Reference on EC 3.4.21.5 - thrombin

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Lundblad, R.L.; Kingdon, H.S.; Mann, K.G.
Thrombin
Methods Enzymol.
45
156-176
1976
Bos taurus, Equus caballus, Homo sapiens, Sus scrofa
Manually annotated by BRENDA team
Landis, B.H.; Koehler, K.A.; Fenton II, J.W.
Human thrombins. Group IA and IIA salt-dependent properties of alpha-thrombin
J. Biol. Chem.
256
4604-4610
1981
Homo sapiens
Manually annotated by BRENDA team
Fenton, J.W.; Fasco, M.J.; Stackrow, A.B.; Aronson, D.L.; Young, A.M.; Finlayson, J.S
Human thrombins. Production, evaluation, and properties of alpha-thrombin
J. Biol. Chem.
252
3587-3598
1977
Homo sapiens
Manually annotated by BRENDA team
Lanchantin, G.F.; Friedmann, J.A.; Hart, D.W.
Two forms of human thrombin. Isolation and characterization
J. Biol. Chem.
248
5956-5966
1973
Homo sapiens
Manually annotated by BRENDA team
Lundblad, R.L.; Uhteg, L.C.; Vogel, C.N.; Kingdon, H.S.; Mann, K.G.
Preparation and partial characterization of two forms of bovine thrombin
Biochem. Biophys. Res. Commun.
66
482-489
1975
Bos taurus
Manually annotated by BRENDA team
Giglio, J.R.; Rossi, A.; Leone, F.A.; Chiericato, G.; Say, J.C.
Isolation and characterization of an active three-chain molecular species of bovine thrombin
Biochem. J.
159
29-33
1976
Bos taurus
Manually annotated by BRENDA team
Bezaud, A.; Guillin, M.C.
Enzymic and nonenzymic properties of human beta-thrombin
J. Biol. Chem.
263
3576-3581
1988
Homo sapiens
Manually annotated by BRENDA team
Ascenzi, P.; Menegatti, E.; Bolognesi, M.; Guarneri, M.; Amiconi, G.
Catalytic properties of bovine alpha-thrombin: a comparative steady-state and pre-steady-state study
Biochim. Biophys. Acta
871
319-323
1986
Bos taurus
Manually annotated by BRENDA team
Thompson, A.R.; Enfield, D.L.; Ericsson, L.H.; Legaz, M.E.; Fenton II, J.W.
Human thrombin: partial primary structure
Arch. Biochem. Biophys.
178
356-367
1977
Homo sapiens
Manually annotated by BRENDA team
Fasco, M.J.; Fenton II, J.W.
Specificity of thrombin. I. Esterolytic properties of thrombin, plasma, trypsin, and chymotrypsin with Nbeta-substituted guanidino derivatives of p-nitrophenyl-p'-guanidinobenzoate
Arch. Biochem. Biophys.
159
802-812
1973
Homo sapiens
-
Manually annotated by BRENDA team
Brandstetter, H.; Turk, D.; Hoeffken, H.W.; Grosse, D.; Sturzebecher, J.; Martin, P.D.; Edwards, B.F.; Bode, W.
Refined 2.3 A X-ray crystal structure of bovine thrombin complexes formed with the benzamidine and arginine-based thrombin inhibitors NAPAP, 4-TAPAP and MQPA. A starting point for improving antithrombotics
J. Mol. Biol.
226
1085-1099
1992
Bos taurus
Manually annotated by BRENDA team
Mazzucato, M.; de Marco, L.; Masotti, A.; Pradella, P.; Bahou, W.F.; Ruggeri, Z.M.
Characterization of the initial alpha-thrombin interaction with glycoprotein Ibaalpha in relation to platelet activation
J. Biol. Chem.
273
1880-1887
1998
Homo sapiens
Manually annotated by BRENDA team
Jhoti, H.; Cleasby, A.; Reid, S.; Thomas, P.J.; Weir, M.; Wonacott, A.
Crystal structures of thombin complexed to a novel series of synthetic inhibitors containing a 5,5-trans lactone template
Biochemistry
38
7969-7977
1999
Homo sapiens
Manually annotated by BRENDA team
Brass, L.F.; Woolkalis, M.J.
Dual regulation of cyclic AMP formation by thrombin in HEL cells, a leukaemic cell line with megakaryocytic properties
Biochem. J.
281
73-80
1992
Homo sapiens
Manually annotated by BRENDA team
Gibbs, C.S.; Coutre, S.E.; Tsiang, M.; Li, W.X.; Jain, A.K.; Dunn, K.E.; Law, V.S.; Mao, C.T.; Matsumura, S.Y.; Mejza, S.J.; Paborsky, L.R.; Leung, L.L.K.
Conversion of thrombin into an anticoagulant by protein engineering
Nature
378
413-416
1995
Homo sapiens
Manually annotated by BRENDA team
Weber, P.C.; Lee, S.L.; Lewandowski, F.A.; Schadt, M.C.; Chang, C.H.; Kettner, C.A.
Kinetic and crystallographic studies of thrombin with Ac-(D)Phe-Pro-boroArg-OH and its lysine, amidine, homolysine, and ornithine analogs
Biochemistry
34
3650-3757
1995
Homo sapiens
-
Manually annotated by BRENDA team
Tsiang, M.; Paborsky, L.R.; Li, W.X.; Jain, A.K.; Mao, C.T.; Dunn, K.E.; Lee, D.W.; Matsumura, S.Y.; Matteucci, M.D.; Coutre, S.E.; Leung, L.L.K.; Gibbs, C.S.
Protein engineering thrombin for optimal specificity and potency of anticoagulant activity in vivo
Biochemistry
35
16449-16457
1996
Homo sapiens
Manually annotated by BRENDA team
Naski, M.C.; Lorand, L.; Shafer, J.A.
Characterization of the kinetic pathway for fibrin promotion of alpha-thrombin-catalyzed activation of plasma factor XIII
Biochemistry
30
934-941
1991
Homo sapiens
Manually annotated by BRENDA team
Rydel, T.J.; Yin, M.; Padmanabhan, K.P.; Blankenship, D.T.; Cardin, A.D.; Correa, P.E.; Fenton 2nd, J.W.; Tulinsky, A.
Crystallographic structure of human gamma-thrombin
J. Biol. Chem.
269
22000-22006
1994
Homo sapiens
Manually annotated by BRENDA team
Engh, R.A.; Brandstetter, H.; Sucher, G.; Eichinger, A.; Baumann, U.; Bode, W.; Huber, R.; Poll, T.; Rudolph, R.; von der Saal, W.
Enzyme flexibility, solvent and ęweak' interactions characterize thrombin-ligand interactions: implications for drug design
Structure
4
1353-1362
1996
Homo sapiens
Manually annotated by BRENDA team
Russo, G.; Gast, A.; Schlaeger, E.J.; Angiolillo, A.; Pietropaolo, C.
Stable expression and purification of a secreted human recombinant prethrombin-2 and its activation to thrombin
Protein Expr. Purif.
10
214-225
1997
Homo sapiens
Manually annotated by BRENDA team
Recacha, R.; Costanzo, M.J.; Maryanoff, B.E.; Carson, M.; DeLucas, L.; Chattopadhyay, D.
Structure of human alpha-thrombin complexed with RWJ-51438 at 1.7 A: unusual perturbation of the 60A-60I insertion loop
Acta Crystallogr. Sect. D
56
1395-1400
2000
Homo sapiens
-
Manually annotated by BRENDA team
Deinum, J.; Gustavsson, L.; Gyzander, E.; Kullman-Magnusson, M.; Edstroem, A.; Karlsson, R.
A thermodynamic characterization of the binding of thrombin inhibitors to human thrombin, combining biosensor technology, stopped-Flow spectrophotometry, and microcalorimetry
Anal. Biochem.
300
152-162
2002
Homo sapiens
Manually annotated by BRENDA team
De Cristofaro, R.; De Filippis, V.
Interaction of the 268-282 region of glycoprotein Ibalpha with the heparin-binding site of thrombin inhibits the enzyme activation of factor VIII
Biochem. J.
373
593-601
2003
Homo sapiens
Manually annotated by BRENDA team
Hayakawa, Y.; Hayashi, T.; Lee, J.; Srisomporn, P.; Maeda, M.; Ozawa, T.; Sakuragawa, N.
Inhibition of thrombin by sulfated polysaccharides isolated from green algae
Biochim. Biophys. Acta
1543
86-94
2000
Homo sapiens
Manually annotated by BRENDA team
Myles, T.; Yun, T.H.; Leung, L.L.
Structural requirements for the activation of human factor VIII by thrombin
Blood
100
2820-2826
2002
Homo sapiens
Manually annotated by BRENDA team
Lange, U.; Keilholz, W.; Schaub, G.A.; Landmann, H.; Markwardt, F.; Nowak, G.
