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3.4.23.39: plasmepsin II

This is an abbreviated version!
For detailed information about plasmepsin II, go to the full flat file.

Word Map on EC 3.4.23.39

Reaction

Hydrolysis of the bonds linking certain hydrophobic residues in hemoglobin or globin. Also cleaves the small molecule substrates such as Ala-Leu-Glu-Arg-Thr-Phe!Phe(NO2)-Ser-Phe-Pro-Thr =

Synonyms

AH II, aspartic hemoglobinase II, malarial aspartic protease, PFAPD, pfpm2, plasmepsin 2, plasmepsin II, PLm II, PLMII, PM II, PMII, PSM2

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.23 Aspartic endopeptidases
                3.4.23.39 plasmepsin II

IC50 Value

IC50 Value on EC 3.4.23.39 - plasmepsin II

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IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.00419
(1R,2R,3R,4S)-3-[(4-butylphenyl)sulfonyl]-N-(naphthalen-2-ylmethyl)-7-azabicyclo[2.2.1]heptan-2-amine
Plasmodium falciparum
pH and temperature not specified in the publication
0.00005
(1R,2R,3R,4S)-3-[(4-heptylphenyl)sulfonyl]-N-(naphthalen-2-ylmethyl)-7-azabicyclo[2.2.1]heptan-2-amine
Plasmodium falciparum
pH and temperature not specified in the publication
0.00013
(1R,2R,3R,4S)-3-[(4-hexylphenyl)sulfonyl]-N-(naphthalen-2-ylmethyl)-7-azabicyclo[2.2.1]heptan-2-amine
Plasmodium falciparum
pH and temperature not specified in the publication
0.00017
(1R,2R,3R,4S)-3-[[4-(2-cyclobutylethyl)phenyl]sulfonyl]-N-(naphthalen-2-ylmethyl)-7-azabicyclo[2.2.1]heptan-2-amine
Plasmodium falciparum
pH and temperature not specified in the publication
0.00003
(1R,2R,3R,4S)-3-[[4-(2-cyclopentylethyl)phenyl]sulfonyl]-N-(naphthalen-2-ylmethyl)-7-azabicyclo[2.2.1]heptan-2-amine
Plasmodium falciparum
pH and temperature not specified in the publication
0.00038
(1R,2R,3R,4S)-3-[[4-(3-cyclohexylpropyl)phenyl]sulfonyl]-N-(naphthalen-2-ylmethyl)-7-azabicyclo[2.2.1]heptan-2-amine
Plasmodium falciparum
pH and temperature not specified in the publication
0.00019
(1R,2R,3R,4S)-3-[[4-(3-cyclopentylpropyl)phenyl]sulfonyl]-N-(naphthalen-2-ylmethyl)-7-azabicyclo[2.2.1]heptan-2-amine
Plasmodium falciparum
pH and temperature not specified in the publication
0.00005
(1R,2R,3R,4S)-3-[[4-(4,4-dimethylpentyl)phenyl]sulfonyl]-N-(naphthalen-2-ylmethyl)-7-azabicyclo[2.2.1]heptan-2-amine
Plasmodium falciparum
pH and temperature not specified in the publication
0.00221
(1R,2R,3R,4S)-3-[[4-(4-fluorobutyl)phenyl]sulfonyl]-N-(naphthalen-2-ylmethyl)-7-azabicyclo[2.2.1]heptan-2-amine
Plasmodium falciparum
pH and temperature not specified in the publication
0.00035
(1R,2R,3R,4S)-3-[[4-(6-fluorohexyl)phenyl]sulfonyl]-N-(naphthalen-2-ylmethyl)-7-azabicyclo[2.2.1]heptan-2-amine
Plasmodium falciparum
pH and temperature not specified in the publication
0.00068
(1R,2R,3R,4S)-N-(naphthalen-2-ylmethyl)-3-[(4-pentylphenyl)sulfonyl]-7-azabicyclo[2.2.1]heptan-2-amine
Plasmodium falciparum
pH and temperature not specified in the publication
0.0009
(1R,2R,3R,4S)-N-(naphthalen-2-ylmethyl)-3-[[4-(2-propoxyethyl)phenyl]sulfonyl]-7-azabicyclo[2.2.1]heptan-2-amine
Plasmodium falciparum
pH and temperature not specified in the publication
0.00015
(1R,2R,3R,4S)-N-(naphthalen-2-ylmethyl)-3-[[4-(pentyloxy)phenyl]sulfonyl]-7-azabicyclo[2.2.1]heptan-2-amine
Plasmodium falciparum
pH and temperature not specified in the publication
0.000089
(1R,2R,3R,4S,5R)-5-[(cyclobutylamino)methyl]-N-(naphthalen-2-ylmethyl)-3-[(4-pentylphenyl)sulfonyl]-7-azabicyclo[2.2.1]heptan-2-amine
Plasmodium falciparum
pH and temperature not specified in the publication
0.0001
(1R,2R,3R,4S,5R)-5-[(cyclopentylamino)methyl]-N-(naphthalen-2-ylmethyl)-3-[(4-pentylphenyl)sulfonyl]-7-azabicyclo[2.2.1]heptan-2-amine
Plasmodium falciparum
pH and temperature not specified in the publication
0.000284
(1R,2R,3R,4S,6R)-6-[(cyclobutylamino)methyl]-N-(naphthalen-2-ylmethyl)-3-[(4-pentylphenyl)sulfonyl]-7-azabicyclo[2.2.1]heptan-2-amine
Plasmodium falciparum
pH and temperature not specified in the publication
0.000289
(1R,2R,3R,4S,6R)-6-[(cyclopentylamino)methyl]-N-(naphthalen-2-ylmethyl)-3-[(4-pentylphenyl)sulfonyl]-7-azabicyclo[2.2.1]heptan-2-amine
Plasmodium falciparum
pH and temperature not specified in the publication
0.7
(1R,2R,3S,4S)-2,3-bis(naphthalen-2-ylmethoxy)-7-azabicyclo[2.2.1]heptane
Plasmodium falciparum
pH and temperature not specified in the publication
0.014
(1R,4S)-6-[2-(1,3-benzothiazol-2-ylsulfanyl)ethoxy]-7-(naphthalen-1-ylmethoxy)-1,2,3,4-tetrahydro-1,4-epiminonaphthalene
Plasmodium falciparum
pH and temperature not specified in the publication
0.01
(1R,4S)-6-[2-(1,3-benzothiazol-2-ylsulfanyl)ethoxy]-7-(naphthalen-2-ylmethoxy)-1,2,3,4-tetrahydro-1,4-epiminonaphthalene
Plasmodium falciparum
pH and temperature not specified in the publication
0.013
(1R,4S)-6-[2-(1,3-benzothiazol-2-ylsulfanyl)ethoxy]-7-[2-(naphthalen-1-yl)ethoxy]-1,2,3,4-tetrahydro-1,4-epiminonaphthalene
Plasmodium falciparum
pH and temperature not specified in the publication
0.005
(1R,4S)-6-[2-[(6-chloro-1,3-benzothiazol-2-yl)sulfanyl]ethoxy]-7-(naphthalen-1-ylmethoxy)-1,2,3,4-tetrahydro-1,4-epiminonaphthalene
Plasmodium falciparum
pH and temperature not specified in the publication
0.004
(1R,4S)-6-[2-[(6-chloro-1,3-benzothiazol-2-yl)sulfanyl]ethoxy]-7-(naphthalen-2-ylmethoxy)-1,2,3,4-tetrahydro-1,4-epiminonaphthalene
