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3.4.21.78: granzyme A

This is an abbreviated version!
For detailed information about granzyme A, go to the full flat file.

Word Map on EC 3.4.21.78

Reaction

Hydrolysis of proteins, including fibronectin, type IV collagen and nucleolin. Preferential cleavage: -Arg-/-, -Lys-/- >> -Phe-/- in small molecule substrates =

Synonyms

Autocrine thymic lymphoma granzyme-like serine protease, CTL tryptase, CTLA3, Cytotoxic T lymphocyte serine protease, GrA, Gzm A, Gzma, GzmA/K, H factor, Hanukkah factor, HuTPS, T-cell associated protease 1, T-cell derived serine proteinase 1, TSP-1

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.21 Serine endopeptidases
                3.4.21.78 granzyme A

Reference

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Reference on EC 3.4.21.78 - granzyme A

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Odake, S.; Kam, C.M.; Narasimhan, L.; Poe, M.; Blake, J.T.; Krahenbuhl, O.; Tschopp, J.; Powers, J.C.
Human and murine cytotoxic T lymphocyte serine proteases: subsite mapping with peptide thioester substrates and inhibition of enzyme activity and cytolysis by isocoumarins
Biochemistry
30
2217-2227
1991
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Gershenfeld, H.K.; Hershberger, R.J.; Shows, T.B.; Weissman, I.L.
Cloning and chromosomal assignment of a human cDNA encoding a T cell- and natural killer cell-specific trypsin-like serine protease
Proc. Natl. Acad. Sci. USA
85
1184-1188
1988
Homo sapiens
Manually annotated by BRENDA team
Simon, M.M.; Hoschutzky, H.; Fruth, U.; Simon, H.G.; Kramer, M.D.
Purification and characterization of a T cell specific serine proteinase (TSP-1) from cloned cytolytic T lymphocytes
EMBO J.
5
3267-3274
1986
Mus musculus
Manually annotated by BRENDA team
Simon, M.M.; Kramer, M.D.
Granzyme A
Methods Enzymol.
244
68-79
1994
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Kummer, J.A.; Kamp, A.M.; Citarella, F.; Horrevoets, A.J.G.; Hack, C.E.
Expression of human recombinant granzyme A zymogen and its activation by the cysteine proteinase cathepsin C
J. Biol. Chem.
271
9281-9286
1996
Homo sapiens
Manually annotated by BRENDA team
Vettel, U.; Brunner, G.; Bar-Shavit, R.; Vlodavsky, I.; Kramer, M.D.
Charge-dependent binding of granzyme A (MTSP-1) to basement membranes
Eur. J. Immunol.
23
279-282
1993
Mus musculus
Manually annotated by BRENDA team
Irmler, M.; Hertig, S.; MacDonald, H.R.; Sadoul, R.; Becherer, J.D.; Proudfoot, A.; Solari, R.; Tschopp, J.
Granzyme A is an interleukin 1 beta-converting enzyme
J. Exp. Med.
181
1917-1922
1995
Mammalia
Manually annotated by BRENDA team
Spaeny-Dekking, E.H.A.; Kamp, A.M.; Froelich, C.J.; Hack, C.E.
Extracellular granzyme A, complexed to proteoglycans, is protected against inactivation by protease inhibitors
Blood
95
1465-1472
2000
Homo sapiens
Manually annotated by BRENDA team
Bell, J.K.; Goetz, D.H.; Mahrus, S.; Harris, J.L.; Fletterick, R.J.; Craik, C.S.
The oligomeric structure of human granzyme A is a determinant of its extended substrate specificity
Nat. Struct. Biol.
10
527-534
2003
Homo sapiens
Manually annotated by BRENDA team
Hink-Schauer, C.; Estebanez-Perpina, E.; Kurschus, F.C.; Bode, W.; Jenne, D.E.
Crystal structure of the apoptosis-inducing human granzyme A dimer
Nat. Struct. Biol.
10
535-540
2003
Homo sapiens
Manually annotated by BRENDA team
Beresford, P.J.; Kam, C.M.; Powers, J.C.; Lieberman, J.
Recombinant human granzyme A binds to putative HLA-associated proteins and cleaves one of them
Proc. Natl. Acad. Sci. USA
94
9285-9290
1997
Homo sapiens
Manually annotated by BRENDA team
Grossman, W.J.; Verbsky, J.W.; Tollefsen, B.L.; Kemper, C.; Atkinson, J.P.; Ley, T.J.
Differential expression of granzymes A and B in human cytotoxic lymphocyte subsets and T regulatory cells
Blood
104
2840-2848
2004
Homo sapiens
Manually annotated by BRENDA team
Mahrus, S.; Craik, C.S.
