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3.4.23.39: plasmepsin II

This is an abbreviated version!
For detailed information about plasmepsin II, go to the full flat file.

Word Map on EC 3.4.23.39

Reaction

Hydrolysis of the bonds linking certain hydrophobic residues in hemoglobin or globin. Also cleaves the small molecule substrates such as Ala-Leu-Glu-Arg-Thr-Phe!Phe(NO2)-Ser-Phe-Pro-Thr =

Synonyms

AH II, aspartic hemoglobinase II, malarial aspartic protease, PFAPD, pfpm2, plasmepsin 2, plasmepsin II, PLm II, PLMII, PM II, PMII, PSM2

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.23 Aspartic endopeptidases
                3.4.23.39 plasmepsin II

Substrates Products

Substrates Products on EC 3.4.23.39 - plasmepsin II

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
4-(4-dimethylaminophenylazo)benzoyl-CH2-CH2-CO-ALERMFLSFP-diaminopimelate-5-[(2-aminoethyl)amino]naphthalene-1-sulfonic acid + H2O
?
show the reaction diagram
-
-
-
-
?
4-(4-dimethylaminophenylazo)benzoyl-CH2-CH2-CO-CO-ALERMFLSFP-diaminopimelate-5-[(2-aminoethyl)amino]naphthalene-1-sulfonic acid + H2O
?
show the reaction diagram
-
-
-
-
?
4-(4-dimethylaminophenylazo)benzoyl-CH2-CH2-CO-ERMFLSFP-diaminopimelate-5-[(2-aminoethyl)amino]naphthalene-1-sulfonic acid + H2O
?
show the reaction diagram
-
-
-
-
?
4-[[4'-(dimethylamino)phenyl]azo]-benzoyl-Glu-Arg-Met-Phe-Leu-Ser-Phe-Pro-(gamma-aminobutyryl)-5-[(2'-aminoethyl)-amino]naphthalenesulfonic acid + H2O
?
show the reaction diagram
-
-
-
-
?
4-[[4'-(dimethylamino)phenyl]azo]-benzoyl-Glu-Arg-Nle-Phe-Leu-Ser-Phe-Pro-5-[(2'-aminoethyl)-amino]naphthalenesulfonic acid + H2O
?
show the reaction diagram
-
-
-
-
?
Abz-Thr-Ile-Nle-(4-nitro)Phe-Gln-Arg-NH2 + H2O
Abz-Thr-Ile-Nle + (4-nitro)Phe-Gln-Arg-NH2
show the reaction diagram
-
-
-
?
actin + H2O
?
show the reaction diagram
-
-
-
-
?
Ala-Leu-Glu-Arg-Nle-Phe-Phe(NO2)-Ser-Phe-Pro + H2O
Ala-Leu-Glu-Arg-Nle-Phe + Phe(NO2)-Ser-Phe-Pro
show the reaction diagram
-
-
-
-
?
Ala-Leu-Glu-Arg-Thr-Phe-Leu-Ser-Phe-Pro-Thr + H2O
Ala-Leu-Glu-Arg-Thr-Phe + Leu-Ser-Phe-Pro-Thr
show the reaction diagram
-
-
-
-
?
Ala-Leu-Glu-Arg-Thr-Phe-Phe(NO2)-Ser-Phe-Pro-Thr + H2O
Ala-Leu-Glu-Arg-Thr-Phe + Phe(NO2)-Ser-Phe-Pro-Thr
