3.4.21.B28: fibroblast activation protein alpha subunit
This is an abbreviated version!
For detailed information about fibroblast activation protein alpha subunit, go to the full flat file.
Word Map on EC 3.4.21.B28
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3.4.21.B28
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polyposis
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adenomatous
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colorectal
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apc
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polyneuropathy
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adenoma
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polyp
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amyloid
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amyloidotic
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transthyretin
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hereditary
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germline
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colectomy
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surveillance
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endoscopic
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bowel
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desmoids
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anastomosis
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abdominal
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proctocolectomy
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duodenal
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ileal
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prophylactic
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pouch
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extracolonic
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amyloidogenic
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ileostomy
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val30met
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rectum
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gardner
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colonoscopy
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pouch-anal
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hnpcc
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sulindac
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pancreaticoduodenectomy
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amyloidoses
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hamartomatous
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periampullary
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lynch
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ampullary
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diagnostics
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mutyh
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domino
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polypectomy
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tafamidis
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fundic
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adenoma-carcinoma
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prealbumin
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peutz-jeghers
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medicine
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fibromatosis
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nonpolyposis
- 3.4.21.B28
- polyposis
-
adenomatous
- colorectal
- apc
- polyneuropathy
- adenoma
- polyp
-
amyloid
-
amyloidotic
- transthyretin
- hereditary
-
germline
-
colectomy
-
surveillance
-
endoscopic
- bowel
- desmoids
-
anastomosis
- abdominal
-
proctocolectomy
- duodenal
- ileal
-
prophylactic
-
pouch
-
extracolonic
-
amyloidogenic
-
ileostomy
-
val30met
- rectum
-
gardner
-
colonoscopy
-
pouch-anal
-
hnpcc
- sulindac
-
pancreaticoduodenectomy
- amyloidoses
-
hamartomatous
-
periampullary
-
lynch
-
ampullary
- diagnostics
-
mutyh
-
domino
-
polypectomy
-
tafamidis
-
fundic
-
adenoma-carcinoma
-
prealbumin
-
peutz-jeghers
- medicine
- fibromatosis
- nonpolyposis
Reaction
fibroblast activation protein requires substrates with Pro at P1 and Gly or D-amino acids at P2. Met-alpha2-antiplasmin is cleaved N-terminally at Pro3-Leu4 and Pro12-Asn13 into Asn-alpha2-antiplasmin that is rapidly cross-linked to fibrin and protects it from digestion by plasmin =
Synonyms
antiplasmin-cleaving enzyme, APCE, FAP, FAP-alpha, FAP-specific protease, FAPalpha, fibroblast activation factor, fibroblast activation protein, fibroblast activation protein alpha, fibroblast activation protein protease, fibroblast activation protein-alpha, fibroblast activation protein-specific protease, gelatinase, S09.007, seprase, surface expressed protease, type II transmembrane serine protease, Z-Pro-prolinal-insensitive peptidase, ZIP
ECTree
3.4.21.B28 fibroblast activation protein alpha subunitAdvanced search results
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Source Tissue on EC 3.4.21.B28 - fibroblast activation protein alpha subunit
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SOURCE TISSUE 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
SOURCE
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mainly located, seprase-expressing carcinoma tissue more often found in the scirrhous type than in other types of gastric carcinoma
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expression in idiopathic pulmonary fibrosis, not expressed in normal lung tissue or tissue with evidence of centriacinar emphysema
transiently expressed in certain normal fetal mesenchymal tissues
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the enzyme is coexpressed with dipeptidyl peptidase-IV in adult humans
