3.4.21.78: granzyme A
This is an abbreviated version!
For detailed information about granzyme A, go to the full flat file.
Word Map on EC 3.4.21.78
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3.4.21.78
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thrombospondin-1
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angiogenesis
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endothelial
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perforin
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killer
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granule
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angiogenic
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antiangiogenic
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cytolytic
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matricellular
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metastasis
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collagen
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microvessels
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t-cells
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microvascular
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integrins
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fibrosis
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fibronectin
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cd8
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tgf-beta1
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neovascularization
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fasl
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fgf-2
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corneal
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alphavbeta3
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exocytosis
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ctl-mediated
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factor-beta
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bfgf
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medicine
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caspase-independent
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angiogenesis-related
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granule-associated
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integrin-associated
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angiostatic
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proangiogenic
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metronomic
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properdin
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endostatin
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granulysin
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tregs
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lymphocyte-mediated
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lymphokine-activated
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ifn-gamma
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vegf-a
- 3.4.21.78
- thrombospondin-1
- angiogenesis
- endothelial
- perforin
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killer
- granule
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angiogenic
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antiangiogenic
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cytolytic
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matricellular
- metastasis
- collagen
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microvessels
- t-cells
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microvascular
- integrins
- fibrosis
- fibronectin
- cd8
- tgf-beta1
- neovascularization
- fasl
- fgf-2
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corneal
- alphavbeta3
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exocytosis
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ctl-mediated
- factor-beta
- bfgf
- medicine
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caspase-independent
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angiogenesis-related
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granule-associated
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integrin-associated
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angiostatic
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proangiogenic
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metronomic
- properdin
- endostatin
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granulysin
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tregs
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lymphocyte-mediated
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lymphokine-activated
- ifn-gamma
- vegf-a
Reaction
Hydrolysis of proteins, including fibronectin, type IV collagen and nucleolin. Preferential cleavage: -Arg-/-, -Lys-/- >> -Phe-/- in small molecule substrates =
Synonyms
Autocrine thymic lymphoma granzyme-like serine protease, CTL tryptase, CTLA3, Cytotoxic T lymphocyte serine protease, GrA, Gzm A, Gzma, GzmA/K, H factor, Hanukkah factor, HuTPS, T-cell associated protease 1, T-cell derived serine proteinase 1, TSP-1
ECTree
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medicine
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diagnosis tool, patients with various viral diseases or with rheumatic arthritis have elevated levels of circulating granzyme A
medicine
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cytolytic T-lymphocytes from enzyme or granzyme B deficient mice similarly induce early proapoptotic features such as phosphatidyl serine exposure on plasma membrane, or reactive oxygen radical generation, though with distinct kinetics. Cytolytic T-lymphocytes from granzyme A, but not granzyme B deficient animals activate caspase 3 and 9. All granzyme-induced apoptotic features depend critically on perforin
medicine
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granzyme A is located in intracellular granules of rectal CD8+ T cells in healthy and HIV-1-positive individuals, while similar amounts of perforin RNA are detected in both groups, but perforin protein is absent in rectal tissue of HIV-1-positive individuals
medicine
investigation of glucocorticoid-induced expression of granzyme A as a potential early biomarker for personalized therapy of acute lymphoblastic leukemia patients
medicine
involvement of granzyme A in development of chronic obstructive pulmonary disease (COPD) shown, increased expression of granzyme A in type II pneumocytes indicated
medicine
involvement of granzyme A in development of chronic obstructive pulmonary disease shown
medicine
involvement of granzyme A in development of chronic obstructive pulmonary disease shown, increased expression of granzyme A in type II pneumocytes
medicine
studies on the role of granzyme A in polymorphonuclear neutrophils (PMNs) in defence against invading pathogens
medicine
studies on the role of granzyme A-mediated cell death in the pathogenesis of familial chilblain lupus
medicine
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both GzmA and GzmB levels are significantly increased in serum of patients with patients with amyotrophic lateral sclerosis
medicine
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construction of a chimeric protein IGA, consisting of interleukin IL-2 and granzyme A, using IL-2 as a targeting moiety and granzyme A as a killing moiety to overcome multidrug resistance MDR in anticancer therapy. The IGA chimeric protein enters the target sensitive and MDR cancer cells overexpressing IL-2 receptor and induces caspase 3-independent cell death. After its entry, IGA causes a decrease in the mitochondrial potential, and triggers translocation of nm23-H1, a granzyme A-dependent DNase, from the cytoplasm to the nucleus, where it causes single-strand DNA nicks, thus causing cell death. IGA is able to overcome MDR and kill cells resistant to chemotherapeutic drugs
medicine
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proinflammatory gzmA and anti-inflammatory gzmB are novel modulators of the Th1/2 balance and defense in helminth infection
medicine
the protease may be a therapeutic target for the prevention of bacterial sepsis without affecting immune control of the pathogen
medicine
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the protease may be a therapeutic target for the prevention of bacterial sepsis without affecting immune control of the pathogen
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