3.4.21.78: granzyme A

This is an abbreviated version!
For detailed information about granzyme A, go to the full flat file.

Word Map on EC 3.4.21.78

3.4.21.78

thrombospondin-1

angiogenesis

endothelial

perforin

killer

granule

angiogenic

antiangiogenic

cytolytic

matricellular

metastasis

collagen

microvessels

t-cells

microvascular

integrins

fibrosis

fibronectin

cd8

tgf-beta1

neovascularization

fasl

fgf-2

corneal

alphavbeta3

exocytosis

ctl-mediated

factor-beta

bfgf

medicine

caspase-independent

angiogenesis-related

granule-associated

integrin-associated

angiostatic

proangiogenic

metronomic

properdin

endostatin

granulysin

tregs

lymphocyte-mediated

lymphokine-activated

ifn-gamma

vegf-a

Reaction

Hydrolysis of proteins, including fibronectin, type IV collagen and nucleolin. Preferential cleavage: -Arg-/-, -Lys-/- >> -Phe-/- in small molecule substrates =

Synonyms

Autocrine thymic lymphoma granzyme-like serine protease, CTL tryptase, CTLA3, Cytotoxic T lymphocyte serine protease, GrA, Gzm A, Gzma, GzmA/K, H factor, Hanukkah factor, HuTPS, T-cell associated protease 1, T-cell derived serine proteinase 1, TSP-1

ECTree

3 Hydrolases

3.4 Acting on peptide bonds (peptidases)

3.4.21 Serine endopeptidases

3.4.21.78 granzyme A

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Results	in table
3	Activating Compound
8	AA Sequence
15	Application
1	CAS Registry Number
16	Cloned(Commentary)
2	Crystallization (Commentary)
3179	Disease/ Diagnostics
1	Expression
22	General Information
1	General Stability
65	Inhibitors
11	KM Value [mM]
13	Localization
4	Molecular Weight [Da]
14	Natural Substrates/ Products (Substrates)
50	Organism
7	PDB ID
5	pH Optimum
1	Posttranslational Modification
7	Protein Variants
6	Purification (Commentary)
1	Reaction
1	Reaction Type
48	Reference
91	Source Tissue
14	Specific Activity [micromol/min/mg]
65	Substrates and Products (Substrate)
8	Subunits
32	Synonyms
1	Temperature Optimum [°C]
15	Turnover Number [1/s]

Posttranslational Modification

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Posttranslational Modification on EC 3.4.21.78 - granzyme A

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glycoprotein

Homo sapiens

proteoglycans containing glycosaminoglycan, various forms of extracellular granzyme A occur in vivo, the regulation of activity may be modified by proteoglycans

650720