3.4.23.39: plasmepsin II
This is an abbreviated version!
For detailed information about plasmepsin II, go to the full flat file.
Word Map on EC 3.4.23.39
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3.4.23.39
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plasmepsins
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plasmodium
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falciparum
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antimalarial
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piperaquine
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artemisinin
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pfmdr1
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cambodia
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proplasmepsins
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hemoglobin-degrading
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pfcrt
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artemisinin-based
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dihydroartemisinin-piperaquine
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prosegment
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molecular biology
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falcipains
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analysis
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medicine
- 3.4.23.39
-
plasmepsins
- plasmodium
- falciparum
-
antimalarial
-
piperaquine
- artemisinin
-
pfmdr1
-
cambodia
-
proplasmepsins
-
hemoglobin-degrading
-
pfcrt
-
artemisinin-based
-
dihydroartemisinin-piperaquine
- prosegment
- molecular biology
-
falcipains
- analysis
- medicine
Reaction
Hydrolysis of the bonds linking certain hydrophobic residues in hemoglobin or globin. Also cleaves the small molecule substrates such as Ala-Leu-Glu-Arg-Thr-Phe!Phe(NO2)-Ser-Phe-Pro-Thr =
Synonyms
AH II, aspartic hemoglobinase II, malarial aspartic protease, PFAPD, pfpm2, plasmepsin 2, plasmepsin II, PLm II, PLMII, PM II, PMII, PSM2
ECTree
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Turnover Number
Turnover Number on EC 3.4.23.39 - plasmepsin II
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0.952 - 2.52
4-(4-dimethylaminophenylazo)benzoyl-CH2-CH2-CO-CO-ALERMFLSFP-diaminopimelate-5-[(2-aminoethyl)amino]naphthalene-1-sulfonic acid
0.431 - 6.08
4-(4-dimethylaminophenylazo)benzoyl-CH2-CH2-CO-ERMFLSFP-diaminopimelate-5-[(2-aminoethyl)amino]naphthalene-1-sulfonic acid
2.31
4-[[4'-(dimethylamino)phenyl]azo]-benzoyl-Glu-Arg-Met-Phe-Leu-Ser-Phe-Pro-(gamma-aminobutyryl)-5-[(2'-aminoethyl)-amino]naphthalenesulfonic acid
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pH 5.0, 37°C
7
Lys-Glu-Phe-Asn-Phe-Phe(NO2)-Ala-Leu-Lys
-
pH 4.4, 37°C, recombinant enzyme
0.84
Lys-Glu-Phe-Val-Lys-Phe(NO2)-Ala-Leu-Lys
-
pH 4.4, 37°C, mutant enzyme S77D
11
Lys-Glu-Phe-Val-Phe-Phe(NO2)-Arg-Leu-Lys
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pH 4.4, 37°C, recombinant enzyme
0.952
4-(4-dimethylaminophenylazo)benzoyl-CH2-CH2-CO-CO-ALERMFLSFP-diaminopimelate-5-[(2-aminoethyl)amino]naphthalene-1-sulfonic acid
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F244E mutant enzyme expressed by a system that bypasses the need for autoactivation
1.05
4-(4-dimethylaminophenylazo)benzoyl-CH2-CH2-CO-CO-ALERMFLSFP-diaminopimelate-5-[(2-aminoethyl)amino]naphthalene-1-sulfonic acid
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delF241 mutant enzyme expressed by a system that bypasses the need for autoactivation
1.51
4-(4-dimethylaminophenylazo)benzoyl-CH2-CH2-CO-CO-ALERMFLSFP-diaminopimelate-5-[(2-aminoethyl)amino]naphthalene-1-sulfonic acid
-
F244K mutant enzyme expressed by a system that bypasses the need for autoactivation
2.33
4-(4-dimethylaminophenylazo)benzoyl-CH2-CH2-CO-CO-ALERMFLSFP-diaminopimelate-5-[(2-aminoethyl)amino]naphthalene-1-sulfonic acid
