Literature summary for 3.4.21.78 extracted from

Hochegger, K.; Eller, P.; Huber, J.M.; Bernhard, D.; Mayer, G.; Zlabinger, G.J.; Rosenkranz, A.R.
Expression of granzyme A in human polymorphonuclear neutrophils (2007), Immunology, 121, 166-173.

Search for more literature for 3.4.21.78

Activating Compound

Activating Compound	Comment	Organism	Structure
additional information	stimulation with opsonized Escherichia coli or the bioincompatible haemodialysis membrane cuprophane reveals up-regulation of granzyme A expression at transcriptional and translational levels	Homo sapiens

Application

Application	Comment	Organism
medicine	studies on the role of granzyme A in polymorphonuclear neutrophils (PMNs) in defence against invading pathogens	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
secretory granule	subcellular fractionation, granzyme A in peroxidase-negative granules identified	Homo sapiens	30141	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P12544	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
HL-60 cell	no expression of granzyme A in promyelocytic cell line HL-60 identified	Homo sapiens	-
leukocyte	whole-blood leucocyte preparation discriminating between the distinct subpopulations, expression in CD8+ CTLs and in CD56+ NK cells shown	Homo sapiens	-
peripheral blood mononuclear cell	PBMCs, expression in	Homo sapiens	-
polymorphonuclear leukocyte	PMNs, polymorphonuclear neutrophils, expression in CD15+ population identified, differentiated cell stage, phagocytic stimuli of PMNs increase expression	Homo sapiens	-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
additional information	-	constitutive expression in human PMNs shown by flow cytometry, Western blot, enzyme-linked immunosorbent assay and quantitative RT-PCR, up-regulation upon PMN stimulation shown	Homo sapiens
additional information	-	expression shown by flow cytometry, Western blot, enzyme-linked immunosorbent assay and quantitative RT-PCR, up-regulation of expression upon stimulation shown	Homo sapiens
additional information	-	expression shown by flow cytometry, Western blot, enzyme-linked immunosorbent assay and quantitative RT-PCR, up-regulation upon stimulation shown	Homo sapiens

Synonyms

Synonyms	Comment	Organism
Gzma	-	Homo sapiens

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Release 2023.1 (January 2023)