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3.4.21.B28: fibroblast activation protein alpha subunit

This is an abbreviated version!
For detailed information about fibroblast activation protein alpha subunit, go to the full flat file.

Word Map on EC 3.4.21.B28

Reaction

fibroblast activation protein requires substrates with Pro at P1 and Gly or D-amino acids at P2. Met-alpha2-antiplasmin is cleaved N-terminally at Pro3-Leu4 and Pro12-Asn13 into Asn-alpha2-antiplasmin that is rapidly cross-linked to fibrin and protects it from digestion by plasmin =

Synonyms

antiplasmin-cleaving enzyme, APCE, FAP, FAP-alpha, FAP-specific protease, FAPalpha, fibroblast activation factor, fibroblast activation protein, fibroblast activation protein alpha, fibroblast activation protein protease, fibroblast activation protein-alpha, fibroblast activation protein-specific protease, gelatinase, S09.007, seprase, surface expressed protease, type II transmembrane serine protease, Z-Pro-prolinal-insensitive peptidase, ZIP

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.21 Serine endopeptidases
                3.4.21.B28 fibroblast activation protein alpha subunit

KI Value

KI Value on EC 3.4.21.B28 - fibroblast activation protein alpha subunit

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Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0000057
acetyl-Arg-(8-amino-3,6-dioxaoctanoic acid)-D-Ala-L-boroPro
-
in 25 mM sodium phosphate buffer, pH 7.5, containing 1.0 mM EDTA and 2% (v/v) methanol, at 22°C
0.001377
acetyl-Arg-(8-amino-3,6-dioxaoctanoic acid)-D-Asp-L-boroPro
-
in 25 mM sodium phosphate buffer, pH 7.5, containing 1.0 mM EDTA and 2% (v/v) methanol, at 22°C
0.0000018
acetyl-Arg-(8-amino-3,6-dioxaoctanoic acid)-Gly-L-boroPro
-
in 25 mM sodium phosphate buffer, pH 7.5, containing 1.0 mM EDTA and 2% (v/v) methanol, at 22°C
0.0000027
acetyl-Arg-(8-amino-3,6-dioxaoctanoic acid)-Ser-Gly-L-boroPro
-
in 25 mM sodium phosphate buffer, pH 7.5, containing 1.0 mM EDTA and 2% (v/v) methanol, at 22°C
0.0000172
acetyl-Arg-Gly-Gly-L-boroPro
-
in 25 mM sodium phosphate buffer, pH 7.5, containing 1.0 mM EDTA and 2% (v/v) methanol, at 22°C
0.023
acetyl-Gly-boro-Pro
0.0000207
acetyl-Gly-L-boroPro
-
in 25 mM sodium phosphate buffer, pH 7.5, containing 1.0 mM EDTA and 2% (v/v) methanol, at 22°C
0.000023
acetyl-Gly-Pro-boronic acid
-
-
6.8
acetyl-Gly-Pro-CN
0.014
FRQLTSG-pipecolinyl-NQEQV
pH 7.5, 22°C
0.00327
Gly-ProP(OPh)2
-
in 25 mM Tris, containing 140 mM NaCl and 10 mM KCl, pH 7.9
0.014
Ile-boro-Pro
0.84
Ile-Pro-CN
0.006
Leu-Pro-PO(OPh)2
-
in 25 mM Tris, containing 140 mM NaCl and 10 mM KCl, pH 7.9
0.000146
N-[2-[(2R)-2-(dihydroxyboranyl)pyrrolidin-1-yl]-2-oxoethyl]-9-N-methyl-5-oxoprolinamide
in 50 mM Tris-HCl, 100 mM NaCl, pH 7.4, at 23°C
0.0553
Phe-Arg-8-amino-3,6-dioxaoctanoyl-Gly-(R)-fluoropyrrolidide
pH 7.5, 22°C
0.0538
