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BRENDA support

3.4.21.118: kallikrein 8

This is an abbreviated version!
For detailed information about kallikrein 8, go to the full flat file.

Word Map on EC 3.4.21.118

Reaction

cleavage of amide substrates following the basic amino acids Arg or Lys at the P1 position, with a preference for Arg over Lys =

Synonyms

Alzheimers associated protease, brain serine protease 1, GK-8, hK8, kallikrein 8, kallikrein 8 protease, kallikrein-8, kallikrein-related peptidase, kallikrein-related peptidase 8, kallikrein-related peptidase-8, KLK8, KRP/hK8, mK8, neuropsin, NP, ovasin, P1 kallikrein, PRSS19, RGK-8, S01.244, TADG-14, TADG14, tissue kallikrein, type I neuropsin, type II neuropsin

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.21 Serine endopeptidases
                3.4.21.118 kallikrein 8

Source Tissue

Source Tissue on EC 3.4.21.118 - kallikrein 8

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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
primary cardiomyocyte
Manually annotated by BRENDA team
-
expression in embryo brain samples
Manually annotated by BRENDA team
-
epithelial ovarian tumor
Manually annotated by BRENDA team
epidermis, keratinocytes
Manually annotated by BRENDA team
KLK8 expression is upregulated in left ventricle of cardiac hypertrophy models
Manually annotated by BRENDA team
in the hippocampal CA1-CA3 subfields
Manually annotated by BRENDA team
-
oligodendrocytes only express Klk8 mRNA after injury to the central nervous system
Manually annotated by BRENDA team
-
epithelial ovarian tumor
Manually annotated by BRENDA team
low activity in nonpregnant uteri, increased activity in pregnant uteri, highest at midgestational period
Manually annotated by BRENDA team
additional information