3.4.21.94: proprotein convertase 2
This is an abbreviated version!
For detailed information about proprotein convertase 2, go to the full flat file.
Word Map on EC 3.4.21.94
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3.4.21.94
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neuropeptides
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proopiomelanocortin
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medicine
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secretogranin
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prodynorphin
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peptidomic
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convertase-1
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molecular biology
- 3.4.21.94
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neuropeptides
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proopiomelanocortin
- medicine
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secretogranin
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prodynorphin
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peptidomic
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convertase-1
- molecular biology
Reaction
release of protein hormones and neuropeptides from their precursors, generally by hydrolysis of -Lys-Arg-/- bonds =
Synonyms
EGL-3/KPC2, More, Neuroendocrine convertase 2, PC2, PC2-like enzyme, PCSK2, pro-protein convertase-2, pro-protein convertase-2/carboxypeptidase-E, prohormone convertase, prohormone convertase 2, prohormone convertase-2, proneuropeptide convertase 2, proprotein convertase 2, proprotein convertase subtilisin/kexin-type 2
ECTree
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Subunits
Subunits on EC 3.4.21.94 - proprotein convertase 2
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additional information
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x * 75000, proPC2, Western blot analysis. x * 68000, mature PC2, Western blot analysis
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x * 75000, pro-PC2 form, SDS-PAGE, x * 64000, mature PC2 form, SDS-PAGE
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amino acid sequence alignment of soluble ectodomain and active site cleft, domain structures, enzyme structure modeling based on the crystal structures of furin and kexin, overview
additional information
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the preproenzyme consists of a signal peptide, a propeptide for autocatalytic activation, a Kex2-like catalytic domain, and a P-domain