Phe-Arg-8-amino-3,6-dioxaoctanoyl-Gly-(S)-fluoropyrrolidide
pH 7.5, 22°C
0.015
Phe-Arg-8-amino-3,6-dioxaoctanoyl-Gly-pipecolinyl-NQEQV
pH 7.5, 22°C
0.264
Phe-Arg-8-amino-3,6-dioxaoctanoyl-Gly-piperidide
pH 7.5, 22°C
0.068
Phe-Arg-8-amino-3,6-dioxaoctanoyl-Gly-pyrrolidide
pH 7.5, 22°C
0.057
Phe-Gly-8-amino-3,6-dioxaoctanoyl-Gly-pipecolinyl-NQEQV
pH 7.5, 22°C
0.0145
Phe-Gly-8-amino-3,6-dioxaoctanoyl-Gly-pipecolinyl-NQGQV
pH 7.5, 22°C
0.703
Phe-Gly-8-amino-3,6-dioxaoctanoyl-Gly-pyrrolidide
pH 7.5, 22°C
0.0046
Pro-ProP(OPh)2
-
in 25 mM Tris, containing 140 mM NaCl and 10 mM KCl, pH 7.9
0.00216
Ser-ProP(OPh)2
-
in 25 mM Tris, containing 140 mM NaCl and 10 mM KCl, pH 7.9
0.00259
Tyr-ProP(OPh)2
-
in 25 mM Tris, containing 140 mM NaCl and 10 mM KCl, pH 7.9
0.0062
Val-boro-Pro
0.034
Val-Pro-CN
0.00363
Val-ProP(OPh)2
-
in 25 mM Tris, containing 140 mM NaCl and 10 mM KCl, pH 7.9
0.000094
[(2R)-1-(4-oxo-4-phenylbutanoyl)pyrrolidin-2-yl]boronic acid
in 50 mM Tris-HCl, 100 mM NaCl, pH 7.4, at 23°C
0.00035
[(2R)-1-(N-acetyl-L-alanyl)pyrrolidin-2-yl]boronic acid
in 50 mM Tris-HCl, 100 mM NaCl, pH 7.4, at 23°C
0.000161
[(2R)-1-(N-acetyl-N-methylglycyl)pyrrolidin-2-yl]boronic acid
in 50 mM Tris-HCl, 100 mM NaCl, pH 7.4, at 23°C
0.000023
[(2R)-1-(N-acetylglycyl)pyrrolidin-2-yl]boronic acid
in 50 mM Tris-HCl, 100 mM NaCl, pH 7.4, at 23°C
0.0000075
[(2R)-1-[(1-oxo-1,3-dihydro-2H-isoindol-2-yl)acetyl]pyrrolidin-2-yl]-9-boronic acid
in 50 mM Tris-HCl, 100 mM NaCl, pH 7.4, at 23°C
0.0029
[(2R)-1-[(2-oxopyridin-1(2H)-yl)acetyl]pyrrolidin-2-yl]-9-boronic acid
in 50 mM Tris-HCl, 100 mM NaCl, pH 7.4, at 23°C
0.000751
[(2R)-1-[N-(2,2-dimethylpropanoyl)glycyl]pyrrolidin-2-yl]-9-boronic acid
in 50 mM Tris-HCl, 100 mM NaCl, pH 7.4, at 23°C
0.000051
[(2R)-1-[N-(2-methylpropanoyl)glycyl]pyrrolidin-2-yl]-9-boronic acid
in 50 mM Tris-HCl, 100 mM NaCl, pH 7.4, at 23°C
0.000014
[(2R)-1-[N-(cyclohexylcarbonyl)glycyl]pyrrolidin-2-yl]-9-boronic acid
in 50 mM Tris-HCl, 100 mM NaCl, pH 7.4, at 23°C
0.00002
[(2R)-1-[N-(cyclopentylcarbonyl)glycyl]pyrrolidin-2-yl]-9-boronic acid
in 50 mM Tris-HCl, 100 mM NaCl, pH 7.4, at 23°C
0.000246
[(2R)-1-[N-(methylsulfonyl)glycyl]pyrrolidin-2-yl]-9-boronic acid
in 50 mM Tris-HCl, 100 mM NaCl, pH 7.4, at 23°C
0.000142
[(2R)-1-[N-(phenylcarbonyl)glycyl]pyrrolidin-2-yl]-9-boronic acid
in 50 mM Tris-HCl, 100 mM NaCl, pH 7.4, at 23°C
0.000265
[(2R)-1-[N-methyl-N-(2-methylpropanoyl)glycyl]pyrrolidin-2-yl]-9-boronic acid
in 50 mM Tris-HCl, 100 mM NaCl, pH 7.4, at 23°C
0.000191
[(2R)-1-[N-methyl-N-(phenylcarbonyl)glycyl]pyrrolidin-2-yl]-9-boronic acid
in 50 mM Tris-HCl, 100 mM NaCl, pH 7.4, at 23°C
0.000029
[(2R)-1-[N-[(2,5-dichlorophenyl)carbonyl]glycyl]-9-pyrrolidin-2-yl]boronic acid
in 50 mM Tris-HCl, 100 mM NaCl, pH 7.4, at 23°C
0.000012
[(2R)-1-[N-[(2,6-dichlorophenyl)carbonyl]glycyl]-9-pyrrolidin-2-yl]boronic acid
in 50 mM Tris-HCl, 100 mM NaCl, pH 7.4, at 23°C