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3.4.24.11: neprilysin

This is an abbreviated version!
For detailed information about neprilysin, go to the full flat file.

Word Map on EC 3.4.24.11

Reaction

preferential cleavage of polypeptides between hydrophobic residues, particularly with Phe or Tyr at P1' =

Synonyms

Abeta-degrading enzyme, acute lymphoblastic leukemia antigen, antigen, CALLA (common acute lymphoblastic leukemia-associated), atriopeptidase, CALLA, CALLA (common acute lymphoblastic leukemia-associated) antigens, CALLA antigen, CALLA glycoproteins, CD10, CD10/neutral endopeptidase, CD10/neutral endopeptidase 24.11, common acute lymphoblastic leukemia antigen, common acute lymphoblastic leukemia-associated antigens, Common acute lymphocytic leukemia antigen, endopeptidase CD10, Endopeptidase-2, endopeptidase-24.11, enkephalinase, EP24.11, glycoprotein, CALLA, kidney-brush-border neutral endopeptidase, kidney-brush-border neutral peptidase, kidney-brush-border neutral proteinase, membrane metallo-endopeptidase, membrane metalloendopeptidase, MME, NEP, NEP 24.11, NEP, enkephalinase, neutrophil cluster-differentiation antigen 10, common acute lymphoblastic leukemia antigen, NEP-1, NEP/CD10, NEP2, NEP4A, NEP4B, neprilypsin, neprilysin, neprilysin 4, neutral endopeptidase, neutral endopeptidase 24.11, neutral endopeptidase 24.11/CD10, neutral metallendopeptidase, NL-1, peptidase, endo-, peptidase, membrane metalloendo-, SEP, skin fibroblast elastase

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.24 Metalloendopeptidases
                3.4.24.11 neprilysin

Expression

Expression on EC 3.4.24.11 - neprilysin

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
decreased expresssion upon treatment with Cu2+
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ethanol induces an increase in NEP mRNA in the frontal cortex
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in neuroblastoma SH-SY5Y cells neprilysin expression is up-regulated estrogen. Upregulation of neprilysin by estrogen is dependent on both estrogen receptor alpha and beta, and ligand-activated estrogen receptor regulates expression of neprilysin through physical interactions between estrogen receptor and estrogen response elements identified in the neprilysin gene
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NEP expression is down-regulated in bovine vascular endothelial cells by physiological laminar shear, possibly via a mechanotransduction mechanism involving NADPH oxidase-induced reactive oxygen species production
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six-week intermittent hypoxia increases NEP expression and activity, selectively in temporal cortex, but not in the hippocampus and frontal cortex. The increase in NEP activity and expression is reverted followed by two weeks recovery in normoxia
treatment of cells with and histone deacetylase inhibitor sodium valproate or trichostatin A significantly increases NEP mRNA levels and NEP enzymatic activity in neuroblastoma SH-SY5Y cells
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treatment of neuroblastoma cells NB7 with 10 mM L685,458 a potent gamma-secretase inhibitor substantially reduces NEP expression
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