3.4.23.39: plasmepsin II

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For detailed information about plasmepsin II, go to the full flat file.

Reaction

Hydrolysis of the bonds linking certain hydrophobic residues in hemoglobin or globin. Also cleaves the small molecule substrates such as Ala-Leu-Glu-Arg-Thr-Phe!Phe(NO2)-Ser-Phe-Pro-Thr =

Synonyms

AH II, aspartic hemoglobinase II, malarial aspartic protease, PFAPD, pfpm2, plasmepsin 2, plasmepsin II, PLm II, PLMII, PM II, PMII, PSM2

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.23 Aspartic endopeptidases

                3.4.23.39 plasmepsin II

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Results	in table
7	AA Sequence
4	Application
1	CAS Registry Number
14	Cloned(Commentary)
14	Crystallization (Commentary)
2	General Information
294	IC50 Value
565	Inhibitors
3	kcat/KM [mM/s]
192	Ki Value [mM]
98	KM Value [mM]
11	Localization
3	Molecular Weight [Da]
15	Natural Substrates/ Products (Substrates)
65	Organism
1	Pathway
53	PDB ID
11	pH Optimum
4	pH Range
10	Posttranslational Modification
16	Protein Variants
13	Purification (Commentary)
1	Reaction
1	Reaction Type
65	Reference
1	Renatured (Commentary)
4	Source Tissue
99	Substrates and Products (Substrate)
7	Subunits
36	Synonyms
6	Temperature Optimum [°C]
102	Turnover Number [1/s]

pH Optimum

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pH Optimum on EC 3.4.23.39 - plasmepsin II

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pH OPTIMUM

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

2.2

Plasmodium falciparum

-

assay at, PSM2 produces more cleavage sites at pH 4.5 than at pH 2.2. At pH 2.2 PSM2 activity is observed only without maturation

708888

4.5

4 entries

4.7

Plasmodium falciparum

-

assay at

709167

5

3 entries

4.5

Plasmodium falciparum

-

-

648194

4.5

Plasmodium falciparum

-

assay at

708120

4.5

Plasmodium falciparum

P46925

assay at

708127

4.5

Plasmodium falciparum

-

assay at, at pH 4.5 the number of cleavage sites is lower at 0°C than at room temperature. PSM2 produces more cleavage sites at pH 4.5 than at pH 2.2

708888

5

Plasmodium falciparum

-

-

648189

5

Plasmodium falciparum

-

assay at

708121, 709477, 710185

5

Plasmodium falciparum

-

optimal pH of wild-type PMII, chimeric PMII and PMII without prosegment

710468