Any feedback?
Please rate this page
(all_enzymes.php)
(0/150)

BRENDA support

3.4.21.78: granzyme A

This is an abbreviated version!
For detailed information about granzyme A, go to the full flat file.

Word Map on EC 3.4.21.78

Reaction

Hydrolysis of proteins, including fibronectin, type IV collagen and nucleolin. Preferential cleavage: -Arg-/-, -Lys-/- >> -Phe-/- in small molecule substrates =

Synonyms

Autocrine thymic lymphoma granzyme-like serine protease, CTL tryptase, CTLA3, Cytotoxic T lymphocyte serine protease, GrA, Gzm A, Gzma, GzmA/K, H factor, Hanukkah factor, HuTPS, T-cell associated protease 1, T-cell derived serine proteinase 1, TSP-1

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.21 Serine endopeptidases
                3.4.21.78 granzyme A

KM Value

KM Value on EC 3.4.21.78 - granzyme A

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.12 - 0.315
benzyloxycarbonyl-Arg thiobenzyl ester
0.105 - 0.16
benzyloxycarbonyl-Gly-Arg thiobenzyl ester
0.13 - 0.19
benzyloxycarbonyl-Lys thiobenzyl ester
0.887
Boc-Ala-Ala-Arg-SBzl
-
pH 7.5, 30°C
0.17
Boc-Trp-Arg-SBzl
-
pH 7.5, 30°C
0.14
tert-butyloxycarbonyl-Ala-Ala-Arg thiobenzyl ester
-
mouse enzyme
0.177
Z-Arg-SBzl
-
pH 7.5, 30°C
0.767
Z-Lys-SBzl
-
pH 7.5, 30°C