3.4.21.5: thrombin

This is an abbreviated version, for detailed information about thrombin, go to the full flat file.

Reaction

selective cleavage of Arg-/-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B =

Synonyms

activated factor II, alpha-thrombin, alphaTh, beta-thrombin, blood-coagulation factor II, activated, blood-coagulation factor IIa, clotting factor IIa, EC 3.4.4.13, factor IIa, fibrinogenase, thrombase, thrombin, E, thrombin-C, thrombofort, topical, tropostasin

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.21 Serine endopeptidases
                3.4.21.5 thrombin

IC50 Value

IC50 Value on EC 3.4.21.5 - thrombin

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IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.4
(2S)-1-(1,3-benzodioxol-5-ylacetyl)-N-(thiophen-2-ylmethyl)pyrrolidine-2-carboxamide
Homo sapiens
-
IC50 above 0.4 mM, at 37C
0.4
(2S)-1-(cyclohexylacetyl)-N-(thiophen-2-ylmethyl)pyrrolidine-2-carboxamide
Homo sapiens
-
IC50 above 0.4 mM, at 37C
0.4
(2S)-1-[(2R)-2-amino-2-cyclohexylacetyl]-N-methylpyrrolidine-2-carboxamide
Homo sapiens
-
IC50 above 0.4 mM, at 37C
0.12
(2S)-1-[(2R)-2-amino-2-cyclohexylacetyl]-N-propylpyrrolidine-2-carboxamide
Homo sapiens
-
at 37C
0.4
(2S)-1-[(2R)-2-amino-3-(1,3-benzodioxol-5-yl)propanoyl]-N-methylpyrrolidine-2-carboxamide
Homo sapiens
-
IC50 above 0.4 mM, at 37C
0.4
(2S)-1-[(2R)-2-amino-3-(1,3-benzodioxol-5-yl)propanoyl]-N-propylpyrrolidine-2-carboxamide
Homo sapiens
-
IC50 above 0.4 mM, at 37C
0.013
(2S)-1-[(2R)-2-amino-3-(4-chlorophenyl)propanoyl]-N-(thiophen-2-ylmethyl)pyrrolidine-2-carboxamide
Homo sapiens
-
at 37C
0.21
(2S)-1-[(2R)-2-amino-3-(4-chlorophenyl)propanoyl]-N-propylpyrrolidine-2-carboxamide
Homo sapiens
-
at 37C
0.4
(2S)-1-[(2R)-2-amino-3-cyclohexylpropanoyl]-N-methylpyrrolidine-2-carboxamide
Homo sapiens
-
IC50 above 0.4 mM, at 37C
0.4
(2S)-1-[(2R)-2-cyclohexyl-2-hydroxyacetyl]-N-(2-methoxyethyl)pyrrolidine-2-carboxamide
Homo sapiens
-
IC50 above 0.4 mM, at 37C
0.4
(2S)-1-[3-(4-chlorophenyl)propanoyl]-N-(2-methoxyethyl)pyrrolidine-2-carboxamide
Homo sapiens
-
IC50 above 0.4 mM, at 37C
0.4
(2S)-1-[3-(4-chlorophenyl)propanoyl]-N-(thiophen-2-ylmethyl)pyrrolidine-2-carboxamide
Homo sapiens
-
IC50 above 0.4 mM, at 37C
0.4
(2S)-1-[3-(4-chlorophenyl)propanoyl]-N-propylpyrrolidine-2-carboxamide
Homo sapiens
-
IC50 above 0.4 mM, at 37C
0.23
1-(2-amino-2-cyclohexyl-acetyl)-pyrrolidine-2-carboxylic acid isobutyl-amide
Homo sapiens
-
at 37C
0.17
1-(2-cyclohexyl-2-phenylmethanesulfonylamino-acetyl)-pyrrolidine-2-carboxylic acid methylamide
Homo sapiens
-
at 37C
0.12
1-(3,3-diphenylpropanoyl)-N-(thiophen-2-ylmethyl)-L-prolinamide
Homo sapiens
-
at 37C
0.4
1-[(2R)-2-amino-2-cyclohexylacetyl]-N-(2-methoxyethyl)-L-prolinamide
Homo sapiens
-
IC50 above 0.4 mM, at 37C
0.02
1-[(2R)-2-amino-2-cyclohexylacetyl]-N-(cyclohexylmethyl)-L-prolinamide
Homo sapiens
-
at 37C
0.0042
1-[(2R)-2-amino-2-cyclohexylacetyl]-N-(thiophen-2-ylmethyl)-L-prolinamide
Homo sapiens
-
at 37C
0.4
1-[(2R)-2-amino-4,4-diphenylbutanoyl]-N-(2-methoxyethyl)-L-prolinamide
Homo sapiens
-
IC50 above 0.4 mM, at 37C
0.4
1-[(2R)-2-amino-4,4-diphenylbutanoyl]-N-propyl-L-prolinamide
Homo sapiens
-
IC50 above 0.4 mM, at 37C
0.049
1-[(9-hydroxy-9H-fluoren-9-yl)acetyl]-N-(thiophen-2-ylmethyl)-L-prolinamide
Homo sapiens
-
at 37C
0.4
3-(1,3-benzodioxol-5-yl)-D-alanyl-N-(2-methoxyethyl)-L-prolinamide
Homo sapiens
-
IC50 above 0.4 mM, at 37C
0.4
3-(9-hydroxy-9H-fluoren-9-yl)-D-alanyl-N-(2-methoxyethyl)-L-prolinamide
Homo sapiens
-
IC50 above 0.4 mM, at 37C
