murine amyloid-beta (Abeta) more efficiently than human Abeta further implication for species-specific amyloid accumulation
Neurosci. Lett.
686
74-79
2018
Homo sapiens (P08473), Homo sapiens, Mus musculus (Q61391), Mus musculus
Chen, P.T.; Chen, C.L.; Lin, L.T.; Lo, C.H.; Hu, C.J.; Chen, R.P.; Wang, S.S.
Design of peptide substrate for sensitively and specifically detecting two Abeta-degrading enzymes neprilysin and angiotensin-converting enzyme
PLoS ONE
11
e0153360
2016
Homo sapiens (P08473)
Burrell, M.; Henderson, S.J.; Ravnefjord, A.; Schweikart, F.; Fowler, S.B.; Witt, S.; Hansson, K.M.; Webster, C.I.
Neprilysin inhibits coagulation through proteolytic inactivation of fibrinogen
PLoS ONE
11
e0158114
2016
Homo sapiens (P08473), Homo sapiens
Smith, A.I.; Rajapakse, N.W.; Kleifeld, O.; Lomonte, B.; Sikanyika, N.L.; Spicer, A.J.; Hodgson, W.C.; Conroy, P.J.; Small, D.H.; Kaye, D.M.; Parkington, H.C.; Whisstock, J.C.; Kuruppu, S.
N-terminal domain of Bothrops asper myotoxin II enhances the activity of endothelin converting enzyme-1 and neprilysin
Sci. Rep.
6
22413
2016
Homo sapiens (P08473)
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