Selective chemical functional probes of granzymes A and B reveal granzyme B Is a major effector of natural killer cell-mediated lysis of target cells
Chem. Biol.
12
567-577
2005
Homo sapiens
Manually annotated by BRENDA team
Zhu, P.; Zhang, D.; Chowdhury, D.; Martinvalet, D.; Keefe, D.; Shi, L.; Lieberman, J.
Granzyme A, which causes single-stranded DNA damage, targets the double-strand break repair protein Ku70
EMBO Rep.
7
431-437
2006
Homo sapiens
Manually annotated by BRENDA team
Martinvalet, D.; Zhu, P.; Lieberman, J.
Granzyme A induces caspase-independent mitochondrial damage, a required first step for apoptosis
Immunity
22
355-370
2005
Homo sapiens
Manually annotated by BRENDA team
Bade, B.; Boettcher, H.E.; Lohrmann, J.; Hink-Schauer, C.; Bratke, K.; Jenne, D.E.; Virchow, J.C., Jr.; Luttmann, W.
Differential expression of the granzymes A, K and M and perforin in human peripheral blood lymphocytes
Int. Immunol.
17
1419-1428
2005
Homo sapiens (P51124)
Manually annotated by BRENDA team
Pardo, J.; Bosque, A.; Brehm, R.; Wallich, R.; Naval, J.; Mullbacher, A.; Anel, A.; Simon, M.M.
Apoptotic pathways are selectively activated by granzyme A and/or granzyme B in CTL-mediated target cell lysis
J. Cell Biol.
167
457-468
2004
Mus musculus
Manually annotated by BRENDA team
Shacklett, B.L.; Cox, C.A.; Quigley, M.F.; Kreis, C.; Stollman, N.H.; Jacobson, M.A.; Andersson, J.; Sandberg, J.K.; Nixon, D.F.
Abundant expression of granzyme A, but not perforin, in granules of CD8+ T cells in GALT: implications for immune control of HIV-1 infection
J. Immunol.
173
641-648
2004
Homo sapiens
Manually annotated by BRENDA team
Vernooy, J.H.; Moeller, G.M.; van Suylen, R.J.; van Spijk, M.P.; Cloots, R.H.; Hoet, P.H.; Pennings, H.J.; Wouters, E.F.
Increased granzyme A expression in type II pneumocytes of patients with severe chronic obstructive pulmonary disease
Am. J. Respir. Crit. Care Med.
175
464-472
2007
Homo sapiens (P12544), Homo sapiens
Manually annotated by BRENDA team
Buzza, M.S.; Bird, P.I.
Extracellular granzymes: current perspectives
Biol. Chem.
387
827-837
2006
Homo sapiens (P12544)
Manually annotated by BRENDA team
Hirayasu, H.; Yoshikawa, Y.; Tsuzuki, S.; Fushiki, T.
A role of a lymphocyte tryptase, granzyme A, in experimental ulcerative colitis
Biosci. Biotechnol. Biochem.
71
234-237
2007
Rattus norvegicus (Q8CJF4)
Manually annotated by BRENDA team
Baschuk, N.; Utermoehlen, O.; Gugel, R.; Warnecke, G.; Karow, U.; Paulsen, D.; Brombacher, F.; Kroenke, M.; Deppert, W.
Interleukin-4 impairs granzyme-mediated cytotoxicity of Simian virus 40 large tumor antigen-specific CTL in BALB/c mice
Cancer Immunol. Immunother.
56
1625-1636
2007
Mus musculus (P11032)
Manually annotated by BRENDA team
Hochegger, K.; Eller, P.; Huber, J.M.; Bernhard, D.; Mayer, G.; Zlabinger, G.J.; Rosenkranz, A.R.
Expression of granzyme A in human polymorphonuclear neutrophils
Immunology
121
166-173
2007
Homo sapiens (P12544), Homo sapiens
Manually annotated by BRENDA team
Kaiserman, D.; Bird, C.H.; Sun, J.; Matthews, A.; Ung, K.; Whisstock, J.C.; Thompson, P.E.; Trapani, J.A.; Bird, P.I.
The major human and mouse granzymes are structurally and functionally divergent
J. Cell Biol.
175
619-630
2006
Mus musculus (P11032), Mus musculus, Homo sapiens (P12544), Homo sapiens
Manually annotated by BRENDA team
Myoumoto, A.; Nakatani, K.; Koshimizu, T.; Matsubara, H.; Adachi, S.; Tsujimoto, G.
Glucocorticoid-induced granzyme A expression can be used as a marker of glucocorticoid sensitivity for acute lymphoblastic leukemia therapy
J. Hum. Genet.
52
328-333
2007
Homo sapiens (P12544), Homo sapiens
Manually annotated by BRENDA team
Lee-Kirsch, M.A.; Chowdhury, D.; Harvey, S.; Gong, M.; Senenko, L.; Engel, K.; Pfeiffer, C.; Hollis, T.; Gahr, M.; Perrino, F.W.; Lieberman, J.; Hubner, N.
A mutation in TREX1 that impairs susceptibility to granzyme A-mediated cell death underlies familial chilblain lupus
J. Mol. Med.
85
531-537
2007
Homo sapiens (P12544)
Manually annotated by BRENDA team
