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3.4.21.78: granzyme A

This is an abbreviated version!
For detailed information about granzyme A, go to the full flat file.

Word Map on EC 3.4.21.78

Reaction

Hydrolysis of proteins, including fibronectin, type IV collagen and nucleolin. Preferential cleavage: -Arg-/-, -Lys-/- >> -Phe-/- in small molecule substrates =

Synonyms

Autocrine thymic lymphoma granzyme-like serine protease, CTL tryptase, CTLA3, Cytotoxic T lymphocyte serine protease, GrA, Gzm A, Gzma, GzmA/K, H factor, Hanukkah factor, HuTPS, T-cell associated protease 1, T-cell derived serine proteinase 1, TSP-1

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.21 Serine endopeptidases
                3.4.21.78 granzyme A

Turnover Number

Turnover Number on EC 3.4.21.78 - granzyme A

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TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
8.8 - 83
benzyloxycarbonyl-Arg thiobenzyl ester
5.83 - 59
benzyloxycarbonyl-Gly-Arg thiobenzyl ester
21
benzyloxycarbonyl-Lys thiobenzyl ester
-
mouse enzyme
3.1
Benzyloxycarbonyl-Lys-thiobenzyl ester
-
human granzyme A
4980
Boc-Ala-Ala-Arg-SBzl
-
pH 7.5, 30°C
3960
Boc-Trp-Arg-SBzl
-
pH 7.5, 30°C
45
tert-butyloxycarbonyl-Ala-Ala-Arg thiobenzyl ester
-
mouse enzyme
30360 - 30400
Z-Arg-SBzl
22100 - 22140
Z-Lys-SBzl
additional information
additional information
-