3.4.23.39: plasmepsin II

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For detailed information about plasmepsin II, go to the full flat file.

Reaction

Hydrolysis of the bonds linking certain hydrophobic residues in hemoglobin or globin. Also cleaves the small molecule substrates such as Ala-Leu-Glu-Arg-Thr-Phe!Phe(NO2)-Ser-Phe-Pro-Thr =

Synonyms

AH II, aspartic hemoglobinase II, malarial aspartic protease, PFAPD, pfpm2, plasmepsin 2, plasmepsin II, PLm II, PLMII, PM II, PMII, PSM2

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.23 Aspartic endopeptidases

                3.4.23.39 plasmepsin II

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Results	in table
7	AA Sequence
4	Application
1	CAS Registry Number
14	Cloned(Commentary)
14	Crystallization (Commentary)
2	General Information
294	IC50 Value
565	Inhibitors
3	kcat/KM [mM/s]
192	Ki Value [mM]
98	KM Value [mM]
11	Localization
3	Molecular Weight [Da]
15	Natural Substrates/ Products (Substrates)
65	Organism
1	Pathway
53	PDB ID
11	pH Optimum
4	pH Range
10	Posttranslational Modification
16	Protein Variants
13	Purification (Commentary)
1	Reaction
1	Reaction Type
65	Reference
1	Renatured (Commentary)
4	Source Tissue
99	Substrates and Products (Substrate)
7	Subunits
36	Synonyms
6	Temperature Optimum [°C]
102	Turnover Number [1/s]

Source Tissue

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Source Tissue on EC 3.4.23.39 - plasmepsin II

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SOURCE TISSUE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

SOURCE

bloodstream form

Plasmodium falciparum

-

-

681296

brenda

hypnozoite

Plasmodium falciparum

-

-

681296

brenda

trophozoite

Plasmodium falciparum

-

the proplasmepsin II gene is not transcribed until the later trophozoite stage of parasite growth

648190

brenda

additional information

Plasmodium falciparum

-

Plasmodium falciparum-infected cultured human erythrocytes

648186

brenda