3.4.23.39: plasmepsin II
This is an abbreviated version!
For detailed information about plasmepsin II, go to the full flat file.
Word Map on EC 3.4.23.39
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3.4.23.39
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plasmepsins
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plasmodium
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falciparum
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antimalarial
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piperaquine
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artemisinin
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pfmdr1
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cambodia
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proplasmepsins
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hemoglobin-degrading
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pfcrt
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artemisinin-based
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dihydroartemisinin-piperaquine
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prosegment
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molecular biology
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falcipains
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analysis
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medicine
- 3.4.23.39
-
plasmepsins
- plasmodium
- falciparum
-
antimalarial
-
piperaquine
- artemisinin
-
pfmdr1
-
cambodia
-
proplasmepsins
-
hemoglobin-degrading
-
pfcrt
-
artemisinin-based
-
dihydroartemisinin-piperaquine
- prosegment
- molecular biology
-
falcipains
- analysis
- medicine
Reaction
Hydrolysis of the bonds linking certain hydrophobic residues in hemoglobin or globin. Also cleaves the small molecule substrates such as Ala-Leu-Glu-Arg-Thr-Phe!Phe(NO2)-Ser-Phe-Pro-Thr =
Synonyms
AH II, aspartic hemoglobinase II, malarial aspartic protease, PFAPD, pfpm2, plasmepsin 2, plasmepsin II, PLm II, PLMII, PM II, PMII, PSM2
ECTree
3.4.23.39 plasmepsin IIAdvanced search results
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results (KM Value
KM Value on EC 3.4.23.39 - plasmepsin II
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KM VALUE [mM] 
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
0.001 - 0.00233
4-(4-dimethylaminophenylazo)benzoyl-CH2-CH2-CO-CO-ALERMFLSFP-diaminopimelate-5-[(2-aminoethyl)amino]naphthalene-1-sulfonic acid
0.00294 - 0.00611
4-(4-dimethylaminophenylazo)benzoyl-CH2-CH2-CO-ERMFLSFP-diaminopimelate-5-[(2-aminoethyl)amino]naphthalene-1-sulfonic acid
0.000489
4-[[4'-(dimethylamino)phenyl]azo]-benzoyl-Glu-Arg-Met-Phe-Leu-Ser-Phe-Pro-(gamma-aminobutyryl)-5-[(2'-aminoethyl)-amino]naphthalenesulfonic acid
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pH 5.0, 37°C
0.063
Abz-Thr-Ile-Nle-(4-nitro)Phe-Gln-Arg-NH2
pH 4.5, temperature not specified in the publication
0.00017 - 0.0012
EDANS-CO-CH2-CH2-CO-Ala-Leu-Glu-Arg-Met-Phe-Leu-Ser-Phe-Pro-Dap-(DABCYL)-OH
0.046
Lys-Glu-Phe-Val-Lys-Phe(NO2)-Ala-Leu-Lys
-
pH 4.4, 37°C, mutant enzyme S77D
0.01
Lys-Glu-Phe-Val-Phe-Phe(NO2)-Arg-Leu-Lys
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pH 4.4, 37°C, recombinant enzyme
0.001
4-(4-dimethylaminophenylazo)benzoyl-CH2-CH2-CO-CO-ALERMFLSFP-diaminopimelate-5-[(2-aminoethyl)amino]naphthalene-1-sulfonic acid
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delF241 mutant enzyme expressed by a system that bypasses the need for autoactivation
0.001
4-(4-dimethylaminophenylazo)benzoyl-CH2-CH2-CO-CO-ALERMFLSFP-diaminopimelate-5-[(2-aminoethyl)amino]naphthalene-1-sulfonic acid
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mature enzyme expressed by a system that bypasses the need for autoactivation
0.00105
