3.4.23.39: plasmepsin II

This is an abbreviated version!
For detailed information about plasmepsin II, go to the full flat file.

Word Map on EC 3.4.23.39

3.4.23.39

plasmepsins

plasmodium

falciparum

antimalarial

piperaquine

artemisinin

pfmdr1

cambodia

proplasmepsins

hemoglobin-degrading

pfcrt

artemisinin-based

dihydroartemisinin-piperaquine

prosegment

molecular biology

falcipains

analysis

medicine

Reaction

Hydrolysis of the bonds linking certain hydrophobic residues in hemoglobin or globin. Also cleaves the small molecule substrates such as Ala-Leu-Glu-Arg-Thr-Phe!Phe(NO2)-Ser-Phe-Pro-Thr =

Synonyms

AH II, aspartic hemoglobinase II, malarial aspartic protease, PFAPD, pfpm2, plasmepsin 2, plasmepsin II, PLm II, PLMII, PM II, PMII, PSM2

ECTree

3 Hydrolases

3.4 Acting on peptide bonds (peptidases)

3.4.23 Aspartic endopeptidases

3.4.23.39 plasmepsin II

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Results	in table
7	AA Sequence
4	Application
1	CAS Registry Number
14	Cloned(Commentary)
14	Crystallization (Commentary)
2	General Information
294	IC50 Value
565	Inhibitors
3	kcat/KM [mM/s]
192	Ki Value [mM]
98	KM Value [mM]
11	Localization
3	Molecular Weight [Da]
15	Natural Substrates/ Products (Substrates)
65	Organism
1	Pathway
53	PDB ID
11	pH Optimum
4	pH Range
10	Posttranslational Modification
16	Protein Variants
13	Purification (Commentary)
1	Reaction
1	Reaction Type
65	Reference
1	Renatured (Commentary)
4	Source Tissue
99	Substrates and Products (Substrate)
7	Subunits
36	Synonyms
6	Temperature Optimum [°C]
102	Turnover Number [1/s]

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Application on EC 3.4.23.39 - plasmepsin II

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analysis

Plasmodium falciparum

cheap and high-throughput heterogeneous enzymatic assay for measuring plasmepsin II activity in order to use it as a tool in the discovery of new inhibitors of this enzyme

669987

medicine

2 entries

molecular biology

Plasmodium falciparum

plasmepsin 2 but not plasmepsin 4 is a pential tool for hydrogen/deuterium exchange coupled to mass spectroscopy (DXMS) studies

708888