3.4.21.5: thrombin

This is an abbreviated version, for detailed information about thrombin, go to the full flat file.

Reaction

selective cleavage of Arg-/-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B =

Synonyms

activated factor II, alpha-thrombin, alphaTh, beta-thrombin, blood-coagulation factor II, activated, blood-coagulation factor IIa, clotting factor IIa, EC 3.4.4.13, factor IIa, fibrinogenase, thrombase, thrombin, E, thrombin-C, thrombofort, topical, tropostasin

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.21 Serine endopeptidases
                3.4.21.5 thrombin

Molecular Weight

Molecular Weight on EC 3.4.21.5 - thrombin

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MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
7300
-
a three-chain molecular species, 1 * 7300 + 1 * 12000 + 1 * 19500, SDS-PAGE
12000
-
a three-chain molecular species, 1 * 7300 + 1 * 12000 + 1 * 19500, SDS-PAGE
19500
-
a three-chain molecular species, 1 * 7300 + 1 * 12000 + 1 * 19500, SDS-PAGE
31500 - 40600
-
thrombin in 0.21 M NaCl, 0.02 M sodium phosphate, pH 7.2, equilibrium sedimentation
33500
-
x * 33500, high-speed equilibrium sedimentation in guanidine
36600
-
equilibrium sedimentation
70000
-
1 * 70000 + 1 * 32000, SDS-PAGE
72000
-
x * 72000, enzyme mutant, SDS-PAGE