3.4.21.118: kallikrein 8

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For detailed information about kallikrein 8, go to the full flat file.

Reaction

cleavage of amide substrates following the basic amino acids Arg or Lys at the P1 position, with a preference for Arg over Lys =

Synonyms

Alzheimers associated protease, brain serine protease 1, GK-8, hK8, kallikrein 8, kallikrein 8 protease, kallikrein-8, kallikrein-related peptidase, kallikrein-related peptidase 8, kallikrein-related peptidase-8, KLK8, KRP/hK8, mK8, neuropsin, NP, ovasin, P1 kallikrein, PRSS19, RGK-8, S01.244, TADG-14, TADG14, tissue kallikrein, type I neuropsin, type II neuropsin

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.21 Serine endopeptidases

                3.4.21.118 kallikrein 8

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6	Activating Compound
7	AA Sequence
14	Application
2	CAS Registry Number
13	Cloned(Commentary)
2	Crystallization (Commentary)
352	Disease/ Diagnostics
7	Expression
9	General Information
1	General Stability
45	Inhibitors
11	kcat/KM [mM/s]
1	Ki Value [mM]
28	KM Value [mM]
11	Localization
6	Metals/Ions
10	Molecular Weight [Da]
21	Natural Substrates/ Products (Substrates)
1	Organic Solvent Stability
198	Organism
5	PDB ID
9	pH Optimum
3	pH Range
8	Posttranslational Modification
17	Protein Variants
7	Purification (Commentary)
11	Reaction
2	Reaction Type
51	Reference
88	Source Tissue
3	Specific Activity [micromol/min/mg]
3	Storage Stability
116	Substrates and Products (Substrate)
8	Subunits
70	Synonyms
6	Temperature Optimum [°C]
21	Turnover Number [1/s]

Reaction

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Reaction on EC 3.4.21.118 - kallikrein 8

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REACTION

REACTION DIAGRAM

COMMENTARY

ORGANISM

UNIPROT

LITERATURE

cleavage of amide substrates following the basic amino acids Arg or Lys at the P1 position, with a preference for Arg over Lys

11 entries

cleavage of amide substrates following the basic amino acids Arg or Lys at the P1 position, with a preference for Arg over Lys

substrate binding pocket contains an Asp residue

Homo sapiens

O60259

647332

cleavage of amide substrates following the basic amino acids Arg or Lys at the P1 position, with a preference for Arg over Lys

enzyme is a trypsin-type serine protease

Mus musculus

Q61955

647321, 647323

cleavage of amide substrates following the basic amino acids Arg or Lys at the P1 position, with a preference for Arg over Lys

enzyme is a trypsin-type serine protease

Mus musculus

-

647323

cleavage of amide substrates following the basic amino acids Arg or Lys at the P1 position, with a preference for Arg over Lys

enzyme is a trypsin-type serine protease

Mus musculus

Q61955

647325, 647326

cleavage of amide substrates following the basic amino acids Arg or Lys at the P1 position, with a preference for Arg over Lys

enzyme is a trypsin-type serine protease

Mus musculus

-

647326

cleavage of amide substrates following the basic amino acids Arg or Lys at the P1 position, with a preference for Arg over Lys

enzyme is a trypsin-type serine protease

Mus musculus

Q61955

647329

cleavage of amide substrates following the basic amino acids Arg or Lys at the P1 position, with a preference for Arg over Lys

enzyme is a trypsin-type serine protease

Homo sapiens

O60259

647324

cleavage of amide substrates following the basic amino acids Arg or Lys at the P1 position, with a preference for Arg over Lys

substrate binding site structure defining the specificity for Arg and Lys in the S1 pocket

Mus musculus

Q61955

647325

cleavage of amide substrates following the basic amino acids Arg or Lys at the P1 position, with a preference for Arg over Lys

the ordered kallikrein loop projects proline towards the active site to restrict smaller residues or proline at the P2 position of substrates

Mus musculus

Q61955

647325

cleavage of amide substrates following the basic amino acids Arg or Lys at the P1 position, with a preference for Arg over Lys

kallikrein k8 exhibit a marked preference for cleavage downstream of Arg residues

Rattus norvegicus

-

647331

cleavage of amide substrates following the basic amino acids Arg or Lys at the P1 position, with a preference for Arg over Lys

-

-

-

-