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0.0068 - 0.0224
(7-methoxycoumarin-4-yl)acetyl-Arg-Pro-Pro-Gly-Phe-Ser-Ala-Phe-Lys(2,4-dinitrophenyl)
0.0687
2-aminobenzoyl-ARFK-2,4-dinitrophenyl ester
-
-
0.0178
2-aminobenzoyl-DRFK-2,4-dinitrophenyl ester
-
-
0.0097
2-aminobenzoyl-FRFK-2,4-dinitrophenyl ester
-
-
0.0161
2-aminobenzoyl-HRFK-2,4-dinitrophenyl ester
-
-
0.0093
2-aminobenzoyl-IRFK-2,4-dinitrophenyl ester
-
-
0.0528
2-aminobenzoyl-KRFK-2,4-dinitrophenyl ester
-
-
0.003
2-aminobenzoyl-LRFK-2,4-dinitrophenyl ester
-
-
0.0214
2-aminobenzoyl-NRFK-2,4-dinitrophenyl ester
-
-
0.0117
2-aminobenzoyl-RAFK-2,4-dinitrophenyl ester
-
-
0.0028
2-aminobenzoyl-RDFK-2,4-dinitrophenyl ester
-
-
0.0043
2-aminobenzoyl-REFK-2,4-dinitrophenyl ester
-
-
0.054
2-aminobenzoyl-rGF-N-(2,4-dinitrophenyl)ethylenediamine
-
-
0.0259
2-aminobenzoyl-RGFK-2,4-dinitrophenyl amide
-
-
0.014
2-aminobenzoyl-RGFK-2,4-dinitrophenyl ester
-
-
0.0273
2-aminobenzoyl-rGL-N-(2,4-dinitrophenyl)ethylenediamine
-
-
0.0089
2-aminobenzoyl-RHFK-2,4-dinitrophenyl ester
-
-
0.9981
2-aminobenzoyl-RKFK-2,4-dinitrophenyl ester
-
-
0.0024
2-aminobenzoyl-RNFK-2,4-dinitrophenyl ester
-
-
0.0075
2-aminobenzoyl-RPFK-2,4-dinitrophenyl ester
-
-
0.0121
2-aminobenzoyl-RQFK-2,4-dinitrophenyl ester
-
-
0.035
2-aminobenzoyl-RRFK-2,4-dinitrophenyl amide
-
-
0.0089
2-aminobenzoyl-RRFK-2,4-dinitrophenyl ester
-
-
0.028
2-aminobenzoyl-rRL-N-(2,4-dinitrophenyl)ethylenediamine
-
-
0.0084
2-aminobenzoyl-RSFK-2,4-dinitrophenyl ester
-
-
0.0259
2-aminobenzoyl-rSL-N-(2,4-dinitrophenyl)ethylenediamine
-
-
0.0108
2-aminobenzoyl-RTFK-2,4-dinitrophenyl ester
-
-
0.0081
2-aminobenzoyl-SRFK-2,4-dinitrophenyl ester
-
-
0.0095
2-aminobenzoyl-TRFK-2,4-dinitrophenyl ester
-
-
0.0109
2-aminobenzoyl-VRFK-2,4-dinitrophenyl ester
-
-
0.051
2-aminobenzoyl-WRFK-2,4-dinitrophenyl ester
-
-
0.0583
2-aminobenzoyl-YRFK-2,4-dinitrophenyl ester
-
-
0.0028
adrenocorticotropic hormone
-
-
-
0.109
Ala-Leu-enkephalin
-
wild type enzyme
0.024
alpha-endorphin
wild-type enzyme, pH and temperature not specified in the publication
0.135
alpha-neoendorphin
-
-
0.014 - 0.104
amyloid beta peptide1-40
-
0.0086
angiotensin
wild-type enzyme, pH and temperature not specified in the publication
0.0004 - 34.1
angiotensin I
0.179
angiotensin II
-
37°C, pH 7.4
0.1114
angiotensin(1-9)
-
37°C, pH 7.4
0.0062
Arg-vasopressin
wild-type enzyme, pH and temperature not specified in the publication
0.25
benzyloxycarbonyl-Ala-Gly-Leu-Ala
-
-
0.00654
beta-endorphin
-
-
0.296
cholecystokinin-8
-
-
0.07 - 2.137
D-Ala2-Leu5-enkephalin
0.773
D-Ala2-Leu5-enkephalinamide
-
-
0.432
D-Ala2-Met5-enkephalinamide
-
-
0.03
dansyl-Gly-Trp-Gly
-
-
0.041
dansyl-Gly-Tyr-Gly
-
-
0.09
dansyl-Gly-Tyr-Gly-NH2
-
-
0.0082
dynorphin A-17
-
-
0.053
endothelin-1
wild-type enzyme, pH and temperature not specified in the publication
0.013
gamma-endorphin