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mature enzyme expressed by a system that bypasses the need for autoactivation
2.51
4-(4-dimethylaminophenylazo)benzoyl-CH2-CH2-CO-CO-ALERMFLSFP-diaminopimelate-5-[(2-aminoethyl)amino]naphthalene-1-sulfonic acid
-
F244A mutant enzyme expressed by a system that bypasses the need for autoactivation
2.52
4-(4-dimethylaminophenylazo)benzoyl-CH2-CH2-CO-CO-ALERMFLSFP-diaminopimelate-5-[(2-aminoethyl)amino]naphthalene-1-sulfonic acid
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autoactivated enzyme
0.431
4-(4-dimethylaminophenylazo)benzoyl-CH2-CH2-CO-ERMFLSFP-diaminopimelate-5-[(2-aminoethyl)amino]naphthalene-1-sulfonic acid
-
F244E mutant enzyme expressed by a system that bypasses the need for autoactivation
0.596
4-(4-dimethylaminophenylazo)benzoyl-CH2-CH2-CO-ERMFLSFP-diaminopimelate-5-[(2-aminoethyl)amino]naphthalene-1-sulfonic acid
-
delF241 mutant enzyme expressed by a system that bypasses the need for autoactivation
0.845
4-(4-dimethylaminophenylazo)benzoyl-CH2-CH2-CO-ERMFLSFP-diaminopimelate-5-[(2-aminoethyl)amino]naphthalene-1-sulfonic acid
-
F244K mutant enzyme expressed by a system that bypasses the need for autoactivation
0.875
4-(4-dimethylaminophenylazo)benzoyl-CH2-CH2-CO-ERMFLSFP-diaminopimelate-5-[(2-aminoethyl)amino]naphthalene-1-sulfonic acid
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mature enzyme expressed by a system that bypasses the need for autoactivation
1.1
4-(4-dimethylaminophenylazo)benzoyl-CH2-CH2-CO-ERMFLSFP-diaminopimelate-5-[(2-aminoethyl)amino]naphthalene-1-sulfonic acid
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autoactivated enzyme
1.11
4-(4-dimethylaminophenylazo)benzoyl-CH2-CH2-CO-ERMFLSFP-diaminopimelate-5-[(2-aminoethyl)amino]naphthalene-1-sulfonic acid
-
F244A mutant enzyme expressed by a system that bypasses the need for autoactivation
6.08
4-(4-dimethylaminophenylazo)benzoyl-CH2-CH2-CO-ERMFLSFP-diaminopimelate-5-[(2-aminoethyl)amino]naphthalene-1-sulfonic acid
-
delF241 mutant enzyme expressed by a system that bypasses the need for autoactivation
6.08
4-(4-dimethylaminophenylazo)benzoyl-CH2-CH2-CO-ERMFLSFP-diaminopimelate-5-[(2-aminoethyl)amino]naphthalene-1-sulfonic acid
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F244K mutant enzyme expressed by a system that bypasses the need for autoactivation
2.1
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pH 4.4, 37°C, mutant enzyme I287E
2.7
Ala-Leu-Glu-Arg-Nle-Phe-Phe(NO2)-Ser-Phe-Pro
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pH 4.4, 37°C, mutant enzyme S77D
5.8
Ala-Leu-Glu-Arg-Nle-Phe-Phe(NO2)-Ser-Phe-Pro
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pH 4.4, 37°C, mutant enzyme M13E
7.4
Ala-Leu-Glu-Arg-Nle-Phe-Phe(NO2)-Ser-Phe-Pro
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pH 4.4, 37°C, mutant enzyme M13E/I287E
0.103
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PMII without prosegment, pH 5, temperature not specified in the publication
1.11
EDANS-CO-CH2-CH2-CO-Ala-Leu-Glu-Arg-Met-Phe-Leu-Ser-Phe-Pro-Dap-(DABCYL)-OH
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chimeric PMII (porcine pepsinogen prosegment fused to the mature region of PMII), pH 5, temperature not specified in the publication
2.1
EDANS-CO-CH2-CH2-CO-Ala-Leu-Glu-Arg-Met-Phe-Leu-Ser-Phe-Pro-Dap-(DABCYL)-OH
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wild-type PMII, pH 5, temperature not specified in the publication
10
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pH 4.4, 37°C, naturally occuring enzyme
13
Leu-Glu-Arg-Ile-Phe-Phe(NO2)-Ser-Phe
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pH 4.4, 37°C, recombinant enzyme
0.8
-
pH 4.4, 37°C, mutant enzyme I287E
0.9
Lys-Ala-Ile-Glu-Phe-Phe(NO2)-Arg-Leu
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pH 4.4, 37°C, mutant enzyme M13E/I287E
