3.4.21.118: kallikrein 8
This is an abbreviated version!
For detailed information about kallikrein 8, go to the full flat file.
Word Map on EC 3.4.21.118
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3.4.21.118
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kallikreins
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klk8
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melanopsin
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desquamation
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photopigment
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iprgcs
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non-visual
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peropsin
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medicine
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biotechnology
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molecular biology
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pharmacology
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analysis
- 3.4.21.118
- kallikreins
- klk8
- melanopsin
-
desquamation
-
photopigment
-
iprgcs
-
non-visual
-
peropsin
- medicine
- biotechnology
- molecular biology
- pharmacology
- analysis
Reaction
cleavage of amide substrates following the basic amino acids Arg or Lys at the P1 position, with a preference for Arg over Lys =
Synonyms
Alzheimers associated protease, brain serine protease 1, GK-8, hK8, kallikrein 8, kallikrein 8 protease, kallikrein-8, kallikrein-related peptidase, kallikrein-related peptidase 8, kallikrein-related peptidase-8, KLK8, KRP/hK8, mK8, neuropsin, NP, ovasin, P1 kallikrein, PRSS19, RGK-8, S01.244, TADG-14, TADG14, tissue kallikrein, type I neuropsin, type II neuropsin
ECTree
3.4.21.118 kallikrein 8Advanced search results
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results (Natural Substrates Products
Natural Substrates Products on EC 3.4.21.118 - kallikrein 8
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
Fibronectin + H2O
?
affects cell adhesion or cell migration by modulating the content and/or chemical characteristics of fibronectin in the extracellular matrix
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?
LL-37 antimicrobial peptide + H2O
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i.e. LLGDFFRKSKEKIGKEFKRIVQRIKDFLRNLVPRTES
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?
polypeptide + H2O
peptides
enzyme has significant limbic effects by changing the extracellular matrix environment
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?
polypeptide + H2O
peptides
enzyme is implicated in various neurological processes including formation of memory
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?
additional information
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enzyme might be involved in ovarian cancer, brain damage and kindling epilepsy
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?
additional information
?
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enzyme may be impicated in extracellular matrix protein degradation in the area surrounding enzyme producing cells
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?
additional information
?
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enzyme may be impicated in extracellular matrix protein degradation in the area surrounding enzyme producing cells
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?
additional information
?
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enzyme is involved in the synaptogenesis/maturation of orphan and small synaptic boutons in the Schaffer-collateral pathway
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?
additional information
?
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enzyme is necessary for establishment of long-term potentiation and has a significant role in memory acquisition
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?