Plasmodium falciparum
pH and temperature not specified in the publication
0.003
(1R,4S)-6-[2-[(6-chloro-1,3-benzothiazol-2-yl)sulfanyl]ethoxy]-7-[2-(naphthalen-1-yl)ethoxy]-1,2,3,4-tetrahydro-1,4-epiminonaphthalene
Plasmodium falciparum
pH and temperature not specified in the publication
0.004
(1R,4S)-6-[3-(1,3-benzothiazol-2-ylsulfanyl)propyl]-7-(naphthalen-1-ylmethoxy)-1,2,3,4-tetrahydro-1,4-epiminonaphthalene
Plasmodium falciparum
pH and temperature not specified in the publication
0.002
(1R,4S)-6-[3-[(6-chloro-1,3-benzothiazol-2-yl)sulfanyl]propyl]-7-(naphthalen-1-ylmethoxy)-1,2,3,4-tetrahydro-1,4-epiminonaphthalene
Plasmodium falciparum
pH and temperature not specified in the publication
0.01
(1RS) 3,3-difluoro-N-[2-(2-naphthyl)ethyl]-4-oxo-N-(4-pentylphenyl)cyclohexanecarboxamide
Plasmodium falciparum
-
pH 5.0, 37°C
0.043
(1RS,4RS)-3,3-difluoro-4-hydroxy-N-[2-(2-naphthyl)ethyl]-N(4-pentylphenyl)cyclohexanecarboxamide
Plasmodium falciparum
-
pH 5.0, 37°C
0.01
(1S)-3,3-difluoro-4,4-dihydroxy-N-(naphthalen-2-ylmethyl)-N-(4-pentylphenyl)cyclohexanecarboxamide
Plasmodium falciparum
pH and temperature not specified in the publication
0.07
(1S,2S,3R,4R)-2-([4-[3-(1,3-benzodioxol-5-yl)propyl]benzyl]oxy)-3-(naphthalen-2-ylmethoxy)-7-azabicyclo[2.2.1]heptane
Plasmodium falciparum
pH and temperature not specified in the publication
1
(1S,2S,3R,4R)-2-[(4-bromobenzyl)oxy]-3-(naphthalen-2-ylmethoxy)-7-azabicyclo[2.2.1]heptane
Plasmodium falciparum
pH and temperature not specified in the publication
0.0148
(1S,2S,3S,4R)-3-(4-bromophenylsulfonyl)-N-(naphthalen-2-ylmethyl)-7-azabicyclo[2.2.1]heptan-2-amine
Plasmodium falciparum
-
-
0.00039
(1S,2S,3S,4R)-3-(4-hexylphenylsulfonyl)-N-((2'-methoxybiphenyl-3-yl)methyl)-7-azabicyclo[2.2.1]heptan-2-amine
Plasmodium falciparum
-
-
0.00013
(1S,2S,3S,4R)-3-(4-hexylphenylsulfonyl)-N-(naphthalen-2-ylmethyl)-7-azabicyclo[2.2.1]heptan-2-amine
Plasmodium falciparum
-
-
0.00021
(1S,2S,3S,4R)-N-(3-bromobenzyl)-3-(4-hexylphenylsulfonyl)-7-azabicyclo[2.2.1]heptan-2-amine
Plasmodium falciparum
-
-
0.038
(1SR,4RS)-3,3-difluoro-4-hydroxy-N-[2-(2-naphthyl)ethyl]-N(4-pentylphenyl)cyclohexanecarboxamide
Plasmodium falciparum
-
pH 5.0, 37°C
0.0000043
(1Z)-(3,4-dimethoxyphenyl)-N'-[[(3,4,5-trichlorophenoxy)acetyl]oxy]ethanimidamide
Plasmodium falciparum
pH and temperature not specified in the publication
0.0000043
(1Z)-N'-{[(4-chloro-3,5-dimethylphenoxy)acetyl]oxy}-2-(3,4-dimethoxyphenyl)ethanimidamide
Plasmodium falciparum
-
pH 4.5, 37°C
0.15
(2E)-2-[(2H-1,3-benzodioxol-5-yl)methylidene]hydrazine-1-carboximidamide
Plasmodium falciparum
pH and temperature not specified in the publication
0.02158
(2R,3R,4R,5R)-2,5-bis(benzyloxy)-3,4-dihydroxy-N,N'-bis[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]hexanediamide
Plasmodium falciparum
-
-
0.000006
(2R,3R,4S,6R)-6-[[(E)-2-(4-acetylphenyl)ethenyl]oxy]-2-[[(2E)-3-(4-acetylphenyl)prop-2-en-1-yl]oxy]-3,4-dihydroxy-N,N'-bis[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]heptanediamide
Plasmodium falciparum
-
predicted inhibition constant, temperature not specified in the publication, pH not specified in the publication
0.0013
(3S,4S)-pyrrolidine-3,4-diyl bis(naphthalen-1-ylacetate)
Plasmodium falciparum
pH and temperature not specified in the publication
0.0244
(3S,4S)-pyrrolidine-3,4-diyl dibenzoate
Plasmodium falciparum
pH and temperature not specified in the publication
0.0005
(5-[[(4-bromobenzoyl)oxy]methyl]-2,3,4,7-tetrahydro-1H-azepin-3-yl)methyl 4-aminobenzoate
Plasmodium falciparum
pH and temperature not specified in the publication
0.00105
1,2-diphenylhydrazine
Plasmodium falciparum
pH and temperature not specified in the publication
0.0212
1-(4-chlorophenyl)-2-[2-(pyridin-2-yl)-1H-benzimidazol-1-yl]ethanone
Plasmodium falciparum
-
pH 5.0, temperature not specified in the publication
0.0305
1-(4-nitrophenyl)-2-[2-(pyridin-2-yl)-1H-benzimidazol-1-yl]ethanone
Plasmodium falciparum
-
pH 5.0, temperature not specified in the publication
0.00947
1-(benzylamino)-3-(3,6-dichloro-9H-carbazol-9-yl)propan-2-ol
Plasmodium falciparum
pH and temperature not specified in the publication
0.0147
1-(biphenyl-4-yl)-2-[2-(pyridin-2-yl)-1H-benzimidazol-1-yl]ethanone
Plasmodium falciparum
-
pH 5.0, temperature not specified in the publication
0.196
1-(diphenylmethyl)azetidin-3-ol
Plasmodium falciparum
pH and temperature not specified in the publication
0.125
1-amino-3-(4-nitroanilino)propan-2-ol
Plasmodium falciparum
pH and temperature not specified in the publication
0.2
1-phenyl-N-(propan-2-yl)methanesulfonamide
Plasmodium falciparum
pH and temperature not specified in the publication
0.02
1-[2-hydroxy-3-(1,2,3,4,5,6,7,8-octahydrophenanthren-9-yloxy)propyl]-4-(3-methoxyphenyl)piperazin-1-ium
Plasmodium falciparum
-
pH 5.0, temperature not specified in the publication
0.002
1-[3-chloro-6-(trifluoromethyl)phenanthren-9-yl]-3-(dibutylamino)propan-1-ol
Plasmodium falciparum
pH and temperature not specified in the publication
0.005
1-[6-chloro-3-(3,4-dichlorophenyl)naphthalen-1-yl]-2-(dibutylamino)ethanol
Plasmodium falciparum
pH and temperature not specified in the publication
0.0016
2,2-diphenylacetohydrazide
Plasmodium falciparum