Biochemical characterization of a thrombin inhibitor from the bloodsucking bug Dipetalogaster maximus
Haemostasis
29
204-211
2000
Homo sapiens
Manually annotated by BRENDA team
Chambers, R.C.; Leoni, P.; Blanc-Brude, O.P.; Wembridge, D.E.; Laurent, G.J.
Thrombin is a potent inducer of connective tissue growth factor production via proteolytic activation of protease-activated receptor-1
J. Biol. Chem.
275
35584-35591
2000
Homo sapiens
Manually annotated by BRENDA team
Sadasivan, C.; Yee, V.C.
Interaction of the factor XIII activation peptide with alpha-thrombin. Crystal structure of its enzyme-substrate analog complex
J. Biol. Chem.
275
36942-36948
2000
Homo sapiens
Manually annotated by BRENDA team
Prasad, S.; Cantwell, A.M.; Bush, L.A.; Shih, P.; Xu, H.; Di Cera, E.
Residue Asp-189 controls both substrate binding and the monovalent cation specificity of thrombin
J. Biol. Chem.
279
10103-10108
2004
Homo sapiens
Manually annotated by BRENDA team
De Cristofaro, R.; Akhavan, S.; Altomare, C.; Carotti, A.; Peyvandi, F.; Mannucci, P.M.
A natural prothrombin mutant reveals an unexpected influence of A-chain structure on the activity of human alpha-thrombin
J. Biol. Chem.
279
13035-13043
2004
Homo sapiens, Homo sapiens (P00734)
Manually annotated by BRENDA team
Lopez, M.; Mende, K.; Steinmetzer, T.; Nowak, G.
Cloning, purification and biochemical characterization of dipetarudin, a new chimeric thrombin inhibitor
J. Chromatogr. B
786
73-80
2003
Homo sapiens
Manually annotated by BRENDA team
Guimaraes, C.R.W.; Bicca de Alencastro, R.
Thrombin inhibition by novel benzamidine derivatives: a free-energy perturbation study
J. Med. Chem.
45
4995-5004
2002
Homo sapiens (P00734)
Manually annotated by BRENDA team
Skordalakes, E.; Dodson, G.G.; Green, D.S.; Goodwin, C.A.; Scully, M.F.; Hudson, H.R.; Kakkar, V.V.; Deadman, J.J.
Inhibition of human alpha-thrombin by a phosphonate tripeptide proceeds via a metastable pentacoordinated phosphorus intermediate
J. Mol. Biol.
311
549-555
2001
Homo sapiens
Manually annotated by BRENDA team
Dullweber, F.; Stubbs, M.T.; Musil, D.; Sturzebecher, J.; Klebe, G.
Factorising ligand affinity: a combined thermodynamic and crystallographic study of trypsin and thrombin inhibition
J. Mol. Biol.
313
593-614
2001
Bos taurus (P00735), Homo sapiens
Manually annotated by BRENDA team
De Cristofaro, R.; De Candia, E.
Thrombin domains: structure, function and interaction with platelet receptors
J. Thromb. Thrombolysis
15
151-163
2003
Homo sapiens
Manually annotated by BRENDA team
Backes, B.J.; Harris, J.L.; Leonetti, F.; Craik, C.S.; Ellman, J.A.
Synthesis of positional-scanning libraries of fluorogenic peptide substrates to define the extended substrate specificity of plasmin and thrombin
Nat. Biotechnol.
18
187-193
2000
Homo sapiens
Manually annotated by BRENDA team
Meh, D.A.; Siebenlist, K.R.; Brennan, S.O.; Holyst, T.; Mosesson, M.W.
The amino acid sequence in fibrin responsible for high affinity thrombin binding
Thromb. Haemost.
85
470-474
2001
Homo sapiens
Manually annotated by BRENDA team
Buchanan, M.R.; Maclean, G.A.; Brister, S.J.
Selective and sustained inhibition of surface-bound thrombin activity by intimatan/heparin cofactor II and its relevance to assessing systemic anticoagulation in vivo, ex vivo and in vitro
Thromb. Haemost.
86
909-913
2001
Bos taurus, Homo sapiens
Manually annotated by BRENDA team
Sekine, O.; Sugo, T.; Ebisawa, K.; Umeyama, H.; Iwahana, H.; Ruiz-Saez, A.; de Bosch, N.; Matsudai, M.
Substitution of Gly-548 to Ala in the substrate binding pocket of prothrombin Perija leads to the loss of thrombin proteolytic activity
Thromb. Haemost.
87
282-287
2002
Homo sapiens
Manually annotated by BRENDA team
de Bosch, N.B.; Mosesson, M.W.; Ruiz-Saez, A.; Echenagucia, M.; Rodriguez-Lemoin, A.
Inhibition of thrombin generation in plasma by fibrin formation (antithrombin I)
Thromb. Haemost.
88
253-258
2002
Homo sapiens
Manually annotated by BRENDA team
Maekawa, H.; Sato, H.; Tollefsen, D.M.
Thrombin inhibition by HCII in the presence of elastase-cleaved HCII and thrombin-HCII complex
Thromb. Res.
100
443-451
2000
Homo sapiens
Manually annotated by BRENDA team
Mourao, P.A.; Boisson-Vidal, C.; Tapon-Bretaudiere, J.; Drouet, B.; Bros, A.; Fischer, A.
Inactivation of thrombin by a fucosylated chondroitin sulfate from echinoderm
Thromb. Res.
102
167-176
2001
Homo sapiens
Manually annotated by BRENDA team
Michaud, S.E.; Wang, L.Z.; Korde, N.; Bucki, R.; Randhawa, P.K.; Pastore, J.J.; Falet, H.; Hoffmeister, K.; Kuuse, R.; Uibo, R.; Herod, J.; Sawyer, E.; Janmey, P.A.
Purification of salmon thrombin and its potential as an alternative to mammalian thrombins in fibrin sealants
Thromb. Res.
107
245-254
2002
Homo sapiens, Salmo salar
Manually annotated by BRENDA team
Weitz, J.I.
A novel approach to thrombin inhibition
Thromb. Res.
109 Suppl 1
S17-22
2003
Homo sapiens
Manually annotated by BRENDA team
De Filippis, V.; De Dea, E.; Lucatello, F.; Frasson, R.
Effect of Na+ binding on the conformation, stability and molecular recognition properties of thrombin
Biochem. J.
390
485-492
2005
Homo sapiens (P00734)
Manually annotated by BRENDA team
Johnson, D.J.; Adams, T.E.; Li, W.; Huntington, J.A.
Crystal structure of wild-type human thrombin in the Na+-free state
Biochem. J.
392
21-28
2005
Homo sapiens, Homo sapiens (P00734)
Manually annotated by BRENDA team
Walker, T.R.; Cadwallader, K.A.; MacKinnon, A.; Chilvers, E.R.
Thrombin induces DNA synthesis and phosphoinositide hydrolysis in airway smooth muscle by activation of distinct receptors
Biochem. Pharmacol.
70
959-967
2005
Bos taurus
Manually annotated by BRENDA team
Isetti, G.; Maurer, M.C.
Thrombin activity is unaltered by N-terminal truncation of factor XIII activation peptides
Biochemistry
43
4150-4159
2004
Bos taurus
Manually annotated by BRENDA team
Croy, C.H.; Koeppe, J.R.; Bergqvist, S.; Komives, E.A.
Allosteric changes in solvent accessibility observed in thrombin upon active site occupation
Biochemistry
43
5246-5255
2004
Bos taurus, Homo sapiens
Manually annotated by BRENDA team
Shi, F.; Winzor, D.J.; Jackson, C.M.
Temperature dependence of the thrombin-catalyzed proteolysis of prothrombin
Biophys. Chem.
110
1-13
2004
Homo sapiens
Manually annotated by BRENDA team
Pineda, A.O.; Zhang, E.; Guinto, E.R.; Savvides, S.N.; Tulinsky, A.; Di Cera, E.
Crystal structure of the thrombin mutant D221A/D222K: the Asp222:Arg187 ion-pair stabilizes the fast form
Biophys. Chem.
112
253-256
2004
Homo sapiens
Manually annotated by BRENDA team
Scheffler, J.E.; Berliner, L.J.
Aspartame and aspartame derivatives effect human thrombin catalytic activity
Biophys. Chem.
112
285-291
2004
Homo sapiens
Manually annotated by BRENDA team
Nogami, K.; Zhou, Q.; Wakabayashi, H.; Fay, P.J.
Thrombin-catalyzed activation of factor VIII with His substituted for Arg372 at the P1 site
Blood
105
4362-4368
2005
Homo sapiens
Manually annotated by BRENDA team
James, C.; Collison, D.J.; Duncan, G.
