3.4.21.5: thrombin

This is an abbreviated version, for detailed information about thrombin, go to the full flat file.

Reaction

selective cleavage of Arg-/-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B =

Synonyms

activated factor II, alpha-thrombin, alphaTh, beta-thrombin, blood-coagulation factor II, activated, blood-coagulation factor IIa, clotting factor IIa, EC 3.4.4.13, factor IIa, fibrinogenase, thrombase, thrombin, E, thrombin-C, thrombofort, topical, tropostasin

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.21 Serine endopeptidases
                3.4.21.5 thrombin

Natural Substrates Products

Natural Substrates Products on EC 3.4.21.5 - thrombin

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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
activated protein C + H2O
?
show the reaction diagram
-
-
-
-
?
ADAMTS-13 + H2O
?
show the reaction diagram
-
proteolysis of ADAMTS-13 by thrombin causes an 8fold reduction in its affinity for von Willebrand factor VWF that contributes to its loss of VWF-cleaving function, physiologic function, overview
-
-
?
factor V + H2O
activated factor V + ?
show the reaction diagram
-
activation
-
-
?
factor V + H2O
factor Va + propeptide
show the reaction diagram
-
proteolytic activation
-
?
factor VIII + H2O
?
show the reaction diagram
-
activation by cleavage of Arg372, Arg74, and Arg1689, plays a fundamental role in the amplification of the coagulation cascade
-
?
factor VIII + H2O
activated factor VIII + ?
show the reaction diagram
-
activation
-
-
?
factor VIII + H2O
factor VIIIa + propeptide
show the reaction diagram
-
proteolytic activation
-
?
factor X + H2O
factor Xa + propeptide
show the reaction diagram
factor XI + H2O
activated factor XI + ?
show the reaction diagram
-
activation
-
-
?
factor XI + H2O
factor XIa
show the reaction diagram
-
activation by thrombin
-
-
?
factor XI + H2O
factor XIa + propeptide
show the reaction diagram
-
proteolytic activation
-
?
factor XII + H2O
activated factor XII + ?
show the reaction diagram
-
activated factor XII cross-links fibrin molecules and stabilizes the fibrin clot
-
-
?
factor XIII + H2O
activated factor XIII + ?
show the reaction diagram
-
the enzyme is involved in the coagulation cascade, overview
-
-
?
factor XIII + H2O
factor XIIIa + propeptide
show the reaction diagram
-
proteolytic activation
-
?
Fibrinogen + H2O
?
show the reaction diagram
fibrinogen + H2O
fibrin
show the reaction diagram
-
-
-
-
?
fibrinogen + H2O
fibrin + ?
show the reaction diagram
fibrinogen + H2O
fibrin + fibrinoepeptide A + fibrinopeptide B
show the reaction diagram
-
-
-
-
?
fibrinogen + H2O
fibrin + fibrinopeptide A + fibrinopeptide B
show the reaction diagram
fibrinogen 1 + H2O
fibrin 1 + fibrinopeptide A + fibrinopeptide B
show the reaction diagram
fibrinogen 2 + H2O
fibrin 2 + fibrinopeptide A + fibrinopeptide B
show the reaction diagram
fibrinopeptide A + H2O
?
show the reaction diagram
-
-
-
-
?
galectin-8 + H2O
?
show the reaction diagram
-
although intact isoform G8L stimulates neutrophil adhesion to substrate more efficiently than isoform G8M, the activity of isoform G8L but not that of isoform G8M decreases on thrombin digestion, overview
-
-
?
galectin-9 + H2O
?
show the reaction diagram
-
thrombin treatment almost completely abolishes eosinophil chemoattractant activity of isoform G9L, overview
-
-
?
pro-factor XIII + H2O
factor XIII
show the reaction diagram
-
activation by cleavage at Arg37 leading to blood coagulation
-
?
protease-activated receptor + H2O
?
show the reaction diagram
-
activation
-
-
?
protease-activated receptor 1 + H2O
?
show the reaction diagram
protease-activated receptor 1 + H2O
activated protease-activated receptor 1 + ?
show the reaction diagram
-
activation
-
-
?
protease-activated receptor-1 + H2O
?
show the reaction diagram
protease-activated receptor-1 + H2O
activated PAR-1
show the reaction diagram
-
i.e. PAR-1, activation, major thrombin receptor
product induces connective tissue growth factor production, a fibroblast mitogen, which promotes extracellular matrix protein production
?
protease-activated receptor-3 + H2O
?
show the reaction diagram
-
activation
-
-
?
protease-activated receptor-4 + H2O
?
show the reaction diagram
-
activation
-
-
?
protein C zymogen + H2O
activated protein C + propeptide
show the reaction diagram
protein kinase C + H2O
?
show the reaction diagram
-
activation
-
-
?
proteinase-activated receptor 1 + H2O
?
show the reaction diagram
-
alpha-thrombin may not effectively catalyze proteinase-activated receptor 1-(1-41) generation
-
-
?
proteinase-activated receptor 4 + H2O
?
show the reaction diagram
-
alpha-thrombin may not effectively catalyze proteinase-activated receptor 4-(1-47) generation
-
-
?
additional information
?
-