0.4
3-(9-hydroxy-9H-fluoren-9-yl)-D-alanyl-N-methyl-L-prolinamide
Homo sapiens
-
IC50 above 0.4 mM, at 37C
0.38
3-(9-hydroxy-9H-fluoren-9-yl)-D-alanyl-N-propyl-L-prolinamide
Homo sapiens
-
at 37C
0.4
3-cyclohexyl-D-alanyl-N-(2-methoxyethyl)-L-prolinamide
Homo sapiens
-
IC50 above 0.4 mM, at 37C
0.4
3-cyclohexyl-D-alanyl-N-propyl-L-prolinamide
Homo sapiens
-
IC50 above 0.4 mM, at 37C
0.4
4-chloro-D-phenylalanyl-N-(2-methoxyethyl)-L-prolinamide
Homo sapiens
-
IC50 above 0.4 mM, at 37C
0.14
acacetin
Bos taurus
-
pH and temperature not specified in the publication
0.18
apigenin
Bos taurus
-
pH and temperature not specified in the publication
0.06
baicalein
Bos taurus
-
pH and temperature not specified in the publication
0.089
beta-phenyl-D-phenylalanyl-N-(2-methoxyethyl)-L-prolinamide
Homo sapiens
-
at 37C
0.0016
beta-phenyl-D-phenylalanyl-N-(thiophen-2-ylmethyl)-L-prolinamide
Homo sapiens
-
at 37C
0.23
beta-phenyl-D-phenylalanyl-N-methyl-L-prolinamide
Homo sapiens
-
at 37C
0.018
beta-phenyl-D-phenylalanyl-N-propyl-L-prolinamide
Homo sapiens
-
at 37C
0.0000454 - 0.0000778
DV23
0.0000129 - 0.000102
DV23K10R
0.0000075 - 0.0000101
DV24
0.0000482 - 0.000141
DV24H12A
0.0000014 - 0.0000078
DV24K10RY
0.000007 - 0.000012
DV24K10RYphos
0.0000087 - 0.0000124
DV24Yphos
0.0000017 - 0.000002
DV24Ysulf
0.0000162 - 0.000177
EP21
0.0000131 - 0.000173
EP25
0.0000135 - 0.000124
EP25A22E
0.0007
glycosaminoglycan AD17
Bos taurus
-
-
-
0.00429
glycosaminoglycan AD4, glycosaminoglycan AD9, glycosaminoglycan AE11
Bos taurus
-
IC50 above 0.00429 mM
-
0.0025
glycosaminoglycan AE15
Bos taurus
-
-
-
0.00092
glycosaminoglycan AE29
Bos taurus
-
-
-
0.00429
glycosaminoglycan AE6
Bos taurus
-
IC50 above 0.00429 mM
-
0.00095
glycosaminoglycan CS-D
Bos taurus
-
-
-
0.0001
glycosaminoglycan CS-E
Bos taurus
-
-
-
0.00015
glycosaminoglycan DE17
Bos taurus
-
-
-
0.00055
glycosaminoglycan DE2
Bos taurus
-
-
-
0.00025
glycosaminoglycan DE9
Bos taurus
-
-
-
0.071
hinokiflavone
Bos taurus
-
pH and temperature not specified in the publication
0.0000726 - 0.000102
hirulog-1
0.246
isorhamnetin
Bos taurus
-
pH and temperature not specified in the publication
0.109
kaempferol
Bos taurus
-
pH and temperature not specified in the publication
0.052
kaempferol 3-O-(2',4'-di-(E)-p-coumaroyl)-rhamnoside
Bos taurus
-
pH and temperature not specified in the publication
-
0.083
kaempferol 3-O-(2'-p-coumaroyl)-rhamnoside
Bos taurus
-
pH and temperature not specified in the publication
-
0.052
luteolin
Bos taurus
-
pH and temperature not specified in the publication
0.0000109 - 0.0000117
MH18
0.000328 - 0.000343
MH18H12A
0.0000012 - 0.0000013
MH18Ysulf
0.0000115 - 0.0000123
MH22
0.0000136 - 0.0000156
MH22A22E
0.006
myricetin
Bos taurus
-
pH and temperature not specified in the publication
0.307
N-(4-carbamimidoylbenzyl)-2-(1-[[(4-chloro-2-methoxyphenyl)sulfonyl]amino]-4-methyl-2-oxo-1,2-dihydropyridin-3-yl)acetamide
Homo sapiens
-
-
0.092
N-(4-carbamimidoylbenzyl)-2-(1-[[2-(2,5-dimethylphenyl)ethyl]amino]-4-methyl-2-oxo-1,2-dihydropyridin-3-yl)acetamide
Homo sapiens
-
-
0.023
N-(4-carbamimidoylbenzyl)-2-(4-methyl-1-[[2-(2-methylphenyl)ethyl]amino]-2-oxo-1,2-dihydropyridin-3-yl)acetamide
Homo sapiens
-
-
0.091
N-(4-carbamimidoylbenzyl)-2-[4-methyl-2-oxo-1-[(2-phenylethyl)amino]-1,2-dihydropyridin-3-yl]acetamide
Homo sapiens
-
-
0.035
quercetin
Bos taurus
-
pH and temperature not specified in the publication
0.0000002
thrombin inhibitor from Naja haje
Bos taurus
-
in 10 mM imidazole buffer (pH 7.4), at 37C
-
0.00000825 - 0.0000104
variegin