Characterization and functional activity of thrombin receptors in the human lens
Invest. Ophthalmol. Vis. Sci.
46
925-932
2005
Homo sapiens
Manually annotated by BRENDA team
Zhang, D.; Kovach, I.M.
Full and partial deuterium solvent isotope effect studies of alpha-thrombin-catalyzed reactions of natural substrates
J. Am. Chem. Soc.
127
3760-3766
2005
Homo sapiens
Manually annotated by BRENDA team
Yonemura, H.; Imamura, T.; Soejima, K.; Nakahara, Y.; Morikawa, W.; Ushio, Y.; Kamachi, Y.; Nakatake, H.; Sugawara, K.; Nakagaki, T.; Nozaki, C.
Preparation of recombinant alpha-thrombin: high-level expression of recombinant human prethrombin-2 and its activation by recombinant ecarin
J. Biochem.
135
577-582
2004
Homo sapiens
Manually annotated by BRENDA team
Carter, W.J.; Myles, T.; Gibbs, C.S.; Leung, L.L.; Huntington, J.A.
Crystal structure of anticoagulant thrombin variant E217K provides insights into thrombin allostery
J. Biol. Chem.
279
26387-26394
2004
Homo sapiens, Homo sapiens (P00734)
Manually annotated by BRENDA team
Pineda, A.O.; Chen, Z.W.; Caccia, S.; Cantwell, A.M.; Savvides, S.N.; Waksman, G.; Mathews, F.S.; Di Cera, E.
The anticoagulant thrombin mutant W215A/E217A has a collapsed primary specificity pocket
J. Biol. Chem.
279
39824-39828
2004
Homo sapiens (P00734)
Manually annotated by BRENDA team
Nogami, K.; Zhou, Q.; Myles, T.; Leung, L.L.; Wakabayashi, H.; Fay, P.J.
Exosite-interactive regions in the A1 and A2 domains of factor VIII facilitate thrombin-catalyzed cleavage of heavy chain
J. Biol. Chem.
280
18476-18487
2005
Homo sapiens
Manually annotated by BRENDA team
Carter, W.J.; Cama, E.; Huntington, J.A.
Crystal structure of thrombin bound to heparin
J. Biol. Chem.
280
2745-2749
2005
Homo sapiens, Homo sapiens (P00734)
Manually annotated by BRENDA team
Panizzi, P.; Friedrich, R.; Fuentes-Prior, P.; Richter, K.; Bock, P.E.; Bode, W.
Fibrinogen substrate recognition by staphylocoagulase.(pro)thrombin complexes
J. Biol. Chem.
281
1179-1187
2006
Homo sapiens
Manually annotated by BRENDA team
Bush, L.A.; Nelson, R.W.; Di Cera, E.
Murine thrombin lacks Na+ activation but retains high catalytic activity
J. Biol. Chem.
281
7183-7188
2006
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Pajdak, W.; Radwan, J.; Guzik, T.J.
Cleavage of prothrombin bound in immune complexes results in high thrombin enzymatic activity
J. Physiol. Pharmacol.
55
477-484
2004
Homo sapiens
Manually annotated by BRENDA team
Hosokawa, K.; Ohnishi, T.; Kawakami, A.; Wakabayashi, S.; Koide, T.
Chemically modified thrombin and anhydrothrombin that differentiate macromolecular substrates of thrombin
J. Thromb. Haemost.
3
2703-2711
2005
Homo sapiens
Manually annotated by BRENDA team
Lam, J.K.; Chion, C.K.; Zanardelli, S.; Lane, D.A.; Crawley, J.T.
Further characterization of ADAMTS-13 inactivation by thrombin
J. Thromb. Haemost.
5
1010-1018
2007
Homo sapiens
Manually annotated by BRENDA team
Rowe, S.L.; Lee, S.; Stegemann, J.P.
Influence of thrombin concentration on the mechanical and morphological properties of cell-seeded fibrin hydrogels
Acta Biomater.
3
59-67
2007
Rattus norvegicus
Manually annotated by BRENDA team
Sutherland, J.S.; Bhakta, V.; Filion, M.L.; Sheffield, W.P.
The transferable tail: fusion of the N-terminal acidic extension of heparin cofactor II to alpha1-proteinase inhibitor M358R specifically increases the rate of thrombin inhibition
Biochemistry
45
11444-11452
2006
Homo sapiens
Manually annotated by BRENDA team
Isetti, G.; Maurer, M.C.
Employing mutants to study thrombin residues responsible for factor XIII activation peptide recognition: a kinetic study
Biochemistry
46
2444-2452
2007
Homo sapiens
Manually annotated by BRENDA team
Carrell, C.J.; Bush, L.A.; Mathews, F.S.; Di Cera, E.
High resolution crystal structures of free thrombin in the presence of K(+) reveal the molecular basis of monovalent cation selectivity and an inactive slow form
Biophys. Chem.
121
177-184
2006
Homo sapiens
Manually annotated by BRENDA team
Pineda, A.O.; Chen, Z.W.; Marino, F.; Mathews, F.S.; Mosesson, M.W.; Di Cera, E.
Crystal structure of thrombin in complex with fibrinogen gamma peptide
Biophys. Chem.
125
556-559
2007
Homo sapiens
Manually annotated by BRENDA team
Gianni, S.; Ivarsson, Y.; Bah, A.; Bush-Pelc, L.A.; Di Cera, E.
Mechanism of Na+ binding to thrombin resolved by ultra-rapid kinetics
Biophys. Chem.
131
111-114
2007
Homo sapiens
Manually annotated by BRENDA team
Bae, J.S.; Yang, L.; Manithody, C.; Rezaie, A.R.
The ligand occupancy of endothelial protein C receptor switches the protease-activated receptor 1-dependent signaling specificity of thrombin from a permeability-enhancing to a barrier-protective response in endothelial cells
Blood
110
3909-3916
2007
Homo sapiens
Manually annotated by BRENDA team
Stief, T.W.
Specific determination of plasmatic thrombin activity
Clin. Appl. Thromb. Hemost.
12
324-329
2006
Homo sapiens
Manually annotated by BRENDA team
Nishi, N.; Itoh, A.; Shoji, H.; Miyanaka, H.; Nakamura, T.
Galectin-8 and galectin-9 are novel substrates for thrombin
Glycobiology
16
15C-20C
2006
Homo sapiens
Manually annotated by BRENDA team
Pineda, A.O.; Chen, Z.W.; Bah, A.; Garvey, L.C.; Mathews, F.S.; Di Cera, E.
Crystal structure of thrombin in a self-inhibited conformation
J. Biol. Chem.
281
32922-32928
2006
Homo sapiens
Manually annotated by BRENDA team
Bukys, M.A.; Kim, P.Y.; Nesheim, M.E.; Kalafatis, M.
A control switch for prothrombinase: characterization of a hirudin-like pentapeptide from the COOH terminus of factor Va heavy chain that regulates the rate and pathway for prothrombin activation
J. Biol. Chem.
281
39194-39204
2006
Homo sapiens
Manually annotated by BRENDA team
Bah, A.; Garvey, L.C.; Ge, J.; Di Cera, E.
Rapid kinetics of Na+ binding to thrombin
J. Biol. Chem.
281
40049-40056
2006
Homo sapiens
Manually annotated by BRENDA team
Smadja, D.M.; Basire, A.; Amelot, A.; Conte, A.; Bieche, I.; Le Bonniec, B.F.; Aiach, M.; Gaussem, P.
Thrombin bound to a fibrin clot confers angiogenic and hemostatic properties on endothelial progenitor cells
J. Cell. Mol. Med.
12
975-986
2007
Homo sapiens
Manually annotated by BRENDA team
Radau, G.; Fokkens, J.
Design and X-ray crystal structures of human thrombin with synthetic cyanopeptide-analogues
Pharmazie
62
83-88
2007
Homo sapiens
Manually annotated by BRENDA team
Bah, A.; Chen, Z.; Bush-Pelc, L.A.; Mathews, F.S.; Di Cera, E.
Crystal structures of murine thrombin in complex with the extracellular fragments of murine protease-activated receptors PAR3 and PAR4
Proc. Natl. Acad. Sci. USA
104
11603-11608
2007
Mus musculus
Manually annotated by BRENDA team
Iyaguchi, D.; Yao, M.; Watanabe, N.; Tanaka, I.; Toyota, E.
Crystallization and preliminary x-ray studies of the unliganded wild-type bovine thrombin
Protein Pept. Lett.
14
923-924
2007
Bos taurus
Manually annotated by BRENDA team
Rock, G.; Neurath, D.; Semple, E.; Harvey, M.; Freedman, M.
