3.4.24.11: neprilysin

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For detailed information about neprilysin, go to the full flat file.

Word Map on EC 3.4.24.11

3.4.24.11

angiotensin

natriuretic

alzheimer

angiotensin-converting

phosphoramidon

atrial

amyloid

thiorphan

cardiovascular

hypertension

bradykinin

neuropeptides

aminopeptidase

ejection

airway

anp

ventricular

blocker

captopril

endothelins

opioids

metallopeptidase

tachykinins

renin-angiotensin

hf

valsartan

enalapril

renin-angiotensin-aldosterone

neurokinin

vasoactive

endothelin-converting

hfref

naloxone

insulin-degrading

bestatin

kinin

diuretic

3.4.15.1

lily

aceis

met-enkephalin

bronchoconstriction

angioedema

amastatin

angiotensin-1-7

kininase

lisinopril

nt-probnp

medicine

bronchoconstrictors

pharmacology

analysis

molecular biology

angiotensin-receptor

Reaction

preferential cleavage of polypeptides between hydrophobic residues, particularly with Phe or Tyr at P1' =

Synonyms

Abeta-degrading enzyme, acute lymphoblastic leukemia antigen, antigen, CALLA (common acute lymphoblastic leukemia-associated), atriopeptidase, CALLA, CALLA (common acute lymphoblastic leukemia-associated) antigens, CALLA antigen, CALLA glycoproteins, CD10, CD10/neutral endopeptidase, CD10/neutral endopeptidase 24.11, common acute lymphoblastic leukemia antigen, common acute lymphoblastic leukemia-associated antigens, Common acute lymphocytic leukemia antigen, endopeptidase CD10, Endopeptidase-2, endopeptidase-24.11, enkephalinase, EP24.11, glycoprotein, CALLA, kidney-brush-border neutral endopeptidase, kidney-brush-border neutral peptidase, kidney-brush-border neutral proteinase, membrane metallo-endopeptidase, membrane metalloendopeptidase, MME, NEP, NEP 24.11, NEP, enkephalinase, neutrophil cluster-differentiation antigen 10, common acute lymphoblastic leukemia antigen, NEP-1, NEP/CD10, NEP2, NEP4A, NEP4B, neprilypsin, neprilysin, neprilysin 4, neutral endopeptidase, neutral endopeptidase 24.11, neutral endopeptidase 24.11/CD10, neutral metallendopeptidase, NL-1, peptidase, endo-, peptidase, membrane metalloendo-, SEP, skin fibroblast elastase

ECTree

3 Hydrolases

3.4 Acting on peptide bonds (peptidases)

3.4.24 Metalloendopeptidases

3.4.24.11 neprilysin

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Results	in table
8	Activating Compound
1426	AA Sequence
16	Application
1	CAS Registry Number
30	Cloned(Commentary)
5	Crystallization (Commentary)
5034	Disease/ Diagnostics
8	Expression
54	General Information
122	IC50 Value
302	Inhibitors
20	kcat/KM [mM/s]
18	Ki Value [mM]
162	KM Value [mM]
41	Localization
26	Metals/Ions
18	Molecular Weight [Da]
67	Natural Substrates/ Products (Substrates)
174	Organism
25	PDB ID
32	pH Optimum
8	pH Range
14	Posttranslational Modification
50	Protein Variants
18	Purification (Commentary)
1	Reaction
6	Reaction Type
173	Reference
229	Source Tissue
9	Specific Activity [micromol/min/mg]
446	Substrates and Products (Substrate)
9	Subunits
145	Synonyms
17	Temperature Optimum [°C]
1	Temperature Stability [°C]
77	Turnover Number [1/s]

KCat KM Value

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KCat KM Value on EC 3.4.24.11 - neprilysin

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390

alpha-endorphin