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3.4.21.94: proprotein convertase 2

This is an abbreviated version!
For detailed information about proprotein convertase 2, go to the full flat file.

Word Map on EC 3.4.21.94

Reaction

release of protein hormones and neuropeptides from their precursors, generally by hydrolysis of -Lys-Arg-/- bonds =

Synonyms

EGL-3/KPC2, More, Neuroendocrine convertase 2, PC2, PC2-like enzyme, PCSK2, pro-protein convertase-2, pro-protein convertase-2/carboxypeptidase-E, prohormone convertase, prohormone convertase 2, prohormone convertase-2, proneuropeptide convertase 2, proprotein convertase 2, proprotein convertase subtilisin/kexin-type 2

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.21 Serine endopeptidases
                3.4.21.94 proprotein convertase 2

Cloned

Cloned on EC 3.4.21.94 - proprotein convertase 2

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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
cDNA construction of PC2 mutants, expressed in CHO/21-kDA 7B2 cells
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co-expression of PC2 and rat pro-islet amyloid polypeptide, proIAPP, in GH3 cells lacking the enzyme, does not lead to complete cleavage of recombinant proIAPP, but to cleavage of the C-terminal site of proIAPP
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DNA and amino acid sequence determination and analysis, the ovarian mRNA is shorter than the mRNA from brain and kidney lacking about 300 bp just before the poly(A)+ tail
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expression of PC2 in human 293T cells, leptin has a stimulatory effect on the PC2 promoter, which is enhanced by co-expression of STAT3, overview
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expression of wild-type and mutant PC2 in CHO-K1 cells
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gene PC2, DNA and amino acid sequence determination and analysis, phylogenetic analysis
gene PC2, genotyping of wild-type and haplotype and holotype PC2-deficient mice
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GH3 cells or INS-1 beta-cells cotransduced with proIAPP and PC2 by adenoviral expression
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overexpressed in Chinese hamster ovary cells supertransfected with rat cDNA
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overexpressed in Chinese hamster ovary cells supertransfected with rat cDNA 7B2
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pcDNA3 plasmid encoding either PC2 wild-type or mutant S383A expressed in CHO-K1/7B2 cells or AtT-20/7B2 cells
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recombinant PC2 is expressed in stably transfected CHO cells
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stable transfection of PC2 in PC12 cells
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transient enzyme expression in enzyme-deficient rat GH4C1 cells, co-expression with wild-type and mutant proglucagon, glicentin, and/or glicentin-related polypeptide-glucagon, and oxyntomodulin from hamster, overview
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transplantation of encapsulated PC2-expressing alpha TC-1 cells with PC1/3-expressing alpha TCdeltaPC2 cells in normal mice and low-dose streptozotocin-treated mice
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