3.4.21.94: proprotein convertase 2
This is an abbreviated version!
For detailed information about proprotein convertase 2, go to the full flat file.
Word Map on EC 3.4.21.94
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3.4.21.94
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neuropeptides
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proopiomelanocortin
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medicine
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secretogranin
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prodynorphin
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peptidomic
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convertase-1
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molecular biology
- 3.4.21.94
-
neuropeptides
-
proopiomelanocortin
- medicine
-
secretogranin
-
prodynorphin
-
peptidomic
-
convertase-1
- molecular biology
Reaction
release of protein hormones and neuropeptides from their precursors, generally by hydrolysis of -Lys-Arg-/- bonds =
Synonyms
EGL-3/KPC2, More, Neuroendocrine convertase 2, PC2, PC2-like enzyme, PCSK2, pro-protein convertase-2, pro-protein convertase-2/carboxypeptidase-E, prohormone convertase, prohormone convertase 2, prohormone convertase-2, proneuropeptide convertase 2, proprotein convertase 2, proprotein convertase subtilisin/kexin-type 2
ECTree
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Reference on EC 3.4.21.94 - proprotein convertase 2
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Steiner, D.F.; Smeekens, S.P.; Ohagi, S.; Chan, S.J.
The new enzymology of precursor processing endoproteases
J. Biol. Chem.
267
23435-23438
1992
Homo sapiens
Seidah, N.G.; Chretien, M.
Pro-protein convertases of subtilisin/kexin family
Methods Enzymol.
244
175-188
1994
Homo sapiens
Rouille, Y.; Westermark, G.; Martin, S.K.; Steiner, D.F.
Proglucagon is processed to glucagon by prohormone convertase PC2 in alpha TC1-6 cells
Proc. Natl. Acad. Sci. USA
91
3242-3246
1994
Mammalia
Smeekens, S.P.; Steiner, D.F.
Identification of a human insulinoma cDNA encoding a novel mammalian protein structurally related to the yeast dibasic processing protease Kex2
J. Biol. Chem.
265
2997-3000
1990
Homo sapiens
Cornwall, G.A.; Cameron, A.; Lindberg, I.; Hardy, D.M.; Cormier, N.; Hsia, N.
The cystatin-related epididymal spermatogenic protein inhibits the serine protease prohormone convertase 2
Endocrinology
144
901-908
2003
Mus musculus
Johanning, K.; Juliano, M.A.; Juliano, L.; Lazure, C.; Lamango, N.S.; Steiner, D.F.; Lindberg, I.
Specificity of prohormone convertase 2 on proenkephalin and proenkephalin-related substrates
J. Biol. Chem.
273
22672-22680
1998
Mus musculus
Day, R.; Lazure, C.; Basak, A.; Boudreault, A.; Limperis, P.; Dong, W.; Lindberg, I.
Prodynorphin processing by proprotein convertase 2. Cleavage at single basic residues and enhanced processing in the presence of carboxypeptidase activity
J. Biol. Chem.
273
829-836
1998
Mus musculus, Rattus norvegicus
Apletalina, E.V.; Muller, L.; Lindberg, I.
Mutations in the catalytic domain of prohormone convertase 2 result in decreased binding to 7B2 and loss of inhibition with 7B2 C-terminal peptide
J. Biol. Chem.
275
14667-14677
2000
Mus musculus
Li, Q.L.; Naqvi, S.; Shen, X.; Liu, Y.J.; Lindberg, I.; Friedman, T.C.
Prohormone convertase 2 enzymatic activity and its regulation in neuro-endocrine cells and tissues
Regul. Pept.
110
197-205
2003
Homo sapiens, Mus musculus, Rattus norvegicus
Tzimas, G.N.; Chevet, E.; Jenna, S.; Nguyen, D.T.; Khatib, A.M.; Marcus, V.; Zhang, Y.; Chretien, M.; Seidah, N.; Metrakos, P.
Abnormal expression and processing of the proprotein convertases PC1 and PC2 in human colorectal liver metastases
BMC Cancer
5
149
2005
Homo sapiens
Marzban, L.; Trigo-Gonzalez, G.; Zhu, X.; Rhodes, C.J.; Halban, P.A.; Steiner, D.F.; Verchere, C.B.
Role of beta-cell prohormone convertase (PC)1/3 in processing of pro-islet amyloid polypeptide
Diabetes
53
141-148
2004
Mus musculus
Dey, A.; Lipkind, G.M.; Rouille, Y.; Norrbom, C.; Stein, J.; Zhang, C.; Carroll, R.; Steiner, D.F.
Significance of prohormone convertase 2, PC2, mediated initial cleavage at the proglucagon interdomain site, Lys70-Arg71, to generate glucagon
Endocrinology
146
713-727
2005
Mus musculus
Ogiwara, K.; Shinohara, M.; Takahashi, T.