Preparation and characterization of human thrombin for use in a fibrin glue
Transfus. Med.
17
187-191
2007
Homo sapiens
Manually annotated by BRENDA team
Hu, J.; Zheng, P.C.; Jiang, J.H.; Shen, G.L.; Yu, R.Q.; Liu, G.K.
Electrostatic interaction based approach to thrombin detection by surface-enhanced Raman spectroscopy
Anal. Chem.
81
87-93
2009
Homo sapiens
Manually annotated by BRENDA team
Kamali, F.; Wood, P.; Ward, A.
Vitamin K deficiency amplifies anticoagulation response to ximelagatran: possible implications for direct thrombin inhibitors and their clinical safety
Ann. Hematol.
88
141-149
2009
Rattus norvegicus
Manually annotated by BRENDA team
Osipov, R.M.; Bianchi, C.; Clements, R.T.; Feng, J.; Liu, Y.; Xu, S.H.; Robich, M.P.; Wagstaff, J.; Sellke, F.W.
Thrombin fragment (TP508) decreases myocardial infarction and apoptosis after ischemia reperfusion injury
Ann. Thorac. Surg.
87
786-793
2009
Sus scrofa
Manually annotated by BRENDA team
Rahgozar, S.; Giannakopoulos, B.; Yan, X.; Wei, J.; Cheng Qi, J.; Gemmell, R.; Krilis, S.A.
beta2-Glycoprotein I protects thrombin from inhibition by heparin cofactor II: potentiation of this effect in the presence of anti-beta2-glycoprotein I autoantibodies
Arthritis Rheum.
58
1146-1155
2008
Homo sapiens
Manually annotated by BRENDA team
Kang, Y.; Feng, K.J.; Chen, J.W.; Jiang, J.H.; Shen, G.L.; Yu, R.Q.
Electrochemical detection of thrombin by sandwich approach using antibody and aptamer
Bioelectrochemistry
73
76-81
2008
Homo sapiens
Manually annotated by BRENDA team
Chao, J.; Huang, W.Y.; Wang, J.; Xiao, S.J.; Tang, Y.C.; Liu, J.N.
Click-chemistry-conjugated oligo-angiomax in the two-dimensional DNA lattice and its interaction with thrombin
Biomacromolecules
10
877-883
2009
Homo sapiens
Manually annotated by BRENDA team
Hanessian, S.; Simard, D.; Bayrakdarian, M.; Therrien, E.; Nilsson, I.; Fjellstroem, O.
Design, synthesis, and thrombin-inhibitory activity of pyridin-2-ones as P2/P3 core motifs
Bioorg. Med. Chem. Lett.
18
1972-1976
2008
Homo sapiens
Manually annotated by BRENDA team
Centi, S.; Messina, G.; Tombelli, S.; Palchetti, I.; Mascini, M.
Different approaches for the detection of thrombin by an electrochemical aptamer-based assay coupled to magnetic beads
Biosens. Bioelectron.
23
1602-1609
2008
Homo sapiens
Manually annotated by BRENDA team
Choi, M.S.; Kim, Y.E.; Lee, W.J.; Choi, J.W.; Park, G.H.; Kim, S.D.; Jeon, S.J.; Go, H.S.; Shin, S.M.; Kim, W.K.; Shin, C.Y.; Ko, K.H.
Activation of protease-activated receptor1 mediates induction of matrix metalloproteinase-9 by thrombin in rat primary astrocytes
Brain Res. Bull.
76
368-375
2008
Rattus norvegicus
Manually annotated by BRENDA team
Hu, L.; Ibrahim, S.; Liu, C.; Skaar, J.; Pagano, M.; Karpatkin, S.
Thrombin induces tumor cell cycle activation and spontaneous growth by down-regulation of p27Kip1, in association with the up-regulation of Skp2 and MiR-222
Cancer Res.
69
3374-3382
2009
Homo sapiens
Manually annotated by BRENDA team
Schellhammer, F.; Steinhaus, D.; Cohnen, M.; Hoppe, J.; Moedder, U.; Fuerst, G.
Minimally invasive therapy of pseudoaneurysms of the trunk: application of thrombin
Cardiovasc. Intervent. Radiol.
31
535-541
2008
Homo sapiens
Manually annotated by BRENDA team
Huang, Y.L.; Shi, G.Y.; Lee, H.; Jiang, M.J.; Huang, B.M.; Wu, H.L.; Yang, H.Y.
Thrombin induces nestin expression via the transactivation of EGFR signalings in rat vascular smooth muscle cells
Cell. Signal.
21
954-968
2009
Rattus norvegicus
Manually annotated by BRENDA team
Alexandru, N.; Constantin, A.; Popov, D.
Carbonylation of platelet proteins occurs as consequence of oxidative stress and thrombin activation, and is stimulated by ageing and type 2 diabetes
Clin. Chem. Lab. Med.
46
528-536
2008
Homo sapiens, Mesocricetus auratus, Rattus norvegicus
Manually annotated by BRENDA team
Eichinger, S.; Hron, G.; Kollars, M.; Kyrle, P.A.
Prediction of recurrent venous thromboembolism by endogenous thrombin potential and D-dimer
Clin. Chem.
54
2042-2048
2008
Homo sapiens
Manually annotated by BRENDA team
Okumura, N.; Haneishi, A.; Terasawa, F.
Citrullinated fibrinogen shows defects in FPA and FPB release and fibrin polymerization catalyzed by thrombin
Clin. Chim. Acta
401
119-123
2009
Homo sapiens
Manually annotated by BRENDA team
Doria, C.; Fischer, C.P.; Wood, C.G.; Li, P.M.; Marra, S.; Hart, J.
Phase 3, randomized, double-blind study of plasma-derived human thrombin versus bovine thrombin in achieving hemostasis in patients undergoing surgery
Curr. Med. Res. Opin.
24
785-794
2008
Bos taurus, Homo sapiens
Manually annotated by BRENDA team
Cuccioloni, M.; Mozzicafreddo, M.; Sparapani, L.; Spina, M.; Eleuteri, A.M.; Fioretti, E.; Angeletti, M.
Pomegranate fruit components modulate human thrombin
Fitoterapia
80
301-305
2009
Homo sapiens
Manually annotated by BRENDA team
Kashyap, V.S.; Ginsberg, J.S.; Davidson, B.L.; Comp, P.C.; Francis, C.W.; Friedman, R.J.; Huo, M.H.; Lieberman, J.R.; Muntz, J.E.; Raskob, G.E.; Clements, M.L.; Hantel, S.; Schnee, J.M.; Caprini, J.A.
Oral thrombin inhibitor dabigatran etexilate vs North American enoxaparin regimen for prevention of venous thromboembolism after knee arthroplasty surgery
J. Arthroplasty
24
1-9
2009
Homo sapiens
Manually annotated by BRENDA team
Feutz, A.C.; Barrandon, Y.; Monard, D.
Control of thrombin signaling through PI3K is a mechanism underlying plasticity between hair follicle dermal sheath and papilla cells
J. Cell Sci.
121
1435-1443
2008
Mus musculus
Manually annotated by BRENDA team
Bae, J.S.; Kim, Y.U.; Park, M.K.; Rezaie, A.R.
Concentration dependent dual effect of thrombin in endothelial cells via Par-1 and Pi3 Kinase
J. Cell. Physiol.
219
744-751
2009
Homo sapiens
Manually annotated by BRENDA team
Song, M.; Zhang, Y.; Li, T.; Wang, Z.; Yin, J.; Wang, H.
Highly sensitive detection of human thrombin in serum by affinity capillary electrophoresis/laser-induced fluorescence polarization using aptamers as probes
J. Chromatogr. A
1216
873-878
2009
Homo sapiens
Manually annotated by BRENDA team
Liao, M.; Zhou, J.; Gong, H.; Boldbaatar, D.; Shirafuji, R.; Battur, B.; Nishikawa, Y.; Fujisaki, K.
Hemalin, a thrombin inhibitor isolated from a midgut cDNA library from the hard tick Haemaphysalis longicornis
J. Insect Physiol.
55
164-173
2009
Bos taurus
Manually annotated by BRENDA team
Erez, O.; Romero, R.; Kim, S.S.; Kim, J.S.; Kim, Y.M.; Wildman, D.E.; Than, N.G.; Mazaki-Tovi, S.; Gotsch, F.; Pineles, B.; Kusanovic, J.P.; Espinoza, J.; Mittal, P.; Mazor, M.; Hassan, S.S.; Kim, C.J.
Over-expression of the thrombin receptor (PAR-1) in the placenta in preeclampsia: a mechanism for the intersection of coagulation and inflammation
J. Matern. Fetal. Neonatal. Med.
21
345-355
2008
Homo sapiens
Manually annotated by BRENDA team
Ilas, J.; Tomasic, T.; Kikelj, D.