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the enzyme is coexpressed with dipeptidyl peptidase-IV in adult humans
the induced seprase expression of ovarian tumor cells influences their collagen contraction and invasion capability. Tumor cells with reduced seprase expression, due to manipulation by RNA interference, show a reduction of type I collagen gel contraction
expressed in both premalignant and malignant forms of squamous cell carcinoma, but are lacking in normal esophageal epithelia, suggesting that the enzyme is involved in squamous cell carcinoma neoplastic progression
additional information
FAP-alpha is significantly increased in breast cancer patients with poor outcome and survival
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colocalized with dipeptidylpeptidase IV in endothelial cells of capillaries, but not of large blood vessels, in invasive breast ductal carcinoma in vivo
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of epithelial cancer and foreskin fibroblasts grown to confluence and maintained in low-serum media for up to 10 days
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reactive stromal fibromlasts of breast, colorectal, lung and other epithelial cancers
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reactive tumor stromal fibroblast and granulation tissue during wound healing
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expressed by cancer-associated fibroblasts in the microenvironment of most solid tumors
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glioma stem-like cell, isolated from a solid glioblastoma in a long term culture, low expression
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increased enzyme expression in a subgroup of high-grade gliomas. The enzyme is expressed by several constituents of the glioblastoma microenvironment, including stromal non-malignant mesenchymal cells recruited to and/or activated in response to glioma growth
the protease fibroblast activation protein is a specific marker of activated mesenchymal cells in tumour stroma and fibrotic liver
the protease fibroblast activation protein is a specific marker of activated mesenchymal cells in tumor stroma and fibrotic liver
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the protease fibroblast activation protein is a specific marker of activated mesenchymal cells in tumour stroma and fibrotic liver. The enzyme activity is 14 to 18fold greater in cirrhotic than in non-diseased human liver, and almost doubled in alcoholic cirrhosis
the protease fibroblast activation protein is a specific marker of activated mesenchymal cells in tumour stroma and fibrotic liver
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the enzyme is expressed by several constituents of the glioblastoma microenvironment, including stromal non-malignant mesenchymal cells recruited to and/or activated in response to glioma growth
the protease fibroblast activation protein is a specific marker of activated mesenchymal cells in tumor stroma and fibrotic liver
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the protease fibroblast activation protein is a specific marker of activated mesenchymal cells in tumour stroma and fibrotic liver
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granulation tissue caused by cancerous ulcer and some goblet cells weakly positive
additional information
seprase is expressed during wound-healing, normal adult tissues as well as malignant epithelial, neural and haematopoietic cells are generally seprase-negative
additional information
quantitative real-time PCR enzyme expression analysis
additional information
the enzyme is not expressed in normal adult tissues, but is highly expressed on stromal fibroblasts in virtually all epithelial carcinomas and on tumor cells of some sarcomas
additional information
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the enzyme is not expressed in normal adult tissues, but is highly expressed on stromal fibroblasts in virtually all epithelial carcinomas and on tumor cells of some sarcomas
additional information
the enzyme is widely expressed in tumor microenvironment. No enzyme expression in wild-type SKOV-3 and HO-8910 cells, two poorly differentiated ovarian serous adenocarcinoma cell lines
additional information
the protease fibroblast activation protein is a specific marker of activated mesenchymal cells in tumour stroma and fibrotic liver
additional information
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the protease fibroblast activation protein is a specific marker of activated mesenchymal cells in tumour stroma and fibrotic liver
additional information
the protease fibroblast activation protein is a specific marker of activated mesenchymal cells in tumor stroma and fibrotic liver. Highest levels of enzyme activity occur in uterus, pancreas, submaxillary gland and skin, whereas the lowest levels ar found in brain, prostate, leukocytes and testis
additional information
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the protease fibroblast activation protein is a specific marker of activated mesenchymal cells in tumor stroma and fibrotic liver. Highest levels of enzyme activity occur in uterus, pancreas, submaxillary gland and skin, whereas the lowest levels ar found in brain, prostate, leukocytes and testis
additional information
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expression is very low in adult organs, but is upregulated by activated fibroblasts in sites of tissue remodeling, including fibrosis, atherosclerosis, arthritis and tumors
additional information
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the protease fibroblast activation protein is a specific marker of activated mesenchymal cells in tumour stroma and fibrotic liver. The enzyme activity is greatly elevated in tumours and associated lymph nodes and in fungal-infected skin of unhealthy baboons
