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Literature summary for 3.4.21.94 extracted from
- Prohormone convertases differentially process pro-neurotensin/neuromedin N in tissues and cell lines (2006), J. Mol. Med., 84, 628-634.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| stable transfection of PC2 in PC12 cells | Rattus norvegicus |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | PC2-/- mice, brain levels of neuromedin N are reduced by more than 50% with a compensatory increase in the levels of large neuromedin N. Processing at site 2 is impaired. 20% reduction in neurotensin levels | Mus musculus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| additional information | stable expression of antisense PC2 mRNA in rMTC 6-23 cells results in a drastic decrease in PC2 protein synthesis by more than 90%, accompanied by a marked reduction in pro-neurotensin/neuromedin N cleavage by more than 80% at sites 2, 3, and 4 | Rattus norvegicus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Mus musculus | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | PC2 is the most abundant PC in the brain | Mus musculus | - |
| brain | PC2 is the most abundant PC in the brain | Homo sapiens | - |
| brain | PC2 is the most abundant PC in the brain | Rattus norvegicus | - |
| additional information | coloDM320 cell line lacks PC2 expression | Homo sapiens | - |
| additional information | present in rMTC 6-23 cells. PC12 cells lack PC2 expression | Rattus norvegicus | - |
| neuroendocrine cell | - |
Mus musculus | - |
| neuroendocrine cell | - |
Homo sapiens | - |
| neuroendocrine cell | - |
Rattus norvegicus | - |
| neuron | - |
Mus musculus | - |
| neuron | - |
Homo sapiens | - |
| neuron | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| pro-neurotensin/neuromedin N + H2O | - |
Mus musculus | neurotensin + neuromedin N | - |
? |  |
| pro-neurotensin/neuromedin N + H2O | - |
Homo sapiens | neurotensin + neuromedin N | - |
? | |
| pro-neurotensin/neuromedin N + H2O | - |
Rattus norvegicus | neurotensin + neuromedin N | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| PC2 | - |
Mus musculus |
| PC2 | - |
Homo sapiens |
| PC2 | - |
Rattus norvegicus |
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