Novel potent and selective thrombin inhibitors based on a central 1,4-benzoxazin-3(4H)-one scaffold
J. Med. Chem.
51
2863-2867
2008
Homo sapiens
Manually annotated by BRENDA team
Esteso, G.; Mora, M.I.; Garrido, J.J.; Corrales, F.; Moreno, A.
Proteomic analysis of the porcine platelet proteome and alterations induced by thrombin activation
J. Proteomics
71
547-560
2008
Sus scrofa
Manually annotated by BRENDA team
Lopez, J.J.; Salido, G.M.; Pariente, J.A.; Rosado, J.A.
Thrombin induces activation and translocation of Bid, Bax and Bak to the mitochondria in human platelets
J. Thromb. Haemost.
6
1780-1788
2008
Homo sapiens
Manually annotated by BRENDA team
Mueller, J.; Freitag, D.; Mayer, G.; Poetzsch, B.
Anticoagulant characteristics of HD1-22, a bivalent aptamer that specifically inhibits thrombin and prothrombinase
J. Thromb. Haemost.
6
2105-2112
2008
Homo sapiens
Manually annotated by BRENDA team
Miah, M.F.; Boffa, M.B.
Functional analysis of mutant variants of thrombin-activatable fibrinolysis inhibitor resistant to activation by thrombin or plasmin
J. Thromb. Haemost.
7
665-672
2009
Homo sapiens
Manually annotated by BRENDA team
Curzio, K.M.; Cheng-Lai, A.; Kheyfets, V.; Sinnet, M.; Billett, H.H.
A comparison of direct thrombin inhibitors in the treatment of heparin-induced thrombocytopenia: a single institution experience
J. Thromb. Thrombolysis
28
117-123
2008
Homo sapiens
Manually annotated by BRENDA team
Mo, W.; Zhang, Y.L.; Chen, H.S.; Wang, L.S.; Song, H.Y.
A novel hirudin derivative characterized with anti-platelet aggregations and thrombin inhibition
J. Thromb. Thrombolysis
28
230-237
2008
Oryctolagus cuniculus
Manually annotated by BRENDA team
Cho, H.; Baker, B.R.; Wachsmann-Hogiu, S.; Pagba, C.V.; Laurence, T.A.; Lane, S.M.; Lee, L.P.; Tok, J.B.
Aptamer-based SERRS sensor for thrombin detection
Nano Lett.
8
4386-4390
2008
Homo sapiens
Manually annotated by BRENDA team
Fitzgibbon, J.; Morrison, J.J.; Smith, T.J.; OBrien, M.
Modulation of human uterine smooth muscle cell collagen contractility by thrombin, Y-27632, TNF alpha and indomethacin
Reprod. Biol. Endocrinol.
7
2-2
2009
Homo sapiens
Manually annotated by BRENDA team
Sugawara, T.; Jadhav, V.; Ayer, R.; Chen, W.; Suzuki, H.; Zhang, J.H.
Thrombin inhibition by argatroban ameliorates early brain injury and improves neurological outcomes after experimental subarachnoid hemorrhage in rats
Stroke
40
1530-1532
2009
Rattus norvegicus
Manually annotated by BRENDA team
Bae, J.S.; Rezaie, A.R.
Protease activated receptor 1 (PAR-1) activation by thrombin is protective in human pulmonary artery endothelial cells if endothelial protein C receptor is occupied by its natural ligand
Thromb. Haemost.
100
101-109
2008
Homo sapiens
Manually annotated by BRENDA team
De Smedt, E.; Wagenvoord, R.; Coen Hemker, H.
The technique of measuring thrombin generation with fluorogenic substrates: 3. The effects of sample dilution
Thromb. Haemost.
101
165-170
2009
Homo sapiens
Manually annotated by BRENDA team
Bae, J.S.; Rezaie, A.R.
Thrombin inhibits nuclear factor kappaB and RhoA pathways in cytokine-stimulated vascular endothelial cells when EPCR is occupied by protein C
Thromb. Haemost.
101
513-520
2009
Homo sapiens
Manually annotated by BRENDA team
Huisse, M.G.; Ajzenberg, N.; Feldman, L.; Guillin, M.C.; Steg, P.G.
Microparticle-linked tissue factor activity and increased thrombin activity play a potential role in fibrinolysis failure in ST-segment elevation myocardial infarction
Thromb. Haemost.
101
734-740
2009
Homo sapiens
Manually annotated by BRENDA team
Aizawa, P.; Winge, S.; Karlsson, G.
Large-scale preparation of thrombin from human plasma
Thromb. Res.
122
560-567
2008
Homo sapiens
Manually annotated by BRENDA team
Ben Mansour, M.; Dhahri, M.; Venisse, L.; Jandrot-Perrus, M.; Chaubet, F.; Maaroufi, R.M.
Mechanism of thrombin inhibition by heparin cofactor II and antithrombin in the presence of the ray (Raja radula) skin dermatan sulfate
Thromb. Res.
123
902-908
2009
Homo sapiens
Manually annotated by BRENDA team
Parrales, A.; Palma-Nicolas, J.P.; Lopez, E.; Lopez-Colome, A.M.
Thrombin stimulates RPE cell proliferation by promoting c-Fos-mediated cyclin D1 expression
J. Cell. Physiol.
222
302-312
2010
Homo sapiens
Manually annotated by BRENDA team
Cooper, T.; Taber, D.; Mazur, J.
Implementation of a collaborative drug therapy management service for inpatients receiving direct thrombin inhibitors
Am. J. Health Syst. Pharm.
66
1297-1303
2009
Homo sapiens
Manually annotated by BRENDA team
Suzuki, T.; Ikewaki, J.; Iwata, H.; Ohashi, Y.; Ichinose, A.
The first two Japanese cases of severe type I congenital plasminogen deficiency with ligneous conjunctivitis: successful treatment with direct thrombin inhibitor and fresh plasma
Am. J. Hematol.
84
363-365
2009
Homo sapiens
Manually annotated by BRENDA team
Yin, X.; Wright, J.; Wall, T.; Grammas, P.
Brain endothelial cells synthesize neurotoxic thrombin in Alzheimers disease
Am. J. Pathol.
176
1600-1606
2010
Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Zhu, W.; Chandrasekharan, U.M.; Bandyopadhyay, S.; Morris, S.M.; DiCorleto, P.E.; Kashyap, V.S.
Thrombin induces endothelial arginase through AP-1 activation
Am. J. Physiol. Cell Physiol.
298
C952-C960
2010
Rattus norvegicus
Manually annotated by BRENDA team
Heil, S.
[Heparin-induced thrombocytopenia type II with thrombosis in an intensive care patient: therapy management using the direct thrombin inhibitor argatroban]
Anaesthesist
58
1119-1122
2009
Homo sapiens
Manually annotated by BRENDA team
Chang, H.; Tang, L.; Wang, Y.; Jiang, J.; Li, J.
Graphene fluorescence resonance energy transfer aptasensor for the thrombin detection
Anal. Chem.
82
2341-2346
2010
Homo sapiens
Manually annotated by BRENDA team
Koelbel, T.; Donath, T.; Strandberg, K.; Flondell-Site, D.; Kuehme, T.; Gottsaeter, A.; Lindblad, B.
Is increased thrombin activation in patients with abdominal aortic aneurysms dependent on area or volume of aneurysm thrombus mass?
Angiology
61
113-118
2010
Homo sapiens
Manually annotated by BRENDA team
Bogatkevich, G.S.; Ludwicka-Bradley, A.; Silver, R.M.
Dabigatran, a direct thrombin inhibitor, demonstrates antifibrotic effects on lung fibroblasts
Arthritis Rheum.
60
3455-3464
2009
Homo sapiens
Manually annotated by BRENDA team
Chang, C.J.; Hsu, L.A.; Ko, Y.H.; Chen, P.L.; Chuang, Y.T.; Lin, C.Y.; Liao, C.H.; Pang, J.H.
Thrombin regulates matrix metalloproteinase-9 expression in human monocytes
Biochem. Biophys. Res. Commun.
385
241-246
2009
Homo sapiens
Manually annotated by BRENDA team
Cheng, D.C.; Zhong, G.C.; Su, J.X.; Liu, Y.H.; Li, Y.; Wang, J.Y.; Hattori, T.; Ling, H.; Zhang, F.M.
A sensitive HIV-1 envelope induced fusion assay identifies fusion enhancement of thrombin
Biochem. Biophys. Res. Commun.
391
1780-1784
2010
Homo sapiens
Manually annotated by BRENDA team
Chung, S.W.; Park, J.W.; Lee, S.A.; Eo, S.K.; Kim, K.
