3.4.21.94: proprotein convertase 2
This is an abbreviated version!
For detailed information about proprotein convertase 2, go to the full flat file.
Word Map on EC 3.4.21.94
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3.4.21.94
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neuropeptides
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proopiomelanocortin
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medicine
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secretogranin
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prodynorphin
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peptidomic
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convertase-1
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molecular biology
- 3.4.21.94
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neuropeptides
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proopiomelanocortin
- medicine
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secretogranin
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prodynorphin
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peptidomic
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convertase-1
- molecular biology
Reaction
release of protein hormones and neuropeptides from their precursors, generally by hydrolysis of -Lys-Arg-/- bonds =
Synonyms
EGL-3/KPC2, More, Neuroendocrine convertase 2, PC2, PC2-like enzyme, PCSK2, pro-protein convertase-2, pro-protein convertase-2/carboxypeptidase-E, prohormone convertase, prohormone convertase 2, prohormone convertase-2, proneuropeptide convertase 2, proprotein convertase 2, proprotein convertase subtilisin/kexin-type 2
ECTree
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APPLICATION 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
medicine
molecular biology
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the regulation of the prohormone processing system by morphine may lead to alterations in the levels of multiple bioactive hormones and may be a compensatory mechanism whereby the organism tries to restore its homeostatic hormonal milieu. The down-regulation of PC1/3, PC2 and P-CREB by short-term morphine and up-regulation by long-term morphine treatment may be a signal mediating the switch from drug use to drug abuse
additional information
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PC2 may be a potential target for the maturation of somatostatin
medicine
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defects in processing, sorting, and/or secretion of (pro)IAPP associated with beta-cell dysfunction in type 2 diabetes and insulinomas may result in production and secretion of elevated levels of proIAPP and its NH(2)-terminally unprocessed form, leading to intracellular and/or fibril formation and beta-cell apoptosis. Restoration of intact IAPP processing may be a potential therapeutic approach to prevent or slow (pro)IAPP-induced beta-cell apoptosis and maintain beta-cell mass in type 2 diabetes
medicine
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PCSK2 is a strong functional candidate for type 2 diabetes. Association with type 2 diabetes among four single nucleotide polymorphisms in an African American population. None of the single nucleotide polymorphisms are associated with age at type 2 diabetes diagnosis. A variant in the PCKS2 gene (rs2021785) appears to play a role in susceptibility to type 2 diabetes-end stage renal disease in this African American population
medicine
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transplantation of PC2-expressing alpha-cells increases plasma glucagon levels and causes mild fasting hyperglycemia, impairs glucose tolerance, and alpha-cell hypoplasia. PC2-expressing alpha-cells neither prevent streptozotocin-induced hyperglycemia nor increased beta-cell proliferation in the context of type 1 diabetes
medicine
in a rat model of transient focal cerebral ischemia by performing 100 min of middle cerebral artery occlusion, proprotein convertase 2 activity gradually decreases in the ischemic cortex with increasing duration of reperfusion. In an in vitro model of experimental oxygen-glucose deprivation using cultured rat cortical neuron, the number of terminal deoxynucleotidyl transferase-mediated 2'-deoxyuridine 5'-triphosphate-biotin nick end labeling-positive neurons significantly increases and proprotein convertase 2 activity also decreases gradually with increasing duration of oxygen-glucose deprivation
medicine
UVB irradiation to the eye and stress loading increase the expression of prohormone convertase 1/3 and prohormone convertase 2 in the pituitary gland. The increase in expression of pituitary prohormone convertase 2 is greater in animals subjected to UVB eye irradiation than to stress, whereas no difference is seen between the two groups for the increase in PC1/3
