3.4.21.94: proprotein convertase 2

This is an abbreviated version!
For detailed information about proprotein convertase 2, go to the full flat file.

Word Map on EC 3.4.21.94

3.4.21.94

neuropeptides

proopiomelanocortin

medicine

secretogranin

prodynorphin

peptidomic

convertase-1

molecular biology

Reaction

release of protein hormones and neuropeptides from their precursors, generally by hydrolysis of -Lys-Arg-/- bonds =

Synonyms

EGL-3/KPC2, More, Neuroendocrine convertase 2, PC2, PC2-like enzyme, PCSK2, pro-protein convertase-2, pro-protein convertase-2/carboxypeptidase-E, prohormone convertase, prohormone convertase 2, prohormone convertase-2, proneuropeptide convertase 2, proprotein convertase 2, proprotein convertase subtilisin/kexin-type 2

ECTree

3 Hydrolases

3.4 Acting on peptide bonds (peptidases)

3.4.21 Serine endopeptidases

3.4.21.94 proprotein convertase 2

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Results	in table
3	Activating Compound
31	AA Sequence
7	Application
3	CAS Registry Number
18	Cloned(Commentary)
96	Disease/ Diagnostics
5	Expression
8	General Information
16	Inhibitors
9	Ki Value [mM]
13	KM Value [mM]
2	Localization
3	Metals/Ions
7	Molecular Weight [Da]
11	Natural Substrates/ Products (Substrates)
62	Organism
7	pH Optimum
3	pH Range
1	pI Value
2	Posttranslational Modification
18	Protein Variants
5	Purification (Commentary)
3	Reaction
1	Reaction Type
49	Reference
61	Source Tissue
1	Specific Activity [micromol/min/mg]
64	Substrates and Products (Substrate)
5	Subunits
64	Synonyms
3	Temperature Optimum [°C]
1	Temperature Stability [°C]
8	Turnover Number [1/s]

Natural Substrates Products

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Natural Substrates Products on EC 3.4.21.94 - proprotein convertase 2

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pro-cholecystokinin + H2O

N-terminal propeptide + C-terminal cholecystokinin 8 Gly Arg Arg peptide + remaining CCK peptide

Mus musculus

the substrate is only cleaved in vivo since defolding proteins are required, in vitro the cleavage site is inaccessible for the enzyme

670480

peptide product analysis

pro-islet amyloid polypeptide + H2O

islet amyloid polypeptide processing intermediate + N-terminal pro-peptide

Mus musculus

precursor of IAPP or amylin, the major component of islet amyloid, cleavage at the N-terminus, but not the C-terminus, which would also be required for activation, the complete activation is catalyzed by PC1, EC 3.4.21.93

668377

proenkephalin + H2O

opioid-active enkephalin + ?

2 entries

Proglucagon + H2O

2 entries

prothyrotropin-releasing hormone + H2O

thyrotropin-releasing hormone + pro-peptide of thyrotropin-releasing hormone

Rattus norvegicus

processing and activation of the inactive prohormone is required for regulation of energy balance via leptin, enzyme regulation, overview

669626

additional information

4 entries