Martinvalet, D.; Dykxhoorn, D.M.; Ferrini, R.; Lieberman, J.
Granzyme A cleaves a mitochondrial complex I protein to initiate caspase-independent cell death
Cell
133
681-692
2008
Homo sapiens
Manually annotated by BRENDA team
Yoshikawa, Y.; Hirayasu, H.; Tsuzuki, S.; Fushiki, T.
Granzyme A and thrombin differentially promote the release of interleukin-8 from alveolar epithelial A549 cells
Cytotechnology
62
325-332
2010
Homo sapiens
Manually annotated by BRENDA team
Van Damme, P.; Maurer-Stroh, S.; Hao, H.; Colaert, N.; Timmerman, E.; Eisenhaber, F.; Vandekerckhove, J.; Gevaert, K.
The substrate specificity profile of human granzyme A
Biol. Chem.
391
983-997
2010
Homo sapiens
Manually annotated by BRENDA team
Ilzecka, J.
Granzymes A and B levels in serum of patients with amyotrophic lateral sclerosis
Clin. Biochem.
44
650-653
2011
Homo sapiens
Manually annotated by BRENDA team
Huang, R.; Zhong, S.; Liu, H.; Kong, R.; Wang, Y.; Hu, W.; Guo, Q.
Identification and characterization of common carp (Cyprinus carpio L.) granzyme A/K, a cytotoxic cell granule-associated serine protease
Fish Shellfish Immunol.
29
388-398
2010
Cyprinus carpio (D8WWX5), Cyprinus carpio
Manually annotated by BRENDA team
Grodzovski, I.; Lichtenstein, M.; Galski, H.; Lorberboum-Galski, H.
IL-2-granzyme A chimeric protein overcomes multidrug resistance (MDR) through a caspase 3-independent apoptotic pathway
Int. J. Cancer
128
1966-1980
2011
Homo sapiens
Manually annotated by BRENDA team
Hartmann, W.; Marsland, B.J.; Otto, B.; Urny, J.; Fleischer, B.; Korten, S.
A novel and divergent role of granzyme A and B in resistance to helminth infection
J. Immunol.
186
2472-2481
2011
Mus musculus
Manually annotated by BRENDA team
Arias, M.A.; Jimenez de Baguees, M.P.; Aguilo, N.; Menao, S.; Hervas-Stubbs, S.; de Martino, A.; Alcaraz, A.; Simon, M.M.; Froelich, C.J.; Pardo, J.
Elucidating sources and roles of granzymes A and B during bacterial infection and sepsis
Cell Rep.
8
420-429
2014
Mus musculus (P11032), Mus musculus, Mus musculus B6 (P11032)
Manually annotated by BRENDA team
Kaiserman, D.; Stewart, S.E.; Plasman, K.; Gevaert, K.; Van Damme, P.; Bird, P.I.
Identification of Serpinb6b as a species-specific mouse granzyme A inhibitor suggests functional divergence between human and mouse granzyme A
J. Biol. Chem.
289
9408-9417
2014
Mus musculus, Homo sapiens (P12544), Homo sapiens
Manually annotated by BRENDA team
van den Boogaard, F.E.; van Gisbergen, K.P.; Vernooy, J.H.; Medema, J.P.; Roelofs, J.J.; van Zoelen, M.A.; Endeman, H.; Biesma, D.H.; Boon, L.; Vant Veer, C.; de Vos, A.F.; van der Poll, T.
Granzyme A impairs host defense during Streptococcus pneumoniae pneumonia
Am. J. Physiol. Lung Cell Mol. Physiol.
311
L507-L516
2016
Mus musculus (P11032), Homo sapiens (P12544), Homo sapiens, Mus musculus C57BL/6 (P11032)
Manually annotated by BRENDA team
Lee, P.; Park, B.; Chi, S.; Bae, K.; Kim, S.; Cho, S.; Kang, S.; Kim, J.; Park, S.
Histone H4 is cleaved by granzyme A during staurosporine-induced cell death in B-lymphoid Raji cells
BMB Rep.
49
560-565
2016
Homo sapiens (P12544)
Manually annotated by BRENDA team
Cheuk, S.; Martini, E.; Bergh, K.; Chang, D.; Rethi, B.; Staehle, M.; Eidsmo, L.
Granzyme A potentiates chemokine production in IL-17-stimulated keratinocytes
Exp. Dermatol.
26
824-827
2017
Homo sapiens (P12544)
Manually annotated by BRENDA team
Velaga, S.; Ukena, S.; Dringenberg, U.; Alter, C.; Pardo, J.; Kershaw, O.; Franzke, A.
Granzyme a is required for regulatory T-cell mediated prevention of gastrointestinal graft-versus-host disease
PLoS ONE
10
e0124927
2015
Mus musculus (P11032), Mus musculus
Manually annotated by BRENDA team
Uranga, S.; Marinova, D.; Martin, C.; Pardo, J.; Aguilo, N.
Granzyme A is expressed in mouse lungs during Mycobacterium tuberculosis infection but does not contribute to protection in vivo
PLoS ONE
11
e0153028
2016
Mus musculus (P11032), Mus musculus, Mus musculus C57BL/6 (P11032)
Manually annotated by BRENDA team