3.4.21.78: granzyme A
This is an abbreviated version!
For detailed information about granzyme A, go to the full flat file.
Word Map on EC 3.4.21.78
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3.4.21.78
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thrombospondin-1
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angiogenesis
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endothelial
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perforin
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killer
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granule
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angiogenic
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antiangiogenic
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cytolytic
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matricellular
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metastasis
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collagen
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microvessels
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t-cells
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microvascular
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integrins
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fibrosis
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fibronectin
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cd8
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tgf-beta1
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neovascularization
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fasl
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fgf-2
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corneal
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alphavbeta3
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exocytosis
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ctl-mediated
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factor-beta
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bfgf
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medicine
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caspase-independent
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angiogenesis-related
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granule-associated
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integrin-associated
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angiostatic
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proangiogenic
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metronomic
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properdin
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endostatin
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granulysin
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tregs
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lymphocyte-mediated
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lymphokine-activated
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ifn-gamma
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vegf-a
- 3.4.21.78
- thrombospondin-1
- angiogenesis
- endothelial
- perforin
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killer
- granule
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angiogenic
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antiangiogenic
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cytolytic
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matricellular
- metastasis
- collagen
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microvessels
- t-cells
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microvascular
- integrins
- fibrosis
- fibronectin
- cd8
- tgf-beta1
- neovascularization
- fasl
- fgf-2
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corneal
- alphavbeta3
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exocytosis
-
ctl-mediated
- factor-beta
- bfgf
- medicine
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caspase-independent
-
angiogenesis-related
-
granule-associated
-
integrin-associated
-
angiostatic
-
proangiogenic
-
metronomic
- properdin
- endostatin
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granulysin
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tregs
-
lymphocyte-mediated
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lymphokine-activated
- ifn-gamma
- vegf-a
Reaction
Hydrolysis of proteins, including fibronectin, type IV collagen and nucleolin. Preferential cleavage: -Arg-/-, -Lys-/- >> -Phe-/- in small molecule substrates =
Synonyms
Autocrine thymic lymphoma granzyme-like serine protease, CTL tryptase, CTLA3, Cytotoxic T lymphocyte serine protease, GrA, Gzm A, Gzma, GzmA/K, H factor, Hanukkah factor, HuTPS, T-cell associated protease 1, T-cell derived serine proteinase 1, TSP-1
ECTree
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Inhibitors
Inhibitors on EC 3.4.21.78 - granzyme A
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Bio-x-IGN(AmPhg)P-(Oph)2
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specific and irreversible inhibition both in vitro and in cells
rotenone
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the complex I inhibitor hinders GzmA-mediated reactive oxygen species production and cell death
Serpinb6b
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potent inhibitor, Serpinb6b employs an exosite to specifically inhibit dimeric but not monomeric murine enzyme. Kinetic analysis and modeling of the mGzmA-Serpinb6b Michaelis complex, overview
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valinomycin
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pretreatment of K562 cells with 16 nmol valinomycin inhibits GzmA and perforin-induced reactive oxygen species generation
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mechanism-based isocoumarin inhibitors substituted with basic guanidino or isothiureidopropoxy groups
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Isocoumarins
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mechanism-based isocoumarin inhibitors substituted with basic guanidino or isothiureidopropoxy groups
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additional information
inhibited by the extracellular serpins anti-thrombin III and C1-inhibitor and by the non-serpin inhibitor alpha2-macroglobulin
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additional information
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GzmA-mediated reactive oxygen species production and cell death are impaired in pseudo rho0 cells depleted of mitochondrial DNA. Expression of the K56A-NDUFS3 cleavage site mutant in 293T and K562 cells inhibits GzmA-mediated reactive oxygen species production and cell death
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additional information
substrate specificity-based screening for potential inhibitors from the intracellular serpin family, no enzyme inhibition by Serpinb6b
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additional information
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substrate specificity-based screening for potential inhibitors from the intracellular serpin family, no enzyme inhibition by Serpinb6b
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additional information
histone H4 cleavage is blocked by the GzmA inhibitor nafamostat mesylate and by GzmA knockdown using siRNA. Recombinant histone H4 is treated with trichostatin A, an inhibitor of histone deacetylation, revealing that only untreated histones are digested by GzmA
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additional information
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not: inhibitors of either thiol-, metallo- or carboxyl-proteinases
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additional information
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substrate specificity-based screening for potential inhibitors from the intracellular serpin family, overview. A lineage-specific increase in enzyme cytotoxic potential has driven cognate inhibitor evolution
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