3.4.23.39: plasmepsin II

This is an abbreviated version!
For detailed information about plasmepsin II, go to the full flat file.

Reaction

Hydrolysis of the bonds linking certain hydrophobic residues in hemoglobin or globin. Also cleaves the small molecule substrates such as Ala-Leu-Glu-Arg-Thr-Phe!Phe(NO2)-Ser-Phe-Pro-Thr =

Synonyms

AH II, aspartic hemoglobinase II, malarial aspartic protease, PFAPD, pfpm2, plasmepsin 2, plasmepsin II, PLm II, PLMII, PM II, PMII, PSM2

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.23 Aspartic endopeptidases

                3.4.23.39 plasmepsin II

Advanced search results

Do not include text mining results

Include results (more...)

Include results (more...)

Results	in table
7	AA Sequence
4	Application
1	CAS Registry Number
14	Cloned(Commentary)
14	Crystallization (Commentary)
2	General Information
294	IC50 Value
565	Inhibitors
3	kcat/KM [mM/s]
192	Ki Value [mM]
98	KM Value [mM]
11	Localization
3	Molecular Weight [Da]
15	Natural Substrates/ Products (Substrates)
65	Organism
1	Pathway
53	PDB ID
11	pH Optimum
4	pH Range
10	Posttranslational Modification
16	Protein Variants
13	Purification (Commentary)
1	Reaction
1	Reaction Type
65	Reference
1	Renatured (Commentary)
4	Source Tissue
99	Substrates and Products (Substrate)
7	Subunits
36	Synonyms
6	Temperature Optimum [°C]
102	Turnover Number [1/s]

Purification

print visible entries

print all entries

Go back to the abbreviated version
of the Enzyme Summary Page.

Purification on EC 3.4.23.39 - plasmepsin II

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

top print hide Go to Purification (commentary) Search

Please wait a moment until the data is sorted. This message will disappear when the data is sorted.

PURIFICATION (Commentary)

ORGANISM

UNIPROT

LITERATURE

-

Plasmodium falciparum

-

648181, 648187, 648193, 648203, 669157, 669349, 669426, 708888

Ni-NTA column chromatography and Superdex 75 gel filtration

Plasmodium falciparum

-

753556

proplasmepsin

Plasmodium falciparum

-

648190

protein is autoactivated at pH 4.7

Plasmodium falciparum

-

709477

using a Q-Sepharose fast flow column

Plasmodium falciparum

-

708120

using nickel affinity chromatography and gel filtration

Plasmodium falciparum

-

710468