pH and temperature not specified in the publication
0.000039
2,3,4-trifluoro-N-([[1-(3-methylbutyl)piperidin-4-yl](4-pentylbenzoyl)amino]methyl)benzamide
Plasmodium falciparum
pH and temperature not specified in the publication
0.000039
2,3-difluoro-4-methyl-N-[4-([[1-(3-methylbutyl)piperidin-4-yl][(4-pentylphenyl)carbonyl]amino]methyl)phenyl]benzamide
Plasmodium falciparum
-
-
0.0000961
2-(1,3-benzothiazol-2-ylamino)-N-(2-chlorophenyl)-6-oxo-1,4,5,6­tetrahydro-4-pyrimidinecarboxamide
Plasmodium falciparum
-
pH 4.5, 37°C
0.0001452
2-(1-naphthyl)-N'-[(4-nitrobenzoyl)oxy]ethanimidamide
Plasmodium falciparum
-
pH 4.5, 37°C
0.019
2-(2-naphthyl)-N-(4-pentylphenyl)-N-piperidin-4-ylacetamide hydrochloride
Plasmodium falciparum
-
pH 5.0, 37°C
0.005
2-(dihexylamino)-1-(1,2,3,4-tetrahydrophenanthren-9-yl)ethanol
Plasmodium falciparum
pH and temperature not specified in the publication
0.009
2-([2-[4-([[(1S,2S,3R,4R)-3-(naphthalen-2-ylmethoxy)-7-azabicyclo[2.2.1]hept-2-yl]oxy]methyl)phenoxy]ethyl]sulfanyl)-1,3-benzothiazole
Plasmodium falciparum
pH and temperature not specified in the publication
0.000441
2-([4'-(([2-(dibutylamino)ethyl](4-pentylbenzyl)amino)methyl)biphenyl-4-yl]oxy)ethanol
Plasmodium falciparum
-
IC50: 441 nM
0.0243
2-amino-3-[(oxolan-2-yl)methyl]quinazolin-4(3H)-one
Plasmodium falciparum
pH and temperature not specified in the publication
0.000189
2-anilino-3-chloro-N-phenyl-4-(phenylimino)-2-butenamide
Plasmodium falciparum
-
pH 4.5, 37°C
0.0001871
2-anilino-4-(3-furyl)-6-oxo-N-phenyl-1-cyclohexene-1-carboxamide
Plasmodium falciparum
-
pH 4.5, 37°C
0.00165
2-methoxybenzohydrazide
Plasmodium falciparum
pH and temperature not specified in the publication
0.001
2-nitrobenzohydrazide
Plasmodium falciparum
pH and temperature not specified in the publication
0.00645
2-[(Z)-1-(4-chlorophenyl)-2-[3-(pyridin-2-yl)isoquinolin-1-yl]ethenyl]hydrazine-1-carboximidothioic acid
Plasmodium falciparum
pH and temperature not specified in the publication
0.00147
2-[4'-(([2-(dibutylamino)ethyl](4-pentylbenzyl)amino)methyl)biphenyl-4-yl]ethanol
Plasmodium falciparum
-
IC50: 0.00147 mM
0.005
2-[bis(4-methylpentyl)amino]-1-(1,2,3,4-tetrahydrophenanthren-9-yl)ethanol
Plasmodium falciparum
pH and temperature not specified in the publication
0.0004
3'-(((1S,2S,3S,4R)-3-(4-hexylphenylsulfonyl)-7-azabicyclo[2.2.1]heptan-2-ylamino)methyl)biphenyl-2-ol
Plasmodium falciparum
-
-
0.018
3,5,12-trihydroxy-3-(hydroxyacetyl)-10-methoxy-6,11-dioxo-1,2,3,4,5a,6,11,11a-octahydrotetracen-1-yl 3,4-di-O-acetyl-2,6-dideoxyhexopyranoside
Plasmodium falciparum
-
pH 5.0, temperature not specified in the publication
0.0002011
3-chloro-N-([2-(2-methoxybenzoyl)hydrazino]carbonothioyl)-1-benzothiophene-2-carboxamide
Plasmodium falciparum
-
pH 4.5, 37°C
0.062
3-[3-(4-chlorophenyl)-3-hydroxy-3-phenylpropyl]-3-azoniabicyclo[4.2.1]nonane
Plasmodium falciparum
-
pH 5.0, temperature not specified in the publication
0.000713 - 0.000918
4'-(([2-(dibutylamino)ethyl](4-pentylbenzyl)amino)methyl)biphenyl-4-carbonitrile
0.000208
4'-(([2-(dibutylamino)ethyl](phenylcarbonyl)amino)methyl)biphenyl-3-carboxylic acid
Plasmodium falciparum
-
IC50: 208 nM
0.000495
4'-(([2-(dibutylamino)ethyl](phenylcarbonyl)amino)methyl)biphenyl-4-carboxylic acid
Plasmodium falciparum
-
IC50: 495 nM
0.000077
4'-(([2-(dibutylamino)ethyl][(4-pentylphenyl)carbonyl]amino)methyl)-N,N-dimethylbiphenyl-4-carboxamide
Plasmodium falciparum
-
IC50: 77 nM
0.00145
4,4'-(hydrazine-1,2-diyl)dipyridine
Plasmodium falciparum
pH and temperature not specified in the publication
0.184
4-(1,2-benzothiazol-3-yl)-N-methylpiperazine-1-carboxamide
Plasmodium falciparum
pH and temperature not specified in the publication
0.15
4-(imidazo[2,1-b][1,3]thiazol-6-yl)aniline
Plasmodium falciparum
pH and temperature not specified in the publication
0.0000064
4-amino-N'-(benzyloxy)-N-(2-methylphenyl)-1,2,5-oxadiazole-3-carboximidamide
Plasmodium falciparum
pH and temperature not specified in the publication
0.0000064
4-amino-N'-(benzyloxy)-N-(2-methylphenyl)-1,2,5-oxadiazole-3­carboximidamide
Plasmodium falciparum
-
pH 4.5, 37°C
0.000305
4-amino-N'-(benzyloxy)-N-(4-methylphenyl)-1,2,5-oxadiazole-3­carboximidamide
Plasmodium falciparum
-
pH 4.5, 37°C
0.0000055
4-amino-N'-[(2,4-dichlorobenzyl)oxy]-N-(2-methylphenyl)-1,2,5­oxadiazole-3-carboximidamide
Plasmodium falciparum
-
pH 4.5, 37°C
0.0000055
4-amino-N'-[(2,4-dichlorophenyl)methoxy]-N-(2-methylphenyl)-1,2,5-oxadiazole-3-carboximidamide
Plasmodium falciparum
pH and temperature not specified in the publication
0.0000426
4-amino-N'-[(2-methyl-1-naphthyl)methoxy]-1,2,5-oxadiazole-3­carboximidamide
Plasmodium falciparum
-
pH 4.5, 37°C
0.0059
4-butoxy-N-[2-(dibutylamino)ethyl]-N-(3-phenoxybenzyl)benzamide
Plasmodium falciparum
-
IC50: 0.0059 mM
0.0103
4-butoxy-N-[2-(dibutylamino)ethyl]-N-[4-(trifluoromethyl)benzyl]benzamide
Plasmodium falciparum
-
IC50: 0.0103 mM
0.0023
4-butyl-N-[2-(dibutylamino)ethyl]-N-(3-phenoxybenzyl)benzamide
Plasmodium falciparum
-
IC50: 0.0023 mM
0.0039
4-butyl-N-[2-(dibutylamino)ethyl]-N-[4-(trifluoromethyl)benzyl]benzamide
Plasmodium falciparum
-
IC50: 0.0039 mM
0.007
4-methyl-N-[2-[2-(naphthalen-2-yl)hydrazinyl]phenyl]benzene-1-sulfonamide
Plasmodium falciparum
pH and temperature not specified in the publication