wild-type enzyme, pH and temperature not specified in the publication
0.15
gastri-releasing peptide
wild-type enzyme, pH and temperature not specified in the publication
0.049 - 0.068
gastrin G-17
0.024
GLP-1
wild-type enzyme, pH and temperature not specified in the publication
-
0.025
glucagon
wild-type enzyme, pH and temperature not specified in the publication
0.59
glutaryl-Ala-Ala-Phe-2-naphthylamide
-
-
0.12
glutaryl-Ala-Ala-Phe-4-methoxy-2-naphthylamine
-
-
0.0685
glutaryl-Gly-Gly-Phe-2-naphthylamide
-
-
0.38
hippuryl-Arg-Arg-Ala-2-naphthylamide
-
-
0.35
hippuryl-Arg-Arg-Leu-2-naphthylamide
-
-
0.133
His-Lys-Thr-Asp-Ser-Phe-Val-Gly-Leu-Met-NH2
-
-
0.074 - 0.2
Leu-enkephalin
0.612
Leu-enkephalinamide
-
-
0.086
Leu5-enkephalin
-
-
0.111
Leu5-enkephalin-Arg6
-
-
0.68
Leu5-enkephalinamide
-
-
0.755
Luteinizing hormone-releasing hormone
0.022 - 0.1
Met-enkephalin
0.41
Met-enkephalin amide
-
-
0.062
Met5-enkephalin
-
-
0.039
Met5-enkephalin-Arg6
-
-
0.05
Met5-enkephalin-Arg6Phe7
-
-
0.011 - 0.087
N-(4-carboxy-1-oxobutyl)-L-alanyl-L-alanyl-N-(4-methoxy-2-naphthalenyl)-L-phenylalaninamide
0.42
N-(4-carboxybutanoyl)-L-alanyl-L-alanyl-N-(4-methoxynaphthalen-2-yl)-L-phenylalaninamide
-
-
0.0408
N-2-aminobenzoyl-rGV-N-(2,4-dinitrophenyl)ethylenediamine
-
-
0.13
N-benzyoxycarbonyl-Gly-Gly-Leu 2-naphthylamide
-
-
0.3
Nalpha-benzoyl-Gly-Arg-Arg-Ala-2-naphthylamide
-
-
0.18
Nalpha-benzoyl-Gly-Arg-Arg-Leu-2-naphthylamide
-
-
0.11
Nalpha-benzoyl-Gly-Arg-Arg-Phe-2-naphthylamide
-
-
0.19
Nalpha-benzoyl-Gly-Arg-Leu-2-naphthylamide
-
-
0.11
Nalpha-benzoyl-Gly-Gly-Arg-Leu-2-naphthylamide
-
-
0.08
Nalpha-benzoyl-Gly-Lys-Arg-Arg-Leu-2-naphthylamide
-
-
0.03
Nalpha-benzoyl-Gly-Lys-Lys-Arg-Arg-Leu-2-naphthylamide
-
-
0.0093
Neurokinin A
wild-type enzyme, pH and temperature not specified in the publication
0.022
neurokinin B
wild-type enzyme, pH and temperature not specified in the publication
0.016 - 0.078
neurotensin
0.02
nociceptin
wild-type enzyme, pH and temperature not specified in the publication
0.0074
somatostatin 14
wild-type enzyme, pH and temperature not specified in the publication
0.031
somatostatin 28
wild-type enzyme, pH and temperature not specified in the publication
0.043 - 0.073
succinyl-Ala-Ala-Phe-4-methylcoumarin 7-amide
0.058
succinyl-Ala-Ala-Phe-AMC
-
plasma enzyme
0.45
succinyl-Arg-Arg-Leu-2-naphthylamide
-
-
0.057
sulfated cholecystokinin octapeptide
-
-
0.018 - 0.019
Tyr-D-Ala-Gly-Phe-Leu
0.013
Tyr-D-Ala-Gly-Phe-Met
-
-
0.061 - 0.32
Tyr-D-Ala-Gly-Phe-met-NH2
0.008
Tyr-Gly-Gly-Phe-Met
-
-
0.033
unsulfated cholecystokinin octapeptide
-
-
0.0018
Vasoactive intestinal peptide
-
-
additional information
additional information
Michaelis-Menten profiles and steady-state kinetic parameters for cleavage of amyloid beta peptide1-40 and off-target peptide by wild-type and mutant enzymes, overview
-
0.0068