show the reaction diagram
-
-
-
-
?
Ala-Leu-Glu-Arg-Thr-Phe-Phe(p-NO2)-Ser-Phe-Pro-Thr + H2O
Ala-Leu-Glu-Arg-Thr-Phe + Phe(p-NO2)-Ser-Phe-Pro-Thr
show the reaction diagram
-
-
-
-
?
Arg-Gln-Phe-Phe(p-NO2)-Ile-Thr + H2O
Arg-Gln-Phe + Phe(p-NO2)-Ile-Thr
show the reaction diagram
-
-
-
?
DABCYL-Glu-Arg-Nle-Phe-Leu-Ser-Phe-Pro-EDANS + H2O
?
show the reaction diagram
-
FRET substrate, substrate is designed to mimic the hemoglobin cleavage site. The substrate is conjugated with the fluorescent donor EDANS and the quencher DABCYL
-
-
?
DABCYL-L-Glu-L-Arg-L-Nle-L-Phe-L-Leu-L-Ser-L-Phe-L-Pro-EDANS + H2O
?
show the reaction diagram
-
FRET-based substrate
-
-
?
EDANS-CO-CH2-CH2-CO-Ala-Leu-Glu-Arg-Met-Phe-Leu-Ser-Phe-Pro-Dap-(DABCYL)-OH + H2O
?
show the reaction diagram
EDANS-CO-CH2-CH2-CO-L-Ala-L-Leu-L-Glu-L-Arg-L-Met-L-Phe-L-Leu-L-Ser-L-Phe-L-Pro-Dap(DABCYL)-OH + H2O
?
show the reaction diagram
-
-
-
-
?
EDANS-CO-CH2-CH2-COALERMFLSFP-diaminopimelate-(DABCYL)OH + H2O
?
show the reaction diagram
-
-
-
-
?
GST-SH3 peptide + H2O
?
show the reaction diagram
-
Y-/-V and L-/-L are major cleavage sites
-
-
?
Hemoglobin + H2O
?
show the reaction diagram
hemoglobin alpha-chain + H2O
?
show the reaction diagram
-
cleavage sites: Phe33-/-Leu34, Thr108-/-Leu109, Leu136-/-Thr137
-
-
?
hemoglobin beta-chain + H2O
?
show the reaction diagram
-
cleavage site: Leu32-/-Val33
-
-
?
Leu-Glu-Arg-Ile-Phe-Phe(NO2)-Ser-Phe + H2O
Leu-Glu-Arg-Ile-Phe + Phe(NO2)-Ser-Phe
show the reaction diagram
-
-
-
-
?
Leu-Glu-Arg-Val-Phe-Phe(NO2)-Ser-Phe + H2O
Leu-Glu-Arg-Val-Phe + Phe(NO2)-Ser-Phe
show the reaction diagram
-
-
-
-
?
Leu-Ser-Phe(NO2)-Nle-Ala-Leu-OMe + H2O
?
show the reaction diagram
-
-
-
-
?
Lys-Ala-Ile-Glu-Phe-Phe(NO2)-Arg-Leu + H2O
Lys-Ala-Ile-Glu-Phe + Phe(NO2)-Arg-Leu
show the reaction diagram
-
-
-
-
?
Lys-Asp-Ile-Glu-Phe-Phe(NO2)-Arg-Leu + H2O
Lys-Asp-Ile-Glu-Phe + Phe(NO2)-Arg-Leu
show the reaction diagram
-
-
-
-
?
Lys-Glu-Leu-Val-Phe-Phe(NO2)-Ala-Leu-Lys + H2O
Lys-Glu-Leu-Val-Phe + Phe(NO2)-Ala-Leu-Lys
show the reaction diagram
-
-
-
-
?
Lys-Glu-Phe-Asn-Phe-Phe(NO2)-Ala-Leu-Lys + H2O
Lys-Glu-Phe-Asn-Phe + Phe(NO2)-Ala-Leu-Lys
show the reaction diagram
-
-
-
-
?
Lys-Glu-Phe-Ile-Phe-Phe(NO2)-Ala-Leu-Lys + H2O
