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3.4.21.118: kallikrein 8

This is an abbreviated version!
For detailed information about kallikrein 8, go to the full flat file.

Word Map on EC 3.4.21.118

Reaction

cleavage of amide substrates following the basic amino acids Arg or Lys at the P1 position, with a preference for Arg over Lys =

Synonyms

Alzheimers associated protease, brain serine protease 1, GK-8, hK8, kallikrein 8, kallikrein 8 protease, kallikrein-8, kallikrein-related peptidase, kallikrein-related peptidase 8, kallikrein-related peptidase-8, KLK8, KRP/hK8, mK8, neuropsin, NP, ovasin, P1 kallikrein, PRSS19, RGK-8, S01.244, TADG-14, TADG14, tissue kallikrein, type I neuropsin, type II neuropsin

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.21 Serine endopeptidases
                3.4.21.118 kallikrein 8

Cloned

Cloned on EC 3.4.21.118 - kallikrein 8

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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
DNA sequence determination and analysis
expressed in Pichia pastoris strain GS115
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expression and secretion of wild-type and mutants from Neuro2a cells
gene KLK6, genetic organization and structure of the kallikrein gene family, clustered on chromosome 19q13.3-q13.4
gene KLK8, genetic organization and structure of the kallikrein gene family, clustered on chromosome 19q13.3-q13.4
into the expression cosmid cassette pAxCAwt as a transfer vector for adenovirus preparation, transfection into primary keratinocyte cultures from the skin of Klk8-/- mice
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KLK8 splice variants K8-2 and K8-R amplified and inserted into the pLNCX retroviral vector, CL1-5 cells transfected with each KLK8 splice variant. Expression of hK8 in s.c. tumors in SCID mice by injection of SCID mice s.c. with CL1-5/K8-2 or CL1-5/K8-R cells
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overexpression of proneuropsin in Spodoptera frugiperda insect cells via baculovirus infection
recombinant KLK 8 type II is expressed using the baculovirus insect cell system
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