(7-methoxycoumarin-4-yl)acetyl-Arg-Pro-Pro-Gly-Phe-Ser-Ala-Phe-Lys(2,4-dinitrophenyl)
pH 7.5, 37°C
0.0224
(7-methoxycoumarin-4-yl)acetyl-Arg-Pro-Pro-Gly-Phe-Ser-Ala-Phe-Lys(2,4-dinitrophenyl)
pH 7.5, 37°C, in presence of activating K49-P1-20
0.014
amyloid beta peptide1-40
mutant G399V/G714K, pH and temperature not specified in the publication
-
0.042
amyloid beta peptide1-40
mutant G714K, pH and temperature not specified in the publication
-
0.055
amyloid beta peptide1-40
mutant G399V, pH and temperature not specified in the publication
-
0.104
amyloid beta peptide1-40
wild-type enzyme, pH and temperature not specified in the publication
-
0.0004
angiotensin I
-
-
34.1
angiotensin I
-
37°C, pH 7.4
0.005
bradykinin
-
-
0.032
bradykinin
wild-type enzyme, pH and temperature not specified in the publication
0.07
D-Ala2-Leu5-enkephalin
-
enzyme from tubules
0.076
D-Ala2-Leu5-enkephalin
-
enzyme from glomeruli
0.088
D-Ala2-Leu5-enkephalin
-
-
0.104
D-Ala2-Leu5-enkephalin
-
-
0.24
D-Ala2-Leu5-enkephalin
-
mutant enzyme R102M/N542G
1.399
D-Ala2-Leu5-enkephalin
-
mutant enzyme N542G
2.137
D-Ala2-Leu5-enkephalin
-
mutant enzyme R102M/N542G
0.049
gastrin G-17
-
sulfated
0.068
gastrin G-17
-
unsulfated
0.074
Leu-enkephalin
-
-
0.755
Luteinizing hormone-releasing hormone
-
-
0.755
Luteinizing hormone-releasing hormone
-
-
0.022
Met-enkephalin
-
-
0.011
N-(4-carboxy-1-oxobutyl)-L-alanyl-L-alanyl-N-(4-methoxy-2-naphthalenyl)-L-phenylalaninamide
pH 6.5, 37°C, mutant NEPS546A
0.051
N-(4-carboxy-1-oxobutyl)-L-alanyl-L-alanyl-N-(4-methoxy-2-naphthalenyl)-L-phenylalaninamide
pH 6.5, 37°C, wild-type enzyme and mutant NEPF563V
0.073
N-(4-carboxy-1-oxobutyl)-L-alanyl-L-alanyl-N-(4-methoxy-2-naphthalenyl)-L-phenylalaninamide
pH 6.5, 37°C, mutant NEPS546T
0.074
N-(4-carboxy-1-oxobutyl)-L-alanyl-L-alanyl-N-(4-methoxy-2-naphthalenyl)-L-phenylalaninamide
pH 6.5, 37°C, mutant NEPS546E
0.081
N-(4-carboxy-1-oxobutyl)-L-alanyl-L-alanyl-N-(4-methoxy-2-naphthalenyl)-L-phenylalaninamide
pH 6.5, 37°C, mutant NEPF563L
0.083
N-(4-carboxy-1-oxobutyl)-L-alanyl-L-alanyl-N-(4-methoxy-2-naphthalenyl)-L-phenylalaninamide
pH 6.5, 37°C, mutant NEPF563I
0.087
N-(4-carboxy-1-oxobutyl)-L-alanyl-L-alanyl-N-(4-methoxy-2-naphthalenyl)-L-phenylalaninamide
pH 6.5, 37°C, mutant NEPF563M
0.016
neurotensin
wild-type enzyme, pH and temperature not specified in the publication
0.01
Substance P
-
-
0.016
Substance P
wild-type enzyme, pH and temperature not specified in the publication
0.043
succinyl-Ala-Ala-Phe-4-methylcoumarin 7-amide
-
enzyme from amniotic fluid
0.052
succinyl-Ala-Ala-Phe-4-methylcoumarin 7-amide
-
-
0.054
succinyl-Ala-Ala-Phe-4-methylcoumarin 7-amide
-
enzyme from cerebrospinal fluid
0.073
succinyl-Ala-Ala-Phe-4-methylcoumarin 7-amide
-
-
0.018
Tyr-D-Ala-Gly-Phe-Leu
-
-
0.019
Tyr-D-Ala-Gly-Phe-Leu
-
-
0.061
Tyr-D-Ala-Gly-Phe-met-NH2
-
-
0.072
Tyr-D-Ala-Gly-Phe-met-NH2
-
-
0.32
Tyr-D-Ala-Gly-Phe-met-NH2
-
-