0.152
5-methyl-N3-phenyl-1H-pyrazole-3,4-diamine
Plasmodium falciparum
pH and temperature not specified in the publication
0.00461
5-[4-([(1S,2R,3R,4R)-3-[(naphthalen-2-ylmethyl)amino]-7-azabicyclo[2.2.1]hept-2-yl]sulfonyl)phenyl]pentan-1-ol
Plasmodium falciparum
pH and temperature not specified in the publication
0.056
5-[bis[(benzyloxy)carbonyl]amino]-6-[[1-hydrazinyl-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-6-oxohexan-1-aminium
Plasmodium falciparum
-
pH 5.0, temperature not specified in the publication
0.0000573
6-((2-[(5-chloro-2-methoxyphenyl)amino]-2-oxoethyl)thio)-5-cyano-N-(2-methoxyphenyl)-2-methyl-4-phenyl-1,4-dihydro-3-pyridinecarboxamide
Plasmodium falciparum
-
pH 4.5, 37°C
0.001831
6-bromo-2,3,4,9-tetrahydro-1H-carbazol-1-one N­phenylthiosemicarbazone
Plasmodium falciparum
-
pH 4.5, 37°C
0.00079
6-[4-([(1S,2R,3R,4R)-3-[(naphthalen-2-ylmethyl)amino]-7-azabicyclo[2.2.1]hept-2-yl]sulfonyl)phenyl]hexan-1-ol
Plasmodium falciparum
pH and temperature not specified in the publication
0.0000006
Ac-Val-Val-Sta-Ala-Sta
Plasmodium falciparum
-
IC50: 0.6 nM
0.00125
butanehydrazide
Plasmodium falciparum
pH and temperature not specified in the publication
0.00015
butyloxycarbonyl-His-Pro-Phe-His-Leu-PSI[CH(OH)-CH2]-Val-Ile-His
Plasmodium falciparum
-
IC50: 150 nM
0.001
butyloxycarbonyl-His-Pro-Phe-His-Sta-Leu-Phe-NH2
Plasmodium falciparum
-
IC50: 1000 nM
0.0000001
Iva-Val-Val-Sta-Ala-Sta
Plasmodium falciparum
-
IC50: 0.1 nM
100
Lac-Val-Sta-Ala-Sta
Plasmodium falciparum
-
IC50: 100 mM
0.014
LCu(CH3COO)2
Plasmodium falciparum
-
pH 4.7, 37°C
0.017
LCuCl2
Plasmodium falciparum
-
pH 4.7, 37°C
0.000124
methyl [4'-(([2-(dibutylamino)ethyl](phenylcarbonyl)amino)methyl)biphenyl-4-yl]acetate
Plasmodium falciparum
-
IC50: 124 nM
0.000183
methyl [4'-(([2-(dibutylamino)ethyl][(4-pentylphenyl)carbonyl]amino)methyl)biphenyl-4-yl]acetate
Plasmodium falciparum
-
IC50: 183 nM
0.000034
methyl [4'-([[1-(1H-imidazol-2-ylmethyl)piperidin-4-yl](4-pentylbenzoyl)amino]methyl)biphenyl-4-yl]acetate
Plasmodium falciparum
pH and temperature not specified in the publication
0.000034
methyl [4'-([[1-(1H-imidazol-2-ylmethyl)piperidin-4-yl][(4-pentylphenyl)carbonyl]amino]methyl)biphenyl-4-yl]acetate
Plasmodium falciparum
-
-
0.000014
methyl [4'-([[1-(3-methylbutyl)piperidin-4-yl][(4-pentylcyclohexyl)carbonyl]amino]methyl)biphenyl-4-yl]acetate
Plasmodium falciparum
-
-
0.000011
methyl [4'-([[1-(3-methylbutyl)piperidin-4-yl][(4-pentylphenyl)carbonyl]amino]methyl)biphenyl-4-yl]acetate
Plasmodium falciparum
-
-
0.0000076
N',N'''-1,2-phenylenebis[N-(3-chlorophenyl)urea]
Plasmodium falciparum
-
pH 4.5, 37°C
0.00462
N',N''-[1,10-phenanthroline-2,9-diyldi(E)methylylidene]bis[N-(2-methylphenyl)pyridine-2-carbohydrazonamide]
Plasmodium falciparum
pH and temperature not specified in the publication
0.000004
N'-(3,4-dimethylacridin-9-yl)-2-hydroxybenzohydrazide
Plasmodium falciparum
pH and temperature not specified in the publication
0.0000005
N'-(3,4-dimethylacridin-9-yl)-3-methylbenzohydrazide
Plasmodium falciparum
pH and temperature not specified in the publication
0.0000076
N'-(4-chlorophenyl)-N'-(2-[[(3-chlorophenyl)carbamoyl]amino]phenyl)urea
Plasmodium falciparum
pH and temperature not specified in the publication
0.0002364
N'-[(4-methoxy-3-nitrobenzoyl)oxy]-2-(1-naphthyl)ethanimidamide
Plasmodium falciparum
-
pH 4.5, 37°C
0.00055
N,N'-(3S,4S)-pyrrolidine-3,4-diylbis(N-benzyl-2-phenylacetamide)
Plasmodium falciparum
pH and temperature not specified in the publication
0.0002374
N,N'-([(4,6-dimethyl-2-quinazolinyl)amino]methylylidene)dipropanamide
Plasmodium falciparum
-
pH 4.5, 37°C
0.095
N,N-dibutyl-3-(1,4-dihydronaphthalen-1-yl)-3-hydroxybutan-1-aminium
Plasmodium falciparum
-
pH 5.0, temperature not specified in the publication
0.0013
N,N-dibutyl-N'-(4-pentylbenzyl)-N'-(4-pyridin-2-ylbenzyl)ethane-1,2-diamine
Plasmodium falciparum
-
IC50: 0.0013 mM
0.001603
N,N-dibutyl-N'-(4-pentylbenzyl)-N'-(4-pyridin-4-ylbenzyl)ethane-1,2-diamine
Plasmodium falciparum
-
IC50: 0.001603 mM
0.000000001631
N,N-dibutyl-N'-(4-pentylbenzyl)-N'-(4-pyrimidin-5-ylbenzyl)ethane-1,2-diamine
Plasmodium falciparum
-
IC50: 0.001631 nM
0.002
N,N-dibutyl-N'-(4-pentylbenzyl)-N'-([4'-(2-pyrrolidin-1-ylethoxy)biphenyl-4-yl]methyl)ethane-1,2-diamine
Plasmodium falciparum
-
IC50: 0.002 mM
0.001022
N,N-dibutyl-N'-[(2'-fluorobiphenyl-4-yl)methyl]-N'-(4-pentylbenzyl)ethane-1,2-diamine
Plasmodium falciparum
-
IC50: 0.001022 mM
0.0000621
N-((2,3-dihydro-1,4-benzodioxin-6-ylamino)[(6-methyl-4-oxo-1,4-dihydro-2-pyrimidinyl)amino]methylene)benzamide
Plasmodium falciparum
-
pH 4.5, 37°C
0.0001181
N-((2,3-dihydro-1,4-benzodioxin-6-ylamino)[(6-oxo-4-propyl-1,6-dihydro-2-pyrimidinyl)amino]methylene)-4-methoxybenzamide
Plasmodium falciparum
-
pH 4.5, 37°C
0.000046
N-((4'-[2-(benzylamino)-2-oxoethyl]biphenyl-4-yl)methyl)-N-[2-(dibutylamino)ethyl]-4-pentylbenzamide
Plasmodium falciparum
-
IC50: 46 nM
0.000022
N-((S)-1-(((2S,3S)-3-hydroxy-5-oxo-5-(((S)-1-oxo-3-phenyl-1-(prop-2-yn-1-ylamino)propan-2-yl)amino)-1-phenylpentan-2-yl)-amino)-3-methyl-1-oxobutan-2-yl)picolinamide
Plasmodium falciparum
-
pH 5.0, 37°C
0.000028
N-((S)-1-(((2S,3S)-5-(((R)-1-(((S)-1-amino-4-methyl-1-oxopentan-2-yl)amino)-3-chloro-1-oxopropan-2-yl)amino)-3-hydroxy-5-oxo-1-phenylpentan-2-yl)amino)-3-methyl-1-oxobutan-2-yl)-picolinamide