0.6
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pH 4.4, 37°C, mutant enzyme I287E
0.9
Lys-Asp-Ile-Glu-Phe-Phe(NO2)-Arg-Leu
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pH 4.4, 37°C, mutant enzyme M13E/I287E
1.5
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pH 4.4, 37°C, recombinant enzyme
6
Lys-Glu-Leu-Val-Phe-Phe(NO2)-Ala-Leu-Lys
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pH 4.4, 37°C, naturally occuring enzyme
17
Lys-Glu-Phe-Val-Phe-Phe(NO2)-Ala-Leu-Lys
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pH 4.4, 37°C, recombinant enzyme
19
Lys-Glu-Phe-Val-Phe-Phe(NO2)-Ala-Leu-Lys
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pH 4.4, 37°C, naturally occuring enzyme
0.19
Lys-Lys-Ile-Glu-Phe-Phe(NO2)-Arg-Leu
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pH 4.4, 37°C, mutant enzyme I287E
0.4
Lys-Lys-Ile-Glu-Phe-Phe(NO2)-Arg-Leu
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pH 4.4, 37°C, mutant enzyme M13E/I287E
1
-
pH 4.4, 37°C, mutant enzyme I287E
2.6
Lys-Phe-Ile-Glu-Phe-Phe(NO2)-Arg-Leu
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pH 4.4, 37°C, mutant enzyme M13E/I287E
0.5
Lys-Pro-Ala-Glu-Phe-Phe(NO2)-Arg-Leu
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pH 4.4, 37°C, mutant enzyme M13E/I287E
0.53
Lys-Pro-Ala-Glu-Phe-Phe(NO2)-Arg-Leu
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pH 4.4, 37°C, mutant enzyme M13E
0.3
-
pH 4.4, 37°C, mutant enzyme M13E/I287E
0.32
Lys-Pro-Asp-Glu-Phe-Phe(NO2)-Arg-Leu
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pH 4.4, 37°C, mutant enzyme M13E
0.89
Lys-Pro-Ile-Ala-Phe-Phe(NO2)-Arg-Leu
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pH 4.4, 37°C, mutant enzyme I287E
1.8
Lys-Pro-Ile-Ala-Phe-Phe(NO2)-Arg-Leu
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pH 4.4, 37°C, mutant enzyme M13E/I287E
0.44
Lys-Pro-Ile-Asp-Phe-Phe(NO2)-Arg-Leu
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pH 4.4, 37°C, mutant enzyme M13E/I287E
0.86
Lys-Pro-Ile-Asp-Phe-Phe(NO2)-Arg-Leu
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pH 4.4, 37°C, mutant enzyme I287E
1.7
-
pH 4.4, 37°C, mutant enzyme I287E
2
Lys-Pro-Ile-Glu-Phe-Phe(NO2)-Arg-Leu
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pH 4.4, 37°C, mutant enzyme S77D
2
Lys-Pro-Ile-Glu-Phe-Phe(NO2)-Arg-Leu
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pH 4.4, 37°C, mutant enzyme M13E
3.5
Lys-Pro-Ile-Glu-Phe-Phe(NO2)-Arg-Leu
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pH 4.4, 37°C, mutant enzyme M13E/I287E
0.03
-
pH 4.4, 37°C, mutant enzyme M13E/I287E
0.06
Lys-Pro-Ile-Lys-Phe-Phe(NO2)-Arg-Leu
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pH 4.4, 37°C, mutant enzyme I287E
0.08
Lys-Pro-Ile-Lys-Phe-Phe(NO2)-Arg-Leu
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pH 4.4, 37°C, mutant enzyme S77D
0.73
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pH 4.4, 37°C, mutant enzyme I287E
1.1
Lys-Pro-Ile-Ser-Phe-Phe(NO2)-Arg-Leu
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pH 4.4, 37°C, mutant enzyme M13E/I287E
0.05
-
pH 4.4, 37°C, mutant enzyme M13E/I287E
0.08
Lys-Pro-Lys-Glu-Phe-Phe(NO2)-Arg-Leu
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pH 4.4, 37°C, mutant enzyme M13E
2.9
Lys-Pro-Phe-Glu-Phe-Phe(NO2)-Arg-Leu
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pH 4.4, 37°C, mutant enzyme M13E/I287E
3.1
Lys-Pro-Phe-Glu-Phe-Phe(NO2)-Arg-Leu
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pH 4.4, 37°C, mutant enzyme M13E
0.2
-
pH 4.4, 37°C, mutant enzyme M13E/I287E
0.27
Lys-Pro-Ser-Glu-Phe-Phe(NO2)-Arg-Leu
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pH 4.4, 37°C, mutant enzyme M13E
1
-
pH 4.4, 37°C, mutant enzyme I287E
1.1
Lys-Ser-Ile-Glu-Phe-Phe(NO2)-Arg-Leu
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pH 4.4, 37°C, mutant enzyme M13E/I287E