3.4.21.118: kallikrein 8
This is an abbreviated version!
For detailed information about kallikrein 8, go to the full flat file.
Word Map on EC 3.4.21.118
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3.4.21.118
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kallikreins
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klk8
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melanopsin
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desquamation
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photopigment
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iprgcs
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non-visual
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peropsin
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medicine
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biotechnology
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molecular biology
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pharmacology
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analysis
- 3.4.21.118
- kallikreins
- klk8
- melanopsin
-
desquamation
-
photopigment
-
iprgcs
-
non-visual
-
peropsin
- medicine
- biotechnology
- molecular biology
- pharmacology
- analysis
Reaction
cleavage of amide substrates following the basic amino acids Arg or Lys at the P1 position, with a preference for Arg over Lys =
Synonyms
Alzheimers associated protease, brain serine protease 1, GK-8, hK8, kallikrein 8, kallikrein 8 protease, kallikrein-8, kallikrein-related peptidase, kallikrein-related peptidase 8, kallikrein-related peptidase-8, KLK8, KRP/hK8, mK8, neuropsin, NP, ovasin, P1 kallikrein, PRSS19, RGK-8, S01.244, TADG-14, TADG14, tissue kallikrein, type I neuropsin, type II neuropsin
ECTree
3.4.21.118 kallikrein 8Advanced search results
results (
results (Engineering
Engineering on EC 3.4.21.118 - kallikrein 8
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PROTEIN VARIANTS 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
medicine
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enzyme expression in epithelial ovarian tumors correlates significantly with favorable patient survival. Use of enzyme as a prognostic marker in patients with ovarian cancer
C108S
oligonucleotide-directed mutagenesis, reduced Km, increased kcat, increased activity with substrate tert-butyloxycarbonyl-Val-Pro-Arg-4-methylcoumaryl-7-amide
C145S
oligonucleotide-directed mutagenesis of disulfide bond SS3, reduced Km and kcat, increased activity with substrate tert-butyloxycarbonyl-Val-Pro-Arg-4-methylcoumaryl-7-amide
C208S
oligonucleotide-directed mutagenesis of disulfide bond SS6, highly reduced Km and reduced kcat, increased activity with substrate tert-butyloxycarbonyl-Val-Pro-Arg-4-methylcoumaryl-7-amide
C233S
oligonucleotide-directed mutagenesis, highly reduced Km and slightly reduced kcat, reduced activity with substrate tert-butyloxycarbonyl-Val-Pro-Arg-4-methylcoumaryl-7-amide
C246S
oligonucleotide-directed mutagenesis, reduced Km and kcat, decreased activity with substrate tert-butyloxycarbonyl-Val-Pro-Arg-4-methylcoumaryl-7-amide
C39S
oligonucleotide-directed mutagenesis of disulfide bond SS1, increased Km, reduced kcat, reduced activity with substrate tert-butyloxycarbonyl-Val-Pro-Arg-4-methylcoumaryl-7-amide
C7S
oligonucleotide-directed mutagenesis, reduced Km and kcat, slightly decreased activity with substrate tert-butyloxycarbonyl-Val-Pro-Arg-4-methylcoumaryl-7-amide
D206V
oligonucleotide-directed mutagenesis, reduced Km and highly reduced kcat, decreased activity with substrate tert-butyloxycarbonyl-Val-Pro-Arg-7-amino-4-methylcoumarin
N110A
oligonucleotide-directed mutagenesis, reduced Km and kcat, slightly increased activity with substrate tert-butyloxycarbonyl-Val-Pro-Arg-4-methylcoumaryl-7-amide
additional information
additional information
a human-specific T to A mutation triggers the change of splicing pattern. Mutation is not only necessary but also sufficient for type II expression
additional information
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a human-specific T to A mutation triggers the change of splicing pattern. Mutation is not only necessary but also sufficient for type II expression
additional information
additional deletion N113-E115 in mutant N110S: decreased kcat and Km, increased activity with substrate tert-butyloxycarbonyl-Val-Pro-Arg-4-methylcoumaryl-7-amide
additional information
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additional deletion N113-E115 in mutant N110S: decreased kcat and Km, increased activity with substrate tert-butyloxycarbonyl-Val-Pro-Arg-4-methylcoumaryl-7-amide
additional information
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enzyme knock-out mice are significantly impaired in the Morris water maze and Y-mazes and fail to exhibit early phase long-term potentiation by a single tetanus. A dose of recombinant enzyme alone, without tetanic stimulation, elicits either long-lasting potentiation or depression, depending on the dose, by increase of phosphorylation at different sites on the GluR1 subunit of the AMPA receptor
additional information
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enzyme-deficient mouse, number of L1-immunoreactive boutons is markedly higher than in wild-type, their number reverts to wild-type level upon microinjection of enzyme. L1-immunoreactive boutons are hypertrophied in the mutant
additional information
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Klk8-/- mice, show less proliferation and an increase in the number of cell layers in the stratum corneum. Inefficient cleavage of adhesion molecules DSG1 and CDSN in Klk8-/- skin, which contributes to a delay in corneocyte shedding, resulting in hyperkeratosis phenotype
additional information
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neuropsin-deficient mice, are significantly impaired in hippocampus-dependent behavioral memory. Synaptic late associativity is impaired
additional information
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Klk8-/- mice, show less proliferation and an increase in the number of cell layers in the stratum corneum. Inefficient cleavage of adhesion molecules DSG1 and CDSN in Klk8-/- skin, which contributes to a delay in corneocyte shedding, resulting in hyperkeratosis phenotype
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