Expression of proprotein convertase 2 mRNA in the ovarian follicles of the medaka, Oryzias latipes
Gene
337
79-89
2004
Oryzias latipes
Kacprzak, M.M.; Than, M.E.; Juliano, L.; Juliano, M.A.; Bode, W.; Lindberg, I.
Mutations of the PC2 substrate binding pocket alter enzyme specificity
J. Biol. Chem.
280
31850-31858
2005
Mus musculus
Ugleholdt, R.; Poulsen, M.L.; Holst, P.J.; Irminger, J.C.; Orskov, C.; Pedersen, J.; Rosenkilde, M.M.; Zhu, X.; Steiner, D.F.; Holst, J.J.
Prohormone convertase 1/3 is essential for processing of the glucose-dependent insulinotropic polypeptide precursor
J. Biol. Chem.
281
11050-11057
2006
Mus musculus
Sanchez, V.C.; Goldstein, J.; Stuart, R.C.; Hovanesian, V.; Huo, L.; Munzberg, H.; Friedman, T.C.; Bjorbaek, C.; Nillni, E.A.
Regulation of hypothalamic prohormone convertases 1 and 2 and effects on processing of prothyrotropin-releasing hormone
J. Clin. Invest.
114
357-369
2004
Rattus norvegicus
Henrich, S.; Lindberg, I.; Bode, W.; Than, M.E.
Proprotein convertase models based on the crystal structures of furin and kexin: explanation of their specificity
J. Mol. Biol.
345
211-227
2004
Homo sapiens
Tagen, M.B.; Beinfeld, M.C.
Recombinant prohormone convertase 1 and 2 cleave purified pro cholecystokinin (CCK) and a synthetic peptide containing CCK 8 Gly Arg Arg and the carboxyl-terminal flanking peptide
Peptides
26
2530-2535
2005
Mus musculus
Lee, S.N.; Kacprzak, M.M.; Day, R.; Lindberg, I.
Processing and trafficking of a prohormone convertase 2 active site mutant
Biochem. Biophys. Res. Commun.
355
825-829
2007
Mus musculus
Portela-Gomes, G.M.; Grimelius, L.; Stridsberg, M.
Prohormone convertases 1/3, 2, furin and protein 7B2 (Secretogranin V) in endocrine cells of the human pancreas
Regul. Pept.
146
117-124
2008
Homo sapiens
Billova, S.; Galanopoulou, A.S.; Seidah, N.G.; Qiu, X.; Kumar, U.
Immunohistochemical expression and colocalization of somatostatin, carboxypeptidase-E and prohormone convertases 1 and 2 in rat brain
Neuroscience
147
403-418
2007
Rattus norvegicus
Marzban, L.; Rhodes, C.J.; Steiner, D.F.; Haataja, L.; Halban, P.A.; Verchere, C.B.
Impaired NH2-terminal processing of human proislet amyloid polypeptide by the prohormone convertase PC2 leads to amyloid formation and cell death
Diabetes
55
2192-2201
2006
Mus musculus
Wideman, R.D.; Covey, S.D.; Webb, G.C.; Drucker, D.J.; Kieffer, T.J.
A switch from prohormone convertase (PC)-2 to PC1/3 expression in transplanted alpha-cells is accompanied by differential processing of proglucagon and improved glucose homeostasis in mice
Diabetes
56
2744-2752
2007
Mus musculus
Kitabgi, P.
Prohormone convertases differentially process pro-neurotensin/neuromedin N in tissues and cell lines
J. Mol. Med.
84
628-634
2006
Homo sapiens, Mus musculus, Rattus norvegicus
Pan, H.; Che, F.Y.; Peng, B.; Steiner, D.F.; Pintar, J.E.; Fricker, L.D.
The role of prohormone convertase-2 in hypothalamic neuropeptide processing: a quantitative neuropeptidomic study
J. Neurochem.
98
1763-1777
2006
Mus musculus
Husson, S.J.; Clynen, E.; Baggerman, G.; Janssen, T.; Schoofs, L.
Defective processing of neuropeptide precursors in Caenorhabditis elegans lacking proprotein convertase 2 (KPC-2/EGL-3): mutant analysis by mass spectrometry
J. Neurochem.
98
1999-2012
2006
Caenorhabditis elegans, Caenorhabditis elegans N2
Leak, T.S.; Keene, K.L.; Langefeld, C.D.; Gallagher, C.J.; Mychaleckyj, J.C.; Freedman, B.I.; Bowden, D.W.; Rich, S.S.; Sale, M.M.
Association of the proprotein convertase subtilisin/kexin-type 2 (PCSK2) gene with type 2 diabetes in an African American population
Mol. Genet. Metab.
92
145-150
2007
Homo sapiens
Croissandeau, G.; Wahnon, F.; Yashpal, K.; Seidah, N.G.; Coderre, T.J.; Chretien, M.; Mbikay, M.
Increased stress-induced analgesia in mice lacking the proneuropeptide convertase PC2
Neurosci. Lett.
406
71-75
2006
Mus musculus
Marandi, M.; Mowla, S.J.; Tavallaei, M.; Yaghoobi, M.M.; Jafarnejad, S.M.
