3.4.21.5: thrombin

This is an abbreviated version, for detailed information about thrombin, go to the full flat file.

Reaction

selective cleavage of Arg-/-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B =

Synonyms

activated factor II, alpha-thrombin, alphaTh, beta-thrombin, blood-coagulation factor II, activated, blood-coagulation factor IIa, clotting factor IIa, EC 3.4.4.13, factor IIa, fibrinogenase, thrombase, thrombin, E, thrombin-C, thrombofort, topical, tropostasin

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.21 Serine endopeptidases
                3.4.21.5 thrombin

Renatured

Renatured on EC 3.4.21.5 - thrombin

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Renatured/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
denaturation by urea, 60% reversible at pH 8.0, completely reversible at pH 6.5. Na+-bound form of enzyme is more stable to urea denaturation than Na+-free form by 2 kcal/mol