3.4.21.5: thrombin

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For detailed information about thrombin, go to the full flat file.

Word Map on EC 3.4.21.5

3.4.21.5

platelet

anticoagulant

heparin

thrombosis

bleeding

endothelial

artery

thromboplastin

collagen

agonist

thromboembolism

coronary

procoagulant

adp

antithrombotic

venous

fibrinolysis

thrombus

hemorrhage

hemostatic

hirudin

plasminogen

antiplatelet

thrombomodulin

protease-activated

arachidonic

plasmin

thromboxane

intravascular

viii

d-dimers

atrial

thrombocytopenia

aspirin

aptamer

hypercoagulability

willebrand

warfarin

percutaneous

p-selectin

rivaroxaban

platelet-rich

unfractionated

coagulopathy

prothrombotic

embolism

haemostasis

diagnostics

analysis

hemophilia

biotechnology

thrombolytic

nutrition

synthesis

clopidogrel

medicine

Reaction

selective cleavage of Arg-/-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B =

Synonyms

activated factor II, alpha-thrombin, alphaTh, beta-thrombin, blood-coagulation factor II, activated, blood-coagulation factor IIa, clotting factor IIa, EC 3.4.4.13, factor IIa, fibrinogenase, thrombase, thrombin, E, thrombin-C, thrombofort, TLE2, topical, tropostasin

ECTree

3 Hydrolases

3.4 Acting on peptide bonds (peptidases)

3.4.21 Serine endopeptidases

3.4.21.5 thrombin

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Results	in table
20	Activating Compound
1007	AA Sequence
51	Application
1	CAS Registry Number
14	Cloned(Commentary)
1	Cofactor
31	Crystallization (Commentary)
28522	Disease/ Diagnostics
6	Expression
43	General Information
2	General Stability
99	IC50 Value
461	Inhibitors
19	kcat/KM [mM/s]
134	Ki Value [mM]
108	KM Value [mM]
11	Localization
27	Metals/Ions
18	Molecular Weight [Da]
116	Natural Substrates/ Products (Substrates)
233	Organism
1062	PDB ID
20	pH Optimum
1	pH Range
1	pH Stability
17	Posttranslational Modification
155	Protein Variants
22	Purification (Commentary)
11	Reaction
1	Reaction Type
233	Reference
1	Renatured (Commentary)
102	Source Tissue
7	Specific Activity [micromol/min/mg]
5	Storage Stability
299	Substrates and Products (Substrate)
12	Subunits
62	Synonyms
19	Temperature Optimum [°C]
1	Temperature Range [°C]
5	Temperature Stability [°C]
97	Turnover Number [1/s]

Storage Stability

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Storage Stability on EC 3.4.21.5 - thrombin

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-50°C, 0.75 M NaCl, pH 6, stable for about 1 year

Homo sapiens

95528

-70°C, stable for at least six months

Homo sapiens

701289

0°C, on ice, 8 h, stable

Salmo salar

653981

22°C, at room temperature, several hours, stable, lyophilized stable for several months

Salmo salar

653981

4°C, 0.75 M NaCl, pH 6, stable for about 1 week

Homo sapiens

95528