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3.4.21.B28: fibroblast activation protein alpha subunit

This is an abbreviated version!
For detailed information about fibroblast activation protein alpha subunit, go to the full flat file.

Word Map on EC 3.4.21.B28

Reaction

fibroblast activation protein requires substrates with Pro at P1 and Gly or D-amino acids at P2. Met-alpha2-antiplasmin is cleaved N-terminally at Pro3-Leu4 and Pro12-Asn13 into Asn-alpha2-antiplasmin that is rapidly cross-linked to fibrin and protects it from digestion by plasmin =

Synonyms

antiplasmin-cleaving enzyme, APCE, FAP, FAP-alpha, FAP-specific protease, FAPalpha, fibroblast activation factor, fibroblast activation protein, fibroblast activation protein alpha, fibroblast activation protein protease, fibroblast activation protein-alpha, fibroblast activation protein-specific protease, gelatinase, S09.007, seprase, surface expressed protease, type II transmembrane serine protease, Z-Pro-prolinal-insensitive peptidase, ZIP

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.21 Serine endopeptidases
                3.4.21.B28 fibroblast activation protein alpha subunit

Turnover Number

Turnover Number on EC 3.4.21.B28 - fibroblast activation protein alpha subunit

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TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.015
7-methoxycoumarin-4-acetic acid-APGSKGDA-dinitrophenyl
-
in 100 mM NaCl, 100 mM Tris, pH 7.8, at 37°C
0.196
7-methoxycoumarin-4-acetic acid-ASGPAGPA-dinitrophenyl
-
in 100 mM NaCl, 100 mM Tris, pH 7.8, at 37°C
0.067
7-methoxycoumarin-4-acetic acid-DKGESGPA-dinitrophenyl
-
in 100 mM NaCl, 100 mM Tris, pH 7.8, at 37°C
0.003
7-methoxycoumarin-4-acetic acid-DRGETGP-dinitrophenyl
-
in 100 mM NaCl, 100 mM Tris, pH 7.8, at 37°C
0.081
7-methoxycoumarin-4-acetic acid-DRGETGPA-dinitrophenyl
-
in 100 mM NaCl, 100 mM Tris, pH 7.8, at 37°C
0.003
7-methoxycoumarin-4-acetic acid-DSGETGP-dinitrophenyl
-
in 100 mM NaCl, 100 mM Tris, pH 7.8, at 37°C
0.059
7-methoxycoumarin-4-acetic acid-DSGETGPA-dinitrophenyl
-
in 100 mM NaCl, 100 mM Tris, pH 7.8, at 37°C
0.115
7-methoxycoumarin-4-acetic acid-EPGPPGPA-dinitrophenyl
-
in 100 mM NaCl, 100 mM Tris, pH 7.8, at 37°C
0.141
7-methoxycoumarin-4-acetic acid-ERGETGPA-dinitrophenyl
-
in 100 mM NaCl, 100 mM Tris, pH 7.8, at 37°C
0.121
7-methoxycoumarin-4-acetic acid-ERGETGPAG-dinitrophenyl
-
in 100 mM NaCl, 100 mM Tris, pH 7.8, at 37°C
0.079
7-methoxycoumarin-4-acetic acid-ERGETGPAGG-dinitrophenyl
-
in 100 mM NaCl, 100 mM Tris, pH 7.8, at 37°C
0.268
7-methoxycoumarin-4-acetic acid-ERGETGPSG-dinitrophenyl
-
in 100 mM NaCl, 100 mM Tris, pH 7.8, at 37°C
0.095
7-methoxycoumarin-4-acetic acid-VGPAGK-dinitrophenyl
-
in 100 mM NaCl, 100 mM Tris, pH 7.8, at 37°C
0.3
acetyl-D-Ala-Pro-7-amido-4-trifluoromethylcoumarin
23°C
0.05 - 14
acetyl-Gly-Pro-7-amido-4-trifluoromethylcoumarin
2
Ala-Pro-4-trifluoromethylcoumarin-7-amide
pH 8.5
0.995 - 14.2
Ala-Pro-7-amido-4-trifluoromethylcoumarin
2.7
Ala-Ser-Gly-Pro-Asn-Gln
23°C
5.5
Ala-Ser-Gly-Pro-Ser-Ser
23°C
1.06 - 1.2
Arg-Lys(4-(4-dimethylaminophenylazo)benzoyl)-Thr-Ser-Gly-Pro-Asn-Gln-Glu-Gln-Glu(5-[(2-aminoethyl)amino]-naphthalene-1-sulfonic acid)-Arg
0.19
Arg-Lys-(4-(4-dimethylaminophenylazo)benzoyl)-Thr-Ser-D-Ala-Pro-Asn-Gln-Glu-Gln-Glu(5-[(2-aminoethyl)amino]naphthalene-1-sulfonic acid)-Arg
23°C
0.22
Arg-Lys-(4-(4-dimethylaminophenylazo)benzoyl)-Thr-Ser-D-Ser-Pro-Asn-Gln-Glu-Gln-Glu(5-[(2-aminoethyl)amino]naphthalene-1-sulfonic acid)-Arg
23°C
0.51 - 36.4
benzyloxycarbonyl-Gly-Pro-7-amido-4-methylcoumarin
1.5
D-Ala-Pro-7-amido-4-trifluoromethylcoumarin
23°C
29.1
Gly-Pro-7-amido-4-methylcoumarin
pH 7.5, 22°C
0.03 - 5.6
Gly-Pro-7-amido-4-trifluoromethylcoumarin
6.9
Ile-Pro-7-amido-4-trifluoromethylcoumarin
-
at 23°C in 50 mM Tris-HCl, 100 mM NaCl, 1 mM EDTA, pH 7.4
1.08
L-Ala-Pro-7-amido-4-trifluoromethylcoumarin
recombinant enzyme
1.2
L-Arg-Lys-(4-(4-dimethylaminophenylazo)benzoyl)-Thr-Ser-Gly-Pro-Asn-Gln-Gln-Gln-Glu(5-[(2-aminoethyl)amino]-naphthalene-1-sulfonic acid)-Arg
recombinant enzyme
0.01
Lys-Ala-7-amido-4-trifluoromethylcoumarin
-
at 23°C in 50 mM Tris-HCl, 100 mM NaCl, 1 mM EDTA, pH 7.4
70.2
MEPLGRQLTSGP-7-amido-4-methylcoumarin
pH 7.5, 22°C
55.3
MEPLGWQLTSGP-7-amido-4-methylcoumarin
pH 7.5, 22°C
1.1
Phe-Pro-7-amido-4-trifluoromethylcoumarin
-
at 23°C in 50 mM Tris-HCl, 100 mM NaCl, 1 mM EDTA, pH 7.4
1.5
Thr-Ala-Gly-Pro-Asn-Gln
23°C
1.6
Thr-Ser-Gly-Pro-Asn-Gln
23°C
3.1
Thr-Ser-Gly-Pro-Asn-Ser
23°C
2
Thr-Ser-Gly-Pro-Ser-Gln
23°C
1.19
Tic-Pro-7-amido-4-trifluoromethylcoumarin
-
in 25 mM sodium phosphate buffer, pH 7.5, containing 1.0 mM EDTA and 2% (v/v) methanol, at 22°C