Thrombin promotes proinflammatory phenotype in human vascular smooth muscle cell
Biochem. Biophys. Res. Commun.
396
748-754
2010
Homo sapiens
Manually annotated by BRENDA team
Ofosu, F.A.; Dewar, L.; Song, Y.; Cedrone, A.C.; Hortelano, G.; Craven, S.J.
Early intraplatelet signaling enhances the release of human platelet PAR-1 and -4 amino-terminal peptides in response to thrombin
Biochemistry
48
1562-1572
2009
Homo sapiens
Manually annotated by BRENDA team
Kovach, I.M.; Kelley, P.; Eddy, C.; Jordan, F.; Baykal, A.
Proton bridging in the interactions of thrombin with small inhibitors
Biochemistry
48
7296-7304
2009
Homo sapiens
Manually annotated by BRENDA team
Qureshi, S.H.; Yang, L.; Manithody, C.; Iakhiaev, A.V.; Rezaie, A.R.
Mutagenesis studies toward understanding allostery in thrombin
Biochemistry
48
8261-8270
2009
Homo sapiens
Manually annotated by BRENDA team
Lima, L.M.; Becker, C.F.; Giesel, G.M.; Marques, A.F.; Cargnelutti, M.T.; de Oliveira Neto, M.; Monteiro, R.Q.; Verli, H.; Polikarpov, I.
Structural and thermodynamic analysis of thrombin:suramin interaction in solution and crystal phases
Biochim. Biophys. Acta
1794
873-881
2009
Homo sapiens, Homo sapiens (P00734)
Manually annotated by BRENDA team
Freitas, S.C.; Barbosa, M.A.; Martins, M.C.
The effect of immobilization of thrombin inhibitors onto self-assembled monolayers on the adsorption and activity of thrombin
Biomaterials
31
3772-3780
2010
Homo sapiens
Manually annotated by BRENDA team
Verghese, J.; Liang, A.; Sidhu, P.P.; Hindle, M.; Zhou, Q.; Desai, U.R.
First steps in the direction of synthetic, allosteric, direct inhibitors of thrombin and factor Xa
Bioorg. Med. Chem. Lett.
19
4126-4129
2009
Homo sapiens
Manually annotated by BRENDA team
Pu, J.; Yang, T.
Thrombin: A potential regulator between head injury and enhanced osteogenesis
Biosci. Hypotheses
2
326-328
2009
Homo sapiens
-
Manually annotated by BRENDA team
Kastl, S.P.; Speidl, W.S.; Katsaros, K.M.; Kaun, C.; Rega, G.; Assadian, A.; Hagmueller, G.W.; Hoeth, M.; de Martin, R.; Ma, Y.; Maurer, G.; Huber, K.; Wojta, J.
Thrombin induces the expression of oncostatin M via AP-1 activation in human macrophages: a link between coagulation and inflammation
Blood
114
2812-2818
2009
Homo sapiens
Manually annotated by BRENDA team
Maki, J.; Hirano, M.; Hoka, S.; Kanaide, H.; Hirano, K.
Thrombin activation of proteinase-activated receptor 1 potentiates the myofilament Ca2+ sensitivity and induces vasoconstriction in porcine pulmonary arteries
Br. J. Pharmacol.
159
919-927
2010
Bos taurus
Manually annotated by BRENDA team
Azizova, O.A.; Piryazev, A.P.; Aseychev, A.V.; Shvachko, A.G.
Oxidative modification of fibrinogen inhibits its transformation into fibrin under the effect of thrombin
Bull. Exp. Biol. Med.
147
201-203
2009
Homo sapiens
Manually annotated by BRENDA team
Dobrovolsky, A.B.; Titaeva, E.V.; Khaspekova, S.G.; Spiridonova, V.A.; Kopylov, A.M.; Mazurov, A.V.
Inhibition of thrombin activity with DNA-aptamers
Bull. Exp. Biol. Med.
148
33-36
2009
Homo sapiens
Manually annotated by BRENDA team
Azizova, O.A.; Shvachko, A.G.; Aseichev, A.V.
Effect of iron ions on functional activity of thrombin
Bull. Exp. Biol. Med.
148
776-779
2009
Homo sapiens
Manually annotated by BRENDA team
Zhang, T.; Ma, Z.; Wang, R.; Wang, Y.; Wang, S.; Cheng, Z.; Xu, H.; Jin, X.; Li, W.; Wang, X.
Thrombin facilitates invasion of ovarian cancer along peritoneum by inducing monocyte differentiation toward tumor-associated macrophage-like cells
Cancer Immunol. Immunother.
59
1097-1108
2010
Homo sapiens
Manually annotated by BRENDA team
Green, D.; Karpatkin, S.
Role of thrombin as a tumor growth factor
Cell Cycle
9
656-661
2010
Homo sapiens
Manually annotated by BRENDA team
Zhu, H.; Hoppensteadt, D.; Adiguzel, C.; Bick, R.L.; Fareed, J.
Comparison of immunogenic potentials of bovine thrombin preparations
Clin. Appl. Thromb. Hemost.
15
41-49
2009
Bos taurus
Manually annotated by BRENDA team
Zhu, H.; Hoppensteadt, D.; Iqbal, O.; Litinas, E.; Adiguzel, C.; Fareed, J.
Relative purity of different bovine thrombin preparations
Clin. Appl. Thromb. Hemost.
15
681-688
2009
Bos taurus
Manually annotated by BRENDA team
Stangier, J.; Clemens, A.
Pharmacology, pharmacokinetics, and pharmacodynamics of dabigatran etexilate, an oral direct thrombin inhibitor
Clin. Appl. Thromb. Hemost.
15
9S-16S
2009
Homo sapiens
Manually annotated by BRENDA team
Walfridsson, H.; Johansson, B.; Englund, A.; Kennebaeck, G.; Schwieler, J.; Kongstad, O.; Wahlander, K.; Malm, A.R.; Edvardsson, N.
Effects of AZD0837, a novel direct thrombin inhibitor, on the electrophysiological properties of the human heart: a randomized, double-blind, parallel-group, placebo-controlled study
Clin. Drug Investig.
30
461-471
2010
Homo sapiens
Manually annotated by BRENDA team
Turpie, A.G.
Direct Factor Xa and direct thrombin inhibitors: a clinical trial update
Curr. Opin. Drug Discov. Devel.
12
497-508
2009
Homo sapiens
Manually annotated by BRENDA team
Yoshikawa, Y.; Hirayasu, H.; Tsuzuki, S.; Fushiki, T.
Granzyme A and thrombin differentially promote the release of interleukin-8 from alveolar epithelial A549 cells
Cytotechnology
62
325-332
2010
Homo sapiens
Manually annotated by BRENDA team
Lip, G.Y.; Rasmussen, L.H.; Olsson, S.B.; Jensen, E.C.; Persson, A.L.; Eriksson, U.; Wahlander, K.F.; Wahlander, K.F.
Oral direct thrombin inhibitor AZD0837 for the prevention of stroke and systemic embolism in patients with non-valvular atrial fibrillation: a randomized dose-guiding, safety, and tolerability study of four doses of AZD0837 vs. vitamin K antagonists
Eur. Heart J.
30
2897-2907
2009
Homo sapiens
Manually annotated by BRENDA team
Numakura, M.; Kusakabe, N.; Ishige, K.; Ohtake-Niimi, S.; Habuchi, H.; Habuchi, O.
Preparation of chondroitin sulfate libraries containing disulfated disaccharide units and inhibition of thrombin by these chondroitin sulfates
Glycoconj. J.
27
479-489
2010
Bos taurus
Manually annotated by BRENDA team
Schaden, E.; Kozek-Langenecker, S.A.
Direct thrombin inhibitors: pharmacology and application in intensive care medicine
Intensive Care Med.
36
1127-1137
2010
Homo sapiens
Manually annotated by BRENDA team
Squizzato, A.; Dentali, F.; Steidl, L.; Ageno, W.
New direct thrombin inhibitors
Intern. Emerg. Med.
4
479-484
2009
Homo sapiens
Manually annotated by BRENDA team
Gandhi, P.S.; Page, M.J.; Chen, Z.; Bush-Pelc, L.; Di Cera, E.
Mechanism of the anticoagulant activity of thrombin mutant W215A/E217A
J. Biol. Chem.
284
24098-24105
2009
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Petrera, N.S.; Stafford, A.R.; Leslie, B.A.; Kretz, C.A.; Fredenburgh, J.C.; Weitz, J.I.
Long range communication between exosites 1 and 2 modulates thrombin function
J. Biol. Chem.
284
25620-25629
2009
Homo sapiens
Manually annotated by BRENDA team
Niu, W.; Chen, Z.; Bush-Pelc, L.A.; Bah, A.; Gandhi, P.S.; Di Cera, E.
