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3.4.21.5: thrombin

This is an abbreviated version!
For detailed information about thrombin, go to the full flat file.

Word Map on EC 3.4.21.5

Reaction

selective cleavage of Arg-/-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B =

Synonyms

activated factor II, alpha-thrombin, alphaTh, beta-thrombin, blood-coagulation factor II, activated, blood-coagulation factor IIa, clotting factor IIa, EC 3.4.4.13, factor IIa, fibrinogenase, thrombase, thrombin, E, thrombin-C, thrombofort, TLE2, topical, tropostasin

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.21 Serine endopeptidases
                3.4.21.5 thrombin

Expression

Expression on EC 3.4.21.5 - thrombin

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
activated protein C down-regulates thrombin formation through proteolytic inactivation of factor Va by cleavage at Arg506 and Arg306 and of factor VIIIa by cleavage at Arg336 and Arg562
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binding of immunoglobulin G to the Fc receptors of the thrombocytes is paralleled by increased synthesis of thrombin
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enhancement of thrombin-stimulated migration and gene expression by high glucose, which can be abolished by endogenous protease-activated receptor-4, PAR-4, knockdown
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oxidative stress or cell signaling perturbations lead to increased expression of thrombin mRNA in brain endothelial cells
sucrose octasulfate suppresses ex vivo thrombin generation in human plasma both in an heparin cofactor II-dependent and -independent process, the latter possibly involving inhibition of prothrombin activation
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