3.4.21.118: kallikrein 8
This is an abbreviated version!
For detailed information about kallikrein 8, go to the full flat file.
Word Map on EC 3.4.21.118
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3.4.21.118
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kallikreins
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klk8
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melanopsin
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desquamation
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photopigment
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iprgcs
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non-visual
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peropsin
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medicine
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biotechnology
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molecular biology
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pharmacology
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analysis
- 3.4.21.118
- kallikreins
- klk8
- melanopsin
-
desquamation
-
photopigment
-
iprgcs
-
non-visual
-
peropsin
- medicine
- biotechnology
- molecular biology
- pharmacology
- analysis
Reaction
cleavage of amide substrates following the basic amino acids Arg or Lys at the P1 position, with a preference for Arg over Lys =
Synonyms
Alzheimers associated protease, brain serine protease 1, GK-8, hK8, kallikrein 8, kallikrein 8 protease, kallikrein-8, kallikrein-related peptidase, kallikrein-related peptidase 8, kallikrein-related peptidase-8, KLK8, KRP/hK8, mK8, neuropsin, NP, ovasin, P1 kallikrein, PRSS19, RGK-8, S01.244, TADG-14, TADG14, tissue kallikrein, type I neuropsin, type II neuropsin
ECTree
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KM Value
KM Value on EC 3.4.21.118 - kallikrein 8
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0.4312
benzyloxycarbonyl-Gly-Gly-Arg-7-amido-4-methylcoumarin
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in 100 mM sodium phosphate, 0.01% (v/v) Tween 20, pH 8.5, at 37°C
0.07
benzyloxycarbonyl-L-Val-L-Val-L-Arg-7-amido-4-methylcoumarin
37°C, pH 8.0
8.36
Pro-Phe-Arg-4-methylcoumaryl-7-amide
recombinant wild-type enzyme, pH 8.0, 25°C
0.1533
Pro-Phe-Arg-7-amido-4-methylcoumarin
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in 100 mM sodium phosphate, 0.01% (v/v) Tween 20, pH 8.5, at 37°C
0.1
t-butyloxycarbonyl-L-Leu-L-Lys-L-Arg-7-amido-4-methylcoumarin
37°C, pH 8.0
0.07
t-butyloxycarbonyl-L-Phe-L-Ser-L-Arg-7-amido-4-methylcoumarin
37°C, pH 8.0
0.1
t-butyloxycarbonyl-L-Val-L-Leu-L-Lys-7-amido-4-methylcoumarin
37°C, pH 8.0
0.07
t-butyloxycarbonyl-L-Val-L-Pro-L-Arg-7-amido-4-methylcoumarin
37°C, pH 8.0
0.32
tert-butyloxycarbonyl-Asp(benzyloxy)-Pro-Arg-4-methylcoumaryl-7-amide
recombinant wild-type enzyme, pH 8.0, 25°C
0.34
tert-butyloxycarbonyl-Asp-Pro-Arg-4-methylcoumaryl-7-amide
recombinant enzyme, pH 8.0, 37°C
0.1844
tert-butyloxycarbonyl-Gln-Ala-Arg-7-amido-4-methylcoumarin
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in 100 mM sodium phosphate, 0.01% (v/v) Tween 20, pH 8.5, at 37°C
0.2247
tert-butyloxycarbonyl-Gln-Arg-Arg-7-amido-4-methylcoumarin
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in 100 mM sodium phosphate, 0.01% (v/v) Tween 20, pH 8.5, at 37°C
0.3699
tert-butyloxycarbonyl-Gln-Gly-Arg-7-amido-4-methylcoumarin
-
in 100 mM sodium phosphate, 0.01% (v/v) Tween 20, pH 8.5, at 37°C
0.1165
tert-butyloxycarbonyl-Leu-Arg-Arg-7-amido-4-methylcoumarin
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in 100 mM sodium phosphate, 0.01% (v/v) Tween 20, pH 8.5, at 37°C
0.1407
tert-butyloxycarbonyl-Leu-Lys-Arg-7-amido-4-methylcoumarin
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in 100 mM sodium phosphate, 0.01% (v/v) Tween 20, pH 8.5, at 37°C
0.2983
tert-butyloxycarbonyl-Phe-Ser-Arg-7-amido-4-methylcoumarin
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in 100 mM sodium phosphate, 0.01% (v/v) Tween 20, pH 8.5, at 37°C
0.3326
tert-butyloxycarbonyl-Val-Leu-Lys-7-amido-4-methylcoumarin
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in 100 mM sodium phosphate, 0.01% (v/v) Tween 20, pH 8.5, at 37°C
0.0238
tert-butyloxycarbonyl-Val-Pro-Arg-7-amido-4-methylcoumarin
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in 100 mM sodium phosphate, 0.01% (v/v) Tween 20, pH 8.5, at 37°C
0.6897
tosyl-Gly-Pro-Arg-7-amido-4-methylcoumarin
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in 100 mM sodium phosphate, 0.01% (v/v) Tween 20, pH 8.5, at 37°C
0.22
recombinant wild-type enzyme, pH 8.0, 25°C
0.5
tert-butyloxycarbonyl-Phe-Ser-Arg-4-methylcoumaryl-7-amide
recombinant enzyme, pH 8.0, 37°C
0.54
tert-butyloxycarbonyl-Phe-Ser-Arg-4-methylcoumaryl-7-amide
native enzyme, pH 8.0, 37°C
0.27
recombinant enzyme, pH 8.0, 37°C
0.28
tert-butyloxycarbonyl-Val-Pro-Arg-4-methylcoumaryl-7-amide
recombinant wild-type enzyme, pH 8.0, 25°C
0.3
tert-butyloxycarbonyl-Val-Pro-Arg-4-methylcoumaryl-7-amide
native enzyme, pH 8.0, 37°C