4-(4-dimethylaminophenylazo)benzoyl-CH2-CH2-CO-CO-ALERMFLSFP-diaminopimelate-5-[(2-aminoethyl)amino]naphthalene-1-sulfonic acid
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autoactivated enzyme
0.00127
4-(4-dimethylaminophenylazo)benzoyl-CH2-CH2-CO-CO-ALERMFLSFP-diaminopimelate-5-[(2-aminoethyl)amino]naphthalene-1-sulfonic acid
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F244A mutant enzyme expressed by a system that bypasses the need for autoactivation
0.00138
4-(4-dimethylaminophenylazo)benzoyl-CH2-CH2-CO-CO-ALERMFLSFP-diaminopimelate-5-[(2-aminoethyl)amino]naphthalene-1-sulfonic acid
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F244E mutant enzyme expressed by a system that bypasses the need for autoactivation
0.00233
4-(4-dimethylaminophenylazo)benzoyl-CH2-CH2-CO-CO-ALERMFLSFP-diaminopimelate-5-[(2-aminoethyl)amino]naphthalene-1-sulfonic acid
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F244K mutant enzyme expressed by a system that bypasses the need for autoactivation
0.00294
4-(4-dimethylaminophenylazo)benzoyl-CH2-CH2-CO-ERMFLSFP-diaminopimelate-5-[(2-aminoethyl)amino]naphthalene-1-sulfonic acid
-
delF241 mutant enzyme expressed by a system that bypasses the need for autoactivation
0.00302
4-(4-dimethylaminophenylazo)benzoyl-CH2-CH2-CO-ERMFLSFP-diaminopimelate-5-[(2-aminoethyl)amino]naphthalene-1-sulfonic acid
-
F244E mutant enzyme expressed by a system that bypasses the need for autoactivation
0.00305
4-(4-dimethylaminophenylazo)benzoyl-CH2-CH2-CO-ERMFLSFP-diaminopimelate-5-[(2-aminoethyl)amino]naphthalene-1-sulfonic acid
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autoactivated enzyme
0.00386
4-(4-dimethylaminophenylazo)benzoyl-CH2-CH2-CO-ERMFLSFP-diaminopimelate-5-[(2-aminoethyl)amino]naphthalene-1-sulfonic acid
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mature enzyme expressed by a system that bypasses the need for autoactivation
0.00433
4-(4-dimethylaminophenylazo)benzoyl-CH2-CH2-CO-ERMFLSFP-diaminopimelate-5-[(2-aminoethyl)amino]naphthalene-1-sulfonic acid
-
F244A mutant enzyme expressed by a system that bypasses the need for autoactivation
0.00611
4-(4-dimethylaminophenylazo)benzoyl-CH2-CH2-CO-ERMFLSFP-diaminopimelate-5-[(2-aminoethyl)amino]naphthalene-1-sulfonic acid
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F244K mutant enzyme expressed by a system that bypasses the need for autoactivation
0.0139
Ala-Leu-Glu-Arg-Nle-Phe-Phe(NO2)-Ser-Phe-Pro
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pH 4.4, 37°C, mutant enzyme I287E
0.0146
Ala-Leu-Glu-Arg-Nle-Phe-Phe(NO2)-Ser-Phe-Pro
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pH 4.4, 37°C, mutant enzyme M13E
0.0192
Ala-Leu-Glu-Arg-Nle-Phe-Phe(NO2)-Ser-Phe-Pro
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pH 4.4, 37°C, mutant enzyme S77D
0.0334
Ala-Leu-Glu-Arg-Nle-Phe-Phe(NO2)-Ser-Phe-Pro
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pH 4.4, 37°C, mutant enzyme M13E/I287E
0.00017
EDANS-CO-CH2-CH2-CO-Ala-Leu-Glu-Arg-Met-Phe-Leu-Ser-Phe-Pro-Dap-(DABCYL)-OH
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PMII without prosegment, pH 5, temperature not specified in the publication
0.0007
EDANS-CO-CH2-CH2-CO-Ala-Leu-Glu-Arg-Met-Phe-Leu-Ser-Phe-Pro-Dap-(DABCYL)-OH
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chimeric PMII (porcine pepsinogen prosegment fused to the mature region of PMII), pH 5, temperature not specified in the publication
0.0012
EDANS-CO-CH2-CH2-CO-Ala-Leu-Glu-Arg-Met-Phe-Leu-Ser-Phe-Pro-Dap-(DABCYL)-OH
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wild-type PMII, pH 5, temperature not specified in the publication
0.006
Leu-Glu-Arg-Ile-Phe-Phe(NO2)-Ser-Phe
-
pH 4.4, 37°C, naturally occuring enzyme
0.01
Leu-Glu-Arg-Ile-Phe-Phe(NO2)-Ser-Phe