Plasmodium falciparum
-
pH 5.0, 37°C
0.000141
N-((S)-1-(((2S,3S)-5-(((S)-1-(((S)-1-amino-4-methyl-1-oxopentan-2-yl)amino)-1-oxopent-4-yn-2-yl)amino)-3-hydroxy-5-oxo-1-phenylpentan-2-yl)amino)-3-methyl-1-oxobutan-2-yl)-picolinamide
Plasmodium falciparum
-
pH 5.0, 37°C
0.000333
N-((S)-1-(((2S,3S)-5-(((S)-1-(((S)-1-amino-4-methyl-1-oxopentan-2-yl)amino)-3-cyano-1-oxopropan-2-yl)amino)-3-hydroxy-5-oxo-1-phenylpentan-2-yl)amino)-3-methyl-1-oxobutan-2-yl)picolinamide
Plasmodium falciparum
-
pH 5.0, 37°C
0.0001464
N-(([2-(4-ethylphenyl)-6-methyl-2H-1,2,3-benzotriazol-5-yl]amino)carbonothioyl)-2-nitrobenzamide
Plasmodium falciparum
-
pH 4.5, 37°C
0.0001229
N-(([6-methyl-2-(4-methylphenyl)-2H-1,2,3-benzotriazol-5-yl]amino)carbonothioyl)-2-nitrobenzamide
Plasmodium falciparum
-
pH 4.5, 37°C
0.094
N-(2,5-dimethyl-1H-pyrrol-1-yl)-4-hydroxybenzamide
Plasmodium falciparum
pH and temperature not specified in the publication
0.0000389
N-(2-([3-(1,3-benzodioxol-5-yl)-3-oxo-1-propen-1-yl]amino)phenyl)-4-nitrobenzenesulfonamide
Plasmodium falciparum
-
pH 4.5, 37°C
0.000000003329
N-(2-aminoethyl)-N-(biphenyl-4-ylmethyl)-4-pentylbenzamide
Plasmodium falciparum
-
IC50: 0.003329 nM
0.0000875
N-(2-methoxyphenyl)-2-(5H-[1,2,4]triazino[5,6-b]indol-3­ylthio)butanamide
Plasmodium falciparum
-
pH 4.5, 37°C
0.0000095
N-(3,4-dichlorophenyl)-2-[(4,6-dimethyl-2-pyrimidinyl)amino]­3a,4,5,6,7,7a-hexahydro-1H-benzimidazole-1-carboxamide
Plasmodium falciparum
-
pH 4.5, 37°C
0.0000095
N-(3,4-dichlorophenyl)-2-[(4,6-dimethylpyrimidin-2-yl)amino]-3a,4,5,6,7,7a-hexahydro-1H-benzimidazole-1-carboxamide
Plasmodium falciparum
pH and temperature not specified in the publication
0.001088
N-(3,4-dimethylphenyl)-N'-(imino[(4,6,7-trimethyl-2-quinazolinyl)amino]methyl)thiourea
Plasmodium falciparum
-
pH 4.5, 37°C
0.1
N-(3-carbamoylthiophen-2-yl)thiophene-2-carboxamide
Plasmodium falciparum
pH and temperature not specified in the publication
0.013
N-(4-hexylphenyl)-2-(2-naphthyl)-N-piperidin-4-ylacetamide hydrochloride
Plasmodium falciparum
-
pH 5.0, 37°C
0.001912
N-(4-[5-(1,3-benzodioxol-5-yl)pyridin-2-yl]benzyl)-N-[2-(dibutylamino)ethyl]-4-pentylbenzamide
Plasmodium falciparum
-
IC50: 1912 nM
0.000437
N-(4-[6-(1,3-benzodioxol-5-yl)pyridin-3-yl]benzyl)-N-[2-(dibutylamino)ethyl]-4-pentylbenzamide
Plasmodium falciparum
-
IC50: 437 nM
0.000289
N-(4-[benzyl(methyl)amino]benzyl)-N-[2-(dibutylamino)ethyl]-4-pentylbenzamide
Plasmodium falciparum
-
IC50: 289 nM
0.0047
N-(biphenyl-4-ylmethyl)-4-butoxy-N-[2-(dibutylamino)ethyl]benzamide
Plasmodium falciparum
-
IC50: 0.0047 mM
0.0015
N-(biphenyl-4-ylmethyl)-4-butyl-N-[2-(dibutylamino)ethyl]benzamide
Plasmodium falciparum
-
IC50: 0.0015 mM
0.002067
N-(biphenyl-4-ylmethyl)-N',N'-dibutyl-N-(4-pentylbenzyl)ethane-1,2-diamine
Plasmodium falciparum
-
IC50: 0.002067 mM
0.003943
N-(biphenyl-4-ylmethyl)-N-(2-[bis(1-methylethyl)amino]ethyl)-4-pentylbenzamide
Plasmodium falciparum
-
IC50: 0.003943 mM
0.001161
N-(biphenyl-4-ylmethyl)-N-[2-(butylamino)ethyl]-4-pentylbenzamide
Plasmodium falciparum
-
IC50: 0.001161 mM
0.000143 - 0.000252
N-(biphenyl-4-ylmethyl)-N-[2-(dibutylamino)ethyl]-4-pentylbenzamide
0.0129
N-(biphenyl-4-ylmethyl)-N-[2-(dibutylamino)ethyl]-4-propylbenzamide
Plasmodium falciparum
-
IC50: 0.0129 mM
0.002317
N-(biphenyl-4-ylmethyl)-N-[2-(diethylamino)ethyl]-4-pentylbenzamide
Plasmodium falciparum
-
IC50: 0.002317 mM
0.0000044
N-(cyclopentylcarbamothioyl)-4-ethoxy-3-nitrobenzamide
Plasmodium falciparum
pH and temperature not specified in the publication
0.007
N-([(1RS)-3,3-difluoro-4-oxocyclohexyl]methyl)-2-(2-naphthyl)-N-(4-pentylphenyl)acetamide
Plasmodium falciparum
-
pH 5.0, 37°C
0.1
N-([(1RS)-3,3-difluoro-4-oxocyclopentyl]methyl)-2-(2-naphthyl)-N-(4-pentylphenyl)acetamide
Plasmodium falciparum
-
value above, pH 5.0, 37°C
0.019
N-([(1RS,4RS)-3,3-difluoro-4-hydroxycyclohexyl]methyl)-2-(2-naphthyl)-N-(4-pentylphenyl)acetamide
Plasmodium falciparum
-
pH 5.0, 37°C
0.016
N-([(1RS,4SR)-3,3-difluoro-4-hydroxycyclohexyl]methyl)-2-(2-naphthyl)-N-(4-pentylphenyl)acetamide
Plasmodium falciparum
-
pH 5.0, 37°C
0.1
N-([(1SR,4RS)-3,3-difluoro-4-hydroxycyclopentyl]methyl)-2-(2-naphthyl)-N-(4-pentylphenyl)acetamide
Plasmodium falciparum
-
value above, pH 5.0, 37°C
0.1
N-([(1SR,4SR)-3,3-difluoro-4-hydroxycyclopentyl]methyl)-2-(2-naphthyl)-N-(4-pentylphenyl)acetamide
Plasmodium falciparum
-
value above, pH 5.0, 37°C
0.0000088
N-([(2,4-dimethylphenyl)amino][(4-oxo-1,4,5,6,7,8-hexahydro-2-quinazolinyl)amino]methylene)benzamide
Plasmodium falciparum
-
pH 4.5, 37°C
0.0017
N-([3',5'-bis(trifluoromethyl)biphenyl-4-yl]methyl)-N-[2-(dibutylamino)ethyl]benzamide
Plasmodium falciparum
-
IC50: 0.0017 mM
0.00119
N-([3',5'-bis(trifluoromethyl)biphenyl-4-yl]methyl)-N-[3-(dibutylamino)propyl]-4-pentylbenzamide
Plasmodium falciparum
-
IC50: 0.00119 mM
0.000019
N-([5-[3,5-bis(trifluoromethyl)phenyl]furan-2-yl]methyl)-N-[1-(3-methylbutyl)piperidin-4-yl]-4-pentylbenzamide
Plasmodium falciparum
pH and temperature not specified in the publication
0.000019
N-([5-[3,5-bis(trifluoromethyl)phenyl]furan-2-yl]methyl)-N-[1-(3-methylbutyl)piperidin-4-yl]-5-pentylpyridine-2-carboxamide
Plasmodium falciparum
-
-
0.000031