Lys-Glu-Phe-Ile-Phe + Phe(NO2)-Ala-Leu-Lys
show the reaction diagram
-
-
-
-
?
Lys-Glu-Phe-Val-Lys-Phe(NO2)-Ala-Leu-Lys + H2O
?
show the reaction diagram
-
-
-
-
?
Lys-Glu-Phe-Val-Lys-Phe(NO2)-Ala-Leu-Lys + H2O
Lys-Glu-Phe-Val-Lys + Phe(NO2)-Ala-Leu-Lys +
show the reaction diagram
-
-
-
-
?
Lys-Glu-Phe-Val-Phe-4-nitrophenylalanine-Ala-Leu-Lys + H2O
?
show the reaction diagram
-
-
-
-
?
Lys-Glu-Phe-Val-Phe-Phe(NO2)-Ala-Leu-Lys + H2O
Lys-Glu-Phe-Val-Phe + Phe(NO2)-Ala-Leu-Lys
show the reaction diagram
-
-
-
-
?
Lys-Glu-Phe-Val-Phe-Phe(NO2)-Arg-Leu-Lys + H2O
Lys-Glu-Phe-Val-Phe + Phe(NO2)-Arg-Leu-Lys
show the reaction diagram
-
-
-
-
?
Lys-Lys-Ile-Glu-Phe-Phe(NO2)-Arg-Leu + H2O
Lys-Lys-Ile-Glu-Phe + Phe(NO2)-Arg-Leu
show the reaction diagram
-
-
-
-
?
Lys-Phe-Ile-Glu-Phe-Phe(NO2)-Arg-Leu + H2O
Lys-Phe-Ile-Glu-Phe + Phe(NO2)-Arg-Leu
show the reaction diagram
-
-
-
-
?
Lys-Pro-Ala-Glu-Phe-Phe(NO2)-Arg-Leu + H2O
Lys-Pro-Ala-Glu-Phe + Phe(NO2)-Arg-Leu
show the reaction diagram
-
-
-
-
?
Lys-Pro-Asp-Glu-Phe-Phe(NO2)-Arg-Leu + H2O
Lys-Pro-Asp-Glu-Phe + Phe(NO2)-Arg-Leu
show the reaction diagram
-
-
-
-
?
Lys-Pro-Ile-Ala-Phe-Phe(NO2)-Arg-Leu + H2O
Lys-Pro-Ile-Ala-Phe + Phe(NO2)-Arg-Leu
show the reaction diagram
-
-
-
-
?
Lys-Pro-Ile-Asp-Phe-Phe(NO2)-Arg-Leu + H2O
Lys-Pro-Ile-Asp-Phe + Phe(NO2)-Arg-Leu
show the reaction diagram
-
-
-
-
?
Lys-Pro-Ile-Glu-Phe-NO2Phe-Arg-Leu + H2O
Lys-Pro-Ile-Glu-Phe + NO2Phe-Arg-Leu
show the reaction diagram
-
-
-
-
?
Lys-Pro-Ile-Glu-Phe-Phe(NO2)-Ala-Leu + H2O
Lys-Pro-Ile-Glu-Phe + Phe(NO2)-Ala-Leu
show the reaction diagram
-
-
-
-
?
Lys-Pro-Ile-Glu-Phe-Phe(NO2)-Arg-Arg + H2O
Lys-Pro-Ile-Glu-Phe + Phe(NO2)-Arg-Arg
show the reaction diagram
-
-
-
-
?
Lys-Pro-Ile-Glu-Phe-Phe(NO2)-Arg-Asp + H2O
Lys-Pro-Ile-Glu-Phe + Phe(NO2)-Arg-Asp
show the reaction diagram
-
-
-
-
?
Lys-Pro-Ile-Glu-Phe-Phe(NO2)-Arg-Ile + H2O
Lys-Pro-Ile-Glu-Phe + Phe(NO2)-Arg-Ile
show the reaction diagram
-
-
-
-
?
Lys-Pro-Ile-Glu-Phe-Phe(NO2)-Arg-Leu + H2O
Lys-Pro-Ile-Glu-Phe + Phe(NO2)-Arg-Leu
show the reaction diagram
-
-
-
-
?
Lys-Pro-Ile-Glu-Phe-Phe(NO2)-Arg-Ser + H2O
Lys-Pro-Ile-Glu-Phe + Phe(NO2)-Arg-Ser
show the reaction diagram
-
-
-
-
?