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pH 4.4, 37°C, recombinant enzyme
0.03
Lys-Ala-Ile-Glu-Phe-Phe(NO2)-Arg-Leu
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pH 4.4, 37°C, mutant enzyme M13E/I287E
0.069
Lys-Ala-Ile-Glu-Phe-Phe(NO2)-Arg-Leu
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pH 4.4, 37°C, mutant enzyme I287E
0.055
Lys-Asp-Ile-Glu-Phe-Phe(NO2)-Arg-Leu
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pH 4.4, 37°C, mutant enzyme M13E/I287E
0.109
Lys-Asp-Ile-Glu-Phe-Phe(NO2)-Arg-Leu
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pH 4.4, 37°C, mutant enzyme I287E
0.006
Lys-Glu-Leu-Val-Phe-Phe(NO2)-Ala-Leu-Lys
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pH 4.4, 37°C, recombinant enzyme
0.008
Lys-Glu-Leu-Val-Phe-Phe(NO2)-Ala-Leu-Lys
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pH 4.4, 37°C, naturally occuring enzyme
0.007
Lys-Glu-Phe-Val-Phe-Phe(NO2)-Ala-Leu-Lys
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pH 4.4, 37°C, naturally occuring enzyme or recombinant enzyme
0.051
Lys-Lys-Ile-Glu-Phe-Phe(NO2)-Arg-Leu
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pH 4.4, 37°C, mutant enzyme I287E
0.075
Lys-Lys-Ile-Glu-Phe-Phe(NO2)-Arg-Leu
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pH 4.4, 37°C, mutant enzyme M13E/I287E
0.045
Lys-Phe-Ile-Glu-Phe-Phe(NO2)-Arg-Leu
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pH 4.4, 37°C, mutant enzyme I287E
0.085
Lys-Phe-Ile-Glu-Phe-Phe(NO2)-Arg-Leu
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pH 4.4, 37°C, mutant enzyme M13E/I287E
0.046
Lys-Pro-Ala-Glu-Phe-Phe(NO2)-Arg-Leu
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pH 4.4, 37°C, mutant enzyme M13E
0.053
Lys-Pro-Ala-Glu-Phe-Phe(NO2)-Arg-Leu
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pH 4.4, 37°C, mutant enzyme M13E/I287E
0.087
Lys-Pro-Asp-Glu-Phe-Phe(NO2)-Arg-Leu
-
pH 4.4, 37°C, mutant enzyme M13E/I287E
0.088
Lys-Pro-Asp-Glu-Phe-Phe(NO2)-Arg-Leu
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pH 4.4, 37°C, mutant enzyme M13E
0.037
Lys-Pro-Ile-Ala-Phe-Phe(NO2)-Arg-Leu
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pH 4.4, 37°C, mutant enzyme I287E
0.041
Lys-Pro-Ile-Ala-Phe-Phe(NO2)-Arg-Leu
-
pH 4.4, 37°C, mutant enzyme M13E/I287E
0.07
Lys-Pro-Ile-Asp-Phe-Phe(NO2)-Arg-Leu
-
pH 4.4, 37°C, mutant enzyme M13E/I287E
0.076
Lys-Pro-Ile-Asp-Phe-Phe(NO2)-Arg-Leu
-
pH 4.4, 37°C, mutant enzyme I287E
0.052
Lys-Pro-Ile-Glu-Phe-Phe(NO2)-Arg-Leu
-
pH 4.4, 37°C, mutant enzyme S77D
0.055
Lys-Pro-Ile-Glu-Phe-Phe(NO2)-Arg-Leu
-
pH 4.4, 37°C, mutant enzyme M13E
0.07
Lys-Pro-Ile-Glu-Phe-Phe(NO2)-Arg-Leu
-
pH 4.4, 37°C, mutant enzyme M13E/I287E
0.07
Lys-Pro-Ile-Glu-Phe-Phe(NO2)-Arg-Leu
-
pH 4.4, 37°C, mutant enzyme I287E
0.004
Lys-Pro-Ile-Lys-Phe-Phe(NO2)-Arg-Leu
-
pH 4.4, 37°C, mutant enzyme M13E/I287E
0.04
Lys-Pro-Ile-Lys-Phe-Phe(NO2)-Arg-Leu
-
pH 4.4, 37°C, mutant enzyme S77D
0.05
Lys-Pro-Ile-Lys-Phe-Phe(NO2)-Arg-Leu
-
pH 4.4, 37°C, mutant enzyme I287E
0.031
Lys-Pro-Ile-Ser-Phe-Phe(NO2)-Arg-Leu
-
pH 4.4, 37°C, mutant enzyme I287E
0.039
Lys-Pro-Ile-Ser-Phe-Phe(NO2)-Arg-Leu
-
pH 4.4, 37°C, mutant enzyme M13E/I287E
0.035
Lys-Pro-Lys-Glu-Phe-Phe(NO2)-Arg-Leu
-
pH 4.4, 37°C, mutant enzyme M13E
0.037
Lys-Pro-Lys-Glu-Phe-Phe(NO2)-Arg-Leu
-
pH 4.4, 37°C, mutant enzyme M13E/I287E
0.064
Lys-Pro-Phe-Glu-Phe-Phe(NO2)-Arg-Leu
-
pH 4.4, 37°C, mutant enzyme M13E/I287E
0.07
Lys-Pro-Phe-Glu-Phe-Phe(NO2)-Arg-Leu
-
pH 4.4, 37°C, mutant enzyme M13E
0.056
Lys-Pro-Ser-Glu-Phe-Phe(NO2)-Arg-Leu
-
pH 4.4, 37°C, mutant enzyme M13E/I287E
0.071
Lys-Pro-Ser-Glu-Phe-Phe(NO2)-Arg-Leu
-
pH 4.4, 37°C, mutant enzyme M13E
0.049
Lys-Ser-Ile-Glu-Phe-Phe(NO2)-Arg-Leu
-
pH 4.4, 37°C, mutant enzyme M13E/I287E
0.1
Lys-Ser-Ile-Glu-Phe-Phe(NO2)-Arg-Leu
-
pH 4.4, 37°C, mutant enzyme I287E