N-([[1-(3-methylbutyl)piperidin-4-yl](4-pentylbenzoyl)amino]methyl)-1-benzothiophene-2-carboxamide
Plasmodium falciparum
pH and temperature not specified in the publication
0.000146
N-([[1-(3-methylbutyl)piperidin-4-yl](4-pentylbenzoyl)amino]methyl)pyridine-3-carboxamide
Plasmodium falciparum
pH and temperature not specified in the publication
0.00003
N-benzyl-2-([3-(3-nitrophenyl)acryloyl]amino)benzamide
Plasmodium falciparum
-
pH 4.5, 37°C
0.00081
N-benzyl-2-bromo-N-[[4-([[3-(2,4-dichlorophenyl)propyl](3-phenylpropyl)amino]methyl)pyrrolidin-3-yl]methyl]-4,5-dimethoxybenzamide
Plasmodium falciparum
pH and temperature not specified in the publication
0.00064
N-benzyl-2-bromo-N-[[4-([[3-(2,4-dichlorophenyl)propyl][2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)ethyl]amino]methyl)pyrrolidin-3-yl]methyl]-4,5-dimethoxybenzamide
Plasmodium falciparum
pH and temperature not specified in the publication
0.000072
N-benzyl-4'-(([2-(dibutylamino)ethyl][(4-pentylphenyl)carbonyl]amino)methyl)biphenyl-4-carboxamide
Plasmodium falciparum
-
IC50: 72 nM
0.002
N-butyl-N-[2-[6-chloro-3-(3,4-dichlorophenyl)naphthalen-1-yl]-2-hydroxyethyl]butan-1-aminium
Plasmodium falciparum
-
pH 5.0, temperature not specified in the publication
0.005
N-hexyl-N-[2-hydroxy-2-(1,2,3,4-tetrahydrophenanthren-9-yl)ethyl]hexan-1-aminium
Plasmodium falciparum
-
pH 5.0, temperature not specified in the publication
0.017
N-hexyl-N-[2-hydroxy-2-(phenanthren-9-yl)ethyl]hexan-1-aminium
Plasmodium falciparum
-
pH 5.0, temperature not specified in the publication
0.024
N-[(1SR,3RS)-4,4-difluoro-3-hydroxycyclohexyl]-2-(2-naphthyl)-N-(4-pentylphenyl)acetamide
Plasmodium falciparum
-
pH 5.0, 37°C
0.02
N-[(1SR,3SR)-4,4-difluoro-3-hydroxycyclohexyl]-2-(2-naphthyl)-N-(4-pentylphenyl)acetamide
Plasmodium falciparum
-
pH 5.0, 37°C
0.000191
N-[(2'-chlorobiphenyl-4-yl)methyl]-N-[2-(dibutylamino)ethyl]benzamide
Plasmodium falciparum
-
IC50: 191 nM
0.0000043
N-[(2S,3S)-2-hydroxy-3-[(phenoxyacetyl)amino]-4-phenylbutyl]-N-[2-(4-methoxyphenyl)ethyl]piperidine-4-carboxamide
Plasmodium falciparum
-
predicted inhibition constant, temperature not specified in the publication, pH not specified in the publication
0.00001
N-[(2S,3S)-5-[[(2S)-1-[[(2S)-1-amino-4-methyl-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-1-[(4-bromobenzyl)oxy]-3-hydroxy-5-oxopentan-2-yl]-2,4,6-trifluorobenzamide
Plasmodium falciparum
-
predicted inhibition constant, temperature not specified in the publication, pH not specified in the publication
0.000018
N-[(3-ethyl-1,2-oxazol-5-yl)methyl]-N-[1-(3-methylbutyl)piperidin-4-yl]-4-pentylbenzamide
Plasmodium falciparum
pH and temperature not specified in the publication
0.000591
N-[(4'-butylbiphenyl-4-yl)methyl]-N-[2-(dibutylamino)ethyl]benzamide
Plasmodium falciparum
-
IC50: 591 nM
0.000446
N-[(4'-chlorobiphenyl-4-yl)methyl]-N-[2-(dibutylamino)ethyl]benzamide
Plasmodium falciparum
-
IC50: 446 nM
0.000407
N-[(4'-chlorobiphenyl-4-yl)methyl]-N-[3-(dibutylamino)propyl]-4-pentylbenzamide
Plasmodium falciparum
-
IC50: 407 nM
0.00016
N-[(4'-cyanobiphenyl-4-yl)methyl]-N-[2-(dibutylamino)ethyl]benzamide
Plasmodium falciparum
-
IC50: 160 nM
0.0000045
N-[(cyclopentylamino)carbonothioyl]-4-ethoxy-3-nitrobenzamide
Plasmodium falciparum
-
pH 4.5, 37°C
0.0000088
N-[(E)-[(2,4-dimethylphenyl)amino][(4-oxo-1,4,5,6,7,8-hexahydroquinolin-2-yl)amino]methylidene]benzamide
Plasmodium falciparum
pH and temperature not specified in the publication
0.000146
N-[1-(3-methylbutyl)piperidin-4-yl]-4-pentyl-N-[4-[(pyridin-3-ylmethyl)carbamoyl]benzyl]benzamide
Plasmodium falciparum
-
-
0.000054
N-[1-(3-methylbutyl)piperidin-4-yl]-5-pentyl-N-[[4'-(piperidin-1-ylcarbonyl)biphenyl-4-yl]methyl]pyridine-2-carboxamide
0.000145
N-[1-(3-methylbutyl)piperidin-4-yl]-N-(2-[4-[methyl(2-methylquinolin-4-yl)amino]phenyl]ethyl)-4-pentylbenzamide
Plasmodium falciparum
pH and temperature not specified in the publication
0.000145
N-[1-(3-methylbutyl)piperidin-4-yl]-N-[4-[(2-methylquinolin-4-yl)amino]benzyl]-4-pentylbenzamide
Plasmodium falciparum
-
-
0.000113
N-[1-(3-methylbutyl)piperidin-4-yl]-N-[4-[methyl(pyridin-4-yl)amino]benzyl]-4-pentylbenzamide
Plasmodium falciparum
-
-
0.000113
N-[1-(3-methylbutyl)piperidin-4-yl]-N-[[methyl(pyridin-3-yl)amino]methyl]-4-pentylbenzamide
Plasmodium falciparum
pH and temperature not specified in the publication
0.000469
N-[2-(dibutylamino)ethyl]-4-pentyl-N-(3-phenoxybenzyl)benzamide
Plasmodium falciparum
-
IC50: 469 nM
0.000369
N-[2-(dibutylamino)ethyl]-4-pentyl-N-(4-piperidin-1-ylbenzyl)benzamide
Plasmodium falciparum
-
IC50: 369 nM
0.00038
N-[2-(dibutylamino)ethyl]-4-pentyl-N-(4-pyridin-2-ylbenzyl)benzamide
Plasmodium falciparum
-
IC50: 380 nM
0.000374
N-[2-(dibutylamino)ethyl]-4-pentyl-N-(4-pyridin-3-ylbenzyl)benzamide
Plasmodium falciparum
-
IC50: 374 nM
0.000212
N-[2-(dibutylamino)ethyl]-4-pentyl-N-(4-pyridin-4-ylbenzyl)benzamide
Plasmodium falciparum
-
IC50: 212 nM
0.000531
N-[2-(dibutylamino)ethyl]-4-pentyl-N-(4-pyrimidin-5-ylbenzyl)benzamide
Plasmodium falciparum
-
IC50: 531 nM
0.000188
N-[2-(dibutylamino)ethyl]-4-pentyl-N-(4-thiomorpholin-4-ylbenzyl)benzamide
Plasmodium falciparum
-
IC50: 188 nM
0.000056
N-[2-(dibutylamino)ethyl]-4-pentyl-N-([4'-(thiomorpholin-4-ylcarbonyl)biphenyl-4-yl]methyl)benzamide