Mutant N143P reveals how Na+ activates thrombin
J. Biol. Chem.
284
36175-36185
2009
Homo sapiens
Manually annotated by BRENDA team
Gandhi, P.S.; Chen, Z.; Di Cera, E.
Crystal structure of thrombin bound to the uncleaved extracellular fragment of PAR1
J. Biol. Chem.
285
15393-15398
2010
Homo sapiens
Manually annotated by BRENDA team
Gambaryan, S.; Kobsar, A.; Rukoyatkina, N.; Herterich, S.; Geiger, J.; Smolenski, A.; Lohmann, S.M.; Walter, U.
Thrombin and collagen induce a feedback inhibitory signaling pathway in platelets involving dissociation of the catalytic subunit of protein kinase A from an NFkappaB-IkappaB complex
J. Biol. Chem.
285
18352-18363
2010
Homo sapiens
Manually annotated by BRENDA team
Sarilla, S.; Habib, S.Y.; Kravtsov, D.V.; Matafonov, A.; Gailani, D.; Verhamme, I.M.
Sucrose octasulfate selectively accelerates thrombin inactivation by heparin cofactor II
J. Biol. Chem.
285
8278-8289
2010
Homo sapiens
Manually annotated by BRENDA team
Nicolaes, G.A.; Bock, P.E.; Segers, K.; Wildhagen, K.C.; Dahlback, B.; Rosing, J.
Inhibition of thrombin formation by active site Ser360 to Ala-substituted activated protein C
J. Biol. Chem.
30
22890-22900
2010
Bos taurus
Manually annotated by BRENDA team
Chen, H.T.; Tsou, H.K.; Tsai, C.H.; Kuo, C.C.; Chiang, Y.K.; Chang, C.H.; Fong, Y.C.; Tang, C.H.
Thrombin enhanced migration and MMPs expression of human chondrosarcoma cells involves PAR receptor signaling pathway
J. Cell. Physiol.
223
737-745
2010
Homo sapiens
Manually annotated by BRENDA team
Bae, J.S.; Kim, I.S.; Rezaie, A.R.
Thrombin down-regulates the TGF-beta-mediated synthesis of collagen and fibronectin by human proximal tubule epithelial cells through the EPCR-dependent activation of PAR-1
J. Cell. Physiol.
225
233-239
2010
Homo sapiens
Manually annotated by BRENDA team
Nicolotti, O.; Giangreco, I.; Miscioscia, T.F.; Convertino, M.; Leonetti, F.; Pisani, L.; Carotti, A.
Screening of benzamidine-based thrombin inhibitors via a linear interaction energy in continuum electrostatics model
J. Comput. Aided Mol. Des.
24
117-129
2010
Homo sapiens
Manually annotated by BRENDA team
Nilsson, M.; Haemaelaeinen, M.; Ivarsson, M.; Gottfries, J.; Xue, Y.; Hansson, S.; Isaksson, R.; Fex, T.
Compounds binding to the S2-S3 pockets of thrombin
J. Med. Chem.
52
2708-2715
2009
Homo sapiens
Manually annotated by BRENDA team
Lu, T.; Markotan, T.; Ballentine, S.K.; Giardino, E.C.; Spurlino, J.; Crysler, C.S.; Brown, K.; Maryanoff, B.E.; Tomczuk, B.E.; Damiano, B.P.; Shukla, U.; End, D.; Andrade-Gordon, P.; Bone, R.F.; Player, M.R.
Discovery and clinical evaluation of 1-{N-[2-(amidinoaminooxy)ethyl]amino}carbonylmethyl-6-methyl-3-[2,2-difluoro-2-phenylethylamino]pyrazinone (RWJ-671818), a thrombin inhibitor with an oxyguanidine P1 motif
J. Med. Chem.
53
1843-1856
2010
Homo sapiens
Manually annotated by BRENDA team
Muley, L.; Baum, B.; Smolinski, M.; Freindorf, M.; Heine, A.; Klebe, G.; Hangauer, D.G.
Enhancement of hydrophobic interactions and hydrogen bond strength by cooperativity: synthesis, modeling, and molecular dynamics simulations of a congeneric series of thrombin inhibitors
J. Med. Chem.
53
2126-2135
2010
Homo sapiens
Manually annotated by BRENDA team
Baum, B.; Muley, L.; Heine, A.; Smolinski, M.; Hangauer, D.; Klebe, G.
Think twice: understanding the high potency of bis(phenyl)methane inhibitors of thrombin
J. Mol. Biol.
391
552-564
2009
Homo sapiens
Manually annotated by BRENDA team
Cuerrier, C.M.; Gagner, A.; Lebel, R.; Gobeil, F.; Grandbois, M.
Effect of thrombin and bradykinin on endothelial cell mechanical properties monitored through membrane deformation
J. Mol. Recognit.
22
389-396
2009
Homo sapiens
Manually annotated by BRENDA team
Thevenet, J.; Angelillo-Scherrer, A.; Price, M.; Hirt, L.
Coagulation factor Xa activates thrombin in ischemic neural tissue
J. Neurochem.
111
828-836
2009
Mus musculus
Manually annotated by BRENDA team
Werthmann, R.C.; von Hayn, K.; Nikolaev, V.O.; Lohse, M.J.; Buenemann, M.
Real-time monitoring of cAMP levels in living endothelial cells: thrombin transiently inhibits adenylyl cyclase 6
J. Physiol.
587
4091-4104
2009
Homo sapiens
Manually annotated by BRENDA team
Adjemian, J.; Anne, A.; Cauet, G.; Demaille, C.
Cleavage-sensing redox peptide monolayers for the rapid measurement of the proteolytic activity of trypsin and alpha-thrombin enzymes
Langmuir
26
10347-10356
2010
Homo sapiens
Manually annotated by BRENDA team
Wang, Z.; Kong, L.; Kang, J.; Morgan, J.H.; Shillcutt, S.D.; Robinson, J.S.; Nakayama, D.K.
Thrombin stimulates mitogenesis in pig cerebrovascular smooth muscle cells involving activation of pro-matrix metalloproteinase-2
Neurosci. Lett.
451
199-203
2009
Homo sapiens
Manually annotated by BRENDA team
Argueelles, S.; Herrera, A.J.; Carreno-Mueller, E.; de Pablos, R.M.; Villaran, R.F.; Espinosa-Oliva, A.M.; Machado, A.; Cano, J.
Degeneration of dopaminergic neurons induced by thrombin injection in the substantia nigra of the rat is enhanced by dexamethasone: role of monoamine oxidase enzyme
Neurotoxicology
31
55-66
2010
Homo sapiens
Manually annotated by BRENDA team
Robert, S.; Ghiotto, J.; Pirotte, B.; David, J.L.; Masereel, B.; Pochet, L.; Dogne, J.M.
Is thrombin generation the new rapid, reliable and relevant pharmacological tool for the development of anticoagulant drugs?
Pharmacol. Res.
59
160-166
2009
Homo sapiens
Manually annotated by BRENDA team
Papareddy, P.; Rydengard, V.; Pasupuleti, M.; Walse, B.; Moergelin, M.; Chalupka, A.; Malmsten, M.; Schmidtchen, A.
Proteolysis of human thrombin generates novel host defense peptides
PLoS Pathog.
6
e1000857
2010
Homo sapiens
Manually annotated by BRENDA team
Grade, S.; Agasse, F.; Bernardino, L.; Silva, C.G.; Cortes, L.; Malva, J.O.
Functional identification of neural stem cell-derived oligodendrocytes by means of calcium transients elicited by thrombin
Rejuvenation Res.
13
27-37
2010
Homo sapiens
Manually annotated by BRENDA team
Zheng, J.; Cheng, G.F.; He, P.G.; Fang, Y.Z.
An aptamer-based assay for thrombin via structure switch based on gold nanoparticles and magnetic nanoparticles
Talanta
80
1868-1872
2010
Homo sapiens
Manually annotated by BRENDA team
Leoncini, G.; Signorello, M.G.; Segantin, A.; Giacobbe, E.; Armani, U.; Piana, A.; Camicione, P.
In retinal vein occlusion platelet response to thrombin is increased
Thromb. Res.
124
e48-e55
2009
Homo sapiens
Manually annotated by BRENDA team
Bae, J.S.; Rezaie, A.R.
Thrombin and activated protein C inhibit the expression of secretory group IIA phospholipase A2 in the TNF-alpha-activated endothelial cells by EPCR and PAR-1 dependent mechanisms
Thromb. Res.
125
e9-e15
2010
Homo sapiens
Manually annotated by BRENDA team
Christersson, C.; Johnell, M.; Siegbahn, A.
The influence of direct thrombin inhibitors on the formation of platelet-leukocyte aggregates and tissue factor expression
Thromb. Res.
