3.4.21.118: kallikrein 8

This is an abbreviated version!
For detailed information about kallikrein 8, go to the full flat file.

Word Map on EC 3.4.21.118

3.4.21.118

kallikreins

klk8

melanopsin

desquamation

photopigment

iprgcs

non-visual

peropsin

medicine

biotechnology

molecular biology

pharmacology

analysis

Reaction

cleavage of amide substrates following the basic amino acids Arg or Lys at the P1 position, with a preference for Arg over Lys =

Synonyms

Alzheimers associated protease, brain serine protease 1, GK-8, hK8, kallikrein 8, kallikrein 8 protease, kallikrein-8, kallikrein-related peptidase, kallikrein-related peptidase 8, kallikrein-related peptidase-8, KLK8, KRP/hK8, mK8, neuropsin, NP, ovasin, P1 kallikrein, PRSS19, RGK-8, S01.244, TADG-14, TADG14, tissue kallikrein, type I neuropsin, type II neuropsin

ECTree

3 Hydrolases

3.4 Acting on peptide bonds (peptidases)

3.4.21 Serine endopeptidases

3.4.21.118 kallikrein 8

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Results	in table
6	Activating Compound
7	AA Sequence
14	Application
2	CAS Registry Number
13	Cloned(Commentary)
2	Crystallization (Commentary)
352	Disease/ Diagnostics
7	Expression
9	General Information
1	General Stability
45	Inhibitors
11	kcat/KM [mM/s]
1	Ki Value [mM]
28	KM Value [mM]
11	Localization
6	Metals/Ions
10	Molecular Weight [Da]
21	Natural Substrates/ Products (Substrates)
1	Organic Solvent Stability
198	Organism
5	PDB ID
9	pH Optimum
3	pH Range
8	Posttranslational Modification
17	Protein Variants
7	Purification (Commentary)
11	Reaction
2	Reaction Type
51	Reference
88	Source Tissue
3	Specific Activity [micromol/min/mg]
3	Storage Stability
116	Substrates and Products (Substrate)
8	Subunits
70	Synonyms
6	Temperature Optimum [°C]
21	Turnover Number [1/s]

Expression

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Expression on EC 3.4.21.118 - kallikrein 8

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expression of Klk8 in the imiquimod-treated skin is significantly higher than that in untreated skin

Mus musculus

Q61955

753510

KLK8 expression is increased 4fold in cell lines with overexpressing urinary type plasminogen activator and receptor versus cell lines with silencing of urinary type plasminogen activator and receptor

2 entries

KLK8 protein expression increases during terminal keratinocyte differentiation

Homo sapiens

717863

neuropsin is upregulated in the epidermis of sodium lauryl sulfate-treated mouse skin

Mus musculus

707907

oligodendrocytes only express Klk8 mRNA after injury to the central nervous system

Mus musculus

707620

skin inflammation increases KLK8/neuropsin expression in the stratum spinosum

Homo sapiens

707907