3.4.21.B28: fibroblast activation protein alpha subunit

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For detailed information about fibroblast activation protein alpha subunit, go to the full flat file.

Word Map on EC 3.4.21.B28

3.4.21.B28

polyposis

adenomatous

colorectal

apc

polyneuropathy

adenoma

polyp

amyloid

amyloidotic

transthyretin

hereditary

germline

colectomy

surveillance

endoscopic

bowel

desmoids

anastomosis

abdominal

proctocolectomy

duodenal

ileal

prophylactic

pouch

extracolonic

amyloidogenic

ileostomy

val30met

rectum

gardner

colonoscopy

pouch-anal

hnpcc

sulindac

pancreaticoduodenectomy

amyloidoses

hamartomatous

periampullary

lynch

ampullary

diagnostics

mutyh

domino

polypectomy

tafamidis

fundic

adenoma-carcinoma

prealbumin

peutz-jeghers

medicine

fibromatosis

nonpolyposis

Reaction

fibroblast activation protein requires substrates with Pro at P1 and Gly or D-amino acids at P2. Met-alpha2-antiplasmin is cleaved N-terminally at Pro3-Leu4 and Pro12-Asn13 into Asn-alpha2-antiplasmin that is rapidly cross-linked to fibrin and protects it from digestion by plasmin =

Synonyms

antiplasmin-cleaving enzyme, APCE, FAP, FAP-alpha, FAP-specific protease, FAPalpha, fibroblast activation factor, fibroblast activation protein, fibroblast activation protein alpha, fibroblast activation protein protease, fibroblast activation protein-alpha, fibroblast activation protein-specific protease, gelatinase, S09.007, seprase, surface expressed protease, type II transmembrane serine protease, Z-Pro-prolinal-insensitive peptidase, ZIP

ECTree

3 Hydrolases

3.4 Acting on peptide bonds (peptidases)

3.4.21 Serine endopeptidases

3.4.21.B28 fibroblast activation protein alpha subunit

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Results	in table
1	Activating Compound
4	AA Sequence
11	Application
1	CAS Registry Number
15	Cloned(Commentary)
1	Crystallization (Commentary)
9104	Disease/ Diagnostics
1	Expression
15	General Information
40	IC50 Value
122	Inhibitors
1	kcat/KM [mM/s]
51	Ki Value [mM]
93	KM Value [mM]
23	Localization
31	Molecular Weight [Da]
34	Natural Substrates/ Products (Substrates)
193	Organism
7	pH Optimum
2	pI Value
9	Posttranslational Modification
28	Protein Variants
14	Purification (Commentary)
4	Reaction
12	Reaction Type
54	Reference
124	Source Tissue
171	Substrates and Products (Substrate)
15	Subunits
111	Synonyms
3	Temperature Optimum [°C]
80	Turnover Number [1/s]

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Cloned on EC 3.4.21.B28 - fibroblast activation protein alpha subunit

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Go to Cloned (commentary) Search

97000 Da subunit

expressed in 293 cells

Homo sapiens

680739

expressed in HEK-293 cells

2 entries

expressed in Schneider S2 cells

Homo sapiens

678329

expressed in WI38 cells

Homo sapiens

Q12884

678473

FAP is expressed in Pichia pastoris

Homo sapiens

678908

into a modified pFastBacHTb vector

Homo sapiens

674436

quantitative real-time PCR enzyme expression analysis

Homo sapiens

Q12844

731551

recombinant expression in Escherichia coli TOP10 cells and transfection of SKOV-3 and HO-8910 cells, two poorly differentiated ovarian serous adenocarcinoma cell lines, using a lentivirus expression vector, quantitative real-time PCR enzyme expression analzsis

Homo sapiens

Q12844

731043

subcloned into tetracyline-inducible vectors

Mus musculus

676253