3.4.23.39: plasmepsin II
This is an abbreviated version!
For detailed information about plasmepsin II, go to the full flat file.
Word Map on EC 3.4.23.39
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3.4.23.39
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plasmepsins
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plasmodium
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falciparum
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antimalarial
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piperaquine
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artemisinin
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pfmdr1
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cambodia
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proplasmepsins
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hemoglobin-degrading
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pfcrt
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artemisinin-based
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dihydroartemisinin-piperaquine
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prosegment
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molecular biology
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falcipains
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analysis
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medicine
- 3.4.23.39
-
plasmepsins
- plasmodium
- falciparum
-
antimalarial
-
piperaquine
- artemisinin
-
pfmdr1
-
cambodia
-
proplasmepsins
-
hemoglobin-degrading
-
pfcrt
-
artemisinin-based
-
dihydroartemisinin-piperaquine
- prosegment
- molecular biology
-
falcipains
- analysis
- medicine
Reaction
Hydrolysis of the bonds linking certain hydrophobic residues in hemoglobin or globin. Also cleaves the small molecule substrates such as Ala-Leu-Glu-Arg-Thr-Phe!Phe(NO2)-Ser-Phe-Pro-Thr =
Synonyms
AH II, aspartic hemoglobinase II, malarial aspartic protease, PFAPD, pfpm2, plasmepsin 2, plasmepsin II, PLm II, PLMII, PM II, PMII, PSM2
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Natural Substrates Products on EC 3.4.23.39 - plasmepsin II
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
plasmepsin 2 + H2O
?
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PSM2 auto-cleavage after F112 is complete after 20 min in 10 mM citrate pH 4.5
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?
Hemoglobin + H2O
?
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enzyme is involved in initial steps of Plasmodium hemoglobin degradation
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?
Hemoglobin + H2O
?
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during the infection of erythrocytes by the human malaria parasite Plasmodium falciparum, up to 80% of the host cell hemoglobin is degraded to provide amino acids for parasite nutrition. Plasmepsin I and plasmepsin II are believed to be responsible for initiating the catabolic process
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-
?
Hemoglobin + H2O
?
the enzyme initiates degradation of hemoglobin by cleavage at the alpha-chain between Phe33 and Leu34
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?
Hemoglobin + H2O
?
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the enzyme participates in the hemoglobin digestive pathway
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?
Hemoglobin + H2O
?
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the enzyme is involved in degradation of the host cell hemoglobin within the acidic food vacuole of the parasite
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?
Hemoglobin + H2O
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pro-plasmepsin II is transported through the secretory system to cytostomal vacuoles and then is carried along with its substrate hemoglobin to the food vacuole where it is proteolytically processed to mature PMII
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?
Hemoglobin + H2O
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the enzyme participates in the hemoglobin digestive pathway
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?
spectrin + H2O
?
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the enzyme catalyzes the degradation of spectrin in the erythrocyte membrane cytoskeletron
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?
