3.4.21.5: thrombin

This is an abbreviated version, for detailed information about thrombin, go to the full flat file.

Reaction

selective cleavage of Arg-/-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B =

Synonyms

activated factor II, alpha-thrombin, alphaTh, beta-thrombin, blood-coagulation factor II, activated, blood-coagulation factor IIa, clotting factor IIa, EC 3.4.4.13, factor IIa, fibrinogenase, thrombase, thrombin, E, thrombin-C, thrombofort, topical, tropostasin

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.21 Serine endopeptidases
                3.4.21.5 thrombin

Turnover Number

Turnover Number on EC 3.4.21.5 - thrombin

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TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1.2
Ac-Gly-Gly-Val-Arg-7-amido-4-methylcoumarin
Homo sapiens
-
pH 8.0, 25C
15.6
Ac-Leu-Gly-Val-Arg-7-amido-4-methylcoumarin
Homo sapiens
-
pH 8.0, 25C
5.8
Ac-Nle-Thr-Leu-Arg-7-amido-4-methylcoumarin
Homo sapiens
-
pH 8.0, 25C
45
Ac-Nle-Thr-Pro-Arg-7-amido-4-methylcoumarin
Homo sapiens
-
pH 8.0, 25C
30.8
Ac-Val-Thr-Pro-Arg-7-amido-4-methylcoumarin
Homo sapiens
-
pH 8.0, 25C
13.7 - 17.8
benzoyl-Arg ethyl ester
14 - 15
benzoyl-Arg methyl ester
38 - 77.8
D-Phe-L-pipecolyl-L-Arg-p-nitroanilide
-
3.5 - 29
D-Phe-Pro-Arg-4-nitroanilide
0.018 - 12
D-Phe-Pro-Lys-4-nitroanilide
0.018 - 8.3
D-Phe-Pro-Phe-4-nitroanilide
0.11 - 209.4
D-phenylalanyl-pipecolyl-L-arginine-4-nitroanilide
217.1 - 278.6
di-L-Glu-L-Pro-L-Arg-4-nitroanilide
3 - 6
factor VIII(341-376) peptide
2.57
factor XIII
Homo sapiens
-
pH 7.4, 25C, wild-type enzyme
-
22.9
factor XIII V34L mutant
Homo sapiens
-
pH 7.4, 25C, wild-type enzyme
-
0.01
Fc-[RFSRPQL]-PEG
Homo sapiens
-
-
2.53 - 7.88
fibrinogen
-
4.53 - 57
fibrinogen Aalpha chain
-
1.82 - 45.3
Fibrinopeptide A
24.3
GLVPRGVNL
Bos taurus
-
pH 7.4, 25C
5.8
GVVPRGVNL
Bos taurus
-
pH 7.4, 25C
0.00102
p-nitrophenyl-p'-(Nbeta,n-butyl-Nalpha-guanidino)benzoate
Homo sapiens
-
-
-
0.00197
p-nitrophenyl-p'-(Nbeta,n-hexyl-Nalpha-guanidino)benzoate
Homo sapiens
-
-
-
0.0018
p-nitrophenyl-p'-guanidinobenzoate
Homo sapiens
-
-
4.2 - 146
PAR1 peptide
25 - 34
platelet thrombin receptor peptide
-
0.065 - 0.65
protein C
-
15 - 91
spectrozyme-TH
0.315
thrombin-activatable fibrinolysis inhibitor
Homo sapiens
-
presence of thrombomodulin, kcat(app) value
-
3.27 - 10.3
tosyl-Arg ethyl ester
192.8 - 251.6
tosyl-Gly-Pro-Arg-4-nitroanilide
15.2
TVELQGLVPRGVNL
Bos taurus
-
pH 7.4, 25C
6.2
TVELQGVVPRGVNL
Bos taurus
-
pH 7.4, 25C
additional information
additional information
Homo sapiens
-
analysis of temperature dependence of pseudo-first order rate constants for enzyme-catalyzed hydrolysis of prothrombin-derived substrates, in presence and absence of Ca2+
-