Lys-Pro-Ile-Glu-Phe-Phe(NO2)-Arg-Val + H2O
Lys-Pro-Ile-Glu-Phe + Phe(NO2)-Arg-Val
show the reaction diagram
-
-
-
-
?
Lys-Pro-Ile-Glu-Phe-Phe(NO2)-Glu-Leu + H2O
Lys-Pro-Ile-Glu-Phe + Phe(NO2)-Glu-Leu
show the reaction diagram
-
-
-
-
?
Lys-Pro-Ile-Glu-Phe-Phe(NO2)-Lys-Leu + H2O
Lys-Pro-Ile-Glu-Phe + Phe(NO2)-Lys-Leu
show the reaction diagram
-
-
-
-
?
Lys-Pro-Ile-Glu-Phe-Phe(NO2)-Ser-Leu + H2O
Lys-Pro-Ile-Glu-Phe + Phe(NO2)-Ser-Leu
show the reaction diagram
-
-
-
-
?
Lys-Pro-Ile-Glu-Phe-Phe(NO2)-Val-Leu + H2O
Lys-Pro-Ile-Glu-Phe + Phe(NO2)-Val-Leu
show the reaction diagram
-
-
-
-
?
Lys-Pro-Ile-Leu-Phe-Nph-Arg-Leu + H2O
?
show the reaction diagram
-
chromogenic peptide substrate
-
-
?
Lys-Pro-Ile-Leu-Phe-Phe(NO2)-Arg-Leu + H2O
Lys-Pro-Ile-Leu-Phe + Phe(NO2)-Arg-Leu
show the reaction diagram
-
-
-
-
?
Lys-Pro-Ile-Lys-Phe-Phe(NO2)-Arg-Leu + H2O
Lys-Pro-Ile-Lys-Phe + Phe(NO2)-Arg-Leu
show the reaction diagram
-
-
-
-
?
Lys-Pro-Ile-Nle-Phe-Phe(NO2)-Arg-Leu + H2O
Lys-Pro-Ile-Nle-Phe + Phe(NO2)-Arg-Leu
show the reaction diagram
-
-
-
-
?
Lys-Pro-Ile-Ser-Phe-Phe(NO2)-Arg-Leu + H2O
Lys-Pro-Ile-Ser-Phe + Phe(NO2)-Arg-Leu
show the reaction diagram
-
-
-
-
?
Lys-Pro-Ile-Val-Phe-Phe(NO2)-Arg-Leu + H2O
Lys-Pro-Ile-Val-Phe + Phe(NO2)-Arg-Leu
show the reaction diagram
-
-
-
-
?
Lys-Pro-Lys-Glu-Phe-Phe(NO2)-Arg-Leu + H2O
Lys-Pro-Lys-Glu-Phe + Phe(NO2)-Arg-Leu
show the reaction diagram
-
-
-
-
?
Lys-Pro-Phe-Glu-Phe-Phe(NO2)-Arg-Leu + H2O
Lys-Pro-Phe-Glu-Phe + Phe(NO2)-Arg-Leu
show the reaction diagram
-
-
-
-
?
Lys-Pro-Ser-Glu-Phe-Phe(NO2)-Arg-Leu + H2O
Lys-Pro-Ser-Glu-Phe + Phe(NO2)-Arg-Leu
show the reaction diagram
-
-
-
-
?
Lys-Ser-Ile-Glu-Phe-Phe(NO2)-Arg-Leu + H2O
Lys-Ser-Ile-Glu-Phe + Phe(NO2)-Arg-Leu
show the reaction diagram
-
-
-
-
?
Myoglobin + H2O
?
show the reaction diagram
-
horse myoglobin is used
-
-
?
p47phox-PX + H2O
?
show the reaction diagram
-
PX domain of p47phox, a cytosolic factor of the neutrophil NADPH oxydase is digested
-
-
?
plasmepsin 2 + H2O
?
show the reaction diagram
-
PSM2 auto-cleavage after F112 is complete after 20 min in 10 mM citrate pH 4.5
-
-
?
protein 4.1 + H2O
?
show the reaction diagram
-
-
-
-
?
spectrin + H2O
?
show the reaction diagram
additional information
?
-