Proprotein convertases 1 and 2 (PC1 and PC2) are expressed in neurally differentiated rat bone marrow stromal stem cells (BMSCs)
Neurosci. Lett.
420
198-203
2007
Rattus norvegicus
Kowalska, D.; Liu, J.; Appel, J.R.; Ozawa, A.; Nefzi, A.; Mackin, R.B.; Houghten, R.A.; Lindberg, I.
Synthetic small-molecule prohormone convertase 2 inhibitors
Mol. Pharmacol.
75
617-625
2009
Mus musculus
Espinosa, V.P.; Liu, Y.; Ferrini, M.; Anghel, A.; Nie, Y.; Tripathi, P.V.; Porche, R.; Jansen, E.; Stuart, R.C.; Nillni, E.A.; Lutfy, K.; Friedman, T.C.
Differential regulation of prohormone convertase 1/3, prohormone convertase 2 and phosphorylated cyclic-AMP-response element binding protein by short-term and long-term morphine treatment: implications for understanding the "switch" to opiate addiction
Neuroscience
156
788-799
2008
Rattus norvegicus
Cummins, S.F.; York, P.S.; Hanna, P.H.; Degnan, B.M.; Croll, R.P.
Expression of prohormone convertase 2 and the generation of neuropeptides in the developing nervous system of the gastropod Haliotis
Int. J. Dev. Biol.
53
1081-1088
2009
Haliotis asinina (B2ZSS9), Haliotis asinina
Zhan, S.; Zhao, H.; J White, A.; Minami, M.; Pignataro, G.; Yang, T.; Zhu, X.; Lan, J.; Xiong, Z.; Steiner, D.F.; Simon, R.P.; Zhou, A.
Defective neuropeptide processing and ischemic brain injury: a study on proprotein convertase 2 and its substrate neuropeptide in ischemic brains
J. Cereb. Blood Flow Metab.
29
698-706
2009
Rattus norvegicus
Zhang, X.; Pan, H.; Peng, B.; Steiner, D.F.; Pintar, J.E.; Fricker, L.D.
Neuropeptidomic analysis establishes a major role for prohormone convertase-2 in neuropeptide biosynthesis
J. Neurochem.
112
1168-1179
2010
Mus musculus
Tang, S.S.; Zhang, J.H.; Liu, H.X.; Zhou, D.; Qi, R.
Pro-protein convertase-2/carboxypeptidase-E mediated neuropeptide processing of RGC-5 cell after in vitro ischemia
Neurosci. Bull.
25
7-14
2009
Rattus norvegicus
Helwig, M.; Lee, S.N.; Hwang, J.R.; Ozawa, A.; Medrano, J.F.; Lindberg, I.
Dynamic modulation of PC2-mediated precursor processing by 7B2: preferential effect on glucagon synthesis
J. Biol. Chem.
286
42504-42513
2011
Mus musculus
Iino, K.; Oki, Y.; Yamashita, M.; Matsushita, F.; Hayashi, C.; Yogo, K.; Nishizawa, S.; Yamada, S.; Maekawa, M.; Sasano, H.; Nakamura, H.
Possible relevance between prohormone convertase 2 expression and tumor growth in human adrenocorticotropin-producing pituitary adenoma
J. Clin. Endocrinol. Metab.
95
4003-4011
2010
Homo sapiens
Hiramoto, K.; Yamate, Y.; Kobayashi, H.; Ishii, M.; Sato, E.F.; Inoue, M.
Ultraviolet B irradiation of the mouse eye induces pigmentation of the skin more strongly than does stress loading, by increasing the levels of prohormone convertase 2 and alpha-melanocyte-stimulating hormone
Clin. Exp. Dermatol.
38
71-76
2013
Mus musculus (P21661)
Chen, Y.; Cao, W.; Zhou, S.; Shen, L.; Wen, J.
Mutant PAX6 downregulates prohormone convertase 2 expression in mouse islets
Exp. Biol. Med. (Maywood)
238
1259-1264
2013
Mus musculus
Tangprasittipap, A.; Chouwdee, S.; Phiwsaiya, K.; Laiphrom, S.; Senapin, S.; Flegel, T.W.; Sritunyalucksana, K.
Structure and expression of a shrimp prohormone convertase 2
Gen. Comp. Endocrinol.
178
185-193
2012
Penaeus monodon (I6M2I5)
Zhan, S.; Zhou, A.; Piper, C.; Yang, T.
Dynamic changes in proprotein convertase 2 activity in cortical neurons after ischemia/reperfusion and oxygen-glucose deprivation
Neural Regen. Res.
8
83-89
2013
Rattus norvegicus (P28841)
Nakamoto, K.; Aizawa, F.; Nishinaka, T.; Tokuyama, S.
Regulation of prohormone convertase 2 protein expression via GPR40/FFA1 in the hypothalamus
Eur. J. Pharmacol.
762
459-463
2015
Mus musculus (P21661)
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