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3.4.21.B28: fibroblast activation protein alpha subunit

This is an abbreviated version!
For detailed information about fibroblast activation protein alpha subunit, go to the full flat file.

Word Map on EC 3.4.21.B28

Reaction

fibroblast activation protein requires substrates with Pro at P1 and Gly or D-amino acids at P2. Met-alpha2-antiplasmin is cleaved N-terminally at Pro3-Leu4 and Pro12-Asn13 into Asn-alpha2-antiplasmin that is rapidly cross-linked to fibrin and protects it from digestion by plasmin =

Synonyms

antiplasmin-cleaving enzyme, APCE, FAP, FAP-alpha, FAP-specific protease, FAPalpha, fibroblast activation factor, fibroblast activation protein, fibroblast activation protein alpha, fibroblast activation protein protease, fibroblast activation protein-alpha, fibroblast activation protein-specific protease, gelatinase, S09.007, seprase, surface expressed protease, type II transmembrane serine protease, Z-Pro-prolinal-insensitive peptidase, ZIP

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.21 Serine endopeptidases
                3.4.21.B28 fibroblast activation protein alpha subunit

Natural Substrates Products

Natural Substrates Products on EC 3.4.21.B28 - fibroblast activation protein alpha subunit

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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
alpha2-antiplasmin + H2O
?
show the reaction diagram
B-type natriuretic peptide + H2O
?
show the reaction diagram
efficiently hydrolysed and mostly preferred substrate
-
-
?
Collagen + H2O
?
show the reaction diagram
-
cleavage of type I collagen by fibroblast activation protein-? enhances class A scavenger receptor mediated macrophage adhesion
-
-
?
complement C1q tumor necrosis factor-related protein 6 + H2O
?
show the reaction diagram
-
cleavage at position 26 after a Val-Pro sequence
-
-
?
CXCL-5 + H2O
?
show the reaction diagram
-
processing of CXCL-5 at position 42, which is after an Ala-Pro sequence
-
-
?
extracellular matrix protein 1 + H2O
?
show the reaction diagram
-
cleavage occurrs at position 142 after a Lys-Pro sequence
-
-
?
extracellular matrix protein CN-I + H2O
?
show the reaction diagram
-
-
-
-
?
extracellular matrix protein CN-III + H2O
?
show the reaction diagram
-
-
-
-
?
extracellular matrix protein CN-V + H2O
?
show the reaction diagram
-
-
-
-
?
fibrillin-2 + H2O
?
show the reaction diagram
-
cleavage occurrs at position 60, in the propeptide domain, after a Gly-Pro sequence
-
-
?
Gelatin + H2O
?
show the reaction diagram
glucagon-like peptide-1 + H2O
?
show the reaction diagram
slow hydrolysis
-
-
?
glucose-dependent insulinotropic peptide + H2O
?
show the reaction diagram
slow hydrolysis
-
-
?
lysyl oxidase homolog 2 + H2O
?
show the reaction diagram
-
cleavage at position 36 after a Tyr-Pro sequence that follows the signal peptide
-
-
?
Met-alpha2-antiplasmin + H2O
?
show the reaction diagram
-
APCE and rFAP cleave both Pro3-Leu4 and Pro12-Asn13 bonds of Met-alpha2-antiplasmin, but relative kcat /Km values for Pro12-Asn13 are about 16fold higher than for Pro3-Leu4. Conversion of Met-alpha2-antiplasmin by membrane or soluble FAP to the more easily fibrin-incorporable form, Asn-alpha2-antiplasmin, may increase plasmin inhibition within fibrin surrounding certain neoplasms and have an impact on growth and therapeutic susceptibility
-
-
?
neuropeptide Y + H2O
?
show the reaction diagram
efficiently hydrolysed and mostly preferred substrate
-
-
?
peptide YY + H2O
?
show the reaction diagram
efficiently hydrolysed substrate
-
-
?
pre-digested collagen + H2O
?
show the reaction diagram
-
-
-
-
?
Substance P + H2O
?
show the reaction diagram
efficiently hydrolysed substrate
-
-
?
Type I collagen + H2O
?
show the reaction diagram
type III collagen + H2O
?
show the reaction diagram
-
-
-
-
?
type V collagen + H2O
?
show the reaction diagram
-
-
-
-
?
additional information
?
-