Plasmodium falciparum
-
IC50: 56 nM
0.00024
N-[2-(dibutylamino)ethyl]-4-pentyl-N-[4-(1H-pyrrol-1-yl)benzyl]benzamide
Plasmodium falciparum
-
IC50: 240 nM
0.0002
N-[2-(dibutylamino)ethyl]-4-pentyl-N-[4-(4-phenylpiperazin-1-yl)benzyl]benzamide
Plasmodium falciparum
-
IC50: 200 nM
0.002345
N-[2-(dibutylamino)ethyl]-4-pentyl-N-[4-(5-phenylpyridin-2-yl)benzyl]benzamide
Plasmodium falciparum
-
IC50: 2345 nM
0.00853
N-[2-(dibutylamino)ethyl]-4-pentyl-N-[4-(5-pyrimidin-5-ylpyridin-2-yl)benzyl]benzamide
Plasmodium falciparum
-
IC50: 8530 nM
0.000589
N-[2-(dibutylamino)ethyl]-4-pentyl-N-[4-(6-phenylpyridin-3-yl)benzyl]benzamide
Plasmodium falciparum
-
IC50: 589 nM
0.002229
N-[2-(dibutylamino)ethyl]-4-pentyl-N-[4-(6-pyrimidin-5-ylpyridin-3-yl)benzyl]benzamide
Plasmodium falciparum
-
IC50: 2229 nM
0.000224
N-[2-(dibutylamino)ethyl]-4-pentyl-N-[4-(phenylamino)benzyl]benzamide
Plasmodium falciparum
-
IC50: 224 nM
0.001816
N-[2-(dibutylamino)ethyl]-4-pentyl-N-[4-(pyridin-4-ylamino)benzyl]benzamide
Plasmodium falciparum
-
IC50: 1816 nM
0.000596
N-[2-(dibutylamino)ethyl]-4-pentyl-N-[4-(trifluoromethyl)benzyl]benzamide
Plasmodium falciparum
-
IC50: 596 nM
0.0396
N-[2-(dibutylamino)ethyl]-4-propyl-N-[4-(trifluoromethyl)benzyl]benzamide
Plasmodium falciparum
-
IC50: 0.0396 mM
0.0159
N-[2-(dibutylamino)ethyl]-N-(3-phenoxybenzyl)-4-propylbenzamide
Plasmodium falciparum
-
IC50: 0.0159 mM
0.000295
N-[2-(dibutylamino)ethyl]-N-(4-pyridin-4-ylbenzyl)benzamide
Plasmodium falciparum
-
IC50: 295 nM
0.000204 - 0.000351
N-[2-(dibutylamino)ethyl]-N-(4-pyrimidin-5-ylbenzyl)benzamide
0.000574
N-[2-(dibutylamino)ethyl]-N-(4-[methyl(phenyl)amino]benzyl)-4-pentylbenzamide
Plasmodium falciparum
-
IC50: 574 nM
0.003015
N-[2-(dibutylamino)ethyl]-N-(4-[methyl(pyridin-4-yl)amino]benzyl)-4-pentylbenzamide
Plasmodium falciparum
-
IC50: 3015 nM
0.00039
N-[2-(dibutylamino)ethyl]-N-([3'-(trifluoromethyl)biphenyl-4-yl]methyl)benzamide
Plasmodium falciparum
-
IC50: 390 nM
0.000511
N-[2-(dibutylamino)ethyl]-N-([4'-(2-hydroxyethoxy)biphenyl-4-yl]methyl)-4-pentylbenzamide
Plasmodium falciparum
-
IC50: 511 nM
0.000104
N-[2-(dibutylamino)ethyl]-N-([4'-(2-hydroxyethoxy)biphenyl-4-yl]methyl)benzamide
Plasmodium falciparum
-
IC50: 104 nM
0.000151
N-[2-(dibutylamino)ethyl]-N-([4'-(2-hydroxyethyl)biphenyl-4-yl]methyl)benzamide
Plasmodium falciparum
-
IC50: 151 nM
0.000074 - 0.000091
N-[2-(dibutylamino)ethyl]-N-([4'-(2-morpholin-4-yl-2-oxoethyl)biphenyl-4-yl]methyl)-4-pentylbenzamide
0.000428
N-[2-(dibutylamino)ethyl]-N-[(3',4'-dimethoxybiphenyl-4-yl)methyl]benzamide
Plasmodium falciparum
-
IC50: 428 nM
0.000293
N-[2-(dibutylamino)ethyl]-N-[(3'-methylbiphenyl-4-yl)methyl]benzamide
Plasmodium falciparum
-
IC50: 293 nM
0.00067
N-[2-(dibutylamino)ethyl]-N-[4-(1H-indol-1-yl)benzyl]-4-pentylbenzamide
Plasmodium falciparum
-
IC50: 670 nM
0.002547
N-[2-(dibutylamino)ethyl]-N-[4-(4-methylpiperazin-1-yl)benzyl]-4-pentylbenzamide
Plasmodium falciparum
-
IC50: 2547 nM
0.001491
N-[2-(dibutylamino)ethyl]-N-[4-(diethylamino)benzyl]-4-pentylbenzamide
Plasmodium falciparum
-
IC50: 1491 nM
0.005
N-[2-hydroxy-2-(1,2,3,4-tetrahydrophenanthren-9-yl)ethyl]-4-methyl-N-(4-methylpentyl)pentan-1-aminium
Plasmodium falciparum
-
pH 5.0, temperature not specified in the publication
0.019
N-[2-hydroxy-2-(1,2,3,4-tetrahydrophenanthren-9-yl)ethyl]-N-pentylpentan-1-aminium
Plasmodium falciparum
-
pH 5.0, temperature not specified in the publication
0.024
N-[3-(2,7-dichloro-9H-fluoren-4-yl)-3-hydroxypropyl]-N-pentylpentan-1-aminium
Plasmodium falciparum
-
pH 5.0, temperature not specified in the publication
0.032
N-[3-(9H-fluoren-2-yl)-3-hydroxypropyl]-N-pentylpentan-1-aminium
Plasmodium falciparum
-
pH 5.0, temperature not specified in the publication
0.000221
N-[3-(dibutylamino)propyl]-4-pentyl-N-([4'-(2-pyrrolidin-1-ylethoxy)biphenyl-4-yl]methyl)benzamide
Plasmodium falciparum
-
IC50: 221 nM
0.000322 - 0.0011
N-[3-(dibutylamino)propyl]-N-[(2'-methoxybiphenyl-4-yl)methyl]-4-pentylbenzamide
0.000597
N-[3-(dibutylamino)propyl]-N-[(2'-methylbiphenyl-4-yl)methyl]-4-pentylbenzamide
Plasmodium falciparum
-
IC50: 597 nM
0.000468
N-[3-(dibutylamino)propyl]-N-[(3',4'-dimethoxybiphenyl-4-yl)methyl]-4-pentylbenzamide
Plasmodium falciparum
-
IC50: 468 nM
0.00058
N-[3-(dibutylamino)propyl]-N-[(3'-methoxybiphenyl-4-yl)methyl]-4-pentylbenzamide
Plasmodium falciparum
-
IC50: 580 nM
0.000246
N-[3-(dibutylamino)propyl]-N-[(4'-methoxybiphenyl-4-yl)methyl]-4-pentylbenzamide
Plasmodium falciparum
-
IC50: 246 nM
0.002
N-[3-[1,3-dichloro-6-(trifluoromethyl)phenanthren-9-yl]-3-hydroxypropyl]-N-pentylpentan-1-aminium
Plasmodium falciparum
-
pH 5.0, temperature not specified in the publication
0.024
N-[4,4-difluoro-3-oxocyclohexyl]-2-(2-naphthyl)-N-(4-pentylphenyl)-acetamide
Plasmodium falciparum
-
pH 5.0, 37°C
0.000154
N-[4-(([2-(dibutylamino)ethyl][(4-pentylphenyl)carbonyl]amino)methyl)phenyl]-2-methoxypyridine-4-carboxamide
Plasmodium falciparum
-
IC50: 154 nM
0.000202
N-[4-(([2-(dibutylamino)ethyl][(4-pentylphenyl)carbonyl]amino)methyl)phenyl]piperidine-3-carboxamide
Plasmodium falciparum
-
IC50: 202 nM
0.000464
N-[4-(([2-(dibutylamino)ethyl][(4-pentylphenyl)carbonyl]amino)methyl)phenyl]piperidine-4-carboxamide
Plasmodium falciparum
-
IC50: 464 nM
0.000243