126
e327-e333
2010
Homo sapiens
Manually annotated by BRENDA team
Osipov, A.V.; Filkin, S.Y.; Makarova, Y.V.; Tsetlin, V.I.; Utkin, Y.N.
A new type of thrombin inhibitor, noncytotoxic phospholipase A2, from the Naja haje cobra venom
Toxicon
55
186-194
2010
Bos taurus, Homo sapiens
Manually annotated by BRENDA team
Russo Krauss, I.; Merlino, A.; Randazzo, A.; Mazzarella, L.; Sica, F.
Crystallization and preliminary X-ray analysis of the complex of human alpha-thrombin with a modified thrombin-binding aptamer
Acta Crystallogr. Sect. F
66
961-963
2010
Homo sapiens
Manually annotated by BRENDA team
Zavyalova, E.G.; Protopopova, A.D.; Yaminsky, I.V.; Kopylov, A.M.
Kinetic characterization of inhibition of human thrombin with DNA aptamers by turbidimetric assay
Anal. Biochem.
421
234-239
2012
Homo sapiens
Manually annotated by BRENDA team
Kasetty, G.; Papareddy, P.; Kalle, M.; Rydengard, V.; Moergelin, M.; Albiger, B.; Malmsten, M.; Schmidtchen, A.
Structure-activity studies and therapeutic potential of host defense peptides of human thrombin
Antimicrob. Agents Chemother.
55
2880-2890
2011
Homo sapiens
Manually annotated by BRENDA team
Wu, G.; Deng, X.; Li, X.; Wang, X.; Wang, S.; Xu, H.
Application of immobilized thrombin for production of S-thanatin expressed in Escherichia coli
Appl. Microbiol. Biotechnol.
92
85-93
2011
Bos taurus
Manually annotated by BRENDA team
Dangwal, S.; Rauch, B.H.; Gensch, T.; Dai, L.; Bretschneider, E.; Vogelaar, C.F.; Schroer, K.; Rosenkranz, A.C.
High glucose enhances thrombin responses via protease-activated receptor-4 in human vascular smooth muscle cells
Arterioscler. Thromb. Vasc. Biol.
31
624-633
2011
Homo sapiens
Manually annotated by BRENDA team
Kawanami, D.; Matoba, K.; Kanazawa, Y.; Ishizawa, S.; Yokota, T.; Utsunomiya, K.
Thrombin induces MCP-1 expression through Rho-kinase and subsequent p38MAPK/NF-kappaB signaling pathway activation in vascular endothelial cells
Biochem. Biophys. Res. Commun.
411
798-803
2011
Homo sapiens
Manually annotated by BRENDA team
Parrales, A.; Lopez, E.; Lopez-Colome, A.M.
Thrombin activation of PI3K/PDK1/Akt signaling promotes cyclin D1 upregulation and RPE cell proliferation
Biochim. Biophys. Acta
1813
1758-1766
2011
Rattus norvegicus
Manually annotated by BRENDA team
Siles, R.; Kawasaki, Y.; Ross, P.; Freire, E.
Synthesis and biochemical evaluation of triazole/tetrazole-containing sulfonamides against thrombin and related serine proteases
Bioorg. Med. Chem. Lett.
21
5305-5309
2011
Homo sapiens
Manually annotated by BRENDA team
Choi, S.H.; Smith, S.A.; Morrissey, J.H.
Polyphosphate is a cofactor for the activation of factor XI by thrombin
Blood
118
6963-6970
2011
Homo sapiens
Manually annotated by BRENDA team
Hsu, C.L.; Chang, H.T.; Chen, C.T.; Wei, S.C.; Shiang, Y.C.; Huang, C.C.
Highly efficient control of thrombin activity by multivalent nanoparticles
Chemistry
17
10994-11000
2011
Homo sapiens
Manually annotated by BRENDA team
Marino, F.; Pelc, L.A.; Vogt, A.; Gandhi, P.S.; Di Cera, E.
Engineering thrombin for selective specificity toward protein C and PAR1
J. Biol. Chem.
285
19145-19152
2010
Homo sapiens
Manually annotated by BRENDA team
Burch, M.L.; Ballinger, M.L.; Yang, S.N.; Getachew, R.; Itman, C.; Loveland, K.; Osman, N.; Little, P.J.
Thrombin stimulation of proteoglycan synthesis in vascular smooth muscle is mediated by protease-activated receptor-1 transactivation of the transforming growth factor beta type I receptor
J. Biol. Chem.
285
26798-26805
2010
Homo sapiens
Manually annotated by BRENDA team
Delekta, P.C.; Apel, I.J.; Gu, S.; Siu, K.; Hattori, Y.; McAllister-Lucas, L.M.; Lucas, P.C.
Thrombin-dependent NF-kappaB activation and monocyte/endothelial adhesion are mediated by the CARMA3/Bcl10/MALT1 signalosome
J. Biol. Chem.
285
41432-41442
2010
Mus musculus
Manually annotated by BRENDA team
Lin, C.H.; Cheng, H.W.; Ma, H.P.; Wu, C.H.; Hong, C.Y.; Chen, B.C.
Thrombin induces NF-kappaB activation and IL-8/CXCL8 expression in lung epithelial cells by a Rac1-dependent PI3K/Akt pathway
J. Biol. Chem.
286
10483-10494
2011
Bos taurus, Homo sapiens
Manually annotated by BRENDA team
Kerk, N.; Strozyk, E.A.; Poeppelmann, B.; Schneider, S.W.
The mechanism of melanoma-associated thrombin activity and von Willebrand factor release from endothelial cells
J. Invest. Dermatol.
130
2259-2268
2010
Homo sapiens
Manually annotated by BRENDA team
Kwong, K.; Nassenstein, C.; de Garavilla, L.; Meeker, S.; Undem, B.J.
Thrombin and trypsin directly activate vagal C-fibres in mouse lung via protease-activated receptor-1
J. Physiol.
588
1171-1177
2010
Bos taurus
Manually annotated by BRENDA team
Koh, C.Y.; Kumar, S.; Kazimirova, M.; Nuttall, P.A.; Radhakrishnan, U.P.; Kim, S.; Jagadeeswaran, P.; Imamura, T.; Mizuguchi, J.; Iwanaga, S.; Swaminathan, K.; Kini, R.M.
Crystal structure of thrombin in complex with s-variegin: insights of a novel mechanism of inhibition and design of tunable thrombin inhibitors
PLoS ONE
6
e26367
2011
Homo sapiens
Manually annotated by BRENDA team
Liu, L.; Ma, H.; Yang, N.; Tang, Y.; Guo, J.; Tao, W.; Duan, J.
A series of natural flavonoids as thrombin inhibitors: structure-activity relationships
Thromb. Res.
126
e365-e378
2010
Bos taurus
Manually annotated by BRENDA team
Liu, Y.; Liu, N.; Ma, X.; Li, X.; Ma, J.; Li, Y.; Zhou, Z.; Gao, Z.
Highly specific detection of thrombin using an aptamer-based suspension array and the interaction analysis via microscale thermophoresis
Analyst
140
2762
2015
Homo sapiens
Manually annotated by BRENDA team
Newell-Caito, J.L.; Griffiths, A.E.; Fay, P.J.
P3-P3' residues flanking scissile bonds in factor VIII modulate rates of substrate cleavage and procofactor activation by thrombin
Biochemistry
51
3451-3459
2012
Homo sapiens
Manually annotated by BRENDA team
Winquist, J.; Geschwindner, S.; Xue, Y.; Gustavsson, L.; Musil, D.; Deinum, J.; Danielson, U.H.
Identification of structural-kinetic and structural-thermodynamic relationships for thrombin inhibitors
Biochemistry
52
613-626
2013
Homo sapiens
Manually annotated by BRENDA team
Zhang, Y.; Li, X.; Zou, R.; Xue, Y.; Lou, X.; He, M.
Bovine thrombin enhances the efficiency and specificity of polymerase chain reaction
Biotechniques
57
289-294
2014
Bos taurus
Manually annotated by BRENDA team
Malovichko, M.; Sabo, T.; Maurer, M.
Ligand binding to anion-binding exosites regulates conformational properties of thrombin
J. Biol. Chem.
288
8667-8678
2013
Homo sapiens (P00734)
Manually annotated by BRENDA team
Gallwitz, M.; Enoksson, M.; Thorpe, M.; Hellman, L.
The extended cleavage specificity of human thrombin
PLoS ONE
7
e31756
2012
Homo sapiens
Manually annotated by BRENDA team
Zavyalova, E.; Kopylov, A.
Multiple inhibitory kinetics reveal an allosteric interplay among thrombin functional sites
Thromb. Res.
135
212-216
2015
Homo sapiens
Manually annotated by BRENDA team