N-[4-(([2-(dibutylamino)ethyl][(4-pentylphenyl)carbonyl]amino)methyl)phenyl]pyrazine-2-carboxamide
Plasmodium falciparum
-
IC50: 243 nM
0.000334
N-[4-(1,3-benzodioxol-5-yl)benzyl]-4-pentyl-N-(2-piperidin-1-ylethyl)benzamide
Plasmodium falciparum
-
IC50: 334 nM
0.000165
N-[4-(1,3-benzodioxol-5-yl)benzyl]-4-pentyl-N-(2-[4-(3-phenylpropyl)piperidin-1-yl]ethyl)benzamide
Plasmodium falciparum
-
IC50: 165 nM
0.000831
N-[4-(1,3-benzodioxol-5-yl)benzyl]-N',N'-dibutyl-N-(4-pentylbenzyl)ethane-1,2-diamine
Plasmodium falciparum
-
IC50: 831 nM
0.000439
N-[4-(1,3-benzodioxol-5-yl)benzyl]-N-(2-([2-(diethylamino)ethyl](ethyl)amino)ethyl)-4-pentylbenzamide
Plasmodium falciparum
-
IC50: 439 nM
0.002897
N-[4-(1,3-benzodioxol-5-yl)benzyl]-N-(2-morpholin-4-ylethyl)-4-pentylbenzamide
Plasmodium falciparum
-
IC50: 2897 nM
0.000334
N-[4-(1,3-benzodioxol-5-yl)benzyl]-N-(2-[benzyl(2-hydroxyethyl)amino]ethyl)-4-pentylbenzamide
Plasmodium falciparum
-
IC50: 334 nM
0.001501
N-[4-(1,3-benzodioxol-5-yl)benzyl]-N-(2-[bis(1-methylethyl)amino]ethyl)-4-pentylbenzamide
Plasmodium falciparum
-
IC50: 1501 nM
0.00019
N-[4-(1,3-benzodioxol-5-yl)benzyl]-N-[2-(4-benzylpiperidin-1-yl)ethyl]-4-pentylbenzamide
Plasmodium falciparum
-
IC50: 190 nM
0.000101
N-[4-(1,3-benzodioxol-5-yl)benzyl]-N-[2-(dibutylamino)ethyl]-4-pentylbenzamide
Plasmodium falciparum
-
IC50: 101 nM
0.000056
N-[4-(1,3-benzodioxol-5-yl)benzyl]-N-[2-(dibutylamino)ethyl]benzamide
Plasmodium falciparum
-
IC50: 56 nM
0.001519
N-[4-(1,3-benzodioxol-5-yl)benzyl]-N-[2-(diethylamino)ethyl]-4-pentylbenzamide
Plasmodium falciparum
-
IC50: 1519 nM
0.000531
N-[4-(1,3-benzodioxol-5-yl)benzyl]-N-[2-(dipropylamino)ethyl]-4-pentylbenzamide
Plasmodium falciparum
-
IC50: 531 nM
0.000195
N-[4-(1,3-benzodioxol-5-yl)benzyl]-N-[3-(dibutylamino)propyl]-4-pentylbenzamide
Plasmodium falciparum
-
IC50:195 nM
0.000587 - 0.000736
N-[4-(2,2'-bipyridin-5-yl)benzyl]-N-[2-(dibutylamino)ethyl]-4-pentylbenzamide
0.000642
N-[4-(2,4'-bipyridin-5-yl)benzyl]-N-[2-(dibutylamino)ethyl]-4-pentylbenzamide
Plasmodium falciparum
-
IC50: 642 nM
0.005266
N-[4-(3,3'-bipyridin-6-yl)benzyl]-N-[2-(dibutylamino)ethyl]-4-pentylbenzamide
Plasmodium falciparum
-
IC50: 5266 nM
0.004553
N-[4-(3,4'-bipyridin-6-yl)benzyl]-N-[2-(dibutylamino)ethyl]-4-pentylbenzamide
Plasmodium falciparum
-
IC50: 4553 nM
0.000018
N-[4-(3,4-diethylisoxazol-5-yl)benzyl]-N-[1-(3-methylbutyl)piperidin-4-yl]-4-pentylbenzamide
Plasmodium falciparum
-
-
0.000646
N-[4-(4-benzylpiperazin-1-yl)benzyl]-N-[2-(dibutylamino)ethyl]-4-pentylbenzamide
Plasmodium falciparum
-
IC50: 646 nM
0.000429
N-[4-(benzylamino)benzyl]-N-[2-(dibutylamino)ethyl]-4-pentylbenzamide
Plasmodium falciparum
-
IC50: 429 nM
0.0034
N-[4-(benzyloxy)benzyl]-4-butoxy-N-[2-(dibutylamino)ethyl]benzamide
Plasmodium falciparum
-
IC50: 0.0034 mM
0.0013
N-[4-(benzyloxy)benzyl]-4-butyl-N-[2-(dibutylamino)ethyl]benzamide
Plasmodium falciparum
-
IC50: 0.0013 mM
0.000845
N-[4-(benzyloxy)benzyl]-N',N'-dibutyl-N-(4-pentylbenzyl)ethane-1,2-diamine
Plasmodium falciparum
-
IC50: 845 nM
0.000112
N-[4-(benzyloxy)benzyl]-N-[2-(dibutylamino)ethyl]-4-pentylbenzamide
Plasmodium falciparum
-
IC50: 112 nM
0.0089
N-[4-(benzyloxy)benzyl]-N-[2-(dibutylamino)ethyl]-4-propylbenzamide
Plasmodium falciparum
-
IC50: 0.0089 mM
0.000031
N-[4-([[1-(3-methylbutyl)piperidin-4-yl][(4-pentylphenyl)carbonyl]amino]methyl)phenyl]-1-benzothiophene-2-carboxamide
Plasmodium falciparum
-
-
0.000032
N-[4-[5-(3,4-dimethoxybenzyl)-1,2,4-oxadiazol-3-yl]benzyl]-N-[1-(3-methylbutyl)piperidin-4-yl]-4-pentylbenzamide
Plasmodium falciparum
-
-
0.007
N-[[(1S)-3,3-difluoro-4,4-dihydroxycyclohexyl]methyl]-N-(4-pentylphenyl)naphthalene-2-carboxamide
Plasmodium falciparum
pH and temperature not specified in the publication
0.000067
N-[[5-(2,5-dichlorophenyl)furan-2-yl]methyl]-N-[1-(3-methylbutyl)piperidin-4-yl]-4-pentylbenzamide
0.000047
N-[[5-(3,4-dichlorophenyl)furan-2-yl]methyl]-N-[1-(3-methylbutyl)piperidin-4-yl]-4-pentylbenzamide
0.000032
N-[[5-(3,4-dimethoxybenzyl)-1,2,4-oxadiazol-3-yl]methyl]-N-[1-(3-methylbutyl)piperidin-4-yl]-4-pentylbenzamide
Plasmodium falciparum
pH and temperature not specified in the publication
0.000236
N-[[5-(4-chlorophenyl)-1,2-oxazol-3-yl]methyl]-N-[1-(3-methylbutyl)piperidin-4-yl]-4-pentylbenzamide
Plasmodium falciparum
pH and temperature not specified in the publication
0.000236
N-[[5-(4-chlorophenyl)isoxazol-3-yl]methyl]-N-[1-(3-methylbutyl)piperidin-4-yl]-4-pentylbenzamide
Plasmodium falciparum
-
-
0.00899
N2-(3-bromophenyl)-N-[4-[(phenylsulfanyl)methyl]phenyl]-N2-(phenylsulfonyl)glycinamide
Plasmodium falciparum
pH and temperature not specified in the publication
0.0000002
pepstatin
Plasmodium falciparum
-
pH 5.0, temperature not specified in the publication
0.0000875
pepstatin A
Plasmodium falciparum
-
pH 4.5, 37°C
0.0003467
SC-50083
Plasmodium falciparum
-
IC50: 0.0003467 mM
0.000197
[4'-(([2-(dibutylamino)ethyl](phenylcarbonyl)amino)methyl)biphenyl-4-yl]acetic acid
Plasmodium falciparum
-
IC50: 197 nM
0.000463
[4'-(([2-(dibutylamino)ethyl][(4-pentylphenyl)carbonyl]amino)methyl)biphenyl-4-yl]acetic acid
Plasmodium falciparum
-
IC50: 463 nM
0.006
[5-[(benzoyloxy)methyl]-2,3,4,7-tetrahydro-1H-azepin-3-yl]methyl 4-aminobenzoate
Plasmodium falciparum
pH and temperature not specified in the publication